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The map label for this gene is mmgC [H]

Identifier: 159900483

GI number: 159900483

Start: 5047747

End: 5048877

Strand: Direct

Name: mmgC [H]

Synonym: Haur_3970

Alternate gene names: 159900483

Gene position: 5047747-5048877 (Clockwise)

Preceding gene: 159900482

Following gene: 159900484

Centisome position: 79.53

GC content: 61.98

Gene sequence:

>1131_bases
ATGCGAATCGAGCTTACTGAACAGCAAGCCAGCGCGAAGGCGGCGTTTCGTGCCTTCGTCGATCATGAAATCGTGCCATA
CGCCGACCAATTCGATCGCGAGGAGCGCGTCCCGGCGGCCGTTATCCAAAAGCTGGCCCGCGAGGGCTACTTGGGCCAGG
TCGTTCCCGAAGAGCAAGGCGGCACCGGCAGCGATATGGTCACCTTTGGTATCCTCAACGAGGAGTTGGGGCGCGGCTGC
TCATCGATCCGGAGCCTGCTGACGGTGCATAGCATGGCGGCGTTCGCCGTGTTGAAGTGGGGCAGCGCAGACCACAAAAG
CCGCTTTCTGTCCCGGCTGGTCAGCGGTGAGATCATCGGCGCGTTTGCCTTGAGTGAGCCGAACGTCGGCAGCGACGCCA
AAAGCGTCGAAACTTCCGCCCGTTTGGTCGGCGACCGCTACGTGCTCAACGGGCGCAAGCGCTGGATGACCTTCGGCCAG
ATCGCCGATGTGTTCCTGCTGTTCGCCCAGGTCGAGGGCAAGGTGACGGCCTTCCTGGTCGAAAGGAACAGCCCCGGTTT
CTCGACCGAGCCAATCACAGGCATCCTGGGCACCCGCGGCTCCATGCTTGCCGAACTGCGCTTGGACGATTGCGAGATCC
CTAAGGAAAATCGCCTCGGCGGGCTGGGCTTCGGCCTAGCGGCGATCGGCACGTCGGCCCTGGACATCGGCCGCTACAGC
GTCGCTTGGGGCAGCGTTGGCATCGCCCAGGCATGCCTGGAAGCCTGCGTGGAGTATACCAGCACCCGGCGGCAGTTCGG
CGTGCCGATCAAAGATCACGATCTGGTGCGCCAGATGATGACCAATATGATCACGAACACCAAGGCGGCCCGCATGCTGT
GCTATCAGGCCGGCTATCTCAAGGATAGCGGCGACTCGCGCACGGTGATGGAAACATGGATCGCCAAATACTTCGCCTCA
ACCGCAGCCATGAAGATCGCTGCGGACGCCGTCCAGCTCCACGGCGCCAACGGCTGCAGCGAGGAGTATCCGGTGCAGCG
TTACTTCCGCGACGCCAAGATCATGGAAATCATCGAGGCCAGCACCCAGCTCCAACAGATGAACATCGCCCAGTACGCCT
ACGAGTACTAA

Upstream 100 bases:

>100_bases
AAGTGCTGTAGCGCTATATGCATAGGCGTCCGGCGGAGATACGGCCATCCGCGTATCCGCCGCCGGACGCCTGTGCGCCT
GGCGCCTGGAGGAATAGTGA

Downstream 100 bases:

>100_bases
GGCATTTACATAACGAAAGGAACCTTGCCAATGGCCGTGCAGCAGACCGCCGAGCTGATCAAAGAAGAGAAAAAAAACAA
ATCGGTCAAGTGTGTCGTCT

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MRIELTEQQASAKAAFRAFVDHEIVPYADQFDREERVPAAVIQKLAREGYLGQVVPEEQGGTGSDMVTFGILNEELGRGC
SSIRSLLTVHSMAAFAVLKWGSADHKSRFLSRLVSGEIIGAFALSEPNVGSDAKSVETSARLVGDRYVLNGRKRWMTFGQ
IADVFLLFAQVEGKVTAFLVERNSPGFSTEPITGILGTRGSMLAELRLDDCEIPKENRLGGLGFGLAAIGTSALDIGRYS
VAWGSVGIAQACLEACVEYTSTRRQFGVPIKDHDLVRQMMTNMITNTKAARMLCYQAGYLKDSGDSRTVMETWIAKYFAS
TAAMKIAADAVQLHGANGCSEEYPVQRYFRDAKIMEIIEASTQLQQMNIAQYAYEY

Sequences:

>Translated_376_residues
MRIELTEQQASAKAAFRAFVDHEIVPYADQFDREERVPAAVIQKLAREGYLGQVVPEEQGGTGSDMVTFGILNEELGRGC
SSIRSLLTVHSMAAFAVLKWGSADHKSRFLSRLVSGEIIGAFALSEPNVGSDAKSVETSARLVGDRYVLNGRKRWMTFGQ
IADVFLLFAQVEGKVTAFLVERNSPGFSTEPITGILGTRGSMLAELRLDDCEIPKENRLGGLGFGLAAIGTSALDIGRYS
VAWGSVGIAQACLEACVEYTSTRRQFGVPIKDHDLVRQMMTNMITNTKAARMLCYQAGYLKDSGDSRTVMETWIAKYFAS
TAAMKIAADAVQLHGANGCSEEYPVQRYFRDAKIMEIIEASTQLQQMNIAQYAYEY
>Mature_376_residues
MRIELTEQQASAKAAFRAFVDHEIVPYADQFDREERVPAAVIQKLAREGYLGQVVPEEQGGTGSDMVTFGILNEELGRGC
SSIRSLLTVHSMAAFAVLKWGSADHKSRFLSRLVSGEIIGAFALSEPNVGSDAKSVETSARLVGDRYVLNGRKRWMTFGQ
IADVFLLFAQVEGKVTAFLVERNSPGFSTEPITGILGTRGSMLAELRLDDCEIPKENRLGGLGFGLAAIGTSALDIGRYS
VAWGSVGIAQACLEACVEYTSTRRQFGVPIKDHDLVRQMMTNMITNTKAARMLCYQAGYLKDSGDSRTVMETWIAKYFAS
TAAMKIAADAVQLHGANGCSEEYPVQRYFRDAKIMEIIEASTQLQQMNIAQYAYEY

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=376, Percent_Identity=37.2340425531915, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI4557231, Length=377, Percent_Identity=32.6259946949602, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI187960098, Length=377, Percent_Identity=32.6259946949602, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI4501859, Length=375, Percent_Identity=32, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI226958412, Length=377, Percent_Identity=32.0954907161804, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI226958414, Length=367, Percent_Identity=32.1525885558583, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI21361497, Length=353, Percent_Identity=32.2946175637394, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI7656849, Length=369, Percent_Identity=28.7262872628726, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI4503943, Length=368, Percent_Identity=30.7065217391304, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI7669494, Length=349, Percent_Identity=32.0916905444126, Blast_Score=178, Evalue=6e-45,
Organism=Homo sapiens, GI76496475, Length=352, Percent_Identity=31.5340909090909, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI4557235, Length=352, Percent_Identity=31.5340909090909, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI4501857, Length=370, Percent_Identity=26.4864864864865, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI211971008, Length=341, Percent_Identity=25.5131964809384, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI48976061, Length=341, Percent_Identity=25.5131964809384, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI38505218, Length=288, Percent_Identity=24.3055555555556, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1786223, Length=377, Percent_Identity=23.8726790450928, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI87081958, Length=370, Percent_Identity=26.7567567567568, Blast_Score=105, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17570075, Length=379, Percent_Identity=34.3007915567282, Blast_Score=228, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17538396, Length=375, Percent_Identity=33.3333333333333, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17534899, Length=383, Percent_Identity=32.1148825065274, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17569725, Length=379, Percent_Identity=31.6622691292876, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17506239, Length=373, Percent_Identity=30.2949061662198, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17508101, Length=374, Percent_Identity=31.0160427807487, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71985184, Length=382, Percent_Identity=30.3664921465969, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17534353, Length=370, Percent_Identity=28.3783783783784, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17533517, Length=363, Percent_Identity=26.1707988980716, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71985192, Length=328, Percent_Identity=29.8780487804878, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71990804, Length=295, Percent_Identity=31.1864406779661, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI32563615, Length=235, Percent_Identity=29.7872340425532, Blast_Score=121, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17505929, Length=348, Percent_Identity=27.2988505747126, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17551932, Length=360, Percent_Identity=26.6666666666667, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71982178, Length=270, Percent_Identity=27.4074074074074, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17562446, Length=359, Percent_Identity=24.5125348189415, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24660351, Length=380, Percent_Identity=34.7368421052632, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI21356377, Length=372, Percent_Identity=36.5591397849462, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24646207, Length=371, Percent_Identity=34.2318059299191, Blast_Score=214, Evalue=8e-56,
Organism=Drosophila melanogaster, GI24666513, Length=373, Percent_Identity=31.3672922252011, Blast_Score=201, Evalue=7e-52,
Organism=Drosophila melanogaster, GI19920834, Length=371, Percent_Identity=32.0754716981132, Blast_Score=185, Evalue=3e-47,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=32.5459317585302, Blast_Score=177, Evalue=7e-45,
Organism=Drosophila melanogaster, GI281363737, Length=373, Percent_Identity=29.2225201072386, Blast_Score=158, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 41286; Mature: 41286

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIELTEQQASAKAAFRAFVDHEIVPYADQFDREERVPAAVIQKLAREGYLGQVVPEEQG
CCEEECHHHHHHHHHHHHHHCCCCCCCHHHCCHHCCCHHHHHHHHHHCCCCCCCCCCCCC
GTGSDMVTFGILNEELGRGCSSIRSLLTVHSMAAFAVLKWGSADHKSRFLSRLVSGEIIG
CCCCCEEEEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEE
AFALSEPNVGSDAKSVETSARLVGDRYVLNGRKRWMTFGQIADVFLLFAQVEGKVTAFLV
EEEECCCCCCCCHHHHHHHHHHHCCHHEECCHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
ERNSPGFSTEPITGILGTRGSMLAELRLDDCEIPKENRLGGLGFGLAAIGTSALDIGRYS
ECCCCCCCCCCCHHHHCCCCHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEE
VAWGSVGIAQACLEACVEYTSTRRQFGVPIKDHDLVRQMMTNMITNTKAARMLCYQAGYL
EHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCC
KDSGDSRTVMETWIAKYFASTAAMKIAADAVQLHGANGCSEEYPVQRYFRDAKIMEIIEA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
STQLQQMNIAQYAYEY
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRIELTEQQASAKAAFRAFVDHEIVPYADQFDREERVPAAVIQKLAREGYLGQVVPEEQG
CCEEECHHHHHHHHHHHHHHCCCCCCCHHHCCHHCCCHHHHHHHHHHCCCCCCCCCCCCC
GTGSDMVTFGILNEELGRGCSSIRSLLTVHSMAAFAVLKWGSADHKSRFLSRLVSGEIIG
CCCCCEEEEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEE
AFALSEPNVGSDAKSVETSARLVGDRYVLNGRKRWMTFGQIADVFLLFAQVEGKVTAFLV
EEEECCCCCCCCHHHHHHHHHHHCCHHEECCHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
ERNSPGFSTEPITGILGTRGSMLAELRLDDCEIPKENRLGGLGFGLAAIGTSALDIGRYS
ECCCCCCCCCCCHHHHCCCCHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEE
VAWGSVGIAQACLEACVEYTSTRRQFGVPIKDHDLVRQMMTNMITNTKAARMLCYQAGYL
EHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCC
KDSGDSRTVMETWIAKYFASTAAMKIAADAVQLHGANGCSEEYPVQRYFRDAKIMEIIEA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
STQLQQMNIAQYAYEY
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]