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The map label for this gene is hemL [H]

Identifier: 160874356

GI number: 160874356

Start: 1473116

End: 1474408

Strand: Reverse

Name: hemL [H]

Synonym: Sbal195_1237

Alternate gene names: 160874356

Gene position: 1474408-1473116 (Counterclockwise)

Preceding gene: 160874357

Following gene: 160874354

Centisome position: 27.57

GC content: 49.11

Gene sequence:

>1293_bases
ATGACCCGTTCCGAAGCGCTATTTGAACAGGCTAAAAAAACCATCCCCGGCGGCGTTAACTCTCCGGTTCGTGCATTTAA
TGGTGTAGGCGGTTCGCCCCTGTTTATTGAAAAAGCAAACGGCGCTTATATTTACGATGCCGATGGCAAAGCTTATATCG
ACTATGTCGGTTCTTGGGGCCCGATGATCCTCGGCCACAATCACCCTAAAATCCGTGCAGCGGTATTAGCGGCAGTGGAA
AATGGCTTGTCTTTTGGCGCACCAACAGAACTTGAAGTGCAAATGGCCGAGAAAGTCATCTCTATGGTGCCTTCTATCGA
GCAAGTGCGTATGGTGAGTTCAGGTACTGAAGCCACTATGAGCGCCATTCGTTTAGCACGCGGTTTTACTAATCGTGACA
AGATCTTAAAATTCGAAGGTTGTTACCACGGCCATGCGGATTGCCTGTTAGTTAAGGCAGGTTCTGGTGCTCTAACCTTA
GGTCAACCTAGCTCACCCGGTATTCCAGAAGATTTCGCCAAGCACACCTTAACGGCTGTGTATAACGACTTAGATTCTGT
TAGAACCCTGTTCGAGCAGTATCCAACTGAGATTTCTTGTATCATTATCGAGCCCGTTGCTGGCAACATGAACTGCATTC
CACCTATCCCAGGTTTCCTTCAAGGTCTGCGTGATATTTGTGATGAGTTCGGCGCCTTAATGATCATCGACGAAGTGATG
ACAGGGTTTCGCGTATCACAAAGTGGCGCTCAAGGTTACTACGGCGTTACACCAGACTTGACCACGCTTGGTAAAGTGAT
TGGTGGCGGTATGCCAGTGGGGGCCTTCGGTGGCCGTAAAGATGTGATGCAGTTTATCGCGCCTACGGGGCCGGTTTATC
AAGCGGGAACGTTATCTGGTAACCCAATTGCGATGTCTGCTGGTCTGGCGCAAATGGAAGCCCTGTGTGAAGAAGGTCTA
TACGAAGAGTTGAGCGCGAAAACCAAACGTATCGCTGAAGGTTTTAAAGCGGCAGCGGATAAACACGGTATTCCAATGGC
GATCAACTATGTTGGCGGCATGTTTGGTTTCTTCTTCACAGAACAACCGGAAATCACCCGTTTTGACCAAGTGACCCAAT
GTAATATTGAGCAGTTCCGTATTTTCTACCACGGTATGTTAGATGAAGGCGTGTACTTGGCACCGAGCGCCTATGAAGCC
GGTTTCCTGTCTATGGCCCATGGCGAAGAAGAAATGCGCTTGACCTTAGAAGCGGCTGACCGCGTATTAGCGAGCATGAA
AGCGGCAAGCTAA

Upstream 100 bases:

>100_bases
CACTCGGCGTTGATCATCAACTCGAAAAATATGAGTGTCCGGTTAATTGGTATTCACGTAAAGCCGATCGCTAGTTGGCT
ACAGACTTTAAGGACTAAAC

Downstream 100 bases:

>100_bases
ACCTAGATTTTAGGGTTGCTACACCTTAAAAATAACAAAGGGACGCAATAGCGTCCCTTTGTTTTTATTAAATTTAATTA
GCTTTACTTAGATTCAGTTA

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MTRSEALFEQAKKTIPGGVNSPVRAFNGVGGSPLFIEKANGAYIYDADGKAYIDYVGSWGPMILGHNHPKIRAAVLAAVE
NGLSFGAPTELEVQMAEKVISMVPSIEQVRMVSSGTEATMSAIRLARGFTNRDKILKFEGCYHGHADCLLVKAGSGALTL
GQPSSPGIPEDFAKHTLTAVYNDLDSVRTLFEQYPTEISCIIIEPVAGNMNCIPPIPGFLQGLRDICDEFGALMIIDEVM
TGFRVSQSGAQGYYGVTPDLTTLGKVIGGGMPVGAFGGRKDVMQFIAPTGPVYQAGTLSGNPIAMSAGLAQMEALCEEGL
YEELSAKTKRIAEGFKAAADKHGIPMAINYVGGMFGFFFTEQPEITRFDQVTQCNIEQFRIFYHGMLDEGVYLAPSAYEA
GFLSMAHGEEEMRLTLEAADRVLASMKAAS

Sequences:

