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The map label for this gene is phoR [H]

Identifier: 159901042

GI number: 159901042

Start: 5795565

End: 5797043

Strand: Direct

Name: phoR [H]

Synonym: Haur_4530

Alternate gene names: 159901042

Gene position: 5795565-5797043 (Clockwise)

Preceding gene: 159901034

Following gene: 159901059

Centisome position: 91.32

GC content: 51.25

Gene sequence:

>1479_bases
ATGAGAATGGCTATGCAGTTGCACGCACGCGGTGGGTTGGCGCTCAATCAGCTAATTCGGCTGGTTTATCTGATGGCAAT
TGCCGTTGGGATGTTGGGGCTTGGTCTGATTGGCTATGGCCTTTGGCTGGCGCGTTTCGATTGGTGGCATTGGTTTTTGA
TCAGCCTTGGGGCTTTATGGTTGCTGCTGCACATTGGCTTAATCGTGATGCTGCAACGCAAACGCCGCGCAATTCAGCAA
TTAACTGCTGTCGTCGATGTGCTAGCAACCGCCGATTTAAGTGTGCGAGCACCCAATCTAGGCACTGATGAGTTGGGCGA
ATTGGCGCAATCGATCAATTTGGCCGCCGAGCATTTTACCAGCTTGCTCGATACCCAGCGCCGCGAAACCCAGCGCGAAC
GGGCAATTTTGGCGGCAATCGACGATGGCGTGATTGTTTGCGATCAGCTTGGTCAGATTATTTTGCTCAATACTGCTGCC
TACAATATTATTGCCATGGCCGAAGCTGAACGCCTGCAAACCAACCACGAACAGCCTAATTTGAGTTTGCGCTTTTATGC
TGCGCTCGAAGCCGTGCAACCAGCCTTGGATCAAGCGCTTGGCCGTCCGCATATCAAGCCTGCCGAACGAGTTTGTTTTG
CTGGCCGCACCTATCGCCTCAGTGCTAACCCGATTTGGATCGACGATCGGCGGATTGGGGCGGTGGCAATTTTGCAAGAT
ATTAGTGCCCGCGTCGAGAGCGAACGCTTACGCAGCGATTTTATGGCTTTGGCTGCCCATGAATTACGTTCGCCGTTGAC
CAGTATTCGTGGCTTTGCTGATATGCTATTGTGGAGCAACCCCGAGCATTTTAGTGCCGAAGAAATTAGCTACATCGAAG
GCATCGGGCGCAACATCCAACGCCTAACCGAGCTGATGAACGATGTGGTTGAGTTGGCGCGATTGGAAACCCAACGCAAT
GAGCATACACCGCAGCCTGTTGATTTACGCCAGGTGTTGAGCGCAGTGCTTGATGAATTTCGGCCACGCGCTGAACGCAA
AAAATTACAATTAGATTGTTTATTGCCGAATGAATTACCGCTGTTGAGCCTTGACCCGCTGCATATTCGCCAAATTAGCC
ATCACCTGATTAGCAATGCGATCAAATATACCCCTGAGCAAGGCCAGATTCAAATTGAAGTGCAACAACGGATCGATGAT
ATCTTAGTGGTGGTACGCGATACGGGGATTGGCATTTCGCTGCGCGAACAGCCGCGCATTTTTGGGCGTTTTTTTCGCAA
CGATAATCCACTTTCACGCGCCGCAGGTGGCACAGGCTTAGGCTTATCGATCGCCAAAGCCCTCGTCGAAATGAACCATG
GTTCAATCTATTTTGAAAGCATCGAGGAAGAAGGTACAACCTTTTATGTGGCGTTTCCCTTGGCTTTGGTATGCGAACCT
TTGCCCTACAATCCAGCCGCCTTGGCCGATGCAGCCTAG

Upstream 100 bases:

>100_bases
TCTAGCCAATACTCAATATTGCCCAAAATGTAAAATATAGCTTAAACATGACCATAATCAAGGCTTAACTTTGGGCTGCT
AGCATTGGGCAATTTGAGTA

Downstream 100 bases:

>100_bases
CGTGGCCCCCAACCTAGCCCAAATTTATTGGCCTCGGAGATTGTAAAGGGCTTGGCTGGCCCGCCCTCGGTTGAGACAAC
CCACACATTGAAGCGCGGAC

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MRMAMQLHARGGLALNQLIRLVYLMAIAVGMLGLGLIGYGLWLARFDWWHWFLISLGALWLLLHIGLIVMLQRKRRAIQQ
LTAVVDVLATADLSVRAPNLGTDELGELAQSINLAAEHFTSLLDTQRRETQRERAILAAIDDGVIVCDQLGQIILLNTAA
YNIIAMAEAERLQTNHEQPNLSLRFYAALEAVQPALDQALGRPHIKPAERVCFAGRTYRLSANPIWIDDRRIGAVAILQD
ISARVESERLRSDFMALAAHELRSPLTSIRGFADMLLWSNPEHFSAEEISYIEGIGRNIQRLTELMNDVVELARLETQRN
EHTPQPVDLRQVLSAVLDEFRPRAERKKLQLDCLLPNELPLLSLDPLHIRQISHHLISNAIKYTPEQGQIQIEVQQRIDD
ILVVVRDTGIGISLREQPRIFGRFFRNDNPLSRAAGGTGLGLSIAKALVEMNHGSIYFESIEEEGTTFYVAFPLALVCEP
LPYNPAALADAA

Sequences:

>Translated_492_residues
MRMAMQLHARGGLALNQLIRLVYLMAIAVGMLGLGLIGYGLWLARFDWWHWFLISLGALWLLLHIGLIVMLQRKRRAIQQ
LTAVVDVLATADLSVRAPNLGTDELGELAQSINLAAEHFTSLLDTQRRETQRERAILAAIDDGVIVCDQLGQIILLNTAA
YNIIAMAEAERLQTNHEQPNLSLRFYAALEAVQPALDQALGRPHIKPAERVCFAGRTYRLSANPIWIDDRRIGAVAILQD
ISARVESERLRSDFMALAAHELRSPLTSIRGFADMLLWSNPEHFSAEEISYIEGIGRNIQRLTELMNDVVELARLETQRN
EHTPQPVDLRQVLSAVLDEFRPRAERKKLQLDCLLPNELPLLSLDPLHIRQISHHLISNAIKYTPEQGQIQIEVQQRIDD
ILVVVRDTGIGISLREQPRIFGRFFRNDNPLSRAAGGTGLGLSIAKALVEMNHGSIYFESIEEEGTTFYVAFPLALVCEP
LPYNPAALADAA
>Mature_492_residues
MRMAMQLHARGGLALNQLIRLVYLMAIAVGMLGLGLIGYGLWLARFDWWHWFLISLGALWLLLHIGLIVMLQRKRRAIQQ
LTAVVDVLATADLSVRAPNLGTDELGELAQSINLAAEHFTSLLDTQRRETQRERAILAAIDDGVIVCDQLGQIILLNTAA
YNIIAMAEAERLQTNHEQPNLSLRFYAALEAVQPALDQALGRPHIKPAERVCFAGRTYRLSANPIWIDDRRIGAVAILQD
ISARVESERLRSDFMALAAHELRSPLTSIRGFADMLLWSNPEHFSAEEISYIEGIGRNIQRLTELMNDVVELARLETQRN
EHTPQPVDLRQVLSAVLDEFRPRAERKKLQLDCLLPNELPLLSLDPLHIRQISHHLISNAIKYTPEQGQIQIEVQQRIDD
ILVVVRDTGIGISLREQPRIFGRFFRNDNPLSRAAGGTGLGLSIAKALVEMNHGSIYFESIEEEGTTFYVAFPLALVCEP
LPYNPAALADAA

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=237, Percent_Identity=35.4430379746835, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI145693157, Length=256, Percent_Identity=30.46875, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1788549, Length=424, Percent_Identity=28.0660377358491, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI48994928, Length=262, Percent_Identity=30.1526717557252, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1788393, Length=229, Percent_Identity=29.2576419213974, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1788713, Length=236, Percent_Identity=30.9322033898305, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1786600, Length=371, Percent_Identity=26.1455525606469, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI87081816, Length=253, Percent_Identity=29.6442687747036, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790436, Length=238, Percent_Identity=27.7310924369748, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786783, Length=223, Percent_Identity=27.3542600896861, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1786912, Length=238, Percent_Identity=27.7310924369748, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790346, Length=227, Percent_Identity=28.1938325991189, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790861, Length=230, Percent_Identity=28.2608695652174, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787894, Length=217, Percent_Identity=27.6497695852535, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1789403, Length=239, Percent_Identity=27.1966527196653, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790551, Length=245, Percent_Identity=27.7551020408163, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1788279, Length=226, Percent_Identity=26.9911504424779, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI87082128, Length=235, Percent_Identity=25.9574468085106, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1789808, Length=229, Percent_Identity=24.4541484716157, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55130; Mature: 55130

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMAMQLHARGGLALNQLIRLVYLMAIAVGMLGLGLIGYGLWLARFDWWHWFLISLGALW
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLLHIGLIVMLQRKRRAIQQLTAVVDVLATADLSVRAPNLGTDELGELAQSINLAAEHFT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHH
SLLDTQRRETQRERAILAAIDDGVIVCDQLGQIILLNTAAYNIIAMAEAERLQTNHEQPN
HHHHHHHHHHHHHHHHHEECCCCEEEHHCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCC
LSLRFYAALEAVQPALDQALGRPHIKPAERVCFAGRTYRLSANPIWIDDRRIGAVAILQD
CEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEECCEEEECCCCCHHHHHHHH
ISARVESERLRSDFMALAAHELRSPLTSIRGFADMLLWSNPEHFSAEEISYIEGIGRNIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCHHHH
RLTELMNDVVELARLETQRNEHTPQPVDLRQVLSAVLDEFRPRAERKKLQLDCLLPNELP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHCEEEEEECCCCCC
LLSLDPLHIRQISHHLISNAIKYTPEQGQIQIEVQQRIDDILVVVRDTGIGISLREQPRI
EECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHEEEEECCCCCEEECCCCHH
FGRFFRNDNPLSRAAGGTGLGLSIAKALVEMNHGSIYFESIEEEGTTFYVAFPLALVCEP
HHHHHCCCCCHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEHHHHHCCC
LPYNPAALADAA
CCCCCCHHCCCC
>Mature Secondary Structure
MRMAMQLHARGGLALNQLIRLVYLMAIAVGMLGLGLIGYGLWLARFDWWHWFLISLGALW
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLLHIGLIVMLQRKRRAIQQLTAVVDVLATADLSVRAPNLGTDELGELAQSINLAAEHFT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHH
SLLDTQRRETQRERAILAAIDDGVIVCDQLGQIILLNTAAYNIIAMAEAERLQTNHEQPN
HHHHHHHHHHHHHHHHHEECCCCEEEHHCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCC
LSLRFYAALEAVQPALDQALGRPHIKPAERVCFAGRTYRLSANPIWIDDRRIGAVAILQD
CEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEECCEEEECCCCCHHHHHHHH
ISARVESERLRSDFMALAAHELRSPLTSIRGFADMLLWSNPEHFSAEEISYIEGIGRNIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCHHHH
RLTELMNDVVELARLETQRNEHTPQPVDLRQVLSAVLDEFRPRAERKKLQLDCLLPNELP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHCEEEEEECCCCCC
LLSLDPLHIRQISHHLISNAIKYTPEQGQIQIEVQQRIDDILVVVRDTGIGISLREQPRI
EECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHEEEEECCCCCEEECCCCHH
FGRFFRNDNPLSRAAGGTGLGLSIAKALVEMNHGSIYFESIEEEGTTFYVAFPLALVCEP
HHHHHCCCCCHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEHHHHHCCC
LPYNPAALADAA
CCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]