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The map label for this gene is aqpZ [H]

Identifier: 160874363

GI number: 160874363

Start: 1479780

End: 1480475

Strand: Reverse

Name: aqpZ [H]

Synonym: Sbal195_1244

Alternate gene names: 160874363

Gene position: 1480475-1479780 (Counterclockwise)

Preceding gene: 160874364

Following gene: 160874362

Centisome position: 27.69

GC content: 50.72

Gene sequence:

>696_bases
ATGAATATGTCACAAAAAATGGCGGCGGAATTTCTTGGCACCTTATGGCTAGTCCTTGGAGGCTGTGGCAGTGCGGTACT
TGCCGCAGCATTTCCCGAGGTAGGCATAGGTTTACTCGGTGTCGCGCTCGCATTTGGTTTAACGGTTCTGACTATGGCGT
TTGCGATTGGCCATATTTCAGGTTGTCACCTAAACCCAGCGGTGTCATTCGGCCTTTGGGCTGGTGGACGTTTTCCCGCA
ACGGAGTTACTGCCTTATATCATTGCCCAAGTCGCGGGCGGGATTGCAGGCGCGGGCATCTTGTATCTTATTGCTTCTGG
ACAGGAAGGATTTTCACTTGCGGGTGGATTTGCCTCTAACGGTTTTGGTGAACATTCACCGGGTGGCTACAGCATGCTGT
CGGTCATGATTTGTGAAATCGTTATGACACTGTTCTTTTTGATCATTATTTTAGGTGCCACCGATGAACGCGCGCCAAAA
GGGTTTGCCCCGATTGCCATAGGTCTAGGCTTAACCTTGATCCACCTTATCAGTATTCCAGTGTCCAATACTTCGGTAAA
TCCTGCTCGCAGTACAGGTCCTGCGTTATTTGTCGGTGACTGGGCGGTATCGCAACTGTGGTTATTCTGGGTCGCACCGA
TTGCCGGCGCCATTTTGGCAGGCTTTATCTATCGCTACTTCCGCCCGGCAGAATAA

Upstream 100 bases:

>100_bases
TTTGCTCACTCAGACAAAATCCGCCAATAGACAGGTAAATAAGGAATAAAGACGCACTCGTTGACAAACAAGTGTCTTTA
ACATAATAGGAAATCAAACA

Downstream 100 bases:

>100_bases
ACACCCAAGATCTAACACAACAGCGCCCTCTTGGCGCTGTTGTTCTTTTTCTAATCCCGCTCTAATGTTACCATTTAGCC
AACTGGTGAATTTTGCTGTG

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MNMSQKMAAEFLGTLWLVLGGCGSAVLAAAFPEVGIGLLGVALAFGLTVLTMAFAIGHISGCHLNPAVSFGLWAGGRFPA
TELLPYIIAQVAGGIAGAGILYLIASGQEGFSLAGGFASNGFGEHSPGGYSMLSVMICEIVMTLFFLIIILGATDERAPK
GFAPIAIGLGLTLIHLISIPVSNTSVNPARSTGPALFVGDWAVSQLWLFWVAPIAGAILAGFIYRYFRPAE

Sequences:

>Translated_231_residues
MNMSQKMAAEFLGTLWLVLGGCGSAVLAAAFPEVGIGLLGVALAFGLTVLTMAFAIGHISGCHLNPAVSFGLWAGGRFPA
TELLPYIIAQVAGGIAGAGILYLIASGQEGFSLAGGFASNGFGEHSPGGYSMLSVMICEIVMTLFFLIIILGATDERAPK
GFAPIAIGLGLTLIHLISIPVSNTSVNPARSTGPALFVGDWAVSQLWLFWVAPIAGAILAGFIYRYFRPAE
>Mature_231_residues
MNMSQKMAAEFLGTLWLVLGGCGSAVLAAAFPEVGIGLLGVALAFGLTVLTMAFAIGHISGCHLNPAVSFGLWAGGRFPA
TELLPYIIAQVAGGIAGAGILYLIASGQEGFSLAGGFASNGFGEHSPGGYSMLSVMICEIVMTLFFLIIILGATDERAPK
GFAPIAIGLGLTLIHLISIPVSNTSVNPARSTGPALFVGDWAVSQLWLFWVAPIAGAILAGFIYRYFRPAE

