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The map label for this gene is aerA [H]

Identifier: 160874711

GI number: 160874711

Start: 1922428

End: 1923627

Strand: Reverse

Name: aerA [H]

Synonym: Sbal195_1594

Alternate gene names: 160874711

Gene position: 1923627-1922428 (Counterclockwise)

Preceding gene: 160874712

Following gene: 160874702

Centisome position: 35.97

GC content: 42.25

Gene sequence:

>1200_bases
ATGGTAGAACACGCTGCCCCTGATCTTGATTCGCTTAAAAATGATGCGATTAACGATCCCTCGTTTATCAGCTCGTTATT
CTCCTTGGGACACCATCTTGGATATGCATGGGCTGGCGGTACGGCATCCCAGTATGTTGGTGAAGACATCGAAGTCAGAA
GAGAATCGAGCAACGAATACAGTCTTAAAGCCCGCTATAACGGCAATGATCCTTATGCAAGCGGATACAGAGCGAATGAA
CGTTTGAAGGTGAATTTGCAAAATATCCATTTCGTGACTAATCCTCAAAGCCTAAAGTTAGGTTCACCTCAAGTTTATGA
TCGTGAAGCTATTTATACCGCTCCCGTAGTGATTTACAACTGGGGCGATACCGAAGATACCGGTGTAGCCACCCTAAACT
ATGATTACACCACTAGCTGGGCCAAAACCGATAATTTCTCCTTCTCCGAGAAAATTGGCGTAACCAATAAATATGAAGTG
GGTATTCCAGGAATAGGTGGAGCGAGTTCTGAAATCAGTGCCGAATTTTCCGCCAGCCAAGGTTGGAGTGAAACCGACGG
CAAAAGTACAACGATTTCAAGTCAGGCACAGTACCGCGCAATTATGCCGCCTCGCAGCAAACGTTATATCTCAATCACTC
TGTTTAAACAAAAGGCAGATGTTCCATACACCTCAAGTTTATATATGATGTACGATATAAAATATGAGAACTTCTTAAAA
TGGGGAGGTAATGCGCATATTAATCATCCAACAAACAGACCTAACTTCCCTTACACCTTTGGCGGAGCGAATGCGAATGC
GAATGCGAATGCGAATAATCTTAATGGGCCAGAAGCCTTAGTCGATCAATATCTTCATCAAGATATAAATGGTTATGGTG
TATGGGATTGGCCTGCTGCGATTAGTTCTGCACAGTCAAAAAGTGGCTTTGAGTGGCAATTGGCGAATATAGTTAGACAA
CATGGCGCACCAATCAGCGGTAAATTTACCGCAATAGATTCGAGTCAATTTAATATCGATGCCAGTGAATCCTATCCGCT
AACGGATGAAGACATTGCTAATCGTCCTAAAAGCGCTCAAAAATTAGGACTGAGTCGTAATATTCAAGTTGCCGTCGGCG
AAATCCAAAATAATGATGAAGATGGTTTAATCAAAAAACTGAATATTTCGCAATCAAGCGAAGTCATGTTAAACAATTAA

Upstream 100 bases:

>100_bases
CCAGCAAACCAACCAAGATAAGAAAAGCTGCATGGAATGGCGATTTTAGGAGCGAGATTTTCTTTGGTTAAGAGATTTAA
CAAAGCTTAATCCCGCCCTG

Downstream 100 bases:

>100_bases
AATGGTGAGCTTAGGCTCTTAATGACAGCTCTGACACGAGTATCAGAGAGATCTAGATACAACTAGCGAATTACTAGAAT
GTTACTAGCAAATTAGAAAT

Product: Aerolysin/hemolysin/leukocidin toxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MVEHAAPDLDSLKNDAINDPSFISSLFSLGHHLGYAWAGGTASQYVGEDIEVRRESSNEYSLKARYNGNDPYASGYRANE
RLKVNLQNIHFVTNPQSLKLGSPQVYDREAIYTAPVVIYNWGDTEDTGVATLNYDYTTSWAKTDNFSFSEKIGVTNKYEV
GIPGIGGASSEISAEFSASQGWSETDGKSTTISSQAQYRAIMPPRSKRYISITLFKQKADVPYTSSLYMMYDIKYENFLK
WGGNAHINHPTNRPNFPYTFGGANANANANANNLNGPEALVDQYLHQDINGYGVWDWPAAISSAQSKSGFEWQLANIVRQ
HGAPISGKFTAIDSSQFNIDASESYPLTDEDIANRPKSAQKLGLSRNIQVAVGEIQNNDEDGLIKKLNISQSSEVMLNN

Sequences:

