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The map label for this gene is ywrD [H]

Identifier: 159897624

GI number: 159897624

Start: 1253220

End: 1254824

Strand: Direct

Name: ywrD [H]

Synonym: Haur_1095

Alternate gene names: 159897624

Gene position: 1253220-1254824 (Clockwise)

Preceding gene: 159897623

Following gene: 159897625

Centisome position: 19.75

GC content: 54.14

Gene sequence:

>1605_bases
ATGAAGTTGATCGATTTACCCTATAGCTCACGGCGCATGCCAGCGATTGCGCGGCGTTCGATGGTGGCAACCAGTCAGCC
ACAGGCGGTTTTGGCTGGCTTATCGATGCTTGAACGTGGCGGTAATGCCGTCGATGCAGCGATTGCCGCCGCCGCAATGT
TGACGGTCGTCGAGCCGACATCCAACGGGATTGGCAGCGATGCTTTTGCCTTGGTCTGGGATGGCCGCAAGTTGCATGGC
CTCAATGGTTCAGGGCGTGCGCCGCAGGCGATCAGCCTAGAAACCATGCTCCAAACAGGCCATCAACAGATGCCAGCCTA
TGGTTGGCCGAGCGTAACTGTGCCTGGTACGCCGCGAGCTTGGCACGATCTGCATCAGCGTTTTGGGCGCTTAAATTTTG
AAGAAGTGCTGATGCCAGCAATTAGTGCCGCCGAAGATGGCTTTGCGGTTACGCCCATAGTTTCACATTATTGGAATTTG
GCTTTGCGCCGCTACGAAGCCATGACTGACCCCGCGACCAGTGCTTGGCTCAACACCTTTTCCTATCGTGGGCGTGCACC
TAGTGCTGGCGATATGTGGCGTTCGCGGCGGCAATCGCGTACCTTGCGCCGCATCGCCCAAACTGGCGCTGATGATTTTT
ATACGGGTGAATTGGCAGGGCAAATTGTTGAATGGGCGCAGCAAACTGGCGGTTTTATCAACGTCGCCGATTTAGCCCAG
CATACCAGCACTTGGATTGAGCCAATCAACACCAGCTATCGCGGCTATCAAGTCTGGGAAATTCCGCCGAATGGTCAAGG
CTTGGCAGCGTTGATGGCCCTGAATATTTTAGAAGGCTTTGATCTGAGCCATACCACCCGCGATACCATTCAATCGTATC
ATATGCAAATCGAAGCCATGAAATTGGCCTTTGCCGATGCCTATCGCTACATTGCCGACCCTGAGCATGTTGAAGTGCCA
ACCAAACAATTGCTTTCTAAGCGCTATGCTGCTAGCCGCCGCAGCCTGATTGGCGAGTATGCGCTTGATCCACAGCATGG
TCAGTTGCCGCAAGGTGGCACGGTCTACCTGTGTGCAGTCGATGGCGATGGCATGATGGTCAGCTTTATTCAATCGAACT
ATATGGGCTTTGGTTCAGGTGTGGTTGTGCCCGAAACCGGCATTGCCCTACAAAATCGTGGCGCGAACTTCTCGCTTGAT
CCGCAGCATCCCAATGTTTTAGCGCCCAATAAACGCCCCTTCCACACGATTATTCCTTCGTTTTTGACTCGCGATGGCGA
GGCGGTTGGGCCGTTTGGGGTGATGGGCGGCGCGATGCAACCTCAAGGCCATGCCCAAATGATTTTGAACCGTGTTGATT
GGCAGCTTAATCCACAAGCTAGCCTTGATGCACCGCGCTGGCAAGTTGGTGCTGGCCGTAAAGTTTATTTGGAATATGGC
GTGCCCCAATTTATCGCTGAAGGCTTACGCGCCATGGGCCACGATGTCGAAATTCATGCTGAAGGTGGCATGTTTGGGCG
TGGCCAAATTATCTGGCGCTTGCCCAATGGCTCATTGATCGGTGGCAGCGATATGCGGGCCGATGGCTGTGCTTTGGGCT
TCTAA

Upstream 100 bases:

>100_bases
TTAGAACTTGTTGTTAAGCGCTGAACTATTACAATTTAAACTGAATAACAATAAAGACAAGCAGCAACATTTAAATCTTA
GCATCTGAGGGCAGCAAACG

Downstream 100 bases:

>100_bases
ATCAAGCTAGTCCTAGATCTAACCTAGTTCAAACAGCTATGGCTTGGCTATAGCTGTTTTTTTGCATTCCAAAGGGCTAA
AATTAAATTAATTATCAAGC

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 534; Mature: 534

Protein sequence:

