BacMap

Definition	Herpetosiphon aurantiacus ATCC 23779 chromosome, complete genome.
Accession	NC_009972
Length	6,346,587

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The map label for this gene is fkpA [H]

Identifier: 159899696

GI number: 159899696

Start: 4016553

End: 4016891

Strand: Reverse

Name: fkpA [H]

Synonym: Haur_3178

Alternate gene names: 159899696

Gene position: 4016891-4016553 (Counterclockwise)

Preceding gene: 159899699

Following gene: 159899692

Centisome position: 63.29

GC content: 49.56

Gene sequence:

>339_bases
ATGCAAACAACTCCATCGGGCTTGCGCTACGAAGAACAGGTTGTCGGAACAGGGGCGCAACCTAAAGCTGGCCAAACGGT
GATTGTTCATTATACAGGTACACTCACCAACGGAACCAAATTCGATAGCTCGGTTGATCGAGGCGAGCCATTTGAATTCA
TTTTGGGCGTTGGCCAAGTGATCAAAGGCTGGGATGAAGGCTTATCGACGATGAATGTTGGTGGTAAGCGGCGCTTGTAT
ATTCCAGGCAATTTGGCCTATGGCGAACGCGGTTACCCTGGCGTGATTCCACCCAATGCTGAATTGATTTTCGATGTGGA
GTTGATCGGGGTTCGTTAA

Upstream 100 bases:

>100_bases
CCAAGCGTACAAATTTGCTAGTTTCTATTATAGCCTGAATTGCGATTTTTCCTATGTTCCTTGATAATTGGCCCAATCAA
TCTCAGAGGAGGCTCTTTCG

Downstream 100 bases:

>100_bases
TATTGTTCGATAAAGCCAACAGCCCTCGACACATTGAGGGCTGTTGGTTTTTCATTTAATCTTTGAGGGCGGTAATTGCG
CCTAATGCCGCTTCATGGAC

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 112; Mature: 112

Protein sequence:

>112_residues
MQTTPSGLRYEEQVVGTGAQPKAGQTVIVHYTGTLTNGTKFDSSVDRGEPFEFILGVGQVIKGWDEGLSTMNVGGKRRLY
IPGNLAYGERGYPGVIPPNAELIFDVELIGVR

Sequences:

>Translated_112_residues
MQTTPSGLRYEEQVVGTGAQPKAGQTVIVHYTGTLTNGTKFDSSVDRGEPFEFILGVGQVIKGWDEGLSTMNVGGKRRLY
IPGNLAYGERGYPGVIPPNAELIFDVELIGVR
>Mature_112_residues
MQTTPSGLRYEEQVVGTGAQPKAGQTVIVHYTGTLTNGTKFDSSVDRGEPFEFILGVGQVIKGWDEGLSTMNVGGKRRLY
IPGNLAYGERGYPGVIPPNAELIFDVELIGVR

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=89, Percent_Identity=57.3033707865169, Blast_Score=116, Evalue=4e-27,
Organism=Homo sapiens, GI4503725, Length=89, Percent_Identity=57.3033707865169, Blast_Score=116, Evalue=4e-27,
Organism=Homo sapiens, GI4758380, Length=91, Percent_Identity=57.1428571428571, Blast_Score=114, Evalue=2e-26,
Organism=Homo sapiens, GI206725530, Length=92, Percent_Identity=53.2608695652174, Blast_Score=102, Evalue=5e-23,
Organism=Homo sapiens, GI17149844, Length=92, Percent_Identity=53.2608695652174, Blast_Score=102, Evalue=5e-23,
Organism=Homo sapiens, GI17149842, Length=92, Percent_Identity=53.2608695652174, Blast_Score=102, Evalue=5e-23,
Organism=Homo sapiens, GI4503729, Length=94, Percent_Identity=53.1914893617021, Blast_Score=98, Evalue=2e-21,
Organism=Homo sapiens, GI4503727, Length=114, Percent_Identity=43.859649122807, Blast_Score=93, Evalue=4e-20,
Organism=Homo sapiens, GI224809331, Length=99, Percent_Identity=50.5050505050505, Blast_Score=92, Evalue=6e-20,
Organism=Homo sapiens, GI224809329, Length=96, Percent_Identity=52.0833333333333, Blast_Score=91, Evalue=2e-19,
Organism=Homo sapiens, GI224809327, Length=96, Percent_Identity=52.0833333333333, Blast_Score=91, Evalue=2e-19,
Organism=Homo sapiens, GI4758384, Length=96, Percent_Identity=52.0833333333333, Blast_Score=91, Evalue=2e-19,
Organism=Homo sapiens, GI192448443, Length=117, Percent_Identity=41.8803418803419, Blast_Score=86, Evalue=7e-18,
Organism=Homo sapiens, GI7706131, Length=94, Percent_Identity=46.8085106382979, Blast_Score=84, Evalue=2e-17,
Organism=Homo sapiens, GI33469985, Length=90, Percent_Identity=47.7777777777778, Blast_Score=84, Evalue=4e-17,
Organism=Homo sapiens, GI206725547, Length=93, Percent_Identity=48.3870967741936, Blast_Score=83, Evalue=6e-17,
Organism=Homo sapiens, GI8923659, Length=96, Percent_Identity=43.75, Blast_Score=79, Evalue=8e-16,
Organism=Homo sapiens, GI31317231, Length=94, Percent_Identity=47.8723404255319, Blast_Score=78, Evalue=1e-15,
Organism=Homo sapiens, GI219842220, Length=80, Percent_Identity=47.5, Blast_Score=73, Evalue=4e-14,
Organism=Homo sapiens, GI17149839, Length=51, Percent_Identity=58.8235294117647, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI87082390, Length=111, Percent_Identity=51.3513513513513, Blast_Score=99, Evalue=1e-22,
Organism=Escherichia coli, GI1789745, Length=112, Percent_Identity=50, Blast_Score=97, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71993519, Length=93, Percent_Identity=58.0645161290323, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17540882, Length=92, Percent_Identity=55.4347826086957, Blast_Score=102, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17561782, Length=90, Percent_Identity=55.5555555555556, Blast_Score=96, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17561778, Length=96, Percent_Identity=45.8333333333333, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71993555, Length=78, Percent_Identity=46.1538461538462, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17506167, Length=89, Percent_Identity=39.3258426966292, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17506169, Length=89, Percent_Identity=39.3258426966292, Blast_Score=66, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324194, Length=98, Percent_Identity=64.2857142857143, Blast_Score=127, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6320727, Length=90, Percent_Identity=64.4444444444444, Blast_Score=119, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323566, Length=106, Percent_Identity=48.1132075471698, Blast_Score=99, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323482, Length=106, Percent_Identity=48.1132075471698, Blast_Score=98, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24655568, Length=91, Percent_Identity=60.4395604395604, Blast_Score=120, Evalue=1e-28,
Organism=Drosophila melanogaster, GI281363946, Length=93, Percent_Identity=59.1397849462366, Blast_Score=115, Evalue=8e-27,
Organism=Drosophila melanogaster, GI17352457, Length=93, Percent_Identity=59.1397849462366, Blast_Score=115, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24583150, Length=96, Percent_Identity=53.125, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24647110, Length=111, Percent_Identity=46.8468468468468, Blast_Score=101, Evalue=9e-23,
Organism=Drosophila melanogaster, GI21356629, Length=102, Percent_Identity=50, Blast_Score=90, Evalue=3e-19,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 12086; Mature: 12086

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTTPSGLRYEEQVVGTGAQPKAGQTVIVHYTGTLTNGTKFDSSVDRGEPFEFILGVGQV
CCCCCCCCCCCHHEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHH
IKGWDEGLSTMNVGGKRRLYIPGNLAYGERGYPGVIPPNAELIFDVELIGVR
HHHHHCCCCEECCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEEECC
>Mature Secondary Structure
MQTTPSGLRYEEQVVGTGAQPKAGQTVIVHYTGTLTNGTKFDSSVDRGEPFEFILGVGQV
CCCCCCCCCCCHHEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHH
IKGWDEGLSTMNVGGKRRLYIPGNLAYGERGYPGVIPPNAELIFDVELIGVR
HHHHHCCCCEECCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]