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The map label for this gene is hemN [H]

Identifier: 159898365

GI number: 159898365

Start: 2141294

End: 2142613

Strand: Reverse

Name: hemN [H]

Synonym: Haur_1841

Alternate gene names: 159898365

Gene position: 2142613-2141294 (Counterclockwise)

Preceding gene: 159898366

Following gene: 159898364

Centisome position: 33.76

GC content: 50.68

Gene sequence:

>1320_bases
ATGCATCTGCGTGAATATGCCAATGCTACGCCTTACATGGGCTATAGCTATAGTTACCCACATAAATCGGCCTATCGCCA
GCTTGAGCCACGTTCATTACGCGAGGTTTGGGCCGACGAAGCCCATGATCAATTATTTTTATATCTGCACATTCCCTTTT
GCGAAATGCGCTGTGGCTTTTGCAATTTGTTCACAACCACCAACCCCAACGAATCGGTGGTGCAACGCTATTTGGCCACT
TTAGAGCTTCAGATGCAAGCATTGCACAACGAACTTGGGGCTGTGCAGTTTAGTCGCATGGCGATTGGCGGCGGCACACC
AACCTATTTAAGTGCCAGCGAATTGGAGCAGCTTTTTAGCATGAGCCAGCGCTGGCTCGGCGTTAATTCACGAGCAATTC
CCTTATCGGTTGAAACGTCGCCGCACACTGCGACCGCCGACCGCATGGCAATATTAGCTCAAGCAGGAGTTGATCGGGTG
AGCATTGGGGTGCAGAGCTTCCTTGATCATGAGGCGCATGCTGCTGGCCGTGCCCAACGCCGACCTGAGGTGGAGCAGGC
GCTAGCCACAGTTCGCGCAGCTCAAATTCCTACATTGAATATTGATTTAATTTATGGCTTGCCCAACCAAAGCGTGGCAA
CATGGCTTGAATCGCTGGAAATTGGCTTGCAGTGGCGGCCTGAAGAATTATATTTGTATCCGTTGTATGTACGACCGTTG
ACTGGCTTGGATCGGCGGGGCACAGGTTGGGAGCATGATTTACGCTTGGAATGCTATCGGGCTGGCCGCGAACGCTTGTT
GGCAGCAGGCTATCAACAAATTTCAATGCGCATGTTTCGCGCCGCCCATGCCCCAGATGACAGCCAAGCACCAAGATATT
GCTGCCAAACTGATGGGATGCTGGGCTTGGGCGCTGGTGCGCGTTCGTACACTCGCAAGCTGCATTACTCCAGTGATTAC
GCGGTTGGGGCTAGTTCTGTTCGCCAAATTATCCAAAATTACAATCAGCGCAGTTTGCTTGATTTGAGTCAGGTGGATTA
TGGCTGTGTTGTTTCGAGCACCGAGCAACGCCGCCGCTTTGTTATTCAATCGCTGTTGCAGGTCAGTGGGCTAGATACGC
AAGCCTATCGGGCGCAATTCGGTAGCGATGTTTTAGCTGATTTAAGCCAAATCAACGAACTAATTGAAATTGGTTGGGCT
GAATATCAGCATGGCATCTATCAATTAACTCCAGCAGGTTTAGAACGCTCAGATCTAATTGGCCCTTGGTTGTATTCGCC
GCAGATTCGTCAGCTTAGCGCGGAGTTTATCCTACGATGA

Upstream 100 bases:

>100_bases
CATGGCACAGCCTATGGCGAAGATGGTTTTTCGGGGCATCGCCTAGCTCATCCCACGGTTTGGACTGTGCCCTATGCTGA
TTGCAGTTTGGAGGAAGCCC

Downstream 100 bases:

>100_bases
AACTAGCAATTTTGTATCGTGGCCCGTTGTCGAGCTGCAATTATGGCTGTAGCTATTGCCCATTTGCCAAGCATCAAGAA
ACTGCTGCCGAACATGCCCA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MHLREYANATPYMGYSYSYPHKSAYRQLEPRSLREVWADEAHDQLFLYLHIPFCEMRCGFCNLFTTTNPNESVVQRYLAT
LELQMQALHNELGAVQFSRMAIGGGTPTYLSASELEQLFSMSQRWLGVNSRAIPLSVETSPHTATADRMAILAQAGVDRV
SIGVQSFLDHEAHAAGRAQRRPEVEQALATVRAAQIPTLNIDLIYGLPNQSVATWLESLEIGLQWRPEELYLYPLYVRPL
TGLDRRGTGWEHDLRLECYRAGRERLLAAGYQQISMRMFRAAHAPDDSQAPRYCCQTDGMLGLGAGARSYTRKLHYSSDY
AVGASSVRQIIQNYNQRSLLDLSQVDYGCVVSSTEQRRRFVIQSLLQVSGLDTQAYRAQFGSDVLADLSQINELIEIGWA
EYQHGIYQLTPAGLERSDLIGPWLYSPQIRQLSAEFILR

Sequences:

>Translated_439_residues
MHLREYANATPYMGYSYSYPHKSAYRQLEPRSLREVWADEAHDQLFLYLHIPFCEMRCGFCNLFTTTNPNESVVQRYLAT
LELQMQALHNELGAVQFSRMAIGGGTPTYLSASELEQLFSMSQRWLGVNSRAIPLSVETSPHTATADRMAILAQAGVDRV
SIGVQSFLDHEAHAAGRAQRRPEVEQALATVRAAQIPTLNIDLIYGLPNQSVATWLESLEIGLQWRPEELYLYPLYVRPL
TGLDRRGTGWEHDLRLECYRAGRERLLAAGYQQISMRMFRAAHAPDDSQAPRYCCQTDGMLGLGAGARSYTRKLHYSSDY
AVGASSVRQIIQNYNQRSLLDLSQVDYGCVVSSTEQRRRFVIQSLLQVSGLDTQAYRAQFGSDVLADLSQINELIEIGWA
EYQHGIYQLTPAGLERSDLIGPWLYSPQIRQLSAEFILR
>Mature_439_residues
MHLREYANATPYMGYSYSYPHKSAYRQLEPRSLREVWADEAHDQLFLYLHIPFCEMRCGFCNLFTTTNPNESVVQRYLAT
LELQMQALHNELGAVQFSRMAIGGGTPTYLSASELEQLFSMSQRWLGVNSRAIPLSVETSPHTATADRMAILAQAGVDRV
SIGVQSFLDHEAHAAGRAQRRPEVEQALATVRAAQIPTLNIDLIYGLPNQSVATWLESLEIGLQWRPEELYLYPLYVRPL
TGLDRRGTGWEHDLRLECYRAGRERLLAAGYQQISMRMFRAAHAPDDSQAPRYCCQTDGMLGLGAGARSYTRKLHYSSDY
AVGASSVRQIIQNYNQRSLLDLSQVDYGCVVSSTEQRRRFVIQSLLQVSGLDTQAYRAQFGSDVLADLSQINELIEIGWA
EYQHGIYQLTPAGLERSDLIGPWLYSPQIRQLSAEFILR

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=268, Percent_Identity=29.8507462686567, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1789325, Length=274, Percent_Identity=29.9270072992701, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI87082341, Length=432, Percent_Identity=25.9259259259259, Blast_Score=102, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 49674; Mature: 49674

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLREYANATPYMGYSYSYPHKSAYRQLEPRSLREVWADEAHDQLFLYLHIPFCEMRCGF
CCCHHHCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCHHHHCCCE
CNLFTTTNPNESVVQRYLATLELQMQALHNELGAVQFSRMAIGGGTPTYLSASELEQLFS
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCHHHHHHHHH
MSQRWLGVNSRAIPLSVETSPHTATADRMAILAQAGVDRVSIGVQSFLDHEAHAAGRAQR
HHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHC
RPEVEQALATVRAAQIPTLNIDLIYGLPNQSVATWLESLEIGLQWRPEELYLYPLYVRPL
CCHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHCCCEECCCEEEEEEEEECCC
TGLDRRGTGWEHDLRLECYRAGRERLLAAGYQQISMRMFRAAHAPDDSQAPRYCCQTDGM
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCC
LGLGAGARSYTRKLHYSSDYAVGASSVRQIIQNYNQRSLLDLSQVDYGCVVSSTEQRRRF
EEECCCCHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCEEECCHHHHHHH
VIQSLLQVSGLDTQAYRAQFGSDVLADLSQINELIEIGWAEYQHGIYQLTPAGLERSDLI
HHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCC
GPWLYSPQIRQLSAEFILR
CCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MHLREYANATPYMGYSYSYPHKSAYRQLEPRSLREVWADEAHDQLFLYLHIPFCEMRCGF
CCCHHHCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCHHHHCCCE
CNLFTTTNPNESVVQRYLATLELQMQALHNELGAVQFSRMAIGGGTPTYLSASELEQLFS
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCHHHHHHHHH
MSQRWLGVNSRAIPLSVETSPHTATADRMAILAQAGVDRVSIGVQSFLDHEAHAAGRAQR
HHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHC
RPEVEQALATVRAAQIPTLNIDLIYGLPNQSVATWLESLEIGLQWRPEELYLYPLYVRPL
CCHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHCCCEECCCEEEEEEEEECCC
TGLDRRGTGWEHDLRLECYRAGRERLLAAGYQQISMRMFRAAHAPDDSQAPRYCCQTDGM
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCC
LGLGAGARSYTRKLHYSSDYAVGASSVRQIIQNYNQRSLLDLSQVDYGCVVSSTEQRRRF
EEECCCCHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCEEECCHHHHHHH
VIQSLLQVSGLDTQAYRAQFGSDVLADLSQINELIEIGWAEYQHGIYQLTPAGLERSDLI
HHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCC
GPWLYSPQIRQLSAEFILR
CCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]