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The map label for this gene is kgtP [H]

Identifier: 159897513

GI number: 159897513

Start: 1126833

End: 1128278

Strand: Direct

Name: kgtP [H]

Synonym: Haur_0984

Alternate gene names: 159897513

Gene position: 1126833-1128278 (Clockwise)

Preceding gene: 159897512

Following gene: 159897519

Centisome position: 17.75

GC content: 49.38

Gene sequence:

>1446_bases
ATGTCAAACACACCCATGCCATCACAGCATTCCACCGTTGTCTCGCAATCCACAATTTGGAAGGTCATCATTGCATCGGC
TTTGGGTACCATGATTGAATGGTACGATTTCTACATTTTTGGCAGTCTTGCTGCGGTCATTGCGACAAATTTCTATCAGT
CGGGCAACGAAACGGCGGCCTTGCTGGAAACCTTTGCCACCTTTGGGGCGGGCTTTGCGGCGCGACCGTTCGGGGCACTG
GTGTTTGGGCGCATTGGCGATATTGTTGGGCGCAAATATGCCTTTTTGGTCACGTTGCTGATCATGGGCGGCGCAACCAC
GGTCATTGGGATTTTGCCCACCTATGCCTCAATTGGCATCCTCGCCCCGATCATTTTGGTGATTATTCGGATCATCCAAG
GTTTGGCGCTTGGTGGTGAATATGGCGGTGCGGCGGTCTATGTCGCTGAACATGTTCCCGACCATAAGCGCGGTTTTTAC
ACCAGTTTTATTCAAATTACCGCCACGCTTGGCTTATTTATCTCGTTGCTGGTAATTTTGATTGTACGAACCTCGATGAG
CAAGGCAGCCTTTGATAGCTGGGGCTGGCGGATTCCCTTCTTGCTCTCAATTGTCTTGGTGGGTGTTTCAGTCTACATTC
GCTCGAAGATGAGTGAATCGCCGTTGTTTACCAAACTCAAACATGCAGGCAAAACCTCGAAAGCTCCGCTTAAAGATAGT
TTTGGCAATCGGCGCAATTGGAAAGTGATTTTGACGGTGTTGTTTGGAGCCGCTGCGGGTCAAGCAGTAATCTGGTATAC
CGCTCAATTTTACGTGAACTCGTGGCTCAAAACCCAAGCCAAAGTGCCAGCTAACACCGTTGATACAATCGTGGCGATTG
CTTTGTTCTTAGGCATGCCGTTTTTCGTCGTCATGGGAGCGCTTTCAGATAAATGGGGGCGCAAAACGGTGATGATGGCA
GGCAATTTAATCGGTGCAATTGCGATTTATCCCGCCTTTATGGCCCTGAAAGCGGCGGCTGGTCCAATTACTCCGGCGGT
TCTCGATGAAGCTGGAAAGGTTATCACGCCTGCGGTCGCCAACAATCCTAACACCGTTCTACTCACCTTGATCATTTTTG
GGTTGGTGTTGTGTGTTTGTATGGTGTATGGCCCGATTGCGGCCTTTTTGGTGGAATCGTTTCCTGCCAAAATTCGCTAT
ACCTCGGTTTCACTGCCCTATCATGTTGGCAACGGCTACTTTGGCGGTTGGTTGCCCTTTATCGCCACAGCAGTGGTTAG
TAGTACCGGCAATATCTATGCTGGCCTATGGTTTCCAATTGCCATCGCTTTGTTGACCTTTGTGGTTGGGATGGTCTTGC
TCAAGGAAACCAAGGATAATTCGCTGCATGAAGAGGCTAGCGATAACCCAATGGCGACTGAAATGGATTTAATTGCCCAA
TCATAA

Upstream 100 bases:

>100_bases
GCTTGGAAGGATATCCCCGTTAATCTCCCCATCGAATGTTCGCTGTCTAGGGCACACACAATTTGGGTTGAATTTGTTGT
TGCAATGAAGGAGCAACACG

Downstream 100 bases:

>100_bases
TTATTGGAATAGCTTTTTCTCTTTCGCATGCCCATTTCCAACGGGCAATCACTCGATCGAACGCCCTTCTCCCACCAAGT
GGGAGAAGGGTTGATACTGC

Product: major facilitator transporter

Products: Proton [Cytoplasm]; 2-oxoglutarate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MSNTPMPSQHSTVVSQSTIWKVIIASALGTMIEWYDFYIFGSLAAVIATNFYQSGNETAALLETFATFGAGFAARPFGAL
VFGRIGDIVGRKYAFLVTLLIMGGATTVIGILPTYASIGILAPIILVIIRIIQGLALGGEYGGAAVYVAEHVPDHKRGFY
TSFIQITATLGLFISLLVILIVRTSMSKAAFDSWGWRIPFLLSIVLVGVSVYIRSKMSESPLFTKLKHAGKTSKAPLKDS
FGNRRNWKVILTVLFGAAAGQAVIWYTAQFYVNSWLKTQAKVPANTVDTIVAIALFLGMPFFVVMGALSDKWGRKTVMMA
GNLIGAIAIYPAFMALKAAAGPITPAVLDEAGKVITPAVANNPNTVLLTLIIFGLVLCVCMVYGPIAAFLVESFPAKIRY
TSVSLPYHVGNGYFGGWLPFIATAVVSSTGNIYAGLWFPIAIALLTFVVGMVLLKETKDNSLHEEASDNPMATEMDLIAQ
S

Sequences:

>Translated_481_residues
MSNTPMPSQHSTVVSQSTIWKVIIASALGTMIEWYDFYIFGSLAAVIATNFYQSGNETAALLETFATFGAGFAARPFGAL
VFGRIGDIVGRKYAFLVTLLIMGGATTVIGILPTYASIGILAPIILVIIRIIQGLALGGEYGGAAVYVAEHVPDHKRGFY
TSFIQITATLGLFISLLVILIVRTSMSKAAFDSWGWRIPFLLSIVLVGVSVYIRSKMSESPLFTKLKHAGKTSKAPLKDS
FGNRRNWKVILTVLFGAAAGQAVIWYTAQFYVNSWLKTQAKVPANTVDTIVAIALFLGMPFFVVMGALSDKWGRKTVMMA
GNLIGAIAIYPAFMALKAAAGPITPAVLDEAGKVITPAVANNPNTVLLTLIIFGLVLCVCMVYGPIAAFLVESFPAKIRY
TSVSLPYHVGNGYFGGWLPFIATAVVSSTGNIYAGLWFPIAIALLTFVVGMVLLKETKDNSLHEEASDNPMATEMDLIAQ
S
>Mature_480_residues
SNTPMPSQHSTVVSQSTIWKVIIASALGTMIEWYDFYIFGSLAAVIATNFYQSGNETAALLETFATFGAGFAARPFGALV
FGRIGDIVGRKYAFLVTLLIMGGATTVIGILPTYASIGILAPIILVIIRIIQGLALGGEYGGAAVYVAEHVPDHKRGFYT
SFIQITATLGLFISLLVILIVRTSMSKAAFDSWGWRIPFLLSIVLVGVSVYIRSKMSESPLFTKLKHAGKTSKAPLKDSF
GNRRNWKVILTVLFGAAAGQAVIWYTAQFYVNSWLKTQAKVPANTVDTIVAIALFLGMPFFVVMGALSDKWGRKTVMMAG
NLIGAIAIYPAFMALKAAAGPITPAVLDEAGKVITPAVANNPNTVLLTLIIFGLVLCVCMVYGPIAAFLVESFPAKIRYT
SVSLPYHVGNGYFGGWLPFIATAVVSSTGNIYAGLWFPIAIALLTFVVGMVLLKETKDNSLHEEASDNPMATEMDLIAQS

Specific function: Uptake of alpha-ketoglutarate across the boundary membrane with the concomitant import of a cation (symport system) [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788942, Length=467, Percent_Identity=34.2612419700214, Blast_Score=221, Evalue=9e-59,
Organism=Escherichia coli, GI1790550, Length=487, Percent_Identity=29.3634496919918, Blast_Score=211, Evalue=6e-56,
Organism=Escherichia coli, GI1788292, Length=449, Percent_Identity=32.739420935412, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1789941, Length=448, Percent_Identity=35.2678571428571, Blast_Score=191, Evalue=8e-50,
Organism=Escherichia coli, GI87082231, Length=240, Percent_Identity=26.6666666666667, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87082404, Length=394, Percent_Identity=23.3502538071066, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004736
- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR005828
- InterPro:   IPR005829 [H]

Pfam domain/function: PF00083 Sugar_tr [H]

EC number: NA

Molecular weight: Translated: 51617; Mature: 51485

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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C
>Mature Secondary Structure 
SNTPMPSQHSTVVSQSTIWKVIIASALGTMIEWYDFYIFGSLAAVIATNFYQSGNETAA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH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C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 2-oxoglutarate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 2-oxoglutarate [Periplasm] = Proton [Cytoplasm] + 2-oxoglutarate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2118499; 9205837; 9278503; 1709493; 2190187; 2053984; 8419306 [H]