>534_residues
MKLIDLPYSSRRMPAIARRSMVATSQPQAVLAGLSMLERGGNAVDAAIAAAAMLTVVEPTSNGIGSDAFALVWDGRKLHG
LNGSGRAPQAISLETMLQTGHQQMPAYGWPSVTVPGTPRAWHDLHQRFGRLNFEEVLMPAISAAEDGFAVTPIVSHYWNL
ALRRYEAMTDPATSAWLNTFSYRGRAPSAGDMWRSRRQSRTLRRIAQTGADDFYTGELAGQIVEWAQQTGGFINVADLAQ
HTSTWIEPINTSYRGYQVWEIPPNGQGLAALMALNILEGFDLSHTTRDTIQSYHMQIEAMKLAFADAYRYIADPEHVEVP
TKQLLSKRYAASRRSLIGEYALDPQHGQLPQGGTVYLCAVDGDGMMVSFIQSNYMGFGSGVVVPETGIALQNRGANFSLD
PQHPNVLAPNKRPFHTIIPSFLTRDGEAVGPFGVMGGAMQPQGHAQMILNRVDWQLNPQASLDAPRWQVGAGRKVYLEYG
VPQFIAEGLRAMGHDVEIHAEGGMFGRGQIIWRLPNGSLIGGSDMRADGCALGF

Sequences:

>Translated_534_residues
MKLIDLPYSSRRMPAIARRSMVATSQPQAVLAGLSMLERGGNAVDAAIAAAAMLTVVEPTSNGIGSDAFALVWDGRKLHG
LNGSGRAPQAISLETMLQTGHQQMPAYGWPSVTVPGTPRAWHDLHQRFGRLNFEEVLMPAISAAEDGFAVTPIVSHYWNL
ALRRYEAMTDPATSAWLNTFSYRGRAPSAGDMWRSRRQSRTLRRIAQTGADDFYTGELAGQIVEWAQQTGGFINVADLAQ
HTSTWIEPINTSYRGYQVWEIPPNGQGLAALMALNILEGFDLSHTTRDTIQSYHMQIEAMKLAFADAYRYIADPEHVEVP
TKQLLSKRYAASRRSLIGEYALDPQHGQLPQGGTVYLCAVDGDGMMVSFIQSNYMGFGSGVVVPETGIALQNRGANFSLD
PQHPNVLAPNKRPFHTIIPSFLTRDGEAVGPFGVMGGAMQPQGHAQMILNRVDWQLNPQASLDAPRWQVGAGRKVYLEYG
VPQFIAEGLRAMGHDVEIHAEGGMFGRGQIIWRLPNGSLIGGSDMRADGCALGF
>Mature_534_residues
MKLIDLPYSSRRMPAIARRSMVATSQPQAVLAGLSMLERGGNAVDAAIAAAAMLTVVEPTSNGIGSDAFALVWDGRKLHG
LNGSGRAPQAISLETMLQTGHQQMPAYGWPSVTVPGTPRAWHDLHQRFGRLNFEEVLMPAISAAEDGFAVTPIVSHYWNL
ALRRYEAMTDPATSAWLNTFSYRGRAPSAGDMWRSRRQSRTLRRIAQTGADDFYTGELAGQIVEWAQQTGGFINVADLAQ
HTSTWIEPINTSYRGYQVWEIPPNGQGLAALMALNILEGFDLSHTTRDTIQSYHMQIEAMKLAFADAYRYIADPEHVEVP
TKQLLSKRYAASRRSLIGEYALDPQHGQLPQGGTVYLCAVDGDGMMVSFIQSNYMGFGSGVVVPETGIALQNRGANFSLD
PQHPNVLAPNKRPFHTIIPSFLTRDGEAVGPFGVMGGAMQPQGHAQMILNRVDWQLNPQASLDAPRWQVGAGRKVYLEYG
VPQFIAEGLRAMGHDVEIHAEGGMFGRGQIIWRLPNGSLIGGSDMRADGCALGF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=511, Percent_Identity=27.9843444227006, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI73915090, Length=511, Percent_Identity=27.9843444227006, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI73915096, Length=511, Percent_Identity=27.9843444227006, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI73915094, Length=511, Percent_Identity=27.9843444227006, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI113429324, Length=506, Percent_Identity=26.6798418972332, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI109148539, Length=512, Percent_Identity=30.859375, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI113429326, Length=508, Percent_Identity=26.5748031496063, Blast_Score=142, Evalue=9e-34,
Organism=Homo sapiens, GI153266885, Length=503, Percent_Identity=24.6520874751491, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI153266901, Length=506, Percent_Identity=24.901185770751, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI153266907, Length=500, Percent_Identity=24, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1789856, Length=558, Percent_Identity=29.7491039426523, Blast_Score=213, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17506189, Length=548, Percent_Identity=25.7299270072993, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI72000294, Length=477, Percent_Identity=24.1090146750524, Blast_Score=112, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI212646519, Length=477, Percent_Identity=24.1090146750524, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI193208247, Length=509, Percent_Identity=24.5579567779961, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI193208245, Length=510, Percent_Identity=24.9019607843137, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17542894, Length=414, Percent_Identity=24.8792270531401, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI161077878, Length=526, Percent_Identity=23.9543726235741, Blast_Score=112, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24642670, Length=526, Percent_Identity=23.9543726235741, Blast_Score=112, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24642666, Length=526, Percent_Identity=23.9543726235741, Blast_Score=112, Evalue=9e-25,
Organism=Drosophila melanogaster, GI161077880, Length=526, Percent_Identity=23.9543726235741, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI45551474, Length=529, Percent_Identity=24.1965973534972, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI18859893, Length=510, Percent_Identity=25.8823529411765, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI18859741, Length=555, Percent_Identity=25.5855855855856, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI161077496, Length=510, Percent_Identity=24.1176470588235, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 58322; Mature: 58322

