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The map label for this gene is pbpC [H]

Identifier: 160873198

GI number: 160873198

Start: 89415

End: 91697

Strand: Direct

Name: pbpC [H]

Synonym: Sbal195_0072

Alternate gene names: 160873198

Gene position: 89415-91697 (Clockwise)

Preceding gene: 160873197

Following gene: 160873203

Centisome position: 1.67

GC content: 50.15

Gene sequence:

>2283_bases
ATGAGATCCGTTTATCTAGCCTTAGTCGCCCTAGCCGTCATATTGCTAGGGCTTAGACTTTGGCCCGCGCAGCCATTGAG
TCAACTGATGCCCAGCTCACGTGAGGTGTTGGCTGCCGATGGCTCTTTAATGCGCCTGACCTTAGCCACTGATGGCCAAT
ATCGACTCTGGCAAGATTTAGAGGATATCTCCCCCATCATGATTAAGGTCATGCTGTTAAAGGAAGATCGCTATTTCTAT
TATCACCCAGGTGTTAATCCAGTCGCATTAGTACGTGCCATATTAGCCACTTATGTTGGCGGTGATCGTCAAGGTGCCTC
GACTCTGACTATGCAGTTAGTTCGTCGAGTCTATGCCATTAACAGTCGCACTGTGTCGGGCAAATTAGAGCAGATCTTGG
CGGCATTCTGGTTAGAGGCTCGTTATAGCAAGCATGAGCTATTAGAGGCTTATCTTAACCTCGCTCCCATGGGGGGCAAT
ATCGAAGGGGTTGGTGCTGCAAGTCAGATTTATTTCCATAAAATCGCGGGTGAGTTGTCTTTGAGCGAAGCCTTGAGCTT
AGCGGTTATGCCTCAGAGTCCGGCGCGTCGGGCTCGGTTTCAGGCAGACTTTCAAGCGGCAAGGGATAGGCTGGCGCTAT
TTTGGCAGCAGACCTATCCAGATGATCCTCGTAATCAAGGCTTGCTGGTGTTGACGGCCCTAGGTGCTGAACGCAACGAG
CTGCCTTTTAAGGCGCCCCATTTTACGCGTCGACAACTACGCCAAGACGCGACCATTATTCACACGACAATAGAGCCTAA
ATTACAAACGCTGCTTGAACTGCGAATTCGTCAGTATGTTGCGGGTAAGCGCCATTTAGGCGTGAATAATGCCACAGCGC
TATTGATCGATACCCGTGATCAGGCGATTAAGGCTTGGGTGGGGTCAGCTGATTTTTTCAATCCCATGATTTATGGTCAG
GTTGATGGTGTTGTCGCCCGCAGATCCCCGGGTTCGACTCTGAAACCCTTTCTCTATGCGTTAGGTTTAGATCAAGGAAT
TATTCATCCCCAAAGTATCATTAAAGATGCGCCTACTGCTTTTGGGAGTTTTGAACCGGAGAATTTCGACCATCGCTTCA
CGGGCCCTATTAGTGCCCATGATGCTTTGATCAAGAGCCGCAATCTACCTGCAGTGTGGTTGGCCGGACAGTTGACTCGT
CCTAATTTGTACGGCTTTTTACGACAAGCCCAGATACTTGGCCTAAGGGGAGAAAGCCATTATGGGCTAGCACTTGCCTT
AGGGGGTGGCGAGTTGACTATGATGGAACTTGGCAGACTCTACCTAATGCTAGCGAGTGAGGGACGTTATTATCCCTTAC
GGGAGAGGACAGATCAGCCCATTAATCCGCCGAGCACTCAGTTATTGAGTCAAGCTGCGAGCTTTCTTGTGTTGGATATG
CTTAAAGACAATCCGCGCGCCGATGGTTTACCTAAGCAGGGCTGGCGTGTGGCTTGGAAGACGGGCACCTCTTGGGGATT
CCATGATGCTTGGAGCGCTGGCGTCGCTGGCCCCTATGTATTGGTGGTCTGGGTAGGGAATTTCGATGCAACGCCGAATG
CTGCTTTTATTGGTGCTGAAATAGCTGGGCCATTATTTTTTAACATCAGTGATGCTTTGCAGGCAAGTCTGCCGAGTACC
GCCGATAAAGCCTTAGCTCAACCCAGTACAGTGAAAAAAGTGAACATTTGCGCCGAGTCAGGTGAGTTGCCTAACCTGTG
GTGCCCTAAAGTGGTTGAGGGTTGGTTTATTCCCGGTGTTTCACCCGTCAAAGTGTCTACGCTACATCGTCCCGTTTGGG
TCGATAATCAAACGGGTATGGCTGTGTGCCCACCCTATGATGCTCACACCCAGCACCAAGAAGTCTTCGCTTTCTGGCCT
TCGGACATGGCGAGTTTATTTGAGCAGGCGGGGCTACCGCGCAAGTTGGCACCACAGTTGCCCGAATCGTGTCGTAACAC
TATTCAGCTCACTAACATAGATCCTGTTATTCGCTCCCCCCTGAGAAATGTCACTTATAGCTTGAGGCAAAGTCATTTAA
ATGAACATATTGCATTGAAGGCCGATGCCGCATCCGACGCGAGTATGTTGTACTGGTTTGTTGGGCGGGATCTCATCGGC
CAAAGCTTACCGAAACAGACCTTAGAGTGGCGGCCCTCGACGGCGGGTGACTATAAGTTATCAGTCACTGACGACAAGGG
TCGCAGTGCGAGTTTGAATCTTAATGTTAGCATCTTGCAGTAA

