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The map label for this gene is phoP [H]

Identifier: 159899985

GI number: 159899985

Start: 4366852

End: 4368090

Strand: Direct

Name: phoP [H]

Synonym: Haur_3468

Alternate gene names: 159899985

Gene position: 4366852-4368090 (Clockwise)

Preceding gene: 159899984

Following gene: 159899986

Centisome position: 68.81

GC content: 49.07

Gene sequence:

>1239_bases
ATGCCTGAACGTATTCTCGTTGCTGACGATAACGAAGCCCTAAGCCAATTGCTTGAACTGATTTTAGTTGAGCATGGGTA
TGAGGTTACTCTTGCCAACGATGGCGGCGACCTGTTAGCCAAGGCCCAACTGCAAATTCCCGATTTGATGATTGTTGATA
TTTTGATGCCGCGCATCGATGGCTATGAGGCGATTCGCCAATTGCGCAACGATACACGGCTGGCCCATATTCCAATTATT
GTGCTCACTGCGCGTACCGCGATTGAGGATGTGGTGACTGGCTTTGAATTGGGCGCTGATGATTATATCGTCAAGCCGTT
TCAAATGCCTGAACTGCTGGCCCGTGTTCGCGCCCAATTGTTGCGAGCAACCCGCCGCCCTGTGCTCAACCCACTGACTG
GCTTGCCCGGCAATATTTTGATCGAAGAAGAAGTTAACCATCGCTTGCGCCAGCAACAAGCCTTTGCTTTGTTGTACCTC
GATTTGGATAATTTCAAAGCCTATAACGATAGCTATGGCTTTGCCCGTGGCGATTTGGTGATCAAGCTGTTGGCCACAAT
TTTGACGGAAATCAAGGCTGAATACAACGATGAAGGGCTATTTATTGGCCATATTGGCGGCGATGATTTTGCCCTGATTA
TGGCATCGGAACATGTCAATGCCCTCTGCGAAGATTTGATTCGGCGCTTTGATCAGCGGATTTTGACCTTGTACGATCCC
AATAGTAGCAACAAACCTGTGCCGATCCAGACGCTCTCGGTTGGCGTGGTGCTGCATCGTGAAGATATGCAACAAACCTA
TCACGACCTAAGTCGCACCGCTGCCGAGATGAAGCGGGTTGCCAAACAACAAACTGGCAGCGTCTATGTGGTTGATCGGC
GTGCGCAAAAACAGACGATTGAGCAAGATCGGCGCAAACGTGGCCCAACAATTGGGGTTATCGCCCAAGATGTTGGCTTA
GTCGATATGCTGAGCGATTTGCTCCAACAACAATCATTATTTGTAATCGAGGCCGATAGTGAAATTATGCCCGATGCTTT
GGTGTTGGGCTATCGCGATGTCTTGCCGCATGTGCCCGAACGTTGGCAGAGCTTGCCACAAATTACCCTAAAACTTAATC
AATCAAGCTATGAACAAGGTTTTGCCCAGCTTCAAATTCAGACTGGTTTGAAGCCGACCATTCCTATTCACGAGTATCTT
TCGTTGGCTTTGCACTTGGTGCGGCTGGAGGCTCGATGA

Upstream 100 bases:

>100_bases
TCACCCGACACCGTGCGCCGCGATTTGAGCCTAGAGAGTTTGTACGCCCAGTTGTTAATCTGAGCCTAGTATTTTTGCTA
GGTGCTGCCTTGGGAACAGT

Downstream 100 bases:

>100_bases
TCGGATGGATTTTTGTCATTTTGTTGTGTGGGCTATTTGGCTATAACTTGTATCGCACTGGCCATGTGCAGCGCTTGATT
GCAATTCGCCAGCGCCGCCC

Product: response regulator receiver modulated diguanylate cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MPERILVADDNEALSQLLELILVEHGYEVTLANDGGDLLAKAQLQIPDLMIVDILMPRIDGYEAIRQLRNDTRLAHIPII
VLTARTAIEDVVTGFELGADDYIVKPFQMPELLARVRAQLLRATRRPVLNPLTGLPGNILIEEEVNHRLRQQQAFALLYL
DLDNFKAYNDSYGFARGDLVIKLLATILTEIKAEYNDEGLFIGHIGGDDFALIMASEHVNALCEDLIRRFDQRILTLYDP
NSSNKPVPIQTLSVGVVLHREDMQQTYHDLSRTAAEMKRVAKQQTGSVYVVDRRAQKQTIEQDRRKRGPTIGVIAQDVGL
VDMLSDLLQQQSLFVIEADSEIMPDALVLGYRDVLPHVPERWQSLPQITLKLNQSSYEQGFAQLQIQTGLKPTIPIHEYL
SLALHLVRLEAR

Sequences:

>Translated_412_residues
MPERILVADDNEALSQLLELILVEHGYEVTLANDGGDLLAKAQLQIPDLMIVDILMPRIDGYEAIRQLRNDTRLAHIPII
VLTARTAIEDVVTGFELGADDYIVKPFQMPELLARVRAQLLRATRRPVLNPLTGLPGNILIEEEVNHRLRQQQAFALLYL
DLDNFKAYNDSYGFARGDLVIKLLATILTEIKAEYNDEGLFIGHIGGDDFALIMASEHVNALCEDLIRRFDQRILTLYDP
NSSNKPVPIQTLSVGVVLHREDMQQTYHDLSRTAAEMKRVAKQQTGSVYVVDRRAQKQTIEQDRRKRGPTIGVIAQDVGL
VDMLSDLLQQQSLFVIEADSEIMPDALVLGYRDVLPHVPERWQSLPQITLKLNQSSYEQGFAQLQIQTGLKPTIPIHEYL
SLALHLVRLEAR
>Mature_411_residues
PERILVADDNEALSQLLELILVEHGYEVTLANDGGDLLAKAQLQIPDLMIVDILMPRIDGYEAIRQLRNDTRLAHIPIIV
LTARTAIEDVVTGFELGADDYIVKPFQMPELLARVRAQLLRATRRPVLNPLTGLPGNILIEEEVNHRLRQQQAFALLYLD
LDNFKAYNDSYGFARGDLVIKLLATILTEIKAEYNDEGLFIGHIGGDDFALIMASEHVNALCEDLIRRFDQRILTLYDPN
SSNKPVPIQTLSVGVVLHREDMQQTYHDLSRTAAEMKRVAKQQTGSVYVVDRRAQKQTIEQDRRKRGPTIGVIAQDVGLV
DMLSDLLQQQSLFVIEADSEIMPDALVLGYRDVLPHVPERWQSLPQITLKLNQSSYEQGFAQLQIQTGLKPTIPIHEYLS
LALHLVRLEAR

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG3706

COG function: function code T; Response regulator containing a CheY-like receiver domain and a GGDEF domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=120, Percent_Identity=41.6666666666667, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI87082012, Length=117, Percent_Identity=41.8803418803419, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1786599, Length=124, Percent_Identity=35.4838709677419, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790860, Length=133, Percent_Identity=36.8421052631579, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789809, Length=137, Percent_Identity=40.8759124087591, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1788394, Length=120, Percent_Identity=38.3333333333333, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1787375, Length=122, Percent_Identity=39.344262295082, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786911, Length=128, Percent_Identity=36.71875, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI2367329, Length=120, Percent_Identity=40, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788550, Length=110, Percent_Identity=35.4545454545455, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787229, Length=122, Percent_Identity=33.6065573770492, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790299, Length=112, Percent_Identity=31.25, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790437, Length=116, Percent_Identity=31.8965517241379, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789402, Length=142, Percent_Identity=33.0985915492958, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790552, Length=124, Percent_Identity=35.4838709677419, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1788191, Length=110, Percent_Identity=32.7272727272727, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1787487, Length=106, Percent_Identity=33.0188679245283, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790863, Length=119, Percent_Identity=35.2941176470588, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787816, Length=107, Percent_Identity=33.6448598130841, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 46532; Mature: 46401

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPERILVADDNEALSQLLELILVEHGYEVTLANDGGDLLAKAQLQIPDLMIVDILMPRID
CCCEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCC
GYEAIRQLRNDTRLAHIPIIVLTARTAIEDVVTGFELGADDYIVKPFQMPELLARVRAQL
CHHHHHHHHCCCCEEEECEEEEEHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHH
LRATRRPVLNPLTGLPGNILIEEEVNHRLRQQQAFALLYLDLDNFKAYNDSYGFARGDLV
HHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCCCCHHHHH
IKLLATILTEIKAEYNDEGLFIGHIGGDDFALIMASEHVNALCEDLIRRFDQRILTLYDP
HHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHEEEEECC
NSSNKPVPIQTLSVGVVLHREDMQQTYHDLSRTAAEMKRVAKQQTGSVYVVDRRAQKQTI
CCCCCCCEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHH
EQDRRKRGPTIGVIAQDVGLVDMLSDLLQQQSLFVIEADSEIMPDALVLGYRDVLPHVPE
HHHHHHCCCEEEEEEHHCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHCHHHHHCCCCH
RWQSLPQITLKLNQSSYEQGFAQLQIQTGLKPTIPIHEYLSLALHLVRLEAR
HHHCCCEEEEEECCCHHHCCHHEEEEECCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PERILVADDNEALSQLLELILVEHGYEVTLANDGGDLLAKAQLQIPDLMIVDILMPRID
CCEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCC
GYEAIRQLRNDTRLAHIPIIVLTARTAIEDVVTGFELGADDYIVKPFQMPELLARVRAQL
CHHHHHHHHCCCCEEEECEEEEEHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHH
LRATRRPVLNPLTGLPGNILIEEEVNHRLRQQQAFALLYLDLDNFKAYNDSYGFARGDLV
HHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCCCCHHHHH
IKLLATILTEIKAEYNDEGLFIGHIGGDDFALIMASEHVNALCEDLIRRFDQRILTLYDP
HHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHEEEEECC
NSSNKPVPIQTLSVGVVLHREDMQQTYHDLSRTAAEMKRVAKQQTGSVYVVDRRAQKQTI
CCCCCCCEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHH
EQDRRKRGPTIGVIAQDVGLVDMLSDLLQQQSLFVIEADSEIMPDALVLGYRDVLPHVPE
HHHHHHCCCEEEEEEHHCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHCHHHHHCCCCH
RWQSLPQITLKLNQSSYEQGFAQLQIQTGLKPTIPIHEYLSLALHLVRLEAR
HHHCCCEEEEEECCCHHHCCHHEEEEECCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]