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The map label for this gene is fhs

Identifier: 159898024

GI number: 159898024

Start: 1746642

End: 1748354

Strand: Reverse

Name: fhs

Synonym: Haur_1499

Alternate gene names: 159898024

Gene position: 1748354-1746642 (Counterclockwise)

Preceding gene: 159898025

Following gene: 159898023

Centisome position: 27.55

GC content: 52.25

Gene sequence:

>1713_bases
ATGAAAACTAGTTTACAAATCGCTGCCGAGGCTACGCCACGCCCCATCACCCAAATTGCCGAAGAATTAGCGATTGCTGA
GCAATTTGTCGAACCGTATGGCCGCTACCGTGCCAAAATTAACCTTGATCTGCTTGATGCGAGCCATGATCGGCCTCGCG
GCAAGCAGATTTTAGTGACCGCCATGACTCCAACACCACTTGGCGAGGGCAAAACTGCCACGACGATCGGCCTTGGAATG
GCCTTAAGTCGCTTGGGCAAACGCGCCATCTGCACGCTGCGCCAAAGCTCGCTTGGCCCAGTTTTTGGGATTAAAGGTGG
TGGCTCAGGTGGCGGCTATTCGCAAGTTATCCCCTTAGAAGATAGCTTGATGCACTTAACTGGTGATATTCACGCCGTGA
CCCAAGCCCACAACCAAATCGCCGCCATGACCGACAATAGTTGGTATCAAAAAAATCGGCTGGGCATCGACCCTGAGCAA
ATTCAGATTCGGCGAGTGCTAGATGTCAATGATCGCTTTTTGCGCTCGATCACAATCGGCCAAGGCGGTTCGCAACATGG
CATTCCACGCCAAACGGGCTTCGATATTACTGCTGCTAGCGAATTAATGGCTATTTTAGCCTTGGTCAGTGGCGAAAACC
ATGCCGATGTGATGCGCGATCTCCGCCAACGCATCGGGCGCATGGTGGTGGCGTTCACTCGTCAAGGCCAACCAATTACT
GCCGATGATATTCAGGCGGCGGGTGCAGCCACGGTGATTATGCGCAATGCCATTCATCCAACCTTGATGCAGACAATTGA
AAATACGCCTGTGTTGATGCATGGCGGGCCATTTGCCAATATCGCTCACGGCAACGCCAGCGTCGTCGCCGATCAAGTTG
GCCTGCGGATCGCCGATTATGTGGTGACCGAGGCTGGTTTTGCCATGGATATGGGCGGCGAGAAGTTTTTCGATATCAAA
TGTCGCGCCTTTGATGCCAAACCTGCGGTCGTGGTGTTGGTCGCTACAATTCGTGCGCTCAAAGCTCACAGCGGGCGCTG
GAATATCAAACCAGGTCGCGATTTGCCCACCGATTTGTTGCAAGAAAATCCTGATGCGGTTTATGCAGGCGGGGCCAATC
TGCAAAAGCATATTCGCAATGCCCAATTATTTGGCCTGCCAGTTGTCGTTGCGCTTAATTCGTTCCCTGATGATCATCCC
TCGGAAATCGAGGCGGTACGCGAAATCGCGATGAGTGCCGGAGCCTTTGATGTAGCGGTGAGCAAGGTATTTAGCCAAGG
CGGGGTTGGCGGCGAAGAATTGGCAGAAAAAGTGCTAGCCGCAATTGACCAAGCAGGCCAAGCCCAATTTTTATACGAAC
TTGAGCAGCCGTTGACCGCTAAGATTGCCACAATTGCCACCAAAATCTACGGAGCAGCGGAAGTTAGTTATAGCGAAGCA
GCCAGCGAACAATTAGCCAAACTTGAGGCCAATGGCTTTGGCAATTTGCCGATTTGTATGGCCAAAACTCACTTGAGCAT
CAGCCATGATCCGGCGCTCAAAGGTGCGCCAACGGGCTATAGCTTCCCAATTCGTGAAGTGCGGGCCAGCATTGGAGCAG
GCTTTATCTACCCCATTGCTGGCGATATGATGACCATGCCAGGGCTTAGCGCTAACCCTGCTGCCCAACAAATTGATATC
GATGAACATGGCAATACAGTTGGCTTATTCTAG

Upstream 100 bases:

>100_bases
AGCGGGATAAGCGGTGGCTTTGCTTTAATCGCCTGCTATTGCATGCAGTAGCAACCGTACCAACGGCGGTACGGACAATT
CATACAAGGACACAGCGTTC

Downstream 100 bases:

>100_bases
CTACATGTCAATGTTCAATGTCTTTTTGTAAAACAAGCATTTCTTTTTGTAAAGCATCCTTGACTTAATCAACATACTGA
TCTATACTCAGGTTAGTCAA

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MKTSLQIAAEATPRPITQIAEELAIAEQFVEPYGRYRAKINLDLLDASHDRPRGKQILVTAMTPTPLGEGKTATTIGLGM
ALSRLGKRAICTLRQSSLGPVFGIKGGGSGGGYSQVIPLEDSLMHLTGDIHAVTQAHNQIAAMTDNSWYQKNRLGIDPEQ
IQIRRVLDVNDRFLRSITIGQGGSQHGIPRQTGFDITAASELMAILALVSGENHADVMRDLRQRIGRMVVAFTRQGQPIT
ADDIQAAGAATVIMRNAIHPTLMQTIENTPVLMHGGPFANIAHGNASVVADQVGLRIADYVVTEAGFAMDMGGEKFFDIK
CRAFDAKPAVVVLVATIRALKAHSGRWNIKPGRDLPTDLLQENPDAVYAGGANLQKHIRNAQLFGLPVVVALNSFPDDHP
SEIEAVREIAMSAGAFDVAVSKVFSQGGVGGEELAEKVLAAIDQAGQAQFLYELEQPLTAKIATIATKIYGAAEVSYSEA
ASEQLAKLEANGFGNLPICMAKTHLSISHDPALKGAPTGYSFPIREVRASIGAGFIYPIAGDMMTMPGLSANPAAQQIDI
DEHGNTVGLF

Sequences:

>Translated_570_residues
MKTSLQIAAEATPRPITQIAEELAIAEQFVEPYGRYRAKINLDLLDASHDRPRGKQILVTAMTPTPLGEGKTATTIGLGM
ALSRLGKRAICTLRQSSLGPVFGIKGGGSGGGYSQVIPLEDSLMHLTGDIHAVTQAHNQIAAMTDNSWYQKNRLGIDPEQ
IQIRRVLDVNDRFLRSITIGQGGSQHGIPRQTGFDITAASELMAILALVSGENHADVMRDLRQRIGRMVVAFTRQGQPIT
ADDIQAAGAATVIMRNAIHPTLMQTIENTPVLMHGGPFANIAHGNASVVADQVGLRIADYVVTEAGFAMDMGGEKFFDIK
CRAFDAKPAVVVLVATIRALKAHSGRWNIKPGRDLPTDLLQENPDAVYAGGANLQKHIRNAQLFGLPVVVALNSFPDDHP
SEIEAVREIAMSAGAFDVAVSKVFSQGGVGGEELAEKVLAAIDQAGQAQFLYELEQPLTAKIATIATKIYGAAEVSYSEA
ASEQLAKLEANGFGNLPICMAKTHLSISHDPALKGAPTGYSFPIREVRASIGAGFIYPIAGDMMTMPGLSANPAAQQIDI
DEHGNTVGLF
>Mature_570_residues
MKTSLQIAAEATPRPITQIAEELAIAEQFVEPYGRYRAKINLDLLDASHDRPRGKQILVTAMTPTPLGEGKTATTIGLGM
ALSRLGKRAICTLRQSSLGPVFGIKGGGSGGGYSQVIPLEDSLMHLTGDIHAVTQAHNQIAAMTDNSWYQKNRLGIDPEQ
IQIRRVLDVNDRFLRSITIGQGGSQHGIPRQTGFDITAASELMAILALVSGENHADVMRDLRQRIGRMVVAFTRQGQPIT
ADDIQAAGAATVIMRNAIHPTLMQTIENTPVLMHGGPFANIAHGNASVVADQVGLRIADYVVTEAGFAMDMGGEKFFDIK
CRAFDAKPAVVVLVATIRALKAHSGRWNIKPGRDLPTDLLQENPDAVYAGGANLQKHIRNAQLFGLPVVVALNSFPDDHP
SEIEAVREIAMSAGAFDVAVSKVFSQGGVGGEELAEKVLAAIDQAGQAQFLYELEQPLTAKIATIATKIYGAAEVSYSEA
ASEQLAKLEANGFGNLPICMAKTHLSISHDPALKGAPTGYSFPIREVRASIGAGFIYPIAGDMMTMPGLSANPAAQQIDI
DEHGNTVGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=624, Percent_Identity=45.5128205128205, Blast_Score=517, Evalue=1e-146,
Organism=Homo sapiens, GI36796743, Length=624, Percent_Identity=46.6346153846154, Blast_Score=514, Evalue=1e-146,
Organism=Homo sapiens, GI310124614, Length=104, Percent_Identity=45.1923076923077, Blast_Score=100, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17568737, Length=628, Percent_Identity=45.859872611465, Blast_Score=501, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17568739, Length=628, Percent_Identity=45.859872611465, Blast_Score=501, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6319558, Length=636, Percent_Identity=43.2389937106918, Blast_Score=514, Evalue=1e-146,
Organism=Saccharomyces cerevisiae, GI6321643, Length=631, Percent_Identity=44.2155309033281, Blast_Score=506, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24645718, Length=624, Percent_Identity=43.1089743589744, Blast_Score=474, Evalue=1e-134,
Organism=Drosophila melanogaster, GI17137370, Length=624, Percent_Identity=43.1089743589744, Blast_Score=474, Evalue=1e-134,
Organism=Drosophila melanogaster, GI62472483, Length=624, Percent_Identity=43.1089743589744, Blast_Score=474, Evalue=1e-134,
Organism=Drosophila melanogaster, GI45551871, Length=624, Percent_Identity=43.1089743589744, Blast_Score=474, Evalue=1e-134,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_HERA2 (A9B4H8)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001544271.1
- ProteinModelPortal:   A9B4H8
- SMR:   A9B4H8
- GeneID:   5733384
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_1499
- HOGENOM:   HBG677721
- OMA:   EIMAVLC
- ProtClustDB:   CLSK983690
- BioCyc:   HAUR316274:HAUR_1499-MONOMER
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 60779; Mature: 60779

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTSLQIAAEATPRPITQIAEELAIAEQFVEPYGRYRAKINLDLLDASHDRPRGKQILVT
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEEECCCCCCCCCEEEEE
AMTPTPLGEGKTATTIGLGMALSRLGKRAICTLRQSSLGPVFGIKGGGSGGGYSQVIPLE
EECCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEECC
DSLMHLTGDIHAVTQAHNQIAAMTDNSWYQKNRLGIDPEQIQIRRVLDVNDRFLRSITIG
HHHHHHHCCHHHHHHHCCCEEEECCCCCHHCCCCCCCHHHHHEEHHHCCCHHHHHEEEEC
QGGSQHGIPRQTGFDITAASELMAILALVSGENHADVMRDLRQRIGRMVVAFTRQGQPIT
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEEECCCCCCC
ADDIQAAGAATVIMRNAIHPTLMQTIENTPVLMHGGPFANIAHGNASVVADQVGLRIADY
HHHHHHCCHHHHHHHHCCCHHHHHHHCCCCEEEECCCCCEECCCCHHHHHHHHCHHHHHH
VVTEAGFAMDMGGEKFFDIKCRAFDAKPAVVVLVATIRALKAHSGRWNIKPGRDLPTDLL
HHHCCCCEEECCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
QENPDAVYAGGANLQKHIRNAQLFGLPVVVALNSFPDDHPSEIEAVREIAMSAGAFDVAV
HCCCCEEEECCCHHHHHHCCCCEECCEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHH
SKVFSQGGVGGEELAEKVLAAIDQAGQAQFLYELEQPLTAKIATIATKIYGAAEVSYSEA
HHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHH
ASEQLAKLEANGFGNLPICMAKTHLSISHDPALKGAPTGYSFPIREVRASIGAGFIYPIA
HHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCEEEECC
GDMMTMPGLSANPAAQQIDIDEHGNTVGLF
CCEEECCCCCCCCCCCEEECCCCCCEECCC
>Mature Secondary Structure
MKTSLQIAAEATPRPITQIAEELAIAEQFVEPYGRYRAKINLDLLDASHDRPRGKQILVT
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEEECCCCCCCCCEEEEE
AMTPTPLGEGKTATTIGLGMALSRLGKRAICTLRQSSLGPVFGIKGGGSGGGYSQVIPLE
EECCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEECC
DSLMHLTGDIHAVTQAHNQIAAMTDNSWYQKNRLGIDPEQIQIRRVLDVNDRFLRSITIG
HHHHHHHCCHHHHHHHCCCEEEECCCCCHHCCCCCCCHHHHHEEHHHCCCHHHHHEEEEC
QGGSQHGIPRQTGFDITAASELMAILALVSGENHADVMRDLRQRIGRMVVAFTRQGQPIT
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEEECCCCCCC
ADDIQAAGAATVIMRNAIHPTLMQTIENTPVLMHGGPFANIAHGNASVVADQVGLRIADY
HHHHHHCCHHHHHHHHCCCHHHHHHHCCCCEEEECCCCCEECCCCHHHHHHHHCHHHHHH
VVTEAGFAMDMGGEKFFDIKCRAFDAKPAVVVLVATIRALKAHSGRWNIKPGRDLPTDLL
HHHCCCCEEECCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
QENPDAVYAGGANLQKHIRNAQLFGLPVVVALNSFPDDHPSEIEAVREIAMSAGAFDVAV
HCCCCEEEECCCHHHHHHCCCCEECCEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHH
SKVFSQGGVGGEELAEKVLAAIDQAGQAQFLYELEQPLTAKIATIATKIYGAAEVSYSEA
HHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHH
ASEQLAKLEANGFGNLPICMAKTHLSISHDPALKGAPTGYSFPIREVRASIGAGFIYPIA
HHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCEEEECC
GDMMTMPGLSANPAAQQIDIDEHGNTVGLF
CCEEECCCCCCCCCCCEEECCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA