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The map label for this gene is icd [H]

Identifier: 159897976

GI number: 159897976

Start: 1689475

End: 1689825

Strand: Reverse

Name: icd [H]

Synonym: Haur_1451

Alternate gene names: 159897976

Gene position: 1689825-1689475 (Counterclockwise)

Preceding gene: 159897977

Following gene: 159897975

Centisome position: 26.63

GC content: 51.28

Gene sequence:

>351_bases
TTGTATGGTGATATTTTGAGCGATTTGTGCGCTGGCATGGTTGGCGGCCTTGGGGTTGCCCCAGGTGGCAACATCGGCGA
ACATGGCGCAGTTTTTGAAGCAACCCACGGCTCAGCTCCAAAATACAAAAATCTCAACAAAGTCAACCCAACTGCCTTGA
TCCTCTCAGGCGAGTTGATGTTGCGCCACTTGGGCGAAATCGAAGCCGCTGATCGGCTCAATGCAGCGGTGGCAACCGTG
ATTGCTGAAGGTAAGGATGTAACCTACGACCTAAAGGATGATCGCAACGATCCAAGCGCGGTTGGGACTGCCGAAATGGC
TGATGCCATTATTGCTAAATTACAAGCCTAA

Upstream 100 bases:

>100_bases
CTGTCTCAGATACGTGAACAGACACGGCTCCATAGCCACCAATGATCGTTGGTTCGTTTCAGCCCAGTGCTGCACAAACA
GGGTTCGCCAGCACTATCAT

Downstream 100 bases:

>100_bases
TTGGGCTATCACTGGCGATCAGTCTTACCTGATCGCCAGCTATCCCCATATTTAGAGACTATACCCAAGAATTAATCCAG
CTTCATGGTACACTTCATCT

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 116; Mature: 116

Protein sequence:

>116_residues
MYGDILSDLCAGMVGGLGVAPGGNIGEHGAVFEATHGSAPKYKNLNKVNPTALILSGELMLRHLGEIEAADRLNAAVATV
IAEGKDVTYDLKDDRNDPSAVGTAEMADAIIAKLQA

Sequences:

>Translated_116_residues
MYGDILSDLCAGMVGGLGVAPGGNIGEHGAVFEATHGSAPKYKNLNKVNPTALILSGELMLRHLGEIEAADRLNAAVATV
IAEGKDVTYDLKDDRNDPSAVGTAEMADAIIAKLQA
>Mature_116_residues
MYGDILSDLCAGMVGGLGVAPGGNIGEHGAVFEATHGSAPKYKNLNKVNPTALILSGELMLRHLGEIEAADRLNAAVATV
IAEGKDVTYDLKDDRNDPSAVGTAEMADAIIAKLQA

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=92, Percent_Identity=55.4347826086957, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1787381, Length=112, Percent_Identity=48.2142857142857, Blast_Score=103, Evalue=3e-24,
Organism=Escherichia coli, GI1788101, Length=118, Percent_Identity=37.2881355932203, Blast_Score=65, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71986051, Length=91, Percent_Identity=56.043956043956, Blast_Score=102, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17550882, Length=118, Percent_Identity=38.135593220339, Blast_Score=66, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324709, Length=116, Percent_Identity=43.1034482758621, Blast_Score=86, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6324291, Length=117, Percent_Identity=41.025641025641, Blast_Score=74, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6322097, Length=114, Percent_Identity=39.4736842105263, Blast_Score=69, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24643268, Length=114, Percent_Identity=46.4912280701754, Blast_Score=99, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24643270, Length=91, Percent_Identity=52.7472527472528, Blast_Score=99, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24661184, Length=115, Percent_Identity=42.6086956521739, Blast_Score=98, Evalue=1e-21,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 11948; Mature: 11948

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYGDILSDLCAGMVGGLGVAPGGNIGEHGAVFEATHGSAPKYKNLNKVNPTALILSGELM
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEEHHHH
LRHLGEIEAADRLNAAVATVIAEGKDVTYDLKDDRNDPSAVGTAEMADAIIAKLQA
HHHHCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MYGDILSDLCAGMVGGLGVAPGGNIGEHGAVFEATHGSAPKYKNLNKVNPTALILSGELM
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEEHHHH
LRHLGEIEAADRLNAAVATVIAEGKDVTYDLKDDRNDPSAVGTAEMADAIIAKLQA
HHHHCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]