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The map label for this gene is qor [C]

Identifier: 159898250

GI number: 159898250

Start: 2010650

End: 2011612

Strand: Reverse

Name: qor [C]

Synonym: Haur_1726

Alternate gene names: 159898250

Gene position: 2011612-2010650 (Counterclockwise)

Preceding gene: 159898251

Following gene: 159898248

Centisome position: 31.7

GC content: 49.33

Gene sequence:

>963_bases
ATGAAAGCAATGCTTTTTTATGAATATGGCAACCCAAACGTACTCCAATTACGTGAGGTTGAACGCCCTTCGCTTCAAGC
TAATCACGTATTGATCAAAGTCCATTCAGCTTCAATTAATACCCTCGATTGGAATCAAATGACTGGGCCAATCATGATTC
GCATGTTGAATGGAGCTTTGCACAAGCCAAAAATCAACTCGCTTGGCTTAGATCTCGCTGGCTGGGTTGAGGCGGTTGGC
CCGCAGGTAACTAAATTTAAGCCTGGTGATGCAGTTTTTGGCACAGCTCAAGGCTCGTTAGCGGAATATGTATGTGCAAC
CGAAGATCAGCTGGTCTTGAAACCTGCGAATGTTGCATTTGAGGCAGCAGCGGCAACTCCTGTGGCAGCATTCACCGCAA
TCTACGCTCTGAGCGATTTGGGCAAGATCCAAGCTGGGCAGCGGGTGTTGATCAATGGCGCTTCGGGGGCGGTTGGCAGC
TTTGCCATCCAAATTGCCAAAGCCTATGGCGCTGAAGTAACTGCGGTCTGTAGTTCGCGCAATGCTGACATTGCCCAAGC
GAGCGGAGCCAGCCATTGGATTGATTATAGCCGTGAGGATTTGCGCCAGCATCGTCAACGTTATGATCTGATACTTGGAG
TCAATGGCTATCAATCGATTTTCACCTATCGTAAAGCGCTTACGCCGACTGGCCGATATATTGCAATTGGCGGTGCTTTA
CCGCAAATTCTGCAAGCGGTCGCTTTAGGCCGCATACTATCGCTAGGAACTAGCAAGACGTTGCAATTTCTGGGGGTTGC
GCCGATTCGCCATACGACCTTATTGAAGCTTCAACAGTTGTTAGAGTCAGGCCAACTTAAGCCCGTCATTGATCGTTGTT
ACCGCTTGCCCGAGGCAGCTGAAGCACTGCGCTACCTTGGGGCTGGCCATGCTCAGGGTAAAATAGTGATTAATGTGCTT
TAA

Upstream 100 bases:

>100_bases
TGTTAACAACCTACCCTTGTAAGTCTCCCACTGCGGCGAGCGAGGGGCATTCCACCCTTTATCATATGAACTATTGCAGC
TAGCAAATATAGGAATTTCG

Downstream 100 bases:

>100_bases
ATGATCAGCTGAATTTGAGCGGCTTCAAGTTTTTGATCGAAGCCGCTCAAATAATTAAGCTAAAGCCTCAGCCGCTGCCC
TTCCGGCGGTGCGCCCAGAG

Product: alcohol dehydrogenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MKAMLFYEYGNPNVLQLREVERPSLQANHVLIKVHSASINTLDWNQMTGPIMIRMLNGALHKPKINSLGLDLAGWVEAVG
PQVTKFKPGDAVFGTAQGSLAEYVCATEDQLVLKPANVAFEAAAATPVAAFTAIYALSDLGKIQAGQRVLINGASGAVGS
FAIQIAKAYGAEVTAVCSSRNADIAQASGASHWIDYSREDLRQHRQRYDLILGVNGYQSIFTYRKALTPTGRYIAIGGAL
PQILQAVALGRILSLGTSKTLQFLGVAPIRHTTLLKLQQLLESGQLKPVIDRCYRLPEAAEALRYLGAGHAQGKIVINVL

Sequences:

>Translated_320_residues
MKAMLFYEYGNPNVLQLREVERPSLQANHVLIKVHSASINTLDWNQMTGPIMIRMLNGALHKPKINSLGLDLAGWVEAVG
PQVTKFKPGDAVFGTAQGSLAEYVCATEDQLVLKPANVAFEAAAATPVAAFTAIYALSDLGKIQAGQRVLINGASGAVGS
FAIQIAKAYGAEVTAVCSSRNADIAQASGASHWIDYSREDLRQHRQRYDLILGVNGYQSIFTYRKALTPTGRYIAIGGAL
PQILQAVALGRILSLGTSKTLQFLGVAPIRHTTLLKLQQLLESGQLKPVIDRCYRLPEAAEALRYLGAGHAQGKIVINVL
>Mature_320_residues
MKAMLFYEYGNPNVLQLREVERPSLQANHVLIKVHSASINTLDWNQMTGPIMIRMLNGALHKPKINSLGLDLAGWVEAVG
PQVTKFKPGDAVFGTAQGSLAEYVCATEDQLVLKPANVAFEAAAATPVAAFTAIYALSDLGKIQAGQRVLINGASGAVGS
FAIQIAKAYGAEVTAVCSSRNADIAQASGASHWIDYSREDLRQHRQRYDLILGVNGYQSIFTYRKALTPTGRYIAIGGAL
PQILQAVALGRILSLGTSKTLQFLGVAPIRHTTLLKLQQLLESGQLKPVIDRCYRLPEAAEALRYLGAGHAQGKIVINVL

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=359, Percent_Identity=31.7548746518106, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI194239674, Length=339, Percent_Identity=29.7935103244838, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI13236495, Length=339, Percent_Identity=29.7935103244838, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI194239676, Length=324, Percent_Identity=30.5555555555556, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI22538446, Length=344, Percent_Identity=29.6511627906977, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI22538444, Length=344, Percent_Identity=29.6511627906977, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI67078404, Length=257, Percent_Identity=28.0155642023346, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI24308257, Length=353, Percent_Identity=23.7960339943343, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI18379349, Length=277, Percent_Identity=27.0758122743682, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI41872631, Length=311, Percent_Identity=27.9742765273312, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1790485, Length=201, Percent_Identity=32.8358208955224, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17507255, Length=314, Percent_Identity=28.343949044586, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71987554, Length=361, Percent_Identity=27.7008310249307, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45550423, Length=183, Percent_Identity=30.6010928961749, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 34447; Mature: 34447

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMLFYEYGNPNVLQLREVERPSLQANHVLIKVHSASINTLDWNQMTGPIMIRMLNGAL
CCEEEEEECCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCC
HKPKINSLGLDLAGWVEAVGPQVTKFKPGDAVFGTAQGSLAEYVCATEDQLVLKPANVAF
CCCCCCCCCCCHHHHHHHCCCCCEEECCCCCEEECCCCCHHHHHHCCCCCEEEECCCCEE
EAAAATPVAAFTAIYALSDLGKIQAGQRVLINGASGAVGSFAIQIAKAYGAEVTAVCSSR
EHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCEEEEEECCC
NADIAQASGASHWIDYSREDLRQHRQRYDLILGVNGYQSIFTYRKALTPTGRYIAIGGAL
CCCHHHCCCCCHHHCCCHHHHHHHHHHCEEEEECCHHHHHHHHHHHCCCCCCEEEECCHH
PQILQAVALGRILSLGTSKTLQFLGVAPIRHTTLLKLQQLLESGQLKPVIDRCYRLPEAA
HHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHH
EALRYLGAGHAQGKIVINVL
HHHHHHCCCCCCCEEEEEEC
>Mature Secondary Structure
MKAMLFYEYGNPNVLQLREVERPSLQANHVLIKVHSASINTLDWNQMTGPIMIRMLNGAL
CCEEEEEECCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCC
HKPKINSLGLDLAGWVEAVGPQVTKFKPGDAVFGTAQGSLAEYVCATEDQLVLKPANVAF
CCCCCCCCCCCHHHHHHHCCCCCEEECCCCCEEECCCCCHHHHHHCCCCCEEEECCCCEE
EAAAATPVAAFTAIYALSDLGKIQAGQRVLINGASGAVGSFAIQIAKAYGAEVTAVCSSR
EHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCEEEEEECCC
NADIAQASGASHWIDYSREDLRQHRQRYDLILGVNGYQSIFTYRKALTPTGRYIAIGGAL
CCCHHHCCCCCHHHCCCHHHHHHHHHHCEEEEECCHHHHHHHHHHHCCCCCCEEEECCHH
PQILQAVALGRILSLGTSKTLQFLGVAPIRHTTLLKLQQLLESGQLKPVIDRCYRLPEAA
HHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHH
EALRYLGAGHAQGKIVINVL
HHHHHHCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]