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The map label for this gene is pgcA [H]

Identifier: 160874707

GI number: 160874707

Start: 1918661

End: 1920382

Strand: Direct

Name: pgcA [H]

Synonym: Sbal195_1590

Alternate gene names: 160874707

Gene position: 1918661-1920382 (Clockwise)

Preceding gene: 160874706

Following gene: 160874708

Centisome position: 35.88

GC content: 51.68

Gene sequence:

>1722_bases
ATGAATACCCATCTGCAGTTACAGGTAAACCATTGGCTTGAAAATGATCCTGACCCTCGCACTCAATCCCAATTACAAAC
CCTAGTCGATAGTGGCAATGAAGCCGAACTCGCGGCGCGCTTTGCCGGTCGCTTAGAGTTTGGTACCGCAGGATTACGCG
GTGTGGTCGGCGCAGGACCCATGGGGATGAACCGTCTGGTGATCCGTCAAACCTCGGCAGGCCTTGGTGCTTATCTACTT
GATCAGATTAAAGATGCTGCCGAGCGTGGTGTGGTGATTGGTTACGATGGTCGCCACGATTCATTCAATTTTGCCCATGA
TGCGGCGAGTGTGCTCACCGCTATGGGCATTAAGGTGCGCTTAACGTCTAAAGTGGCGCCGACACCGCTGGTGGCTTTTG
GGGTGAAACATTTTAATGCGGCAGCAGGCATTGTAGTGACCGCGAGTCATAACCCGCCGCAATACAATGGCTATAAAGTG
TATTGGGACAATGGCGCGCAGATTATTCCGCCCCACGATTCTGGCATTGCCGCGCAAATTGAGCGCGCCGCGAATCAAGT
GATTCCGTTTTTAGAACATGATGAGGCGGTAAAACAAGGTAAGTTAATTATTCTGCAGGACGATTTTTACCAAAGCTATC
GCCATGGCGTGCAGCACGCTGAGGTGCTGCAAAACCATACGGCTCCAGAAAAGGTCAGTTTAGCCTATACCGCCATGCAC
GGCGTGGGCGCTGAAATGGCTGAAACCGTATTGAAAGATGCGGGTTTCACCCAAGTGTATTCGGTAGCCTCCCAGCGCGA
ACCCGATGGGGATTTCCCAACGGTGAACTTCCCCAATCCGGAAGAAAAGGGCGCGATGGATTTAGTGATCGCCGAGGCGA
AAAAACACGGCGCTATGCTCGCCTGTGCCAACGATCCCGATGCCGACCGTTTTGCGGTCGCAGTGCGCCGCGATGATGGC
GAATACCAGATGCTAACGGGCGATCAAGTCGGTGTGCTCTTTGGGCATTACTTGTTATCTCACGCCAAAGATAATCAGCG
ACTTACGGGCACCACGATAGTGTCATCGAGCCTGTTATCTAAAATTGCTCAAGGTTTTGGCACGCAAAGCTTTACCACGC
TCACCGGCTTTAAGTGGCTGATGAATGTGGGTATCGCGAAAACGTCCCCTGAGGATCAGTTCCTGTTTGCCTATGAAGAA
GCCCTTGGTTACACAGTTGGCAGCATGGTGTGGGATAAAGATGGCTTGTCGGCGCTGGTGGCATTTGCCCAATTAACTGC
CGAGCTGGTGGCGAAGGGGCAAACGATTTGGGACAGACTTGAGCAAATTTACCGTGAGCATGGCTTCCATCTCAATGCGC
AGGTGAGTATTGCACTAAAACCTGACACGCCTAATATTGGCGCCTATTTACGCGAACATCCCCCTGTGAAGATTGGCGAG
CAAGACGTGCTATCAACCGATGATTTAAAAGCCCTTGAGCGTCGTTTTGCCGATGGTCGGGTTGAGAAAATCGACTTGCC
ACCGAGCGATGTATTAACCTACCGCTTAGCGGGTGGCGCTCGGGTAATCGTTAGGCCATCTGGCACTGAACCCAAAATTA
AGTGCTACTACGAAGTAGTCGAAACTATGGTCGATACAGATACCTTAGCCAACGCTCAGGCGAGGGCGAGCAAAGCCATG
GATGATTTTATTCAGGCCCATCAAGCCAGTTTGCCAAAGTAA

Upstream 100 bases:

>100_bases
AAATTAAGCCTCAGCTGATTTTGAAATTAATGCAAATTAGCTTGTTCTTCGCCGCTGTTTTTCCTAATGTGATTGCAAAT
GATTTTCAATGAGGCGTGTT

Downstream 100 bases:

>100_bases
CGCTTTTAACAGCTAAGCCAAAACCCTCAACATTCACTTTTATTAAAAGGCTACTGACATCATGCTGTCAGTAGCCTTGT
TTTATTCTTGTTGTCGCCCG

Product: phosphoglucomutase/phosphomannomutase subunit alpha/beta

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 573; Mature: 573

Protein sequence:

>573_residues
MNTHLQLQVNHWLENDPDPRTQSQLQTLVDSGNEAELAARFAGRLEFGTAGLRGVVGAGPMGMNRLVIRQTSAGLGAYLL
DQIKDAAERGVVIGYDGRHDSFNFAHDAASVLTAMGIKVRLTSKVAPTPLVAFGVKHFNAAAGIVVTASHNPPQYNGYKV
YWDNGAQIIPPHDSGIAAQIERAANQVIPFLEHDEAVKQGKLIILQDDFYQSYRHGVQHAEVLQNHTAPEKVSLAYTAMH
GVGAEMAETVLKDAGFTQVYSVASQREPDGDFPTVNFPNPEEKGAMDLVIAEAKKHGAMLACANDPDADRFAVAVRRDDG
EYQMLTGDQVGVLFGHYLLSHAKDNQRLTGTTIVSSSLLSKIAQGFGTQSFTTLTGFKWLMNVGIAKTSPEDQFLFAYEE
ALGYTVGSMVWDKDGLSALVAFAQLTAELVAKGQTIWDRLEQIYREHGFHLNAQVSIALKPDTPNIGAYLREHPPVKIGE
QDVLSTDDLKALERRFADGRVEKIDLPPSDVLTYRLAGGARVIVRPSGTEPKIKCYYEVVETMVDTDTLANAQARASKAM
DDFIQAHQASLPK

Sequences:

>Translated_573_residues
MNTHLQLQVNHWLENDPDPRTQSQLQTLVDSGNEAELAARFAGRLEFGTAGLRGVVGAGPMGMNRLVIRQTSAGLGAYLL
DQIKDAAERGVVIGYDGRHDSFNFAHDAASVLTAMGIKVRLTSKVAPTPLVAFGVKHFNAAAGIVVTASHNPPQYNGYKV
YWDNGAQIIPPHDSGIAAQIERAANQVIPFLEHDEAVKQGKLIILQDDFYQSYRHGVQHAEVLQNHTAPEKVSLAYTAMH
GVGAEMAETVLKDAGFTQVYSVASQREPDGDFPTVNFPNPEEKGAMDLVIAEAKKHGAMLACANDPDADRFAVAVRRDDG
EYQMLTGDQVGVLFGHYLLSHAKDNQRLTGTTIVSSSLLSKIAQGFGTQSFTTLTGFKWLMNVGIAKTSPEDQFLFAYEE
ALGYTVGSMVWDKDGLSALVAFAQLTAELVAKGQTIWDRLEQIYREHGFHLNAQVSIALKPDTPNIGAYLREHPPVKIGE
QDVLSTDDLKALERRFADGRVEKIDLPPSDVLTYRLAGGARVIVRPSGTEPKIKCYYEVVETMVDTDTLANAQARASKAM
DDFIQAHQASLPK
>Mature_573_residues
MNTHLQLQVNHWLENDPDPRTQSQLQTLVDSGNEAELAARFAGRLEFGTAGLRGVVGAGPMGMNRLVIRQTSAGLGAYLL
DQIKDAAERGVVIGYDGRHDSFNFAHDAASVLTAMGIKVRLTSKVAPTPLVAFGVKHFNAAAGIVVTASHNPPQYNGYKV
YWDNGAQIIPPHDSGIAAQIERAANQVIPFLEHDEAVKQGKLIILQDDFYQSYRHGVQHAEVLQNHTAPEKVSLAYTAMH
GVGAEMAETVLKDAGFTQVYSVASQREPDGDFPTVNFPNPEEKGAMDLVIAEAKKHGAMLACANDPDADRFAVAVRRDDG
EYQMLTGDQVGVLFGHYLLSHAKDNQRLTGTTIVSSSLLSKIAQGFGTQSFTTLTGFKWLMNVGIAKTSPEDQFLFAYEE
ALGYTVGSMVWDKDGLSALVAFAQLTAELVAKGQTIWDRLEQIYREHGFHLNAQVSIALKPDTPNIGAYLREHPPVKIGE
QDVLSTDDLKALERRFADGRVEKIDLPPSDVLTYRLAGGARVIVRPSGTEPKIKCYYEVVETMVDTDTLANAQARASKAM
DDFIQAHQASLPK

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=578, Percent_Identity=36.159169550173, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI31377548, Length=597, Percent_Identity=32.3283082077052, Blast_Score=297, Evalue=2e-80,
Organism=Escherichia coli, GI1789566, Length=292, Percent_Identity=26.027397260274, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71993870, Length=551, Percent_Identity=35.7531760435572, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI71993878, Length=318, Percent_Identity=36.7924528301887, Blast_Score=199, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6323934, Length=597, Percent_Identity=35.3433835845896, Blast_Score=286, Evalue=5e-78,
Organism=Drosophila melanogaster, GI20129809, Length=569, Percent_Identity=36.3796133567663, Blast_Score=322, Evalue=6e-88,
Organism=Drosophila melanogaster, GI24651977, Length=553, Percent_Identity=35.8047016274864, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24653722, Length=569, Percent_Identity=31.4586994727592, Blast_Score=259, Evalue=5e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 62483; Mature: 62483

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTHLQLQVNHWLENDPDPRTQSQLQTLVDSGNEAELAARFAGRLEFGTAGLRGVVGAGP
CCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCEECCCCCCCCCCCCC
MGMNRLVIRQTSAGLGAYLLDQIKDAAERGVVIGYDGRHDSFNFAHDAASVLTAMGIKVR
CCCCEEEEEECCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHCCEEEE
LTSKVAPTPLVAFGVKHFNAAAGIVVTASHNPPQYNGYKVYWDNGAQIIPPHDSGIAAQI
EECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCEEECCCCCCHHHHH
ERAANQVIPFLEHDEAVKQGKLIILQDDFYQSYRHGVQHAEVLQNHTAPEKVSLAYTAMH
HHHHHHCCCCCCCCHHHHCCCEEEEECHHHHHHHHCHHHHHHHHCCCCCCCEEEEEHHHH
GVGAEMAETVLKDAGFTQVYSVASQREPDGDFPTVNFPNPEEKGAMDLVIAEAKKHGAML
CCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHCCCEE
ACANDPDADRFAVAVRRDDGEYQMLTGDQVGVLFGHYLLSHAKDNQRLTGTTIVSSSLLS
EECCCCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCCEECHHHHHHHHHHH
KIAQGFGTQSFTTLTGFKWLMNVGIAKTSPEDQFLFAYEEALGYTVGSMVWDKDGLSALV
HHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHEECCCHHHHHH
AFAQLTAELVAKGQTIWDRLEQIYREHGFHLNAQVSIALKPDTPNIGAYLREHPPVKIGE
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCHHHHCCCCCCCCC
QDVLSTDDLKALERRFADGRVEKIDLPPSDVLTYRLAGGARVIVRPSGTEPKIKCYYEVV
CCCCCCHHHHHHHHHHCCCCEEEECCCCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHH
ETMVDTDTLANAQARASKAMDDFIQAHQASLPK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNTHLQLQVNHWLENDPDPRTQSQLQTLVDSGNEAELAARFAGRLEFGTAGLRGVVGAGP
CCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCEECCCCCCCCCCCCC
MGMNRLVIRQTSAGLGAYLLDQIKDAAERGVVIGYDGRHDSFNFAHDAASVLTAMGIKVR
CCCCEEEEEECCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHCCEEEE
LTSKVAPTPLVAFGVKHFNAAAGIVVTASHNPPQYNGYKVYWDNGAQIIPPHDSGIAAQI
EECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCEEECCCCCCHHHHH
ERAANQVIPFLEHDEAVKQGKLIILQDDFYQSYRHGVQHAEVLQNHTAPEKVSLAYTAMH
HHHHHHCCCCCCCCHHHHCCCEEEEECHHHHHHHHCHHHHHHHHCCCCCCCEEEEEHHHH
GVGAEMAETVLKDAGFTQVYSVASQREPDGDFPTVNFPNPEEKGAMDLVIAEAKKHGAML
CCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHCCCEE
ACANDPDADRFAVAVRRDDGEYQMLTGDQVGVLFGHYLLSHAKDNQRLTGTTIVSSSLLS
EECCCCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCCEECHHHHHHHHHHH
KIAQGFGTQSFTTLTGFKWLMNVGIAKTSPEDQFLFAYEEALGYTVGSMVWDKDGLSALV
HHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHEECCCHHHHHH
AFAQLTAELVAKGQTIWDRLEQIYREHGFHLNAQVSIALKPDTPNIGAYLREHPPVKIGE
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCHHHHCCCCCCCCC
QDVLSTDDLKALERRFADGRVEKIDLPPSDVLTYRLAGGARVIVRPSGTEPKIKCYYEVV
CCCCCCHHHHHHHHHHCCCCEEEECCCCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHH
ETMVDTDTLANAQARASKAMDDFIQAHQASLPK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]