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The map label for this gene is folP [H]

Identifier: 159899684

GI number: 159899684

Start: 3998559

End: 3999815

Strand: Direct

Name: folP [H]

Synonym: Haur_3166

Alternate gene names: 159899684

Gene position: 3998559-3999815 (Clockwise)

Preceding gene: 159899681

Following gene: 159899685

Centisome position: 63.0

GC content: 50.44

Gene sequence:

>1257_bases
ATGCCTGAATTTGCCTATAACATCCGTCAATATTATCCTCAGCAACGCCAAGAACTGTTGCAGATGATCGCCCAAATTGA
AACCTATCCCAATGCTGCTGAGCGCGTATTGACCAAAGCCAACTTGATTATGCTGCATTGCGATCAGGTTGATCCACATA
CGGCCATGATTGTGAAGCAAGAATTATTGGCGCTCGATGGCGATGCCTTGGTTAGCCCACACGTCTATCTGGGCCAAAGC
ACGCAGCCAACCAATCTGCTGGCGTGGGCCAATGAACGCTCGTGGCGAGCCTTATGTGGCAAGTTTCAAGCGATTCCTTT
ACCTGCCTTGCAAGCCTTAGCCCAACAAATTGGCGCGTTGCTGTTGCATAATCAAGCACGAGGCAGCCTCAAACTTGGCG
CAACTCAATGGGATTGGGGTCGAAAAACCTTGGTGATGGGCATTGTCAATGTTACACCCGATTCTTTCTCTAACGATGGA
TTGCTTGAGGTCGGAACCAGCCAGATTCAGCAGCAAGCGCTTGAGTTTGCCGCAGCTGGAGCCGATATTTTGGATGTTGG
CGGTGAATCGACGCGGCCTGGAGCCAGCAGTGTCAGTATCGCACAGGAGATTGCGCGGGTTGTGCCAGCGATTCAAGCGA
TTCGTCACGTTTGCCAATTGCCAATTTCGATTGATAGCTACAAAGCTGAGGTTGTGGCGGCTGCGCTTGAAGCTGGTGCA
AATGTGGTTAATGATATTTGGGGTTTGCGCCAAGCCGATGGTAGTTGGAATACGGCACTGGCGCAGTTGGTGGCACAAGC
AAACGTGCCAATTATTTTGATGCACAATCGAGTCAGCACGGTTGAGCAATTTGCCCATGGCACAAATTACGCTGCTAGCG
ACTATGGCGATATTATCGGCGAAGTTTGTGCCGAATTACGCCAAAGCATCGATTTCGCCCTGCAAGCGGGCATTGCCAAC
GATTTAATTGTGCTTGATCCAGGCATTGGTTTCGGCAAAAGCCCTGAACAAAATCTACAAGTATTACGTCAACTACGGAC
AATTGCAAGCTTAGGCTACCCGTTGTTGGTTGGCACTAGCCGAAAATCCATGATTGGGATAACATTAAACCGACCTGTTG
ATCAACGCCTGTGGGGCACAGCCGCCACCGTGGCCTATGCAATTCAGGCAGGAGCCGATATTGTGCGGGTGCACGATGTT
GCGGCAATGGTCGATGTTTGTCGAATGACCGACGCTTTAGTTCGTCACGAAGGATAG

Upstream 100 bases:

>100_bases
GGCAGAATGCGGATTAACCCTTAAAATCAGCTATTGAACTGAGTCGCACGCAACGACATATCAGCTAGAATAGCCATGGC
TTAGCACGAAAGATTGAATC

Downstream 100 bases:

>100_bases
AATATGCAACAAGCGCAAACACAGCGCCAACCCTCCCGACTGTTTACCATGGCTATCATTGGGCTAGCCGTGTTTGTGGT
AGCCGCAATTTTGCTGATTG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MPEFAYNIRQYYPQQRQELLQMIAQIETYPNAAERVLTKANLIMLHCDQVDPHTAMIVKQELLALDGDALVSPHVYLGQS
TQPTNLLAWANERSWRALCGKFQAIPLPALQALAQQIGALLLHNQARGSLKLGATQWDWGRKTLVMGIVNVTPDSFSNDG
LLEVGTSQIQQQALEFAAAGADILDVGGESTRPGASSVSIAQEIARVVPAIQAIRHVCQLPISIDSYKAEVVAAALEAGA
NVVNDIWGLRQADGSWNTALAQLVAQANVPIILMHNRVSTVEQFAHGTNYAASDYGDIIGEVCAELRQSIDFALQAGIAN
DLIVLDPGIGFGKSPEQNLQVLRQLRTIASLGYPLLVGTSRKSMIGITLNRPVDQRLWGTAATVAYAIQAGADIVRVHDV
AAMVDVCRMTDALVRHEG

Sequences:

