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The map label for this gene is rsbRA [H]

Identifier: 159897627

GI number: 159897627

Start: 1257638

End: 1259182

Strand: Direct

Name: rsbRA [H]

Synonym: Haur_1098

Alternate gene names: 159897627

Gene position: 1257638-1259182 (Clockwise)

Preceding gene: 159897625

Following gene: 159897628

Centisome position: 19.82

GC content: 48.48

Gene sequence:

>1545_bases
ATGAAAGTAGCCTATCAACAATATGTGCATAAAAGTGTTCGTGGCAAAATTAGCCTTGCCTTATTGGGCATTATGCTGAT
TGTTGTGCTGGTTTTGTTGATTCCGCTGCGCTATATTGTCAATAGCTCAAGCCTTTTTGCTGAACAACAGGAAATGCAAG
ATCACCTTGAACGGGTACGACGAGCAATTAATAGTGAGCTTGCCCAGATCGATGCCTTGGTCTTGTCGATGGCAACCTGG
GATGAATCATACGATTTTATCAATCAACGTACTCCCACCTATATTGAAGAAAATACCAATAACGAGATTTTTGAGCTGTA
TAACGTTCAGGCGATGCTCTATACCGATCAGAACGGCACAATTGTGTTCGCCAAAACCTATGACTCGCAACAACGGAAGT
CGGTGGCAGTGCCATTTGAGTTTTTTGATATCAACAATTTCTATCCCCAATTACTCAATCATCCGCAGCTTGATCAAGGT
ACAACTAGCGTGGTGCGGGCTGGCACCAAACTATGGCTTTTGGCGGCACGACCAATTCTCACCAGCGATGCTCAAGGTCC
ATCGCGTGGTACGTTGATTTATGGTCGGATGGTCGATCAAGCGGTGGTTGATCGGATTAATTACCAAACCTTGTTACCAG
TTGAGTTGAGTGATTATCGCTTGCTTGCGCCAACACGGCAGCAGGTTGTCAGCGAATTAGCCAATGAGCAGCGCTTAGTT
TCGCGAGCTTTCAACGACGATACCCTCGAAGGCTTTGTGGTTTTTCCGTCAATCGACGGTAAACCTTTGTTGGTTGCAAC
GTTGGCCTTGCCCCGTACAATTTATATTCAAGGTGAACGCACCTTCTGGTTAATTGCTAGTGTGGTGGGGATTGCTGGCT
GCTTGGGGTTGTTGAGCCTCTTTTGGGCTTTGCGACGCTTTATTTTCTATCCGCTAACGTCGATGGTGGGCGATTTGCGC
CAGATCGATCCCAATCAGCCTGAGCAACATCAGATTAATTTTGCTAGCCCCGACGAGCTAGGCTTATTGGCTAAAACCGT
CAATCAAGCGCTTGATTCGTTGGCTGTCGCCCAGCGCGAACAACTGGCGGCTGAGGCCAAACGTAGCGCCTTGCAAGCCG
AAATGCTGCAAAATCAACAAAGCCAATTGCAAACCCAAGCGGCTTTGCTCGAACTCCAAGAGCAAAGTTTGGCCGAACAA
GCCTTGCCGTTGATTCCAGTTTCGCGTGAGGTTTTGGCAATGCCCTTGATCGGCCAAATCGATTTCAATCGGGCTGAGCG
TTTGCAAACCACGATTTTGCATGGAATTGAAACCTATCGTGCTCGCACGGTTATCCTCGATCTGACTGGGATTTCGCAGC
TTGAGCAACGGGCAGCGGTTGCGCTCGGCCAAACGGCCCAAGCCGTGCAATTGCTTGGGGCACGCTTGTTGCTGACTGGG
GCAAACCCATCAATTGCTGAAGAAATTGTTGCTGCCAATATCGATTTGGGCCAAATTGCGATCTATCAAACCTTGGCTGC
TGGTATGCAAGCGGCTCTCCGCTAA

Upstream 100 bases:

>100_bases
AAAGGTGGTTTTGAGATGGTGTATAGTTAGCCTAACCACAATTCTATGCGTTGCATTCCAATTCGCATCAAAGCCAACGA
TGGCATAAGGAAGTTCAGCG

Downstream 100 bases:

