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The map label for this gene is thrA [C]

Identifier: 159901021

GI number: 159901021

Start: 5772058

End: 5773494

Strand: Direct

Name: thrA [C]

Synonym: Haur_4508

Alternate gene names: 159901021

Gene position: 5772058-5773494 (Clockwise)

Preceding gene: 159901020

Following gene: 159901022

Centisome position: 90.95

GC content: 54.14

Gene sequence:

>1437_bases
ATGCGTTTGCTAGTGACGAAATTTGGTGGTACGTCGGTCGGTTCAGCTGAAGCTATTCGTGGCTTAACTGCAATCACTAC
CACTAATCGCACTACTTGGGATCATGTTGTTGTGGTGGTGTCGGCCCTCAGCGGTGTCACCGATAAATTGTTGAATATTG
TGCGGGTTGCCCAAACAACGGGCGATGCTGCTGCGGTTGCTACGCTGCACGCCGAGTTGCGCCAGCGCCATCATGATGTG
ATTGGTGAGTTGCTCGATGCTGAACAGGCCGCAATCCAAACCGAAATTGATGGCTTGCTCGATGAGTGTGCCCGTTTGTG
CGAAGGTGTGCGAGTATTGGGCGAATTGACTCCGCGCACACTCGATGCGATTGCTGGCTTGGGTGAGCGCATGAGCGCCC
GCATCGTCGCTGCAACCTTACGCCATCTAGGAGTGCCAGCTCAACATTTTGACGCTAGCGATCTGATCGTTACCGATGAT
CGTTATCAAGATGCTTCGCCGTTGATGCCCGAAACCACCGAGCGCACCACCGCAACTCTTGGCCCAATCTTGGATCAAGG
AATTACGCCAGTGGTCACAGGTTTTATTGGCGCAACCTTGGCAGGCGTAAAAACCACGCTTGGCCGTGGTGGCTCCGATT
GGAGTGCAGCGATTTTGGGCGCGGCGCTCGAAGCCAGCGAAGTTTGGATCTATACCGATGTGGATGGGGTGATGACTGCC
GACCCACGAATTGCCCCCGATGCCCATGTGATCAGCACACTTTCCTACAATGAAATCAGCGAATTGGCTTATTACGGCGC
GAAAGTGCTACATCCCAAAACGATTCGGCCTGTAGTCGAGCGTGGCATCCCCTTGCGAGTCAAAAACACCTTCAATCCCA
GCCATCCTGGCACAGTGATTGTGGGCAAAACTGAGCCAATCGTTGGCGCAATCAAAGCCGTTACTGCAATCCACAATCTG
ACCATGATTACCGTGGCAGGCCGTGGCATGTTGGGCGTGCCTGGGATCGCTGCCCGAACTTTTGGCGCGGTAGCGCGTGA
AGATGCCAGCATTTTGATGATTTCACAAGCCTCATCCGAGCAAAGCATCTGTTTTGTCATCCCCGATGGTGGAGCAAAAC
GGGTGGTCGAATCGCTGAACCAAGAACTAGCGGTCGAACTCGAACGCCGCGATATCGACACGATTGCCTTGGAAGAAGGC
GTTTCGATCATTACGGCGGTTGGCGCTGGCATGCGTGGCACAACTGGGGTGGCCAAACGGGTCTTTAGCGCAATTGGCGA
TGCTGAAATCAATGTGATTGCGATTGCTCAAGGTTCATCTGAATGTGCAATTAGCTTGGTGGTTTCGGGCGATAGCGCCA
AGGCGGGTGTGCGAGCGATTCATGCCCTGACCTACCGCGAAACGATCAACGCCCAACATCGCCCACCATGTGAGTAA

Upstream 100 bases:

>100_bases
ATTCAGGCTTTTGAGCAGCAACTTAATTGCTGGGGGCAAAAGGTTGTTGAGTTGTTGCTCGCCTTCAAGGTGGATTCAAT
TTTTTCATTTGGAGCACGTT

Downstream 100 bases:

>100_bases
ATTTCAAGCCTCAATCAAACTTAGACCCTCAGTTCTCGTGCTGAACTGAGGGTCTTTCTATGCCAATAAGTACAAAATCA
TGACTTTAGTCCTATACCTA

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MRLLVTKFGGTSVGSAEAIRGLTAITTTNRTTWDHVVVVVSALSGVTDKLLNIVRVAQTTGDAAAVATLHAELRQRHHDV
IGELLDAEQAAIQTEIDGLLDECARLCEGVRVLGELTPRTLDAIAGLGERMSARIVAATLRHLGVPAQHFDASDLIVTDD
RYQDASPLMPETTERTTATLGPILDQGITPVVTGFIGATLAGVKTTLGRGGSDWSAAILGAALEASEVWIYTDVDGVMTA
DPRIAPDAHVISTLSYNEISELAYYGAKVLHPKTIRPVVERGIPLRVKNTFNPSHPGTVIVGKTEPIVGAIKAVTAIHNL
TMITVAGRGMLGVPGIAARTFGAVAREDASILMISQASSEQSICFVIPDGGAKRVVESLNQELAVELERRDIDTIALEEG
VSIITAVGAGMRGTTGVAKRVFSAIGDAEINVIAIAQGSSECAISLVVSGDSAKAGVRAIHALTYRETINAQHRPPCE

Sequences:

>Translated_478_residues
MRLLVTKFGGTSVGSAEAIRGLTAITTTNRTTWDHVVVVVSALSGVTDKLLNIVRVAQTTGDAAAVATLHAELRQRHHDV
IGELLDAEQAAIQTEIDGLLDECARLCEGVRVLGELTPRTLDAIAGLGERMSARIVAATLRHLGVPAQHFDASDLIVTDD
RYQDASPLMPETTERTTATLGPILDQGITPVVTGFIGATLAGVKTTLGRGGSDWSAAILGAALEASEVWIYTDVDGVMTA
DPRIAPDAHVISTLSYNEISELAYYGAKVLHPKTIRPVVERGIPLRVKNTFNPSHPGTVIVGKTEPIVGAIKAVTAIHNL
TMITVAGRGMLGVPGIAARTFGAVAREDASILMISQASSEQSICFVIPDGGAKRVVESLNQELAVELERRDIDTIALEEG
VSIITAVGAGMRGTTGVAKRVFSAIGDAEINVIAIAQGSSECAISLVVSGDSAKAGVRAIHALTYRETINAQHRPPCE
>Mature_478_residues
MRLLVTKFGGTSVGSAEAIRGLTAITTTNRTTWDHVVVVVSALSGVTDKLLNIVRVAQTTGDAAAVATLHAELRQRHHDV
IGELLDAEQAAIQTEIDGLLDECARLCEGVRVLGELTPRTLDAIAGLGERMSARIVAATLRHLGVPAQHFDASDLIVTDD
RYQDASPLMPETTERTTATLGPILDQGITPVVTGFIGATLAGVKTTLGRGGSDWSAAILGAALEASEVWIYTDVDGVMTA
DPRIAPDAHVISTLSYNEISELAYYGAKVLHPKTIRPVVERGIPLRVKNTFNPSHPGTVIVGKTEPIVGAIKAVTAIHNL
TMITVAGRGMLGVPGIAARTFGAVAREDASILMISQASSEQSICFVIPDGGAKRVVESLNQELAVELERRDIDTIALEEG
VSIITAVGAGMRGTTGVAKRVFSAIGDAEINVIAIAQGSSECAISLVVSGDSAKAGVRAIHALTYRETINAQHRPPCE

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=473, Percent_Identity=35.7293868921776, Blast_Score=272, Evalue=3e-74,
Organism=Escherichia coli, GI1790455, Length=476, Percent_Identity=31.5126050420168, Blast_Score=181, Evalue=6e-47,
Organism=Escherichia coli, GI1790376, Length=300, Percent_Identity=32.6666666666667, Blast_Score=123, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6320893, Length=507, Percent_Identity=27.6134122287968, Blast_Score=182, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 50185; Mature: 50185

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLVTKFGGTSVGSAEAIRGLTAITTTNRTTWDHVVVVVSALSGVTDKLLNIVRVAQTT
CEEEEEECCCCCCCCHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GDAAAVATLHAELRQRHHDVIGELLDAEQAAIQTEIDGLLDECARLCEGVRVLGELTPRT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LDAIAGLGERMSARIVAATLRHLGVPAQHFDASDLIVTDDRYQDASPLMPETTERTTATL
HHHHHCCCHHHHHHHHHHHHHHHCCCHHHCCCCCEEEECCCCCCCCCCCCCCCCHHHHHH
GPILDQGITPVVTGFIGATLAGVKTTLGRGGSDWSAAILGAALEASEVWIYTDVDGVMTA
HHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEECCCEEEC
DPRIAPDAHVISTLSYNEISELAYYGAKVLHPKTIRPVVERGIPLRVKNTFNPSHPGTVI
CCCCCCCCHHEEECCHHHHHHHHHHCHHHCCCHHHHHHHHCCCCEEEECCCCCCCCCEEE
VGKTEPIVGAIKAVTAIHNLTMITVAGRGMLGVPGIAARTFGAVAREDASILMISQASSE
EECCCCHHHHHHHHHHHHCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCC
QSICFVIPDGGAKRVVESLNQELAVELERRDIDTIALEEGVSIITAVGAGMRGTTGVAKR
CCEEEEECCCCHHHHHHHHCHHHEEHHHHCCCCHHHHHCCCCEEEHHCCCCCCCHHHHHH
VFSAIGDAEINVIAIAQGSSECAISLVVSGDSAKAGVRAIHALTYRETINAQHRPPCE
HHHHCCCCCEEEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRLLVTKFGGTSVGSAEAIRGLTAITTTNRTTWDHVVVVVSALSGVTDKLLNIVRVAQTT
CEEEEEECCCCCCCCHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GDAAAVATLHAELRQRHHDVIGELLDAEQAAIQTEIDGLLDECARLCEGVRVLGELTPRT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LDAIAGLGERMSARIVAATLRHLGVPAQHFDASDLIVTDDRYQDASPLMPETTERTTATL
HHHHHCCCHHHHHHHHHHHHHHHCCCHHHCCCCCEEEECCCCCCCCCCCCCCCCHHHHHH
GPILDQGITPVVTGFIGATLAGVKTTLGRGGSDWSAAILGAALEASEVWIYTDVDGVMTA
HHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEECCCEEEC
DPRIAPDAHVISTLSYNEISELAYYGAKVLHPKTIRPVVERGIPLRVKNTFNPSHPGTVI
CCCCCCCCHHEEECCHHHHHHHHHHCHHHCCCHHHHHHHHCCCCEEEECCCCCCCCCEEE
VGKTEPIVGAIKAVTAIHNLTMITVAGRGMLGVPGIAARTFGAVAREDASILMISQASSE
EECCCCHHHHHHHHHHHHCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCC
QSICFVIPDGGAKRVVESLNQELAVELERRDIDTIALEEGVSIITAVGAGMRGTTGVAKR
CCEEEEECCCCHHHHHHHHCHHHEEHHHHCCCCHHHHHCCCCEEEHHCCCCCCCHHHHHH
VFSAIGDAEINVIAIAQGSSECAISLVVSGDSAKAGVRAIHALTYRETINAQHRPPCE
HHHHCCCCCEEEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]