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The map label for this gene is hpd [H]

Identifier: 159899283

GI number: 159899283

Start: 3519540

End: 3520661

Strand: Direct

Name: hpd [H]

Synonym: Haur_2764

Alternate gene names: 159899283

Gene position: 3519540-3520661 (Clockwise)

Preceding gene: 159899282

Following gene: 159899284

Centisome position: 55.46

GC content: 49.11

Gene sequence:

>1122_bases
ATGACGATGGCAGAACAAGAAACCACGAATGCCCATGATCCTTTAGCATTACGTGGCATCGATTATGTCGAAATGTATGT
TGGTAATGCCCGCCAAGCAGCTCATTACTATCGGACGGCCTTTGGTTTTACGCCAGTCGCTTATGCTGGCTTGGAAACAG
GCACGCGCGACCGCGTTTCGTTTGTGATGCAACAGCGCAACATCCGCTTGGTTCTGACTGGGGCACTCAATCCTGATTCG
CCAATTGCTGAGCATGTTAAATTGCATGGTGATGGGGTTAAGGATATTGCGCTCGAAGTTGAAAACGCCACTGCTGCGTT
CGAAGCAGCACTTGCCCGCGGCGCAACCGCAGTGCTTGAGCCAACCGTGCTGGAAAGCAAATGGGGCAAAGTGGTTAAAG
CGACCATTCGTACCTATGGTCATACGGTGCATACGTTTGTTGAGCGCGATGGCTATACTGGTACGTTTATGCCAGGCTAC
AACAAGGTTAAAAATCCGGCCAAAGCTGAGCCAACTGGTTTAGCCGCGGTTGATCATATTGTGGGTAACGTTGAGCTAGG
CAAAATGGATGAATGGGTCAATTTCTATGCCCGCATCCTTGGGTTTAGCCAACTCCAACAATTTACCGACGACGATATTT
CAACCGAATATAGCGCCTTGATGTCGAAAGTCGTGCAAAATGGCACAGGCCGGATCAAATTCCCAATTAATGAGCCAGCC
GAAGGTCGCAAAAAATCACAAATCGATGAATATCTCGATTATTACCGTGGCCCCGGTGCTCAACACATCGCCTTGATCAC
GCCTGACATTATCAAAACTGTGCAGCAGCTGCGTGATAATGGCGTGGAATTTTTGCGCACGCCGGATACATATTACTCGG
CCTTGGCCGGTCGGGTTGGCCATATCGACGAGGACTACAATACCCTGCAACAATTGGGTATTTTAGTCGATCGTGACGAT
GAAGGCTATCTCTTGCAAATCTTCACCAAACCAGTTGGCGATCGACCAACCGTGTTCTACGAGATTATTCAACGCAAGGG
CAGCCGTGGCTTTGGTGCTGGAAATTTCAAAGCCCTATTTGAAGCGATTGAGCGCGAACAAGCCAAACGTGGCAATTTGT
AA

Upstream 100 bases:

>100_bases
GCTAGCGCAAACCTTACGGGTCGCGTTCGAGGCATTCTGGGCGCAAGCTCAGCCCTATAGCGATTAATCGTTGCGGCGTT
TCATCAAAAGGAGGCTATCA

Downstream 100 bases:

>100_bases
TTAATCGCCAATACTAAGCCCGCAGTGCTGCCCCTACTCGGCACTACGGGCTTAGTATTGTTATTTAATCAGCTTAATTG
TAAGAATTCCTAGCTGTTTT

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MTMAEQETTNAHDPLALRGIDYVEMYVGNARQAAHYYRTAFGFTPVAYAGLETGTRDRVSFVMQQRNIRLVLTGALNPDS
PIAEHVKLHGDGVKDIALEVENATAAFEAALARGATAVLEPTVLESKWGKVVKATIRTYGHTVHTFVERDGYTGTFMPGY
NKVKNPAKAEPTGLAAVDHIVGNVELGKMDEWVNFYARILGFSQLQQFTDDDISTEYSALMSKVVQNGTGRIKFPINEPA
EGRKKSQIDEYLDYYRGPGAQHIALITPDIIKTVQQLRDNGVEFLRTPDTYYSALAGRVGHIDEDYNTLQQLGILVDRDD
EGYLLQIFTKPVGDRPTVFYEIIQRKGSRGFGAGNFKALFEAIEREQAKRGNL

Sequences:

>Translated_373_residues
MTMAEQETTNAHDPLALRGIDYVEMYVGNARQAAHYYRTAFGFTPVAYAGLETGTRDRVSFVMQQRNIRLVLTGALNPDS
PIAEHVKLHGDGVKDIALEVENATAAFEAALARGATAVLEPTVLESKWGKVVKATIRTYGHTVHTFVERDGYTGTFMPGY
NKVKNPAKAEPTGLAAVDHIVGNVELGKMDEWVNFYARILGFSQLQQFTDDDISTEYSALMSKVVQNGTGRIKFPINEPA
EGRKKSQIDEYLDYYRGPGAQHIALITPDIIKTVQQLRDNGVEFLRTPDTYYSALAGRVGHIDEDYNTLQQLGILVDRDD
EGYLLQIFTKPVGDRPTVFYEIIQRKGSRGFGAGNFKALFEAIEREQAKRGNL
>Mature_372_residues
TMAEQETTNAHDPLALRGIDYVEMYVGNARQAAHYYRTAFGFTPVAYAGLETGTRDRVSFVMQQRNIRLVLTGALNPDSP
IAEHVKLHGDGVKDIALEVENATAAFEAALARGATAVLEPTVLESKWGKVVKATIRTYGHTVHTFVERDGYTGTFMPGYN
KVKNPAKAEPTGLAAVDHIVGNVELGKMDEWVNFYARILGFSQLQQFTDDDISTEYSALMSKVVQNGTGRIKFPINEPAE
GRKKSQIDEYLDYYRGPGAQHIALITPDIIKTVQQLRDNGVEFLRTPDTYYSALAGRVGHIDEDYNTLQQLGILVDRDDE
GYLLQIFTKPVGDRPTVFYEIIQRKGSRGFGAGNFKALFEAIEREQAKRGNL

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=363, Percent_Identity=49.3112947658402, Blast_Score=335, Evalue=5e-92,
Organism=Homo sapiens, GI285002264, Length=345, Percent_Identity=49.2753623188406, Blast_Score=315, Evalue=4e-86,
Organism=Homo sapiens, GI14249394, Length=376, Percent_Identity=26.8617021276596, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17555220, Length=366, Percent_Identity=50, Blast_Score=329, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI17550752, Length=367, Percent_Identity=35.6948228882834, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24667510, Length=364, Percent_Identity=49.4505494505495, Blast_Score=330, Evalue=7e-91,
Organism=Drosophila melanogaster, GI21356105, Length=294, Percent_Identity=51.3605442176871, Blast_Score=281, Evalue=6e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 41477; Mature: 41346

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMAEQETTNAHDPLALRGIDYVEMYVGNARQAAHYYRTAFGFTPVAYAGLETGTRDRVS
CCCCCCCCCCCCCCEEECCCHHHHHHHCCHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHH
FVMQQRNIRLVLTGALNPDSPIAEHVKLHGDGVKDIALEVENATAAFEAALARGATAVLE
HHHHHCCEEEEEEECCCCCCCHHHHHEECCCCCEEHEEEECCHHHHHHHHHHCCCHHHHC
PTVLESKWGKVVKATIRTYGHTVHTFVERDGYTGTFMPGYNKVKNPAKAEPTGLAAVDHI
CHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHH
VGNVELGKMDEWVNFYARILGFSQLQQFTDDDISTEYSALMSKVVQNGTGRIKFPINEPA
HCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCC
EGRKKSQIDEYLDYYRGPGAQHIALITPDIIKTVQQLRDNGVEFLRTPDTYYSALAGRVG
CCCHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHCC
HIDEDYNTLQQLGILVDRDDEGYLLQIFTKPVGDRPTVFYEIIQRKGSRGFGAGNFKALF
CCCHHHHHHHHHCCEEECCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCHHHHHH
EAIEREQAKRGNL
HHHHHHHHHCCCC
>Mature Secondary Structure 
TMAEQETTNAHDPLALRGIDYVEMYVGNARQAAHYYRTAFGFTPVAYAGLETGTRDRVS
CCCCCCCCCCCCCEEECCCHHHHHHHCCHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHH
FVMQQRNIRLVLTGALNPDSPIAEHVKLHGDGVKDIALEVENATAAFEAALARGATAVLE
HHHHHCCEEEEEEECCCCCCCHHHHHEECCCCCEEHEEEECCHHHHHHHHHHCCCHHHHC
PTVLESKWGKVVKATIRTYGHTVHTFVERDGYTGTFMPGYNKVKNPAKAEPTGLAAVDHI
CHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHH
VGNVELGKMDEWVNFYARILGFSQLQQFTDDDISTEYSALMSKVVQNGTGRIKFPINEPA
HCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCC
EGRKKSQIDEYLDYYRGPGAQHIALITPDIIKTVQQLRDNGVEFLRTPDTYYSALAGRVG
CCCHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHCC
HIDEDYNTLQQLGILVDRDDEGYLLQIFTKPVGDRPTVFYEIIQRKGSRGFGAGNFKALF
CCCHHHHHHHHHCCEEECCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCHHHHHH
EAIEREQAKRGNL
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8071207; 11572948; 12692562 [H]