>100_bases
ACCTAATTTAAATTCCCACCGTCAAAAGCTGAGAATCAGCTCGCGTAATTCCGCAATGCCGCTGTAGGAGCGGGTTGGGC
GCAGCAACCCAGTGCCAATC

Product: anti-sigma-factor antagonist

Products: NA

Alternate protein names: Stressosome protein rsbRA [H]

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MKVAYQQYVHKSVRGKISLALLGIMLIVVLVLLIPLRYIVNSSSLFAEQQEMQDHLERVRRAINSELAQIDALVLSMATW
DESYDFINQRTPTYIEENTNNEIFELYNVQAMLYTDQNGTIVFAKTYDSQQRKSVAVPFEFFDINNFYPQLLNHPQLDQG
TTSVVRAGTKLWLLAARPILTSDAQGPSRGTLIYGRMVDQAVVDRINYQTLLPVELSDYRLLAPTRQQVVSELANEQRLV
SRAFNDDTLEGFVVFPSIDGKPLLVATLALPRTIYIQGERTFWLIASVVGIAGCLGLLSLFWALRRFIFYPLTSMVGDLR
QIDPNQPEQHQINFASPDELGLLAKTVNQALDSLAVAQREQLAAEAKRSALQAEMLQNQQSQLQTQAALLELQEQSLAEQ
ALPLIPVSREVLAMPLIGQIDFNRAERLQTTILHGIETYRARTVILDLTGISQLEQRAAVALGQTAQAVQLLGARLLLTG
ANPSIAEEIVAANIDLGQIAIYQTLAAGMQAALR

Sequences:

>Translated_514_residues
MKVAYQQYVHKSVRGKISLALLGIMLIVVLVLLIPLRYIVNSSSLFAEQQEMQDHLERVRRAINSELAQIDALVLSMATW
DESYDFINQRTPTYIEENTNNEIFELYNVQAMLYTDQNGTIVFAKTYDSQQRKSVAVPFEFFDINNFYPQLLNHPQLDQG
TTSVVRAGTKLWLLAARPILTSDAQGPSRGTLIYGRMVDQAVVDRINYQTLLPVELSDYRLLAPTRQQVVSELANEQRLV
SRAFNDDTLEGFVVFPSIDGKPLLVATLALPRTIYIQGERTFWLIASVVGIAGCLGLLSLFWALRRFIFYPLTSMVGDLR
QIDPNQPEQHQINFASPDELGLLAKTVNQALDSLAVAQREQLAAEAKRSALQAEMLQNQQSQLQTQAALLELQEQSLAEQ
ALPLIPVSREVLAMPLIGQIDFNRAERLQTTILHGIETYRARTVILDLTGISQLEQRAAVALGQTAQAVQLLGARLLLTG
ANPSIAEEIVAANIDLGQIAIYQTLAAGMQAALR
>Mature_514_residues
MKVAYQQYVHKSVRGKISLALLGIMLIVVLVLLIPLRYIVNSSSLFAEQQEMQDHLERVRRAINSELAQIDALVLSMATW
DESYDFINQRTPTYIEENTNNEIFELYNVQAMLYTDQNGTIVFAKTYDSQQRKSVAVPFEFFDINNFYPQLLNHPQLDQG
TTSVVRAGTKLWLLAARPILTSDAQGPSRGTLIYGRMVDQAVVDRINYQTLLPVELSDYRLLAPTRQQVVSELANEQRLV
SRAFNDDTLEGFVVFPSIDGKPLLVATLALPRTIYIQGERTFWLIASVVGIAGCLGLLSLFWALRRFIFYPLTSMVGDLR
QIDPNQPEQHQINFASPDELGLLAKTVNQALDSLAVAQREQLAAEAKRSALQAEMLQNQQSQLQTQAALLELQEQSLAEQ
ALPLIPVSREVLAMPLIGQIDFNRAERLQTTILHGIETYRARTVILDLTGISQLEQRAAVALGQTAQAVQLLGARLLLTG
ANPSIAEEIVAANIDLGQIAIYQTLAAGMQAALR

Specific function: Negative regulator of sigma-B activity. Non- phosphorylated rsbS binds to rsbT, preventing its association with rsbU. Requires any one of rsbRA, rsbRB, rsbRC or rsbRD to sequester rsbT. When rsbS and the rsbR paralog(s) are phosphorylated, they release rs

COG id: COG3322

COG function: function code T; Predicted periplasmic ligand-binding sensor domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014792
- InterPro:   IPR002645 [H]

Pfam domain/function: PF08678 Rsbr_N; PF01740 STAS [H]

EC number: NA

Molecular weight: Translated: 57290; Mature: 57290

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS50885 HAMP ; PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVAYQQYVHKSVRGKISLALLGIMLIVVLVLLIPLRYIVNSSSLFAEQQEMQDHLERVR
CCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
RAINSELAQIDALVLSMATWDESYDFINQRTPTYIEENTNNEIFELYNVQAMLYTDQNGT
HHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEECCCCCCCEEEEEEEEEEEECCCCE
IVFAKTYDSQQRKSVAVPFEFFDINNFYPQLLNHPQLDQGTTSVVRAGTKLWLLAARPIL
EEEEECCCCCCCCCEECCEEEEECCCHHHHHCCCCCCCCCHHHHHHCCCCEEEEEECCCC
TSDAQGPSRGTLIYGRMVDQAVVDRINYQTLLPVELSDYRLLAPTRQQVVSELANEQRLV
CCCCCCCCCCCEEEHHHHHHHHHHHCCCCEEEEEECCCCEEECCHHHHHHHHHHHHHHHH
SRAFNDDTLEGFVVFPSIDGKPLLVATLALPRTIYIQGERTFWLIASVVGIAGCLGLLSL
HHHCCCCCCCCEEEEECCCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
FWALRRFIFYPLTSMVGDLRQIDPNQPEQHQINFASPDELGLLAKTVNQALDSLAVAQRE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QLAAEAKRSALQAEMLQNQQSQLQTQAALLELQEQSLAEQALPLIPVSREVLAMPLIGQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCC
DFNRAERLQTTILHGIETYRARTVILDLTGISQLEQRAAVALGQTAQAVQLLGARLLLTG
CCCHHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHCCHHHHHHHHCCEEEEEC
ANPSIAEEIVAANIDLGQIAIYQTLAAGMQAALR
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVAYQQYVHKSVRGKISLALLGIMLIVVLVLLIPLRYIVNSSSLFAEQQEMQDHLERVR
CCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
RAINSELAQIDALVLSMATWDESYDFINQRTPTYIEENTNNEIFELYNVQAMLYTDQNGT
HHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEECCCCCCCEEEEEEEEEEEECCCCE
IVFAKTYDSQQRKSVAVPFEFFDINNFYPQLLNHPQLDQGTTSVVRAGTKLWLLAARPIL
EEEEECCCCCCCCCEECCEEEEECCCHHHHHCCCCCCCCCHHHHHHCCCCEEEEEECCCC
TSDAQGPSRGTLIYGRMVDQAVVDRINYQTLLPVELSDYRLLAPTRQQVVSELANEQRLV
CCCCCCCCCCCEEEHHHHHHHHHHHCCCCEEEEEECCCCEEECCHHHHHHHHHHHHHHHH
SRAFNDDTLEGFVVFPSIDGKPLLVATLALPRTIYIQGERTFWLIASVVGIAGCLGLLSL
HHHCCCCCCCCEEEEECCCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
FWALRRFIFYPLTSMVGDLRQIDPNQPEQHQINFASPDELGLLAKTVNQALDSLAVAQRE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QLAAEAKRSALQAEMLQNQQSQLQTQAALLELQEQSLAEQALPLIPVSREVLAMPLIGQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCC
DFNRAERLQTTILHGIETYRARTVILDLTGISQLEQRAAVALGQTAQAVQLLGARLLLTG
CCCHHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHCCHHHHHHHHCCEEEEEC
ANPSIAEEIVAANIDLGQIAIYQTLAAGMQAALR
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8002610; 9384377; 11157946; 10329124 [H]