>Translated_430_residues
MTRSEALFEQAKKTIPGGVNSPVRAFNGVGGSPLFIEKANGAYIYDADGKAYIDYVGSWGPMILGHNHPKIRAAVLAAVE
NGLSFGAPTELEVQMAEKVISMVPSIEQVRMVSSGTEATMSAIRLARGFTNRDKILKFEGCYHGHADCLLVKAGSGALTL
GQPSSPGIPEDFAKHTLTAVYNDLDSVRTLFEQYPTEISCIIIEPVAGNMNCIPPIPGFLQGLRDICDEFGALMIIDEVM
TGFRVSQSGAQGYYGVTPDLTTLGKVIGGGMPVGAFGGRKDVMQFIAPTGPVYQAGTLSGNPIAMSAGLAQMEALCEEGL
YEELSAKTKRIAEGFKAAADKHGIPMAINYVGGMFGFFFTEQPEITRFDQVTQCNIEQFRIFYHGMLDEGVYLAPSAYEA
GFLSMAHGEEEMRLTLEAADRVLASMKAAS
>Mature_429_residues
TRSEALFEQAKKTIPGGVNSPVRAFNGVGGSPLFIEKANGAYIYDADGKAYIDYVGSWGPMILGHNHPKIRAAVLAAVEN
GLSFGAPTELEVQMAEKVISMVPSIEQVRMVSSGTEATMSAIRLARGFTNRDKILKFEGCYHGHADCLLVKAGSGALTLG
QPSSPGIPEDFAKHTLTAVYNDLDSVRTLFEQYPTEISCIIIEPVAGNMNCIPPIPGFLQGLRDICDEFGALMIIDEVMT
GFRVSQSGAQGYYGVTPDLTTLGKVIGGGMPVGAFGGRKDVMQFIAPTGPVYQAGTLSGNPIAMSAGLAQMEALCEEGLY
EELSAKTKRIAEGFKAAADKHGIPMAINYVGGMFGFFFTEQPEITRFDQVTQCNIEQFRIFYHGMLDEGVYLAPSAYEAG
FLSMAHGEEEMRLTLEAADRVLASMKAAS

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=301, Percent_Identity=29.2358803986711, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI284507298, Length=144, Percent_Identity=34.0277777777778, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=70.18779342723, Blast_Score=645, Evalue=0.0,
Organism=Escherichia coli, GI1789016, Length=362, Percent_Identity=30.939226519337, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1788044, Length=337, Percent_Identity=29.080118694362, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI145693181, Length=414, Percent_Identity=27.0531400966184, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1789759, Length=336, Percent_Identity=28.5714285714286, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI1787560, Length=369, Percent_Identity=28.7262872628726, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1786991, Length=426, Percent_Identity=26.056338028169, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI25144271, Length=300, Percent_Identity=27.3333333333333, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71992977, Length=462, Percent_Identity=26.6233766233766, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI32564660, Length=338, Percent_Identity=27.810650887574, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI25144274, Length=148, Percent_Identity=33.7837837837838, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323470, Length=308, Percent_Identity=27.9220779220779, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324432, Length=353, Percent_Identity=25.7790368271955, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357415, Length=297, Percent_Identity=29.2929292929293, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21356575, Length=343, Percent_Identity=29.1545189504373, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 46110; Mature: 45979

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRSEALFEQAKKTIPGGVNSPVRAFNGVGGSPLFIEKANGAYIYDADGKAYIDYVGSWG
CCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCEEEEECCCEEEEECCCCEEEEEECCCC
PMILGHNHPKIRAAVLAAVENGLSFGAPTELEVQMAEKVISMVPSIEQVRMVSSGTEATM
CEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHH
SAIRLARGFTNRDKILKFEGCYHGHADCLLVKAGSGALTLGQPSSPGIPEDFAKHTLTAV
HHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHH
YNDLDSVRTLFEQYPTEISCIIIEPVAGNMNCIPPIPGFLQGLRDICDEFGALMIIDEVM
HHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHH
TGFRVSQSGAQGYYGVTPDLTTLGKVIGGGMPVGAFGGRKDVMQFIAPTGPVYQAGTLSG
HCCEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCC
NPIAMSAGLAQMEALCEEGLYEELSAKTKRIAEGFKAAADKHGIPMAINYVGGMFGFFFT
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCC
EQPEITRFDQVTQCNIEQFRIFYHGMLDEGVYLAPSAYEAGFLSMAHGEEEMRLTLEAAD
CCCCCCHHHHHHHCCHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHCCCHHHEEHHHHHH
RVLASMKAAS
HHHHHHHCCC
>Mature Secondary Structure 
TRSEALFEQAKKTIPGGVNSPVRAFNGVGGSPLFIEKANGAYIYDADGKAYIDYVGSWG
CCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCEEEEECCCEEEEECCCCEEEEEECCCC
PMILGHNHPKIRAAVLAAVENGLSFGAPTELEVQMAEKVISMVPSIEQVRMVSSGTEATM
CEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHH
SAIRLARGFTNRDKILKFEGCYHGHADCLLVKAGSGALTLGQPSSPGIPEDFAKHTLTAV
HHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHH
YNDLDSVRTLFEQYPTEISCIIIEPVAGNMNCIPPIPGFLQGLRDICDEFGALMIIDEVM
HHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHH
TGFRVSQSGAQGYYGVTPDLTTLGKVIGGGMPVGAFGGRKDVMQFIAPTGPVYQAGTLSG
HCCEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCC
NPIAMSAGLAQMEALCEEGLYEELSAKTKRIAEGFKAAADKHGIPMAINYVGGMFGFFFT
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCC
EQPEITRFDQVTQCNIEQFRIFYHGMLDEGVYLAPSAYEAGFLSMAHGEEEMRLTLEAAD
CCCCCCHHHHHHHCCHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHCCCHHHEEHHHHHH
RVLASMKAAS
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA