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The map label for this gene is rsbW [H]

Identifier: 159898147

GI number: 159898147

Start: 1883060

End: 1883524

Strand: Reverse

Name: rsbW [H]

Synonym: Haur_1623

Alternate gene names: 159898147

Gene position: 1883524-1883060 (Counterclockwise)

Preceding gene: 159898148

Following gene: 159898146

Centisome position: 29.68

GC content: 52.69

Gene sequence:

>465_bases
ATGGCGCAAACCCAAGCCACCATCGAACTGATATTTCCCAGCCAGCTTGGCTATGAAAAAATCGCCCGTGAAGCAATTGG
TACGCTCGCACGGAATATGGGGTTTGACCCAGAGCGCGTTGAGGATTTACGCACGGCACTAAGCGAGGCCTGTATCAACG
CCATCGAGCATGGCAATCAGCGCCAAGTCCAACGCCGAATTCATATCACCTGCACGATTTCTCGCAATCGGCTGGTGCTG
GTTATTAGCGATGAAGGTCTTCGTTTTCACCCCTCCCAAGAGATCGAAGCAGCAACCATCGAGCAAAAACTTGCTGGGCT
GGCATCGGCGCGAGGGATGGGCTTAATGCTCATTGAACAGCTTGTTGATGAGTGCGGCTTTCTACCGTCGCGTCCCGGAC
AAGGTAATCGTTTTCGATTAGCAATGTATAATCCACCACGACGGCATGGATCAGCCTCAGCCTAG

Upstream 100 bases:

>100_bases
TTAATTAAAGAACTGATGGATGAAGTCCAGTTTTCGGTCGCTCCATCAGGTGGCAATAAATTACGGATGGTTATCCACCT
AGATCGTTGAGTTGAAGAAC

Downstream 100 bases:

>100_bases
CGCGATCCTTGGTCAAGGAGTTTTGGACCTATGATTGACGATGAATTGAAAGTTACGACCCGTCAACGCGACGGGATTTG
GATTATTGACCTCGAAGGTG

Product: putative anti-sigma regulatory factor, serine/threonine protein kinase

Products: NA

Alternate protein names: Anti-sigma-B factor; Sigma-B negative effector rsbW [H]

Number of amino acids: Translated: 154; Mature: 153

Protein sequence:

>154_residues
MAQTQATIELIFPSQLGYEKIAREAIGTLARNMGFDPERVEDLRTALSEACINAIEHGNQRQVQRRIHITCTISRNRLVL
VISDEGLRFHPSQEIEAATIEQKLAGLASARGMGLMLIEQLVDECGFLPSRPGQGNRFRLAMYNPPRRHGSASA

Sequences:

>Translated_154_residues
MAQTQATIELIFPSQLGYEKIAREAIGTLARNMGFDPERVEDLRTALSEACINAIEHGNQRQVQRRIHITCTISRNRLVL
VISDEGLRFHPSQEIEAATIEQKLAGLASARGMGLMLIEQLVDECGFLPSRPGQGNRFRLAMYNPPRRHGSASA
>Mature_153_residues
AQTQATIELIFPSQLGYEKIAREAIGTLARNMGFDPERVEDLRTALSEACINAIEHGNQRQVQRRIHITCTISRNRLVLV
ISDEGLRFHPSQEIEAATIEQKLAGLASARGMGLMLIEQLVDECGFLPSRPGQGNRFRLAMYNPPRRHGSASA

Specific function: Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, rsbV. Upon phosphorylation of rsbV, rsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B

COG id: COG2172

COG function: function code T; Anti-sigma regulatory factor (Ser/Thr protein kinase)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anti-sigma-factor family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010193
- InterPro:   IPR003594 [H]

Pfam domain/function: PF02518 HATPase_c [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 17112; Mature: 16981

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQTQATIELIFPSQLGYEKIAREAIGTLARNMGFDPERVEDLRTALSEACINAIEHGNQ
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCH
RQVQRRIHITCTISRNRLVLVISDEGLRFHPSQEIEAATIEQKLAGLASARGMGLMLIEQ
HHHHEEEEEEEEEECCEEEEEECCCCCEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
LVDECGFLPSRPGQGNRFRLAMYNPPRRHGSASA
HHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
AQTQATIELIFPSQLGYEKIAREAIGTLARNMGFDPERVEDLRTALSEACINAIEHGNQ
CCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCH
RQVQRRIHITCTISRNRLVLVISDEGLRFHPSQEIEAATIEQKLAGLASARGMGLMLIEQ
HHHHEEEEEEEEEECCEEEEEECCCCCEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
LVDECGFLPSRPGQGNRFRLAMYNPPRRHGSASA
HHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2170324; 3027048; 9384377; 8012595; 1592822; 8468294; 8144446; 12270815 [H]