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The map label for this gene is 159899281

Identifier: 159899281

GI number: 159899281

Start: 3517256

End: 3518413

Strand: Direct

Name: 159899281

Synonym: Haur_2762

Alternate gene names: NA

Gene position: 3517256-3518413 (Clockwise)

Preceding gene: 159899276

Following gene: 159899282

Centisome position: 55.42

GC content: 51.81

Gene sequence:

>1158_bases
ATGCCCTTCTATCACAAACTTGGCAACATTCCACACAAGCGCCATACCCAATTTCGCAAGCCCGACGGGTCGCTGTATTC
GGAACAGTTGATGGGAACCAAGGGATTTAGCGGGGTCGAAGCCTTGCTCTATCACCATTATCCGCCAACTGCAATTCTCA
AAGTGGAAGATCTTGGTTCAACCGCGATTGAACTTGAACCTGATGGAGCACTTCGCCATCGCCATCTCAAAACCTTTGCC
CATCAGCCAGGCGGCGATCCCATCGGTGGGCGACGTATGTTGTTGGTCAACAATGACGTGCGCATGGGAATTGTCCACCC
CACCGAACCCCAAACCTATTTCTATCGCAACGGCGAAGGCGATGAAATGTTGTTCATTCACGAAGGTGAGGGAGTGCTCG
AAACCATTTTTGGCAATATTCCCTATCGTCGTGGCGATTACTTGGTGATTCCGATTGGCACAACCTATCGGGTCAATACC
AATGGCACGCCCACCAAAATGTTGGTGCTCGAAACCATGGGCGAAATCACCACGCCCAATCGTTATCGCAATGAACATGG
CCAATTGCTTGAGCACGCCCCCTTCTGCGAACGCGATATTCGGGTGCCGCTGGAGCTTACCCCTCACGACGAAAAAGGTG
AATTTGCCGTCCATGTGCGGGCGCATGGCCGCATGACCAAACATGTGCTCAATCATCATCCCTTTGATGTAGTGGGCTGG
GATGGCTATCTCTATCCATTTGCCTTCAACATCGAAGATTTCGAGCCAATTACGGGGCGGGTACACCAACCGCCACCAGT
TCATCAAACCTTCAGCGGGCCAAATTTTGTGGTCTGCTCGTTCGTGCCACGGCTGTTCGATTATCATCCTGAGGCAATTC
CCGCACCCTATAATCACTCAAATGTCGAAAGTGATGAGGTGTTGTATTATGTCGAGGGCAACTTTATGTCACGGCGTGGG
GTTGATCTTGGTTCGATCACCTTGCATCCATCGGGCATGCCGCACGGGCCGCACCCTGGCACGGTCGAGGGTTCAATTGG
CAAAGCGGCCACTGAAGAATTAGCGGTAATGGTCGATACCTTCAAGCCGCTCTACCTCACCAAAGCTGCCTTGAACCTTG
AAGAACCCAACTACACCTATTCATGGGTCAACCACTAA

Upstream 100 bases:

>100_bases
TTTTCCTCATTTTGCAATTTAGCTTTATAATCAAGGCGTGGCCAATGCAGAAGTAGGGCTGAATTGGTCTTGTCGTTTTC
ATTTTTGCGGGAGGTCAAAG

Downstream 100 bases:

>100_bases
AACCCACGACGGCCAAGCAGTGCATTGCTTGGCCGTTTTGTTACCCCCTACCTCAGGTTAGCACCCCAACTCCATCCAGT
AACCCTATTTTGGCAAGGCC

Product: homogentisate 12-dioxygenase

Products: 4-maleylacetoacetate

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MPFYHKLGNIPHKRHTQFRKPDGSLYSEQLMGTKGFSGVEALLYHHYPPTAILKVEDLGSTAIELEPDGALRHRHLKTFA
HQPGGDPIGGRRMLLVNNDVRMGIVHPTEPQTYFYRNGEGDEMLFIHEGEGVLETIFGNIPYRRGDYLVIPIGTTYRVNT
NGTPTKMLVLETMGEITTPNRYRNEHGQLLEHAPFCERDIRVPLELTPHDEKGEFAVHVRAHGRMTKHVLNHHPFDVVGW
DGYLYPFAFNIEDFEPITGRVHQPPPVHQTFSGPNFVVCSFVPRLFDYHPEAIPAPYNHSNVESDEVLYYVEGNFMSRRG
VDLGSITLHPSGMPHGPHPGTVEGSIGKAATEELAVMVDTFKPLYLTKAALNLEEPNYTYSWVNH

Sequences:

>Translated_385_residues
MPFYHKLGNIPHKRHTQFRKPDGSLYSEQLMGTKGFSGVEALLYHHYPPTAILKVEDLGSTAIELEPDGALRHRHLKTFA
HQPGGDPIGGRRMLLVNNDVRMGIVHPTEPQTYFYRNGEGDEMLFIHEGEGVLETIFGNIPYRRGDYLVIPIGTTYRVNT
NGTPTKMLVLETMGEITTPNRYRNEHGQLLEHAPFCERDIRVPLELTPHDEKGEFAVHVRAHGRMTKHVLNHHPFDVVGW
DGYLYPFAFNIEDFEPITGRVHQPPPVHQTFSGPNFVVCSFVPRLFDYHPEAIPAPYNHSNVESDEVLYYVEGNFMSRRG
VDLGSITLHPSGMPHGPHPGTVEGSIGKAATEELAVMVDTFKPLYLTKAALNLEEPNYTYSWVNH
>Mature_384_residues
PFYHKLGNIPHKRHTQFRKPDGSLYSEQLMGTKGFSGVEALLYHHYPPTAILKVEDLGSTAIELEPDGALRHRHLKTFAH
QPGGDPIGGRRMLLVNNDVRMGIVHPTEPQTYFYRNGEGDEMLFIHEGEGVLETIFGNIPYRRGDYLVIPIGTTYRVNTN
GTPTKMLVLETMGEITTPNRYRNEHGQLLEHAPFCERDIRVPLELTPHDEKGEFAVHVRAHGRMTKHVLNHHPFDVVGWD
GYLYPFAFNIEDFEPITGRVHQPPPVHQTFSGPNFVVCSFVPRLFDYHPEAIPAPYNHSNVESDEVLYYVEGNFMSRRGV
DLGSITLHPSGMPHGPHPGTVEGSIGKAATEELAVMVDTFKPLYLTKAALNLEEPNYTYSWVNH

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Drosophila melanogaster, GI24583650, Length=270, Percent_Identity=24.8148148148148, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR014710 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: 1.13.11.5

Molecular weight: Translated: 43561; Mature: 43430

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFYHKLGNIPHKRHTQFRKPDGSLYSEQLMGTKGFSGVEALLYHHYPPTAILKVEDLGS
CCCHHHHCCCCCHHCCCCCCCCCCHHHHHHCCCCCCCHHHHHEEECCCCEEEEEEECCCC
TAIELEPDGALRHRHLKTFAHQPGGDPIGGRRMLLVNNDVRMGIVHPTEPQTYFYRNGEG
EEEEECCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCEEEEEECCCCCCEEEEECCCC
DEMLFIHEGEGVLETIFGNIPYRRGDYLVIPIGTTYRVNTNGTPTKMLVLETMGEITTPN
CEEEEEECCCCHHHHHHCCCCCCCCCEEEEECCCEEEECCCCCCEEEEEEEHHCCCCCCH
RYRNEHGQLLEHAPFCERDIRVPLELTPHDEKGEFAVHVRAHGRMTKHVLNHHPFDVVGW
HHHCHHHHHHHCCCCCCCCCCCCEEECCCCCCCCEEEEEEECCCHHHHHHCCCCCEEEEC
DGYLYPFAFNIEDFEPITGRVHQPPPVHQTFSGPNFVVCSFVPRLFDYHPEAIPAPYNHS
CCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHCCCCCCCCCCCCC
NVESDEVLYYVEGNFMSRRGVDLGSITLHPSGMPHGPHPGTVEGSIGKAATEELAVMVDT
CCCCCCEEEEEECCEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHEEEECC
FKPLYLTKAALNLEEPNYTYSWVNH
CCCEEEEEEEECCCCCCCEEEECCC
>Mature Secondary Structure 
PFYHKLGNIPHKRHTQFRKPDGSLYSEQLMGTKGFSGVEALLYHHYPPTAILKVEDLGS
CCHHHHCCCCCHHCCCCCCCCCCHHHHHHCCCCCCCHHHHHEEECCCCEEEEEEECCCC
TAIELEPDGALRHRHLKTFAHQPGGDPIGGRRMLLVNNDVRMGIVHPTEPQTYFYRNGEG
EEEEECCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCEEEEEECCCCCCEEEEECCCC
DEMLFIHEGEGVLETIFGNIPYRRGDYLVIPIGTTYRVNTNGTPTKMLVLETMGEITTPN
CEEEEEECCCCHHHHHHCCCCCCCCCEEEEECCCEEEECCCCCCEEEEEEEHHCCCCCCH
RYRNEHGQLLEHAPFCERDIRVPLELTPHDEKGEFAVHVRAHGRMTKHVLNHHPFDVVGW
HHHCHHHHHHHCCCCCCCCCCCCEEECCCCCCCCEEEEEEECCCHHHHHHCCCCCEEEEC
DGYLYPFAFNIEDFEPITGRVHQPPPVHQTFSGPNFVVCSFVPRLFDYHPEAIPAPYNHS
CCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHCCCCCCCCCCCCC
NVESDEVLYYVEGNFMSRRGVDLGSITLHPSGMPHGPHPGTVEGSIGKAATEELAVMVDT
CCCCCCEEEEEECCEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHEEEECC
FKPLYLTKAALNLEEPNYTYSWVNH
CCCEEEEEEEECCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: homogentisate; O2

Specific reaction: homogentisate + O2 = 4-maleylacetoacetate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11427726 [H]