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502183, Length=225, Percent_Identity=37.7777777777778, Blast_Score=124, Evalue=9e-29,
Organism=Homo sapiens, GI4502179, Length=232, Percent_Identity=35.3448275862069, Blast_Score=121, Evalue=4e-28,
Organism=Homo sapiens, GI37694062, Length=230, Percent_Identity=38.2608695652174, Blast_Score=117, Evalue=9e-27,
Organism=Homo sapiens, GI4755125, Length=225, Percent_Identity=34.2222222222222, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI4502181, Length=225, Percent_Identity=34.2222222222222, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI6912506, Length=220, Percent_Identity=34.5454545454545, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI86792455, Length=225, Percent_Identity=32.4444444444444, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI45446752, Length=207, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI157266307, Length=242, Percent_Identity=30.5785123966942, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4826645, Length=241, Percent_Identity=31.9502074688797, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI22538420, Length=247, Percent_Identity=27.9352226720648, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI297307120, Length=90, Percent_Identity=41.1111111111111, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1787101, Length=224, Percent_Identity=71.4285714285714, Blast_Score=296, Evalue=6e-82,
Organism=Escherichia coli, GI1790362, Length=253, Percent_Identity=28.0632411067194, Blast_Score=79, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71993722, Length=233, Percent_Identity=32.1888412017167, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17558372, Length=237, Percent_Identity=29.1139240506329, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71992966, Length=247, Percent_Identity=27.1255060728745, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17531429, Length=241, Percent_Identity=27.3858921161826, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17531431, Length=241, Percent_Identity=27.3858921161826, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24652747, Length=218, Percent_Identity=37.6146788990826, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45551084, Length=218, Percent_Identity=37.6146788990826, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24652751, Length=227, Percent_Identity=32.15859030837, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19922038, Length=227, Percent_Identity=32.15859030837, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136672, Length=191, Percent_Identity=30.8900523560209, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24762342, Length=191, Percent_Identity=29.8429319371728, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45550503, Length=232, Percent_Identity=26.7241379310345, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24762346, Length=218, Percent_Identity=28.4403669724771, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24762348, Length=218, Percent_Identity=28.4403669724771, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI20130305, Length=218, Percent_Identity=28.4403669724771, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24762344, Length=218, Percent_Identity=28.4403669724771, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 23864; Mature: 23864

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMSQKMAAEFLGTLWLVLGGCGSAVLAAAFPEVGIGLLGVALAFGLTVLTMAFAIGHIS
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GCHLNPAVSFGLWAGGRFPATELLPYIIAQVAGGIAGAGILYLIASGQEGFSLAGGFASN
CCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHEEEECCCCCCEECCCCCCC
GFGEHSPGGYSMLSVMICEIVMTLFFLIIILGATDERAPKGFAPIAIGLGLTLIHLISIP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
VSNTSVNPARSTGPALFVGDWAVSQLWLFWVAPIAGAILAGFIYRYFRPAE
CCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNMSQKMAAEFLGTLWLVLGGCGSAVLAAAFPEVGIGLLGVALAFGLTVLTMAFAIGHIS
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GCHLNPAVSFGLWAGGRFPATELLPYIIAQVAGGIAGAGILYLIASGQEGFSLAGGFASN
CCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHEEEECCCCCCEECCCCCCC
GFGEHSPGGYSMLSVMICEIVMTLFFLIIILGATDERAPKGFAPIAIGLGLTLIHLISIP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
VSNTSVNPARSTGPALFVGDWAVSQLWLFWVAPIAGAILAGFIYRYFRPAE
CCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]