>Translated_418_residues
MPEFAYNIRQYYPQQRQELLQMIAQIETYPNAAERVLTKANLIMLHCDQVDPHTAMIVKQELLALDGDALVSPHVYLGQS
TQPTNLLAWANERSWRALCGKFQAIPLPALQALAQQIGALLLHNQARGSLKLGATQWDWGRKTLVMGIVNVTPDSFSNDG
LLEVGTSQIQQQALEFAAAGADILDVGGESTRPGASSVSIAQEIARVVPAIQAIRHVCQLPISIDSYKAEVVAAALEAGA
NVVNDIWGLRQADGSWNTALAQLVAQANVPIILMHNRVSTVEQFAHGTNYAASDYGDIIGEVCAELRQSIDFALQAGIAN
DLIVLDPGIGFGKSPEQNLQVLRQLRTIASLGYPLLVGTSRKSMIGITLNRPVDQRLWGTAATVAYAIQAGADIVRVHDV
AAMVDVCRMTDALVRHEG
>Mature_417_residues
PEFAYNIRQYYPQQRQELLQMIAQIETYPNAAERVLTKANLIMLHCDQVDPHTAMIVKQELLALDGDALVSPHVYLGQST
QPTNLLAWANERSWRALCGKFQAIPLPALQALAQQIGALLLHNQARGSLKLGATQWDWGRKTLVMGIVNVTPDSFSNDGL
LEVGTSQIQQQALEFAAAGADILDVGGESTRPGASSVSIAQEIARVVPAIQAIRHVCQLPISIDSYKAEVVAAALEAGAN
VVNDIWGLRQADGSWNTALAQLVAQANVPIILMHNRVSTVEQFAHGTNYAASDYGDIIGEVCAELRQSIDFALQAGIAND
LIVLDPGIGFGKSPEQNLQVLRQLRTIASLGYPLLVGTSRKSMIGITLNRPVDQRLWGTAATVAYAIQAGADIVRVHDVA
AMVDVCRMTDALVRHEG

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=268, Percent_Identity=41.044776119403, Blast_Score=182, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6324073, Length=326, Percent_Identity=31.9018404907975, Blast_Score=144, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 45193; Mature: 45062

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS50972 PTERIN_BINDING ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEFAYNIRQYYPQQRQELLQMIAQIETYPNAAERVLTKANLIMLHCDQVDPHTAMIVKQ
CCCHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEEECCCCCHHHHHHHH
ELLALDGDALVSPHVYLGQSTQPTNLLAWANERSWRALCGKFQAIPLPALQALAQQIGAL
HHHHCCCCCEECCCEEECCCCCCCCEEEECCCCHHHHHHCCCCCCCHHHHHHHHHHHHHH
LLHNQARGSLKLGATQWDWGRKTLVMGIVNVTPDSFSNDGLLEVGTSQIQQQALEFAAAG
HHHCCCCCCEEECCCCCCCCCCEEEEEEEECCCCCCCCCCCEECCHHHHHHHHHHHHHCC
ADILDVGGESTRPGASSVSIAQEIARVVPAIQAIRHVCQLPISIDSYKAEVVAAALEAGA
CCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCH
NVVNDIWGLRQADGSWNTALAQLVAQANVPIILMHNRVSTVEQFAHGTNYAASDYGDIIG
HHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCCCCHHHHHHHHH
EVCAELRQSIDFALQAGIANDLIVLDPGIGFGKSPEQNLQVLRQLRTIASLGYPLLVGTS
HHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECC
RKSMIGITLNRPVDQRLWGTAATVAYAIQAGADIVRVHDVAAMVDVCRMTDALVRHEG
CCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PEFAYNIRQYYPQQRQELLQMIAQIETYPNAAERVLTKANLIMLHCDQVDPHTAMIVKQ
CCHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEEECCCCCHHHHHHHH
ELLALDGDALVSPHVYLGQSTQPTNLLAWANERSWRALCGKFQAIPLPALQALAQQIGAL
HHHHCCCCCEECCCEEECCCCCCCCEEEECCCCHHHHHHCCCCCCCHHHHHHHHHHHHHH
LLHNQARGSLKLGATQWDWGRKTLVMGIVNVTPDSFSNDGLLEVGTSQIQQQALEFAAAG
HHHCCCCCCEEECCCCCCCCCCEEEEEEEECCCCCCCCCCCEECCHHHHHHHHHHHHHCC
ADILDVGGESTRPGASSVSIAQEIARVVPAIQAIRHVCQLPISIDSYKAEVVAAALEAGA
CCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCH
NVVNDIWGLRQADGSWNTALAQLVAQANVPIILMHNRVSTVEQFAHGTNYAASDYGDIIG
HHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCCCCHHHHHHHHH
EVCAELRQSIDFALQAGIANDLIVLDPGIGFGKSPEQNLQVLRQLRTIASLGYPLLVGTS
HHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECC
RKSMIGITLNRPVDQRLWGTAATVAYAIQAGADIVRVHDVAAMVDVCRMTDALVRHEG
CCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]