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The map label for this gene is pan [H]

Identifier: 160874490

GI number: 160874490

Start: 1641668

End: 1642846

Strand: Reverse

Name: pan [H]

Synonym: Sbal195_1372

Alternate gene names: 160874490

Gene position: 1642846-1641668 (Counterclockwise)

Preceding gene: 160874491

Following gene: 160874484

Centisome position: 30.72

GC content: 43.26

Gene sequence:

>1179_bases
ATGAACGAGGTATTACTACAAATAAAGGCGCTCACCAATGGTGATCCTTTGTTGACGGCTGTCATTGTTGGAGTATTAAC
ATTAACGTTAATTGGATTCGTAGGCTACATACTAAAAGATGTCCCCGCGAAGCTGTTAAGTTGGCTCAATTGCCTACTGT
TTGTGCGGCTCACTATCGACGATAGCCATCAGGCGCGCACAGAGGTATTCAATAAACTGTCCTTTTTGATCAGTAATACT
ACCATTCCGTTTTTTTCACGCTCTATCTCTGAGGCTGTGTACTTTGACTATAGTGCGAGTTACGACGGGCGTGTCAGTGT
TAAGTCTATTGGCTACGGTATGCACCTGTTTAAATACGCTGGTTGTTTCATGTTGGCGACCCGTACTAAGGTCGATAGTA
CTATGGCATACGATACTATTACTGTAAGTGCACCCTGGTGGGCAAAAGATAAACTACATAGTTTTTTAGAAGATACTCGT
GGGGACATCTCTACTGAGCCAAAAGTGAATATTTTCGAGGAAACCGAATGGTGTCGCTATGGCACATTGAAATCATCGGG
TTTTAGTGAATTAGTGCTCGATGAAGGGTTTAAGCAGGAGTTGATGGGGGAAGTTGATAACTTCGCCAGTCGGGGAAAAT
CGGTTGTCAGTAAGCTAACCATATTACTACATGGAAAAACGGGCACAGGTAAGACGGGTATAGCGAGGGCCTTAGCGGTT
GAGTATCATCGCGATCTATACATATTGAATCTATCGACTGTCAATGATGCCACTATTCATAAGGCTATTAGAAAAGTACC
GCCCGGAGCTATGTTGTTAATCGAGGACTGTGACTGTGTAAAGGCTACGGTATCACGTACTGCTGAAAGCAATGTAGATA
ACCCACCACTCACTTTAGGTGGCGTACTCAACGCGTTAGACGGCGTCATTCCACTTGATGACTGCCTTGTCATAATGACC
ACAAATCATCTTGATAATCTTGACCCTGCGTTGATACGTAAAGGTCGTGTAGATGTCAGTATTGAAGTACCACTTATCAG
TGCAAAACAAGTTAATGAAGACTACTTTGAACGTTTTGGCGCAGTGCTTAATAGAACTGAGCCATTGTTAGGTTGTGAAG
TCTATGAACTCCATCGCAGAGCGAACTTAAGATATGGTAGTGTCCATAATGCTGTGTGA

Upstream 100 bases:

>100_bases
TGCGATAGCGCACATACTGAGGAGACCTTGGTCGTATCCTCGACTCGGTTGGCTGTATTCTCGACTATGTCTATTAGGCA
TTTATAGTAAAGGTGAGTAA

Downstream 100 bases:

>100_bases
TTTCAGCAAAAATCTGGCCATCCATTTTAGATCAACAACATAATGCACTTTTGGTTTGTCTACAACTTGTACGAGCAAAA
ATTGCTTAAATTAGAGTCAT

Product: ATPase central domain-containing protein

Products: NA

Alternate protein names: PAN; Proteasomal ATPase; Proteasome regulatory ATPase; Proteasome regulatory particle [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MNEVLLQIKALTNGDPLLTAVIVGVLTLTLIGFVGYILKDVPAKLLSWLNCLLFVRLTIDDSHQARTEVFNKLSFLISNT
TIPFFSRSISEAVYFDYSASYDGRVSVKSIGYGMHLFKYAGCFMLATRTKVDSTMAYDTITVSAPWWAKDKLHSFLEDTR
GDISTEPKVNIFEETEWCRYGTLKSSGFSELVLDEGFKQELMGEVDNFASRGKSVVSKLTILLHGKTGTGKTGIARALAV
EYHRDLYILNLSTVNDATIHKAIRKVPPGAMLLIEDCDCVKATVSRTAESNVDNPPLTLGGVLNALDGVIPLDDCLVIMT
TNHLDNLDPALIRKGRVDVSIEVPLISAKQVNEDYFERFGAVLNRTEPLLGCEVYELHRRANLRYGSVHNAV

Sequences:

>Translated_392_residues
MNEVLLQIKALTNGDPLLTAVIVGVLTLTLIGFVGYILKDVPAKLLSWLNCLLFVRLTIDDSHQARTEVFNKLSFLISNT
TIPFFSRSISEAVYFDYSASYDGRVSVKSIGYGMHLFKYAGCFMLATRTKVDSTMAYDTITVSAPWWAKDKLHSFLEDTR
GDISTEPKVNIFEETEWCRYGTLKSSGFSELVLDEGFKQELMGEVDNFASRGKSVVSKLTILLHGKTGTGKTGIARALAV
EYHRDLYILNLSTVNDATIHKAIRKVPPGAMLLIEDCDCVKATVSRTAESNVDNPPLTLGGVLNALDGVIPLDDCLVIMT
TNHLDNLDPALIRKGRVDVSIEVPLISAKQVNEDYFERFGAVLNRTEPLLGCEVYELHRRANLRYGSVHNAV
>Mature_392_residues
MNEVLLQIKALTNGDPLLTAVIVGVLTLTLIGFVGYILKDVPAKLLSWLNCLLFVRLTIDDSHQARTEVFNKLSFLISNT
TIPFFSRSISEAVYFDYSASYDGRVSVKSIGYGMHLFKYAGCFMLATRTKVDSTMAYDTITVSAPWWAKDKLHSFLEDTR
GDISTEPKVNIFEETEWCRYGTLKSSGFSELVLDEGFKQELMGEVDNFASRGKSVVSKLTILLHGKTGTGKTGIARALAV
EYHRDLYILNLSTVNDATIHKAIRKVPPGAMLLIEDCDCVKATVSRTAESNVDNPPLTLGGVLNALDGVIPLDDCLVIMT
TNHLDNLDPALIRKGRVDVSIEVPLISAKQVNEDYFERFGAVLNRTEPLLGCEVYELHRRANLRYGSVHNAV

Specific function: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereb

COG id: COG0465

COG function: function code O; ATP-dependent Zn proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AAA ATPase family [H]

Homologues:

Organism=Homo sapiens, GI4757852, Length=315, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI119964730, Length=315, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71990340, Length=178, Percent_Identity=34.8314606741573, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71990335, Length=178, Percent_Identity=34.8314606741573, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17508701, Length=156, Percent_Identity=31.4102564102564, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320583, Length=296, Percent_Identity=31.4189189189189, Blast_Score=116, Evalue=5e-27,
Organism=Drosophila melanogaster, GI20129417, Length=278, Percent_Identity=29.4964028776978, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24583262, Length=278, Percent_Identity=29.4964028776978, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005937
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR003960 [H]

Pfam domain/function: PF00004 AAA [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 43422; Mature: 43422

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEVLLQIKALTNGDPLLTAVIVGVLTLTLIGFVGYILKDVPAKLLSWLNCLLFVRLTID
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEC
DSHQARTEVFNKLSFLISNTTIPFFSRSISEAVYFDYSASYDGRVSVKSIGYGMHLFKYA
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEEECCCCCCEEEEEHHCCHHHHHHHH
GCFMLATRTKVDSTMAYDTITVSAPWWAKDKLHSFLEDTRGDISTEPKVNIFEETEWCRY
CHHEEEEHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCHHHC
GTLKSSGFSELVLDEGFKQELMGEVDNFASRGKSVVSKLTILLHGKTGTGKTGIARALAV
CCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHH
EYHRDLYILNLSTVNDATIHKAIRKVPPGAMLLIEDCDCVKATVSRTAESNVDNPPLTLG
HHCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCHHH
GVLNALDGVIPLDDCLVIMTTNHLDNLDPALIRKGRVDVSIEVPLISAKQVNEDYFERFG
HHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHCCCCEEEEEEEEECHHHCCHHHHHHHH
AVLNRTEPLLGCEVYELHRRANLRYGSVHNAV
HHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNEVLLQIKALTNGDPLLTAVIVGVLTLTLIGFVGYILKDVPAKLLSWLNCLLFVRLTID
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEC
DSHQARTEVFNKLSFLISNTTIPFFSRSISEAVYFDYSASYDGRVSVKSIGYGMHLFKYA
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEEECCCCCCEEEEEHHCCHHHHHHHH
GCFMLATRTKVDSTMAYDTITVSAPWWAKDKLHSFLEDTRGDISTEPKVNIFEETEWCRY
CHHEEEEHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCHHHC
GTLKSSGFSELVLDEGFKQELMGEVDNFASRGKSVVSKLTILLHGKTGTGKTGIARALAV
CCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHH
EYHRDLYILNLSTVNDATIHKAIRKVPPGAMLLIEDCDCVKATVSRTAESNVDNPPLTLG
HHCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCHHH
GVLNALDGVIPLDDCLVIMTTNHLDNLDPALIRKGRVDVSIEVPLISAKQVNEDYFERFG
HHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHCCCCEEEEEEEEECHHHCCHHHHHHHH
AVLNRTEPLLGCEVYELHRRANLRYGSVHNAV
HHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Metalloendopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]