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The map label for this gene is hmuU [H]

Identifier: 160874169

GI number: 160874169

Start: 1243416

End: 1244432

Strand: Reverse

Name: hmuU [H]

Synonym: Sbal195_1049

Alternate gene names: 160874169

Gene position: 1244432-1243416 (Counterclockwise)

Preceding gene: 160874170

Following gene: 160874168

Centisome position: 23.27

GC content: 54.18

Gene sequence:

>1017_bases
ATGTTCCTCAATCGCTGGCTCTGGCCCGGTTTAGTCACACTGTTAGCCCTAAGCTGCTTACTCTCGGTCAGTACTGGGCC
AGTCAGTATCAGCCTAGTGGATGCCCTAAGCGCAGTGCTTAATTGGGCGACCCAGCAAAACATCGGCAATATTGCACCCC
ACGAGCAACTGGTGATCAACAATGTTCGCCTGCCGCGGACATTATTGGCACTGGCGGTGGGCGCCACGCTCGCTCAATGC
GGCGCAGTGATGCAGGGACTGTTTCGTAATCCATTGGCGGATCCCGGTATTATCGGGGTGTCATCTGGCGCAGCTCTTGG
CGCGGCCATCTGTATCGTGCTGTTACCCAATGCAAATCCATTCATGATCCCCATCAGTGCCTTTGTATCGGGTTTAATCA
CCACCCTTGTTGTCTATCGCCTCGCCAGTAGCCCAACCGGAACATCGGTCGTGTTATTACTACTGTCGGGGGTCGCTATT
GCAGCACTGGCAGGCGCAGGAATTGGCATGCTCACGTACCTTGCCAACGACATGGCGCTACGTGACTTAACCTTGTGGCA
GATGGGCTCGATAGCAGGTGCGCAGTGGATGTATGTCAGCCTGTGTCTCGTGACTTTAGCATTACTAAGCTGGCTATTTC
GCCAAGATGCGGCGGCGCTCAATGCCTTATTGCTTGGCGAATCCGAAGCGCGCCACTTAGGGATAGATGTCGATAGGCTC
AAGCTTAGACTTATTTTACTTTGCGCCTTAGGCGTTGGCGTAAGCGTCGCGGCGACCGGCATTATTGGCTTTATCGGCCT
AGTGGTACCGCATTTAGTGCGGATGATGTTAGGGCCAGATCATCGCCAACTGCTGCCCATCAGCGCCCTTTTAGGTGCAG
CCCTATTAGCCTTAGCCGATATCGGCGCTCGCGCCTTCTTGCCACCAGCAGAGTTACCGGTTGGGTTAGTGACCGCGCTC
ATAGGTGCGCCATTCTTCATCTTCTTACTACTGCAACAACGCAGTAAGCTCATCTAA

Upstream 100 bases:

>100_bases
TTTGAATGGCTTGTATGAGTCACTAATCGGACTCGCAGACTTGCACTACTGACTCACACACCAGATTAGTCACCTGATAA
AAATAGAAAGGATAGTTGAG

Downstream 100 bases:

>100_bases
GCGAGGCGTTATGACAGCCACTTCCTATGCCGAATCAGAATCAAGATCAGATTTTGAATTAGCACCTAGAGCACATCTAA
CTCATTCAGTTAATGCACAG

Product: transport system permease

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MFLNRWLWPGLVTLLALSCLLSVSTGPVSISLVDALSAVLNWATQQNIGNIAPHEQLVINNVRLPRTLLALAVGATLAQC
GAVMQGLFRNPLADPGIIGVSSGAALGAAICIVLLPNANPFMIPISAFVSGLITTLVVYRLASSPTGTSVVLLLLSGVAI
AALAGAGIGMLTYLANDMALRDLTLWQMGSIAGAQWMYVSLCLVTLALLSWLFRQDAAALNALLLGESEARHLGIDVDRL
KLRLILLCALGVGVSVAATGIIGFIGLVVPHLVRMMLGPDHRQLLPISALLGAALLALADIGARAFLPPAELPVGLVTAL
IGAPFFIFLLLQQRSKLI

Sequences:

>Translated_338_residues
MFLNRWLWPGLVTLLALSCLLSVSTGPVSISLVDALSAVLNWATQQNIGNIAPHEQLVINNVRLPRTLLALAVGATLAQC
GAVMQGLFRNPLADPGIIGVSSGAALGAAICIVLLPNANPFMIPISAFVSGLITTLVVYRLASSPTGTSVVLLLLSGVAI
AALAGAGIGMLTYLANDMALRDLTLWQMGSIAGAQWMYVSLCLVTLALLSWLFRQDAAALNALLLGESEARHLGIDVDRL
KLRLILLCALGVGVSVAATGIIGFIGLVVPHLVRMMLGPDHRQLLPISALLGAALLALADIGARAFLPPAELPVGLVTAL
IGAPFFIFLLLQQRSKLI
>Mature_338_residues
MFLNRWLWPGLVTLLALSCLLSVSTGPVSISLVDALSAVLNWATQQNIGNIAPHEQLVINNVRLPRTLLALAVGATLAQC
GAVMQGLFRNPLADPGIIGVSSGAALGAAICIVLLPNANPFMIPISAFVSGLITTLVVYRLASSPTGTSVVLLLLSGVAI
AALAGAGIGMLTYLANDMALRDLTLWQMGSIAGAQWMYVSLCLVTLALLSWLFRQDAAALNALLLGESEARHLGIDVDRL
KLRLILLCALGVGVSVAATGIIGFIGLVVPHLVRMMLGPDHRQLLPISALLGAALLALADIGARAFLPPAELPVGLVTAL
IGAPFFIFLLLQQRSKLI

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=284, Percent_Identity=45.0704225352113, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1790740, Length=287, Percent_Identity=40.7665505226481, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1790741, Length=287, Percent_Identity=35.8885017421603, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1786805, Length=289, Percent_Identity=37.0242214532872, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1786347, Length=278, Percent_Identity=34.1726618705036, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1786804, Length=296, Percent_Identity=31.7567567567568, Blast_Score=105, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 35291; Mature: 35291

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLNRWLWPGLVTLLALSCLLSVSTGPVSISLVDALSAVLNWATQQNIGNIAPHEQLVIN
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHC
NVRLPRTLLALAVGATLAQCGAVMQGLFRNPLADPGIIGVSSGAALGAAICIVLLPNANP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHEECCCCCC
FMIPISAFVSGLITTLVVYRLASSPTGTSVVLLLLSGVAIAALAGAGIGMLTYLANDMAL
CEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
RDLTLWQMGSIAGAQWMYVSLCLVTLALLSWLFRQDAAALNALLLGESEARHLGIDVDRL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHH
KLRLILLCALGVGVSVAATGIIGFIGLVVPHLVRMMLGPDHRQLLPISALLGAALLALAD
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
IGARAFLPPAELPVGLVTALIGAPFFIFLLLQQRSKLI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFLNRWLWPGLVTLLALSCLLSVSTGPVSISLVDALSAVLNWATQQNIGNIAPHEQLVIN
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHC
NVRLPRTLLALAVGATLAQCGAVMQGLFRNPLADPGIIGVSSGAALGAAICIVLLPNANP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHEECCCCCC
FMIPISAFVSGLITTLVVYRLASSPTGTSVVLLLLSGVAIAALAGAGIGMLTYLANDMAL
CEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
RDLTLWQMGSIAGAQWMYVSLCLVTLALLSWLFRQDAAALNALLLGESEARHLGIDVDRL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHH
KLRLILLCALGVGVSVAATGIIGFIGLVVPHLVRMMLGPDHRQLLPISALLGAALLALAD
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
IGARAFLPPAELPVGLVTALIGAPFFIFLLLQQRSKLI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]