Upstream 100 bases:

>100_bases
ATGTTGGCCATTTCCAAGTGCCAGCTGCCTATGCTGAAGGGCTGTATGATCCTCTGCAACAAGCACTGGGGGCGGGCAGT
GAATTAGTGATCTCTGCTCC

Downstream 100 bases:

>100_bases
CCCTAATGGTTTTACTAACTCTTATTTTAACGCGCTAATCTGTTGCTTTAGATCGTACTCTGGCTCTGTCACTATTTTTT
CAAGCACTTGCACTCGCTCG

Product: penicillin-binding protein 1C

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 760; Mature: 760

Protein sequence:

>760_residues
MRSVYLALVALAVILLGLRLWPAQPLSQLMPSSREVLAADGSLMRLTLATDGQYRLWQDLEDISPIMIKVMLLKEDRYFY
YHPGVNPVALVRAILATYVGGDRQGASTLTMQLVRRVYAINSRTVSGKLEQILAAFWLEARYSKHELLEAYLNLAPMGGN
IEGVGAASQIYFHKIAGELSLSEALSLAVMPQSPARRARFQADFQAARDRLALFWQQTYPDDPRNQGLLVLTALGAERNE
LPFKAPHFTRRQLRQDATIIHTTIEPKLQTLLELRIRQYVAGKRHLGVNNATALLIDTRDQAIKAWVGSADFFNPMIYGQ
VDGVVARRSPGSTLKPFLYALGLDQGIIHPQSIIKDAPTAFGSFEPENFDHRFTGPISAHDALIKSRNLPAVWLAGQLTR
PNLYGFLRQAQILGLRGESHYGLALALGGGELTMMELGRLYLMLASEGRYYPLRERTDQPINPPSTQLLSQAASFLVLDM
LKDNPRADGLPKQGWRVAWKTGTSWGFHDAWSAGVAGPYVLVVWVGNFDATPNAAFIGAEIAGPLFFNISDALQASLPST
ADKALAQPSTVKKVNICAESGELPNLWCPKVVEGWFIPGVSPVKVSTLHRPVWVDNQTGMAVCPPYDAHTQHQEVFAFWP
SDMASLFEQAGLPRKLAPQLPESCRNTIQLTNIDPVIRSPLRNVTYSLRQSHLNEHIALKADAASDASMLYWFVGRDLIG
QSLPKQTLEWRPSTAGDYKLSVTDDKGRSASLNLNVSILQ

Sequences:

>Translated_760_residues
MRSVYLALVALAVILLGLRLWPAQPLSQLMPSSREVLAADGSLMRLTLATDGQYRLWQDLEDISPIMIKVMLLKEDRYFY
YHPGVNPVALVRAILATYVGGDRQGASTLTMQLVRRVYAINSRTVSGKLEQILAAFWLEARYSKHELLEAYLNLAPMGGN
IEGVGAASQIYFHKIAGELSLSEALSLAVMPQSPARRARFQADFQAARDRLALFWQQTYPDDPRNQGLLVLTALGAERNE
LPFKAPHFTRRQLRQDATIIHTTIEPKLQTLLELRIRQYVAGKRHLGVNNATALLIDTRDQAIKAWVGSADFFNPMIYGQ
VDGVVARRSPGSTLKPFLYALGLDQGIIHPQSIIKDAPTAFGSFEPENFDHRFTGPISAHDALIKSRNLPAVWLAGQLTR
PNLYGFLRQAQILGLRGESHYGLALALGGGELTMMELGRLYLMLASEGRYYPLRERTDQPINPPSTQLLSQAASFLVLDM
LKDNPRADGLPKQGWRVAWKTGTSWGFHDAWSAGVAGPYVLVVWVGNFDATPNAAFIGAEIAGPLFFNISDALQASLPST
ADKALAQPSTVKKVNICAESGELPNLWCPKVVEGWFIPGVSPVKVSTLHRPVWVDNQTGMAVCPPYDAHTQHQEVFAFWP
SDMASLFEQAGLPRKLAPQLPESCRNTIQLTNIDPVIRSPLRNVTYSLRQSHLNEHIALKADAASDASMLYWFVGRDLIG
QSLPKQTLEWRPSTAGDYKLSVTDDKGRSASLNLNVSILQ
>Mature_760_residues
MRSVYLALVALAVILLGLRLWPAQPLSQLMPSSREVLAADGSLMRLTLATDGQYRLWQDLEDISPIMIKVMLLKEDRYFY
YHPGVNPVALVRAILATYVGGDRQGASTLTMQLVRRVYAINSRTVSGKLEQILAAFWLEARYSKHELLEAYLNLAPMGGN
IEGVGAASQIYFHKIAGELSLSEALSLAVMPQSPARRARFQADFQAARDRLALFWQQTYPDDPRNQGLLVLTALGAERNE
LPFKAPHFTRRQLRQDATIIHTTIEPKLQTLLELRIRQYVAGKRHLGVNNATALLIDTRDQAIKAWVGSADFFNPMIYGQ
VDGVVARRSPGSTLKPFLYALGLDQGIIHPQSIIKDAPTAFGSFEPENFDHRFTGPISAHDALIKSRNLPAVWLAGQLTR
PNLYGFLRQAQILGLRGESHYGLALALGGGELTMMELGRLYLMLASEGRYYPLRERTDQPINPPSTQLLSQAASFLVLDM
LKDNPRADGLPKQGWRVAWKTGTSWGFHDAWSAGVAGPYVLVVWVGNFDATPNAAFIGAEIAGPLFFNISDALQASLPST
ADKALAQPSTVKKVNICAESGELPNLWCPKVVEGWFIPGVSPVKVSTLHRPVWVDNQTGMAVCPPYDAHTQHQEVFAFWP
SDMASLFEQAGLPRKLAPQLPESCRNTIQLTNIDPVIRSPLRNVTYSLRQSHLNEHIALKADAASDASMLYWFVGRDLIG
QSLPKQTLEWRPSTAGDYKLSVTDDKGRSASLNLNVSILQ

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=799, Percent_Identity=31.9148936170213, Blast_Score=310, Evalue=2e-85,
Organism=Escherichia coli, GI1786343, Length=546, Percent_Identity=27.1062271062271, Blast_Score=121, Evalue=2e-28,
Organism=Escherichia coli, GI87082258, Length=312, Percent_Identity=30.1282051282051, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1789601, Length=141, Percent_Identity=32.6241134751773, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 84105; Mature: 84105

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSVYLALVALAVILLGLRLWPAQPLSQLMPSSREVLAADGSLMRLTLATDGQYRLWQDL
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCEEEECCCCEEEEEEECCCCCHHHHHH
EDISPIMIKVMLLKEDRYFYYHPGVNPVALVRAILATYVGGDRQGASTLTMQLVRRVYAI
HHCCHHHEEEEEEECCCEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
NSRTVSGKLEQILAAFWLEARYSKHELLEAYLNLAPMGGNIEGVGAASQIYFHKIAGELS
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCC
LSEALSLAVMPQSPARRARFQADFQAARDRLALFWQQTYPDDPRNQGLLVLTALGAERNE
HHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCC
LPFKAPHFTRRQLRQDATIIHTTIEPKLQTLLELRIRQYVAGKRHLGVNNATALLIDTRD
CCCCCCCHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCH
QAIKAWVGSADFFNPMIYGQVDGVVARRSPGSTLKPFLYALGLDQGIIHPQSIIKDAPTA
HHHHHHCCCCHHCCCEEEECCCCEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCC
FGSFEPENFDHRFTGPISAHDALIKSRNLPAVWLAGQLTRPNLYGFLRQAQILGLRGESH
CCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHEEEECCCCC
YGLALALGGGELTMMELGRLYLMLASEGRYYPLRERTDQPINPPSTQLLSQAASFLVLDM
CCEEEEECCCCEEHHHHCCEEEEEECCCCEECCHHCCCCCCCCCHHHHHHHHHHHHHHHH
LKDNPRADGLPKQGWRVAWKTGTSWGFHDAWSAGVAGPYVLVVWVGNFDATPNAAFIGAE
HHCCCCCCCCCCCCCEEEEECCCCCCCCHHCCCCCCCCEEEEEEECCCCCCCCCEEEEHH
IAGPLFFNISDALQASLPSTADKALAQPSTVKKVNICAESGELPNLWCPKVVEGWFIPGV
HCCCEEEEHHHHHHHCCCCHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHCCEECCCC
SPVKVSTLHRPVWVDNQTGMAVCPPYDAHTQHQEVFAFWPSDMASLFEQAGLPRKLAPQL
CCEEEEECCCCEEECCCCCEEECCCCCCCCCCCEEEEECCHHHHHHHHHCCCCHHHCCCC
PESCRNTIQLTNIDPVIRSPLRNVTYSLRQSHLNEHIALKADAASDASMLYWFVGRDLIG
CHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEHHHHHHHH
QSLPKQTLEWRPSTAGDYKLSVTDDKGRSASLNLNVSILQ
CCCCCHHHCCCCCCCCCEEEEEECCCCCEEEEEEEEEEEC
>Mature Secondary Structure
MRSVYLALVALAVILLGLRLWPAQPLSQLMPSSREVLAADGSLMRLTLATDGQYRLWQDL
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCEEEECCCCEEEEEEECCCCCHHHHHH
EDISPIMIKVMLLKEDRYFYYHPGVNPVALVRAILATYVGGDRQGASTLTMQLVRRVYAI
HHCCHHHEEEEEEECCCEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
NSRTVSGKLEQILAAFWLEARYSKHELLEAYLNLAPMGGNIEGVGAASQIYFHKIAGELS
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCC
LSEALSLAVMPQSPARRARFQADFQAARDRLALFWQQTYPDDPRNQGLLVLTALGAERNE
HHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCC
LPFKAPHFTRRQLRQDATIIHTTIEPKLQTLLELRIRQYVAGKRHLGVNNATALLIDTRD
CCCCCCCHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCH
QAIKAWVGSADFFNPMIYGQVDGVVARRSPGSTLKPFLYALGLDQGIIHPQSIIKDAPTA
HHHHHHCCCCHHCCCEEEECCCCEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCC
FGSFEPENFDHRFTGPISAHDALIKSRNLPAVWLAGQLTRPNLYGFLRQAQILGLRGESH
CCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHEEEECCCCC
YGLALALGGGELTMMELGRLYLMLASEGRYYPLRERTDQPINPPSTQLLSQAASFLVLDM
CCEEEEECCCCEEHHHHCCEEEEEECCCCEECCHHCCCCCCCCCHHHHHHHHHHHHHHHH
LKDNPRADGLPKQGWRVAWKTGTSWGFHDAWSAGVAGPYVLVVWVGNFDATPNAAFIGAE
HHCCCCCCCCCCCCCEEEEECCCCCCCCHHCCCCCCCCEEEEEEECCCCCCCCCEEEEHH
IAGPLFFNISDALQASLPSTADKALAQPSTVKKVNICAESGELPNLWCPKVVEGWFIPGV
HCCCEEEEHHHHHHHCCCCHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHCCEECCCC
SPVKVSTLHRPVWVDNQTGMAVCPPYDAHTQHQEVFAFWPSDMASLFEQAGLPRKLAPQL
CCEEEEECCCCEEECCCCCEEECCCCCCCCCCCEEEEECCHHHHHHHHHCCCCHHHCCCC
PESCRNTIQLTNIDPVIRSPLRNVTYSLRQSHLNEHIALKADAASDASMLYWFVGRDLIG
CHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEHHHHHHHH
QSLPKQTLEWRPSTAGDYKLSVTDDKGRSASLNLNVSILQ
CCCCCHHHCCCCCCCCCEEEEEECCCCCEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]