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIDLPYSSRRMPAIARRSMVATSQPQAVLAGLSMLERGGNAVDAAIAAAAMLTVVEPT
CEEEECCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCC
SNGIGSDAFALVWDGRKLHGLNGSGRAPQAISLETMLQTGHQQMPAYGWPSVTVPGTPRA
CCCCCCCEEEEEECCCEEECCCCCCCCCCEEHHHHHHHCCHHCCCCCCCCCEECCCCCHH
WHDLHQRFGRLNFEEVLMPAISAAEDGFAVTPIVSHYWNLALRRYEAMTDPATSAWLNTF
HHHHHHHHCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
SYRGRAPSAGDMWRSRRQSRTLRRIAQTGADDFYTGELAGQIVEWAQQTGGFINVADLAQ
HCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEHHHHHH
HTSTWIEPINTSYRGYQVWEIPPNGQGLAALMALNILEGFDLSHTTRDTIQSYHMQIEAM
HHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
KLAFADAYRYIADPEHVEVPTKQLLSKRYAASRRSLIGEYALDPQHGQLPQGGTVYLCAV
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEE
DGDGMMVSFIQSNYMGFGSGVVVPETGIALQNRGANFSLDPQHPNVLAPNKRPFHTIIPS
CCCCEEEEEEHHCCCCCCCCEEECCCCCEEECCCCCCEECCCCCCEECCCCCCHHHHHHH
FLTRDGEAVGPFGVMGGAMQPQGHAQMILNRVDWQLNPQASLDAPRWQVGAGRKVYLEYG
HHCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEECCCCCEEEEECC
VPQFIAEGLRAMGHDVEIHAEGGMFGRGQIIWRLPNGSLIGGSDMRADGCALGF
CHHHHHHHHHHCCCCEEEEECCCCEECCEEEEECCCCCEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKLIDLPYSSRRMPAIARRSMVATSQPQAVLAGLSMLERGGNAVDAAIAAAAMLTVVEPT
CEEEECCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCC
SNGIGSDAFALVWDGRKLHGLNGSGRAPQAISLETMLQTGHQQMPAYGWPSVTVPGTPRA
CCCCCCCEEEEEECCCEEECCCCCCCCCCEEHHHHHHHCCHHCCCCCCCCCEECCCCCHH
WHDLHQRFGRLNFEEVLMPAISAAEDGFAVTPIVSHYWNLALRRYEAMTDPATSAWLNTF
HHHHHHHHCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
SYRGRAPSAGDMWRSRRQSRTLRRIAQTGADDFYTGELAGQIVEWAQQTGGFINVADLAQ
HCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEHHHHHH
HTSTWIEPINTSYRGYQVWEIPPNGQGLAALMALNILEGFDLSHTTRDTIQSYHMQIEAM
HHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
KLAFADAYRYIADPEHVEVPTKQLLSKRYAASRRSLIGEYALDPQHGQLPQGGTVYLCAV
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEE
DGDGMMVSFIQSNYMGFGSGVVVPETGIALQNRGANFSLDPQHPNVLAPNKRPFHTIIPS
CCCCEEEEEEHHCCCCCCCCEEECCCCCEEECCCCCCEECCCCCCEECCCCCCHHHHHHH
FLTRDGEAVGPFGVMGGAMQPQGHAQMILNRVDWQLNPQASLDAPRWQVGAGRKVYLEYG
HHCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEECCCCCEEEEECC
VPQFIAEGLRAMGHDVEIHAEGGMFGRGQIIWRLPNGSLIGGSDMRADGCALGF
CHHHHHHHHHHCCCCEEEEECCCCEECCEEEEECCCCCEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]