Click here to switch to the map view.

The map label for this gene is proA [H]

Identifier: 159899726

GI number: 159899726

Start: 4057323

End: 4058585

Strand: Direct

Name: proA [H]

Synonym: Haur_3208

Alternate gene names: 159899726

Gene position: 4057323-4058585 (Clockwise)

Preceding gene: 159899725

Following gene: 159899737

Centisome position: 63.93

GC content: 53.52

Gene sequence:

>1263_bases
ATGCTTGAGGCAATGGGTCAGCGAGCAAAGCTGGCAGCACGCATATTGGCCCGCACAACCACAGCTCAACGGAATGCCGC
CGTCGAGGCCATGGCCGAAGAACTAAGCCTGGATCGCGAATCGATTCTTTCGGCCAACGAGGCTGATATGCGGCTTGGGC
GCGAGGCTGGCTTAACTCCGGCCTTGCTCGATCGTTTATTACTCAATGAGCAGCGACTTGAAGCAATTGCCAACGATGTG
CGCACTGTGGCGGTCTTGCCTGATCCGGTTGGCGAGGTGTTTGAGCAAGGTGTACTGCCAAATGGCTTGCGCATCGAAAA
GCGCCGCGTGCCGCTGGGGGTAGTTGGCGTGATCTACGAGGCGCGGCCAAATGTCACTGCTGATGTGGCGGCATTGTGTA
TCAAAGCGGGCAGTGCGGTAATTTTACGCGGTGGCAAGGAAATTACCCGTTCAGCTGGAGCATTAGTGCAAGCTTTACGT
CGTGCCTTAGAACGGGTCGATCTGCCAGCTGATGCCTTACAACTAATCGATAATCCTGATCGTGAGCTAGTGCGCGGCTT
GCTAACCTTAGATCGCTATGTGGACATGATTATTCCACGCGGTGGTTCGGGCTTGCACGATTTTTGTCGTAAAACCGCCA
CAATTCCGGTAATTACGGGCGGCATTGGGGTTTGCCACGCCTATGTTGACCATACCGCGCCACTTGAGCAAGTTGTGCCG
ATTATTGTTAATGCCAAAGTGCAACGTCCAAGCGTCTGCAACTCGCTCGAAACCGTCTTGATTGAGCGCAGTGCTGCGGC
CAAAGTGTTACCACGGCTTGGTGCAGCGTTGCAAGAACACAAGGTTGAATTACGTTGTGATCCTGAGTCGTTGGCGATTT
TGCGCGAAGCTGGTAGCGCTGATTGGAACTTGGTTTCAGCTCAGCCCGCTGATTTCGGCCAAGAATTTTCGGCATTAATT
TTGGCAGTACGCGTGGTCGATGGGCTTGATCAGGCAATTGAGCATATTGATCAATTTGGCACCGACCATTCCGACACGAT
TTTATCGCAAGATCCGGCGGCGATTGAGCGCTTTTTGAACGAGGTGGATTCGGCGGTGGTATATGCCAATTCCTCAACCC
GTTTCACCGATGGCTCGCAAATGGGCTTGGGTGCTGAAATTGCGATCAGCACCCAAAAATTGCATGCGCGTGGTCCGATG
GCTTTGCGCGAATTGACCTCATACAAATGGGTAGTCCGTGGCGCTGGCCACGTTCGCGATTGA

Upstream 100 bases:

>100_bases
CATGCCGCCGTTCGTTGGCAACTCGAAGGCGATTTGGAAGGTGAAGATCATCCAGCCGCCCCGCTTGGCGAGTTATGACG
GCTAGCATGAGGAGTATCCA

Downstream 100 bases:

>100_bases
TATTGCTAGTGGGCAATCGCGCTGGTTTGGCGTGGATTGCCCATTTGTTGATCGACCCGCAAGCCCCAAAGCGTTGCAAG
TGCGCCAACCACATCAGCGC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MLEAMGQRAKLAARILARTTTAQRNAAVEAMAEELSLDRESILSANEADMRLGREAGLTPALLDRLLLNEQRLEAIANDV
RTVAVLPDPVGEVFEQGVLPNGLRIEKRRVPLGVVGVIYEARPNVTADVAALCIKAGSAVILRGGKEITRSAGALVQALR
RALERVDLPADALQLIDNPDRELVRGLLTLDRYVDMIIPRGGSGLHDFCRKTATIPVITGGIGVCHAYVDHTAPLEQVVP
IIVNAKVQRPSVCNSLETVLIERSAAAKVLPRLGAALQEHKVELRCDPESLAILREAGSADWNLVSAQPADFGQEFSALI
LAVRVVDGLDQAIEHIDQFGTDHSDTILSQDPAAIERFLNEVDSAVVYANSSTRFTDGSQMGLGAEIAISTQKLHARGPM
ALRELTSYKWVVRGAGHVRD

Sequences:

>Translated_420_residues
MLEAMGQRAKLAARILARTTTAQRNAAVEAMAEELSLDRESILSANEADMRLGREAGLTPALLDRLLLNEQRLEAIANDV
RTVAVLPDPVGEVFEQGVLPNGLRIEKRRVPLGVVGVIYEARPNVTADVAALCIKAGSAVILRGGKEITRSAGALVQALR
RALERVDLPADALQLIDNPDRELVRGLLTLDRYVDMIIPRGGSGLHDFCRKTATIPVITGGIGVCHAYVDHTAPLEQVVP
IIVNAKVQRPSVCNSLETVLIERSAAAKVLPRLGAALQEHKVELRCDPESLAILREAGSADWNLVSAQPADFGQEFSALI
LAVRVVDGLDQAIEHIDQFGTDHSDTILSQDPAAIERFLNEVDSAVVYANSSTRFTDGSQMGLGAEIAISTQKLHARGPM
ALRELTSYKWVVRGAGHVRD
>Mature_420_residues
MLEAMGQRAKLAARILARTTTAQRNAAVEAMAEELSLDRESILSANEADMRLGREAGLTPALLDRLLLNEQRLEAIANDV
RTVAVLPDPVGEVFEQGVLPNGLRIEKRRVPLGVVGVIYEARPNVTADVAALCIKAGSAVILRGGKEITRSAGALVQALR
RALERVDLPADALQLIDNPDRELVRGLLTLDRYVDMIIPRGGSGLHDFCRKTATIPVITGGIGVCHAYVDHTAPLEQVVP
IIVNAKVQRPSVCNSLETVLIERSAAAKVLPRLGAALQEHKVELRCDPESLAILREAGSADWNLVSAQPADFGQEFSALI
LAVRVVDGLDQAIEHIDQFGTDHSDTILSQDPAAIERFLNEVDSAVVYANSSTRFTDGSQMGLGAEIAISTQKLHARGPM
ALRELTSYKWVVRGAGHVRD

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361368, Length=420, Percent_Identity=36.4285714285714, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI62912457, Length=420, Percent_Identity=36.4285714285714, Blast_Score=250, Evalue=2e-66,
Organism=Escherichia coli, GI1786438, Length=419, Percent_Identity=52.9832935560859, Blast_Score=436, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17569967, Length=421, Percent_Identity=34.4418052256532, Blast_Score=240, Evalue=8e-64,
Organism=Caenorhabditis elegans, GI17569969, Length=421, Percent_Identity=34.4418052256532, Blast_Score=240, Evalue=8e-64,
Organism=Saccharomyces cerevisiae, GI6324899, Length=430, Percent_Identity=34.4186046511628, Blast_Score=242, Evalue=6e-65,
Organism=Drosophila melanogaster, GI21357643, Length=421, Percent_Identity=34.916864608076, Blast_Score=243, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45301; Mature: 45301

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEAMGQRAKLAARILARTTTAQRNAAVEAMAEELSLDRESILSANEADMRLGREAGLTP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHCHHCCCCH
ALLDRLLLNEQRLEAIANDVRTVAVLPDPVGEVFEQGVLPNGLRIEKRRVPLGVVGVIYE
HHHHHHHHCHHHHHHHHHCCEEEEECCCHHHHHHHCCCCCCCCEEECCCCCEEEEEEEEE
ARPNVTADVAALCIKAGSAVILRGGKEITRSAGALVQALRRALERVDLPADALQLIDNPD
CCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
RELVRGLLTLDRYVDMIIPRGGSGLHDFCRKTATIPVITGGIGVCHAYVDHTAPLEQVVP
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEECCHHHHHHHHCCCCCHHHHHH
IIVNAKVQRPSVCNSLETVLIERSAAAKVLPRLGAALQEHKVELRCDPESLAILREAGSA
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHCCCC
DWNLVSAQPADFGQEFSALILAVRVVDGLDQAIEHIDQFGTDHSDTILSQDPAAIERFLN
CCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
EVDSAVVYANSSTRFTDGSQMGLGAEIAISTQKLHARGPMALRELTSYKWVVRGAGHVRD
HHCCEEEEECCCCCCCCCCCCCCCCEEEEEHHHHHCCCCHHHHHHHHHHHEEECCCCCCC
>Mature Secondary Structure
MLEAMGQRAKLAARILARTTTAQRNAAVEAMAEELSLDRESILSANEADMRLGREAGLTP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHCHHCCCCH
ALLDRLLLNEQRLEAIANDVRTVAVLPDPVGEVFEQGVLPNGLRIEKRRVPLGVVGVIYE
HHHHHHHHCHHHHHHHHHCCEEEEECCCHHHHHHHCCCCCCCCEEECCCCCEEEEEEEEE
ARPNVTADVAALCIKAGSAVILRGGKEITRSAGALVQALRRALERVDLPADALQLIDNPD
CCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
RELVRGLLTLDRYVDMIIPRGGSGLHDFCRKTATIPVITGGIGVCHAYVDHTAPLEQVVP
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEECCHHHHHHHHCCCCCHHHHHH
IIVNAKVQRPSVCNSLETVLIERSAAAKVLPRLGAALQEHKVELRCDPESLAILREAGSA
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHCCCC
DWNLVSAQPADFGQEFSALILAVRVVDGLDQAIEHIDQFGTDHSDTILSQDPAAIERFLN
CCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
EVDSAVVYANSSTRFTDGSQMGLGAEIAISTQKLHARGPMALRELTSYKWVVRGAGHVRD
HHCCEEEEECCCCCCCCCCCCCCCCEEEEEHHHHHCCCCHHHHHHHHHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA