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The map label for this gene is phhA [H]

Identifier: 160874632

GI number: 160874632

Start: 1826496

End: 1827296

Strand: Direct

Name: phhA [H]

Synonym: Sbal195_1515

Alternate gene names: 160874632

Gene position: 1826496-1827296 (Clockwise)

Preceding gene: 160874625

Following gene: 160874633

Centisome position: 34.16

GC content: 47.32

Gene sequence:

>801_bases
ATGACGAAAGGAACAGAGTACATCGCTCACAGAGCCGATGACACTGGGTTTATCCATTACCCGCAAGAAGAGCACGATAT
ATGGCGTCAGCTTTACGCCCGTCAAGCCGTTAATCTCCCCGGTCGTGCCTGCAAGGAATATCTGCAAGGGCTCGATGCCT
TGGGTATGCCAAAGGATCGCATTCCGCAACTTGCCGAAATTGATACGGTATTACAAGCGACCACTGGTTGGAAAACGGCG
GCGGTACCTGCGTTGATTTCCTTCGGCCGTTTCTTTGAATTACTGGCCAATAAAGAGTTTCCTGTGGCCACCTTTATTCG
CCGCAAGGAAGAGTTTGATTACCTGCAAGAGCCAGATATTTTCCACGAGATTTTTGGTCACTGCCCTTTGCTCACCAATC
CTTCATTTGCCAATTTCTCTCATATGTATGGCCAGTTAGGTTTACATGCCAGCAAAGAGGAAAGGGTATTTTTAGCGCGT
TTGTACTGGTTTACGGTTGAGTTTGGCATACTGCAACCTAAAGATGGTCCCTTATGTATCTATGGCGGCGGCATTTTAAG
CTCTCCCGGGGAAACCTTGTATGCGATGGAAAGTGATGTGCCAGAGCGTCAACCCTTTGATTTGTTGGATGTGCTGCGCA
CCCCATATCGGATCGACATTATGCAACCGATTTATTATGTGATTGAGCATATTGATATGCTGGATGAAATTGCCAAGATG
GACATCATGGGTTACGTCACTAAGGCCCGTCAGTTAGGTTTATTTGCCCCTAAATTTCCGCCAAAAGCCAAGGCGAGTTA
G

Upstream 100 bases:

>100_bases
ACGTCACAGTAGCGGCACAAGAATAAAGTGTGAGGGAGTTAACAAATTTAATGCCTTAGACCACTATGGAGTCATGAGTG
TTAGCCACCAAGTGAAGATT

Downstream 100 bases:

>100_bases
CCTCGATTAGATTGATGAGTTGACTCGTTATTTGGCTGGCATCTAATTTAGCCATCTGATTGAGTGATGTGATTTAAGTT
ATTAATAGAAAATGAGTAAA

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MTKGTEYIAHRADDTGFIHYPQEEHDIWRQLYARQAVNLPGRACKEYLQGLDALGMPKDRIPQLAEIDTVLQATTGWKTA
AVPALISFGRFFELLANKEFPVATFIRRKEEFDYLQEPDIFHEIFGHCPLLTNPSFANFSHMYGQLGLHASKEERVFLAR
LYWFTVEFGILQPKDGPLCIYGGGILSSPGETLYAMESDVPERQPFDLLDVLRTPYRIDIMQPIYYVIEHIDMLDEIAKM
DIMGYVTKARQLGLFAPKFPPKAKAS

Sequences:

>Translated_266_residues
MTKGTEYIAHRADDTGFIHYPQEEHDIWRQLYARQAVNLPGRACKEYLQGLDALGMPKDRIPQLAEIDTVLQATTGWKTA
AVPALISFGRFFELLANKEFPVATFIRRKEEFDYLQEPDIFHEIFGHCPLLTNPSFANFSHMYGQLGLHASKEERVFLAR
LYWFTVEFGILQPKDGPLCIYGGGILSSPGETLYAMESDVPERQPFDLLDVLRTPYRIDIMQPIYYVIEHIDMLDEIAKM
DIMGYVTKARQLGLFAPKFPPKAKAS
>Mature_265_residues
TKGTEYIAHRADDTGFIHYPQEEHDIWRQLYARQAVNLPGRACKEYLQGLDALGMPKDRIPQLAEIDTVLQATTGWKTAA
VPALISFGRFFELLANKEFPVATFIRRKEEFDYLQEPDIFHEIFGHCPLLTNPSFANFSHMYGQLGLHASKEERVFLARL
YWFTVEFGILQPKDGPLCIYGGGILSSPGETLYAMESDVPERQPFDLLDVLRTPYRIDIMQPIYYVIEHIDMLDEIAKMD
IMGYVTKARQLGLFAPKFPPKAKAS

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI88900503, Length=248, Percent_Identity=34.2741935483871, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI88900505, Length=248, Percent_Identity=34.2741935483871, Blast_Score=127, Evalue=8e-30,
Organism=Homo sapiens, GI88900501, Length=248, Percent_Identity=34.2741935483871, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI4759248, Length=216, Percent_Identity=35.6481481481481, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI4557819, Length=219, Percent_Identity=36.0730593607306, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI31795563, Length=223, Percent_Identity=34.0807174887892, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71980736, Length=232, Percent_Identity=34.9137931034483, Blast_Score=138, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17531391, Length=218, Percent_Identity=40.3669724770642, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI115533973, Length=194, Percent_Identity=33.5051546391753, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI115532103, Length=237, Percent_Identity=30.379746835443, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71980731, Length=156, Percent_Identity=32.0512820512821, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI17136774, Length=220, Percent_Identity=36.8181818181818, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17136776, Length=217, Percent_Identity=37.3271889400922, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24660393, Length=223, Percent_Identity=33.6322869955157, Blast_Score=121, Evalue=4e-28,
Organism=Drosophila melanogaster, GI62472054, Length=223, Percent_Identity=33.6322869955157, Blast_Score=121, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24654994, Length=186, Percent_Identity=34.4086021505376, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 30441; Mature: 30310

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKGTEYIAHRADDTGFIHYPQEEHDIWRQLYARQAVNLPGRACKEYLQGLDALGMPKDR
CCCCHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHH
IPQLAEIDTVLQATTGWKTAAVPALISFGRFFELLANKEFPVATFIRRKEEFDYLQEPDI
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHH
FHEIFGHCPLLTNPSFANFSHMYGQLGLHASKEERVFLARLYWFTVEFGILQPKDGPLCI
HHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCEECCCCCCEEE
YGGGILSSPGETLYAMESDVPERQPFDLLDVLRTPYRIDIMQPIYYVIEHIDMLDEIAKM
ECCCCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHH
DIMGYVTKARQLGLFAPKFPPKAKAS
HHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TKGTEYIAHRADDTGFIHYPQEEHDIWRQLYARQAVNLPGRACKEYLQGLDALGMPKDR
CCCHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHH
IPQLAEIDTVLQATTGWKTAAVPALISFGRFFELLANKEFPVATFIRRKEEFDYLQEPDI
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHH
FHEIFGHCPLLTNPSFANFSHMYGQLGLHASKEERVFLARLYWFTVEFGILQPKDGPLCI
HHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCEECCCCCCEEE
YGGGILSSPGETLYAMESDVPERQPFDLLDVLRTPYRIDIMQPIYYVIEHIDMLDEIAKM
ECCCCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHH
DIMGYVTKARQLGLFAPKFPPKAKAS
HHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8108417; 10984043 [H]