>Translated_399_residues
MVEHAAPDLDSLKNDAINDPSFISSLFSLGHHLGYAWAGGTASQYVGEDIEVRRESSNEYSLKARYNGNDPYASGYRANE
RLKVNLQNIHFVTNPQSLKLGSPQVYDREAIYTAPVVIYNWGDTEDTGVATLNYDYTTSWAKTDNFSFSEKIGVTNKYEV
GIPGIGGASSEISAEFSASQGWSETDGKSTTISSQAQYRAIMPPRSKRYISITLFKQKADVPYTSSLYMMYDIKYENFLK
WGGNAHINHPTNRPNFPYTFGGANANANANANNLNGPEALVDQYLHQDINGYGVWDWPAAISSAQSKSGFEWQLANIVRQ
HGAPISGKFTAIDSSQFNIDASESYPLTDEDIANRPKSAQKLGLSRNIQVAVGEIQNNDEDGLIKKLNISQSSEVMLNN
>Mature_399_residues
MVEHAAPDLDSLKNDAINDPSFISSLFSLGHHLGYAWAGGTASQYVGEDIEVRRESSNEYSLKARYNGNDPYASGYRANE
RLKVNLQNIHFVTNPQSLKLGSPQVYDREAIYTAPVVIYNWGDTEDTGVATLNYDYTTSWAKTDNFSFSEKIGVTNKYEV
GIPGIGGASSEISAEFSASQGWSETDGKSTTISSQAQYRAIMPPRSKRYISITLFKQKADVPYTSSLYMMYDIKYENFLK
WGGNAHINHPTNRPNFPYTFGGANANANANANNLNGPEALVDQYLHQDINGYGVWDWPAAISSAQSKSGFEWQLANIVRQ
HGAPISGKFTAIDSSQFNIDASESYPLTDEDIANRPKSAQKLGLSRNIQVAVGEIQNNDEDGLIKKLNISQSSEVMLNN

Specific function: Aerolysin is a cytolytic toxin exported by the Gram negative Aeromonas bacteria. The mature toxin binds to eukaryotic cells and aggregates to form holes approximatively 3 nm in diameter, leading to destruction of the membrane permeability barrier and osmo

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Host cell membrane [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerolysin family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005832
- InterPro:   IPR005831
- InterPro:   IPR005830
- InterPro:   IPR005138
- InterPro:   IPR016187 [H]

Pfam domain/function: PF01117 Aerolysin; PF03440 APT [H]

EC number: NA

Molecular weight: Translated: 44041; Mature: 44041

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEHAAPDLDSLKNDAINDPSFISSLFSLGHHLGYAWAGGTASQYVGEDIEVRRESSNEY
CCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCEEECCCCHHHHCCCCCEEEECCCCCE
SLKARYNGNDPYASGYRANERLKVNLQNIHFVTNPQSLKLGSPQVYDREAIYTAPVVIYN
EEEEEECCCCCCCCCCCCCCEEEEEEEEEEEEECCCCEECCCCCCCCCCEEEECCEEEEE
WGDTEDTGVATLNYDYTTSWAKTDNFSFSEKIGVTNKYEVGIPGIGGASSEISAEFSASQ
CCCCCCCCEEEEECCCCCCCCCCCCCCCHHHCCCCCEEEECCCCCCCCCCCCEEEECCCC
GWSETDGKSTTISSQAQYRAIMPPRSKRYISITLFKQKADVPYTSSLYMMYDIKYENFLK
CCCCCCCCCEEECCCCCEEEECCCCCCCEEEEEEEEECCCCCCCCCEEEEEEECHHHHHC
WGGNAHINHPTNRPNFPYTFGGANANANANANNLNGPEALVDQYLHQDINGYGVWDWPAA
CCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEECHHHH
ISSAQSKSGFEWQLANIVRQHGAPISGKFTAIDSSQFNIDASESYPLTDEDIANRPKSAQ
HHCCCCCCCCEEHHHHHHHHHCCCCCCEEEEECCCEEEECCCCCCCCCCHHHHCCCCHHH
KLGLSRNIQVAVGEIQNNDEDGLIKKLNISQSSEVMLNN
HCCCCCCEEEEEEECCCCCCCCEEEEECCCCCCCEEECC
>Mature Secondary Structure
MVEHAAPDLDSLKNDAINDPSFISSLFSLGHHLGYAWAGGTASQYVGEDIEVRRESSNEY
CCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCEEECCCCHHHHCCCCCEEEECCCCCE
SLKARYNGNDPYASGYRANERLKVNLQNIHFVTNPQSLKLGSPQVYDREAIYTAPVVIYN
EEEEEECCCCCCCCCCCCCCEEEEEEEEEEEEECCCCEECCCCCCCCCCEEEECCEEEEE
WGDTEDTGVATLNYDYTTSWAKTDNFSFSEKIGVTNKYEVGIPGIGGASSEISAEFSASQ
CCCCCCCCEEEEECCCCCCCCCCCCCCCHHHCCCCCEEEECCCCCCCCCCCCEEEECCCC
GWSETDGKSTTISSQAQYRAIMPPRSKRYISITLFKQKADVPYTSSLYMMYDIKYENFLK
CCCCCCCCCEEECCCCCEEEECCCCCCCEEEEEEEEECCCCCCCCCEEEEEEECHHHHHC
WGGNAHINHPTNRPNFPYTFGGANANANANANNLNGPEALVDQYLHQDINGYGVWDWPAA
CCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEECHHHH
ISSAQSKSGFEWQLANIVRQHGAPISGKFTAIDSSQFNIDASESYPLTDEDIANRPKSAQ
HHCCCCCCCCEEHHHHHHHHHCCCCCCEEEEECCCEEEECCCCCCCCCCHHHHCCCCHHH
KLGLSRNIQVAVGEIQNNDEDGLIKKLNISQSSEVMLNN
HCCCCCCEEEEEEECCCCCCCCEEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3584074; 3020368; 1382579; 8845373; 12219082; 7510043 [H]