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The map label for this gene is trpC [H]

Identifier: 159899509

GI number: 159899509

Start: 3776641

End: 3777459

Strand: Direct

Name: trpC [H]

Synonym: Haur_2990

Alternate gene names: 159899509

Gene position: 3776641-3777459 (Clockwise)

Preceding gene: 159899501

Following gene: 159899510

Centisome position: 59.51

GC content: 50.06

Gene sequence:

>819_bases
ATGACTGCGACAATTCTAGATCAGATTTTTGCCCATAAACGCACCGAGGTCGAGCGCCAAAAATTGAAGATCCCCCAAGC
TAAACTTGAACAACAACTTGGCAACGCCCCCAAGCCGCGTAGCTTGCGCCAAGCCTTGCGCCAACCTGATCGGATTAGCT
TGATCGCTGAGGTCAAAAAGGCCAGTCCATCCAAAGGGGTCTTTTTAGAGAATTTCAACCCAACTGAACTAGCTGAAACC
TACGCTAGCAATGGGGCGGCTGCGATTTCGGTGTTAACTGATGTGCGCTTTTTTCAAGGCAGCTTAATCTATTTACGCTC
AATTCATGAGCACCTTGATACATTGGGCTATGCTACGCCCCTGTTGCGCAAAGATTTTCTCTATGATCCCTATCAAATTT
ATGAGGCCCGCGTATCGGGAGCCGATGCAATTTTGTTGATCGTGGGCATGCTCGATGATCAAACGCTGCATGAGTTGTAT
CAATTAACCTATGGCTTGGGTATGGAAGCCTTGGTTGAGGTGCATACTGAGGCTGAAATGGCCCGTGCTCAGGCATTACA
AGCCCAAATTATCGGCATCAACAATCGTGATCTGCATAGTTTTAGCGTTGATCTTGCGACAACTCAACGGGTTAGCGCTA
GTTTGCCTGCAATTGGCGACCCTCAGCGGCCTGTGTTGGTGGCCGAAAGTGGCATCCATGGCCCTGATGTGCTGCCAACG
TTGCGTGAATGGGGTGTTGAGGCAATTCTCGTAGGCGAATCGATCGTGCTAGCCCCCGATCATGCGGCCCATGTTCGCGC
CTTGAGCCAAAAAGCGTAA

Upstream 100 bases:

>100_bases
ACGAATTGTTGCCTCCCAACAATAAAGCCAATTGGCATAGCCCGCAACGATATGCTACTCTAGCGGCATGCACACCGGTT
TCTAGCCCACGAGGTTTCTG

Downstream 100 bases:

>100_bases
AGAATAGAGCGCATAGCATCGAGAACCTAAGGTTTTTTAGCGCAGATGGGATTTAGGGATCAGGGGCTAGCGATTAGGAA
TCAGGATTGCTGATAGGGCT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MTATILDQIFAHKRTEVERQKLKIPQAKLEQQLGNAPKPRSLRQALRQPDRISLIAEVKKASPSKGVFLENFNPTELAET
YASNGAAAISVLTDVRFFQGSLIYLRSIHEHLDTLGYATPLLRKDFLYDPYQIYEARVSGADAILLIVGMLDDQTLHELY
QLTYGLGMEALVEVHTEAEMARAQALQAQIIGINNRDLHSFSVDLATTQRVSASLPAIGDPQRPVLVAESGIHGPDVLPT
LREWGVEAILVGESIVLAPDHAAHVRALSQKA

Sequences:

>Translated_272_residues
MTATILDQIFAHKRTEVERQKLKIPQAKLEQQLGNAPKPRSLRQALRQPDRISLIAEVKKASPSKGVFLENFNPTELAET
YASNGAAAISVLTDVRFFQGSLIYLRSIHEHLDTLGYATPLLRKDFLYDPYQIYEARVSGADAILLIVGMLDDQTLHELY
QLTYGLGMEALVEVHTEAEMARAQALQAQIIGINNRDLHSFSVDLATTQRVSASLPAIGDPQRPVLVAESGIHGPDVLPT
LREWGVEAILVGESIVLAPDHAAHVRALSQKA
>Mature_271_residues
TATILDQIFAHKRTEVERQKLKIPQAKLEQQLGNAPKPRSLRQALRQPDRISLIAEVKKASPSKGVFLENFNPTELAETY
ASNGAAAISVLTDVRFFQGSLIYLRSIHEHLDTLGYATPLLRKDFLYDPYQIYEARVSGADAILLIVGMLDDQTLHELYQ
LTYGLGMEALVEVHTEAEMARAQALQAQIIGINNRDLHSFSVDLATTQRVSASLPAIGDPQRPVLVAESGIHGPDVLPTL
REWGVEAILVGESIVLAPDHAAHVRALSQKA

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=266, Percent_Identity=39.0977443609023, Blast_Score=153, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6322638, Length=279, Percent_Identity=39.426523297491, Blast_Score=167, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 29959; Mature: 29828

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATILDQIFAHKRTEVERQKLKIPQAKLEQQLGNAPKPRSLRQALRQPDRISLIAEVKK
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHH
ASPSKGVFLENFNPTELAETYASNGAAAISVLTDVRFFQGSLIYLRSIHEHLDTLGYATP
CCCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LLRKDFLYDPYQIYEARVSGADAILLIVGMLDDQTLHELYQLTYGLGMEALVEVHTEAEM
HHHHHHCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHH
ARAQALQAQIIGINNRDLHSFSVDLATTQRVSASLPAIGDPQRPVLVAESGIHGPDVLPT
HHHHHHHHHEECCCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCHHH
LREWGVEAILVGESIVLAPDHAAHVRALSQKA
HHHCCCEEEEECCEEEECCCHHHHHHHHHCCC
>Mature Secondary Structure 
TATILDQIFAHKRTEVERQKLKIPQAKLEQQLGNAPKPRSLRQALRQPDRISLIAEVKK
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHH
ASPSKGVFLENFNPTELAETYASNGAAAISVLTDVRFFQGSLIYLRSIHEHLDTLGYATP
CCCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LLRKDFLYDPYQIYEARVSGADAILLIVGMLDDQTLHELYQLTYGLGMEALVEVHTEAEM
HHHHHHCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHH
ARAQALQAQIIGINNRDLHSFSVDLATTQRVSASLPAIGDPQRPVLVAESGIHGPDVLPT
HHHHHHHHHEECCCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCHHH
LREWGVEAILVGESIVLAPDHAAHVRALSQKA
HHHCCCEEEEECCEEEECCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA