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The map label for this gene is cvrA [H]

Identifier: 159899852

GI number: 159899852

Start: 4203546

End: 4205408

Strand: Direct

Name: cvrA [H]

Synonym: Haur_3335

Alternate gene names: 159899852

Gene position: 4203546-4205408 (Clockwise)

Preceding gene: 159899850

Following gene: 159899853

Centisome position: 66.23

GC content: 49.97

Gene sequence:

>1863_bases
ATGGATGCACATAGTTTGTTGTTGATGGCGGGGATGGTGATTTGTTTTGGGATTGCCACCTTCGTGCTGGCCGAACGAAT
TGGCATCCCGTCGATTGTATTGTTGCTGTTGGTGGGAGTGCTGGTTGGCCCCGAAGTTTTCGGCTTGGTTGATCCATCGG
CCTTAGGGGTTGGGCTGCGGGTGTTGATTCCGCTGTTTGTGGCGATTATTGTGTTTGAAGGTGGTTTGGTGCTCGATATC
AACGATTTGCGCCGTTTATCCTACCCATTGCAAATGTTGATGAGTGTTGGAGCCTTGGTGACATGGGGCAGTGCAACCCT
GGTAGCACATTTTGTGGCGGGATTATCGTGGCCACTGGCAACCCTGTTTGGAGCATTAATGAGCGTGACTGGGCCAACCG
TGATCACGCCTTTGATGCGGTGTAGCAATGCCAAAGAACGCTTAAAAGTGTTGTTACAAGCGGAAGGCGTATTGGTTGAT
GCGGTTGGGGCAATTTTGGCGGTGGTTGTGCTCGATGTTTTGCTTACCAGCGGCACAACGATTAGTGGAGCCTTCGATTG
GGCCGAACGCTTATTGATTGGCTCGTTAATTGGCTTGATTGGCGGCATTGGCTTAGCCTATGCGTTGCGCTTTATTGGCT
CGAAACTTAATGCTGAAACCACCCGTTTGAGCGCGTTGGGTGGCGCAATCGCGATCTTTATTATTGCCGAAGCAATTTCG
CATGAGGCTGGCATTGCGGCAGCAGCAGTTTCGGGGATTGTCGTTGGCAATATCGATTTTCCCCACGAAGAAGAAGTTGT
GTTGTTCAAGGGCGACTTAACCATGCTGGCAATTACGATTATTTTTATTTTGCTGGCAGCTCGTTTGAAATTTGCCGATT
TGGCCGCGCTTGGCTGGTGGGGTGTGTTAGCGGTTGTATTGATGATTGTGGTGGTGCGGCCATTGTGTGTCTTTGCTTCG
ACGCTTGGCTCAACCTTAACTTGGCGCGAACGAGCATTTATTGCTGCGGTTTGCCCACGCGGAGTTGTCGCCGCTTCAGT
TGCCACCTTTGCCGCGATCTCATTGGAAGAAGCCGGATTTGCTGGGGGCAATTTGTTGATTGGCTTGGTCTTTATGACCG
TGATTGGCACAGTTGTGTTGCAAAGCTTCACCACCCCATTGTTTGCCCGTTTGTTAGGAGTTGAACCGATGACCACTTTA
GTTATTGGCGCGAATGATTTGGGCCAGCTGTTTGCCCGCCAACTGCATAGCCAACATCACGATGTAGTCGTAATCGATAC
CGATCAGCAGTTGATCGATCGAGTGCGCCAGCATGGCATTAGCACAATCACTGGTGATGCGACTGATCTGCAAGTGTTGC
GTAAAGCTGGCGTTGAACGGGACAAAGCGGTTGTAGCCTTGACCCCGAGTGATAAACTCAATCTGTTGGTGAGCCAAGTT
GTGCGTTCGCATTTCAAGGTTACAACAATTGTGGCTCAGGCTGAAAATGAGAGTACCAGCAGTGTTTTGCGCGATCTTGG
CATTACGGTTTTGAATCCCTTACAAGCATCGGTTGATGCTTTAACCCAATTGGTTCAAGGCCCATCAGCCATGAGCATGC
TCTTAAGTCATCAAGCCGACCAAAGCATTTACGAAGTTGAAGTATCCAATCCGCGGGTGGTGGGTAAGCCGTTGAAACAG
CTTAATTTGCCAAATAATGTCTTGATTGTGGCAATTCGGCGGGCGGGCAACTTATTTGTGCCCGATGGTCAAACCCAATT
GCAAGCAGCCGATCAACTAACCTTGATTGGCACAGCCAGCACAATTCAACAGGCTGATCAACAACTGCGTGAGGGAGCGA
GCGAGGCAATGTATCAAGCATGA

Upstream 100 bases:

>100_bases
GGGTCCTTTTGTTAACTAAGTTAAACGACAAACCTAACAATAATAGCATAACATAGCTTAGGTTTGTGTCAATGTGGCAA
GGCGCACAGAAAGGAGTTGT

Downstream 100 bases:

>100_bases
AACCAGCCAAAACCCCTAGTCGCAAAGCGCGTTGGCGAAGACTGATCGCGGCCTCGTTGCGCGATGGTTGGATTGTGTTT
CGCGATTCGGGAATTTGGCT

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 620; Mature: 620

Protein sequence:

>620_residues
MDAHSLLLMAGMVICFGIATFVLAERIGIPSIVLLLLVGVLVGPEVFGLVDPSALGVGLRVLIPLFVAIIVFEGGLVLDI
NDLRRLSYPLQMLMSVGALVTWGSATLVAHFVAGLSWPLATLFGALMSVTGPTVITPLMRCSNAKERLKVLLQAEGVLVD
AVGAILAVVVLDVLLTSGTTISGAFDWAERLLIGSLIGLIGGIGLAYALRFIGSKLNAETTRLSALGGAIAIFIIAEAIS
HEAGIAAAAVSGIVVGNIDFPHEEEVVLFKGDLTMLAITIIFILLAARLKFADLAALGWWGVLAVVLMIVVVRPLCVFAS
TLGSTLTWRERAFIAAVCPRGVVAASVATFAAISLEEAGFAGGNLLIGLVFMTVIGTVVLQSFTTPLFARLLGVEPMTTL
VIGANDLGQLFARQLHSQHHDVVVIDTDQQLIDRVRQHGISTITGDATDLQVLRKAGVERDKAVVALTPSDKLNLLVSQV
VRSHFKVTTIVAQAENESTSSVLRDLGITVLNPLQASVDALTQLVQGPSAMSMLLSHQADQSIYEVEVSNPRVVGKPLKQ
LNLPNNVLIVAIRRAGNLFVPDGQTQLQAADQLTLIGTASTIQQADQQLREGASEAMYQA

Sequences:

>Translated_620_residues
MDAHSLLLMAGMVICFGIATFVLAERIGIPSIVLLLLVGVLVGPEVFGLVDPSALGVGLRVLIPLFVAIIVFEGGLVLDI
NDLRRLSYPLQMLMSVGALVTWGSATLVAHFVAGLSWPLATLFGALMSVTGPTVITPLMRCSNAKERLKVLLQAEGVLVD
AVGAILAVVVLDVLLTSGTTISGAFDWAERLLIGSLIGLIGGIGLAYALRFIGSKLNAETTRLSALGGAIAIFIIAEAIS
HEAGIAAAAVSGIVVGNIDFPHEEEVVLFKGDLTMLAITIIFILLAARLKFADLAALGWWGVLAVVLMIVVVRPLCVFAS
TLGSTLTWRERAFIAAVCPRGVVAASVATFAAISLEEAGFAGGNLLIGLVFMTVIGTVVLQSFTTPLFARLLGVEPMTTL
VIGANDLGQLFARQLHSQHHDVVVIDTDQQLIDRVRQHGISTITGDATDLQVLRKAGVERDKAVVALTPSDKLNLLVSQV
VRSHFKVTTIVAQAENESTSSVLRDLGITVLNPLQASVDALTQLVQGPSAMSMLLSHQADQSIYEVEVSNPRVVGKPLKQ
LNLPNNVLIVAIRRAGNLFVPDGQTQLQAADQLTLIGTASTIQQADQQLREGASEAMYQA
>Mature_620_residues
MDAHSLLLMAGMVICFGIATFVLAERIGIPSIVLLLLVGVLVGPEVFGLVDPSALGVGLRVLIPLFVAIIVFEGGLVLDI
NDLRRLSYPLQMLMSVGALVTWGSATLVAHFVAGLSWPLATLFGALMSVTGPTVITPLMRCSNAKERLKVLLQAEGVLVD
AVGAILAVVVLDVLLTSGTTISGAFDWAERLLIGSLIGLIGGIGLAYALRFIGSKLNAETTRLSALGGAIAIFIIAEAIS
HEAGIAAAAVSGIVVGNIDFPHEEEVVLFKGDLTMLAITIIFILLAARLKFADLAALGWWGVLAVVLMIVVVRPLCVFAS
TLGSTLTWRERAFIAAVCPRGVVAASVATFAAISLEEAGFAGGNLLIGLVFMTVIGTVVLQSFTTPLFARLLGVEPMTTL
VIGANDLGQLFARQLHSQHHDVVVIDTDQQLIDRVRQHGISTITGDATDLQVLRKAGVERDKAVVALTPSDKLNLLVSQV
VRSHFKVTTIVAQAENESTSSVLRDLGITVLNPLQASVDALTQLVQGPSAMSMLLSHQADQSIYEVEVSNPRVVGKPLKQ
LNLPNNVLIVAIRRAGNLFVPDGQTQLQAADQLTLIGTASTIQQADQQLREGASEAMYQA

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI1786232, Length=546, Percent_Identity=23.4432234432234, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI87081854, Length=387, Percent_Identity=27.1317829457364, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 65430; Mature: 65430

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAHSLLLMAGMVICFGIATFVLAERIGIPSIVLLLLVGVLVGPEVFGLVDPSALGVGLR
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHH
VLIPLFVAIIVFEGGLVLDINDLRRLSYPLQMLMSVGALVTWGSATLVAHFVAGLSWPLA
HHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHH
TLFGALMSVTGPTVITPLMRCSNAKERLKVLLQAEGVLVDAVGAILAVVVLDVLLTSGTT
HHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCE
ISGAFDWAERLLIGSLIGLIGGIGLAYALRFIGSKLNAETTRLSALGGAIAIFIIAEAIS
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
HEAGIAAAAVSGIVVGNIDFPHEEEVVLFKGDLTMLAITIIFILLAARLKFADLAALGWW
HHCCHHHHHHCCEEEECCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVLAVVLMIVVVRPLCVFASTLGSTLTWRERAFIAAVCPRGVVAASVATFAAISLEEAGF
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
AGGNLLIGLVFMTVIGTVVLQSFTTPLFARLLGVEPMTTLVIGANDLGQLFARQLHSQHH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEECCCHHHHHHHHHHHCCCC
DVVVIDTDQQLIDRVRQHGISTITGDATDLQVLRKAGVERDKAVVALTPSDKLNLLVSQV
CEEEEECCHHHHHHHHHCCCCEECCCHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHH
VRSHFKVTTIVAQAENESTSSVLRDLGITVLNPLQASVDALTQLVQGPSAMSMLLSHQAD
HHHHHHHHHEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
QSIYEVEVSNPRVVGKPLKQLNLPNNVLIVAIRRAGNLFVPDGQTQLQAADQLTLIGTAS
CCEEEEECCCCCCCCCCHHHCCCCCCEEEEEEECCCCEECCCCCHHHHHCCCEEEEECHH
TIQQADQQLREGASEAMYQA
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDAHSLLLMAGMVICFGIATFVLAERIGIPSIVLLLLVGVLVGPEVFGLVDPSALGVGLR
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHH
VLIPLFVAIIVFEGGLVLDINDLRRLSYPLQMLMSVGALVTWGSATLVAHFVAGLSWPLA
HHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHH
TLFGALMSVTGPTVITPLMRCSNAKERLKVLLQAEGVLVDAVGAILAVVVLDVLLTSGTT
HHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCE
ISGAFDWAERLLIGSLIGLIGGIGLAYALRFIGSKLNAETTRLSALGGAIAIFIIAEAIS
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
HEAGIAAAAVSGIVVGNIDFPHEEEVVLFKGDLTMLAITIIFILLAARLKFADLAALGWW
HHCCHHHHHHCCEEEECCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVLAVVLMIVVVRPLCVFASTLGSTLTWRERAFIAAVCPRGVVAASVATFAAISLEEAGF
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
AGGNLLIGLVFMTVIGTVVLQSFTTPLFARLLGVEPMTTLVIGANDLGQLFARQLHSQHH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEECCCHHHHHHHHHHHCCCC
DVVVIDTDQQLIDRVRQHGISTITGDATDLQVLRKAGVERDKAVVALTPSDKLNLLVSQV
CEEEEECCHHHHHHHHHCCCCEECCCHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHH
VRSHFKVTTIVAQAENESTSSVLRDLGITVLNPLQASVDALTQLVQGPSAMSMLLSHQAD
HHHHHHHHHEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
QSIYEVEVSNPRVVGKPLKQLNLPNNVLIVAIRRAGNLFVPDGQTQLQAADQLTLIGTAS
CCEEEEECCCCCCCCCCHHHCCCCCCEEEEEEECCCCEECCCCCHHHHHCCCEEEEECHH
TIQQADQQLREGASEAMYQA
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA