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The map label for this gene is phoR [H]

Identifier: 159897435

GI number: 159897435

Start: 1037535

End: 1039121

Strand: Direct

Name: phoR [H]

Synonym: Haur_0906

Alternate gene names: 159897435

Gene position: 1037535-1039121 (Clockwise)

Preceding gene: 159897434

Following gene: 159897436

Centisome position: 16.35

GC content: 50.22

Gene sequence:

>1587_bases
ATGATGAAGTTTTGGTTGCGCTGGTATGGGCAGGCGGAGCTTTGGCGAGCGTTTGCCATAATGCTGCTGTTCGATGGCTT
GTGCTTAGCAATCTTGCTCGCGATTATTTACCTCTTGCCAGTTGAAGTTTTTGTGTTGATGACTGGTGGTTTCTTTGTTT
TAGGCGTTGGCACGGTGATTTTTGGCTTGAGTTTGGTGTTGTCTGAGGGTGGTTTTTGGCGACAACTGCTGCTTGATCTT
GGGGCATTTGGGCTGGCGATGATTTGCCTCGTGGGGCTGGGCGGCCTGATTTCGTGGCATGAACTTTCCCGGATTATGAG
TCCTTGGAATGATGGTGATTTTGCTCAGTCGTTCCCAGATATGCTGATTTTCTTTGCGCTGCATGGCATCACATTTTTGG
GCACACGCTTTTTGATGCGCGTCTGGCGCTGGTGGAATCGCTTGCGCAAACGCTCATTGCTTTGGACATTAACTCACGAT
CAATTGACGATTGTGTTTGTGCTGATGCTGATTTTTGGCATGGGCATGGTACTGCTTTCGATCCAGTTGCGCAGCGAAGA
ATTAAGCCAATCGAATGATGCTGTGGTGTTTTTGATTGAACATGTGGTGCAATATTCGTTGCTCGGCTCAATTTATGGCG
TGCTCATGGTGATCGGCTTATTTGTGTTTCTGCCAGTGGCTATGCTGCTTTCATACATGTTGGTGCGGCGCATTATGCAG
CGCATCGCCGCCCTTGCTAACGCTACCACGGCCTTGCGGGAAGGCGATTATAGTTCGCGAATTGTGGTCAATGGTACTGA
TGAGATTGCCCAACTCCAAGCCAATTTCAATGCAATGGCTGAGCAATTGTCCACTACCGTCAATGCCCTGAAAACCGAGC
GCGATCGGGTGGCGGCATTGCTTGATGATCGGCGAGCCTTAGTTGCCAGCGTTTCGCACGAATTACGCACGCCGGTTGCC
ACCCTGCGCGGCTACCTAGAATCGAGCTTGCAAACCGAACAAGCCTTAGCACCGCAAGTTCAGCGCGATTTACTCGTGAT
GGAGCGCGAAACGTTGCGTTTGCAACAACTAATCGAAGATCTCTTTTTGCTTTCGGCGAGTGAGGTTGGTCGTTTGACCC
TCAAGCTTGAAGCGCATGCTGTAGCTCCCTTAATCAATCGCATCGTACAAACAGTACAGCCGTTGGCTTGGCGACAATCG
CGGGTTGAAGTGCTGGCCGATTGTGCTGCTGAGCTTGATCAAGCCCTGATTGATCCCCAACGCTTTGAGCAGATTTTGCG
TAACTTGCTGCATAATGCCTTGCGCTACACTCCGCCTGGTGGTTTGGTGGTGGTACAAGCGCTTAATCAGGCTAACTCGA
TTGATATTTATGTTCGTGATACTGGCAGCGGCATCGACCCCACCGAACTTAGCGCAATTTGGCAGCGTTTTTATCGTGCC
AACAATCGCGCCAACGAACAATATCAAGGTGCAGGCTTAGGCTTGGCGTTGGTCAAAGAACTTACTGAATCGATGGCTGG
TTCGGTAGCAGTTGAAAGCCAGCTTGGCGTTGGCACCAGCTTTTGTATTTGTTTCCCCAAAGCCTAA

Upstream 100 bases:

>100_bases
ATAATGCCATGCTGCGGTTGCGCAAAAAATTGGCCGATTTTGGCGATGCAATCGAGACGGTTTGGGGCTTGGGCTATCGT
TTGCAGGCGGAAGCACCACG

Downstream 100 bases:

>100_bases
ATCGTATTTCCTCAATCCAACCCCTCTCTTTACAAGGATAGGGTTTACCAACCATTAATCACCACCCTTCCGTCCCGCCT
CGAGGCGGGAAACGCAGGGG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MMKFWLRWYGQAELWRAFAIMLLFDGLCLAILLAIIYLLPVEVFVLMTGGFFVLGVGTVIFGLSLVLSEGGFWRQLLLDL
GAFGLAMICLVGLGGLISWHELSRIMSPWNDGDFAQSFPDMLIFFALHGITFLGTRFLMRVWRWWNRLRKRSLLWTLTHD
QLTIVFVLMLIFGMGMVLLSIQLRSEELSQSNDAVVFLIEHVVQYSLLGSIYGVLMVIGLFVFLPVAMLLSYMLVRRIMQ
RIAALANATTALREGDYSSRIVVNGTDEIAQLQANFNAMAEQLSTTVNALKTERDRVAALLDDRRALVASVSHELRTPVA
TLRGYLESSLQTEQALAPQVQRDLLVMERETLRLQQLIEDLFLLSASEVGRLTLKLEAHAVAPLINRIVQTVQPLAWRQS
RVEVLADCAAELDQALIDPQRFEQILRNLLHNALRYTPPGGLVVVQALNQANSIDIYVRDTGSGIDPTELSAIWQRFYRA
NNRANEQYQGAGLGLALVKELTESMAGSVAVESQLGVGTSFCICFPKA

Sequences:

>Translated_528_residues
MMKFWLRWYGQAELWRAFAIMLLFDGLCLAILLAIIYLLPVEVFVLMTGGFFVLGVGTVIFGLSLVLSEGGFWRQLLLDL
GAFGLAMICLVGLGGLISWHELSRIMSPWNDGDFAQSFPDMLIFFALHGITFLGTRFLMRVWRWWNRLRKRSLLWTLTHD
QLTIVFVLMLIFGMGMVLLSIQLRSEELSQSNDAVVFLIEHVVQYSLLGSIYGVLMVIGLFVFLPVAMLLSYMLVRRIMQ
RIAALANATTALREGDYSSRIVVNGTDEIAQLQANFNAMAEQLSTTVNALKTERDRVAALLDDRRALVASVSHELRTPVA
TLRGYLESSLQTEQALAPQVQRDLLVMERETLRLQQLIEDLFLLSASEVGRLTLKLEAHAVAPLINRIVQTVQPLAWRQS
RVEVLADCAAELDQALIDPQRFEQILRNLLHNALRYTPPGGLVVVQALNQANSIDIYVRDTGSGIDPTELSAIWQRFYRA
NNRANEQYQGAGLGLALVKELTESMAGSVAVESQLGVGTSFCICFPKA
>Mature_528_residues
MMKFWLRWYGQAELWRAFAIMLLFDGLCLAILLAIIYLLPVEVFVLMTGGFFVLGVGTVIFGLSLVLSEGGFWRQLLLDL
GAFGLAMICLVGLGGLISWHELSRIMSPWNDGDFAQSFPDMLIFFALHGITFLGTRFLMRVWRWWNRLRKRSLLWTLTHD
QLTIVFVLMLIFGMGMVLLSIQLRSEELSQSNDAVVFLIEHVVQYSLLGSIYGVLMVIGLFVFLPVAMLLSYMLVRRIMQ
RIAALANATTALREGDYSSRIVVNGTDEIAQLQANFNAMAEQLSTTVNALKTERDRVAALLDDRRALVASVSHELRTPVA
TLRGYLESSLQTEQALAPQVQRDLLVMERETLRLQQLIEDLFLLSASEVGRLTLKLEAHAVAPLINRIVQTVQPLAWRQS
RVEVLADCAAELDQALIDPQRFEQILRNLLHNALRYTPPGGLVVVQALNQANSIDIYVRDTGSGIDPTELSAIWQRFYRA
NNRANEQYQGAGLGLALVKELTESMAGSVAVESQLGVGTSFCICFPKA

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=295, Percent_Identity=28.8135593220339, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786600, Length=226, Percent_Identity=31.4159292035398, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1788713, Length=256, Percent_Identity=28.90625, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1789149, Length=327, Percent_Identity=26.9113149847095, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI145693157, Length=225, Percent_Identity=32.4444444444444, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786783, Length=261, Percent_Identity=28.3524904214559, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI87081816, Length=371, Percent_Identity=27.4932614555256, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1787894, Length=315, Percent_Identity=26.6666666666667, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=30.316742081448, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790551, Length=310, Percent_Identity=26.7741935483871, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788279, Length=317, Percent_Identity=24.9211356466877, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI48994928, Length=240, Percent_Identity=25.4166666666667, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1790861, Length=208, Percent_Identity=35.0961538461538, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787374, Length=291, Percent_Identity=29.2096219931272, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI87082128, Length=235, Percent_Identity=25.1063829787234, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788549, Length=222, Percent_Identity=28.3783783783784, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1786912, Length=243, Percent_Identity=24.2798353909465, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789403, Length=292, Percent_Identity=27.7397260273973, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 59115; Mature: 59115

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKFWLRWYGQAELWRAFAIMLLFDGLCLAILLAIIYLLPVEVFVLMTGGFFVLGVGTVI
CCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
FGLSLVLSEGGFWRQLLLDLGAFGLAMICLVGLGGLISWHELSRIMSPWNDGDFAQSFPD
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCHHHHHHH
MLIFFALHGITFLGTRFLMRVWRWWNRLRKRSLLWTLTHDQLTIVFVLMLIFGMGMVLLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHH
IQLRSEELSQSNDAVVFLIEHVVQYSLLGSIYGVLMVIGLFVFLPVAMLLSYMLVRRIMQ
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIAALANATTALREGDYSSRIVVNGTDEIAQLQANFNAMAEQLSTTVNALKTERDRVAAL
HHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDDRRALVASVSHELRTPVATLRGYLESSLQTEQALAPQVQRDLLVMERETLRLQQLIED
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFLLSASEVGRLTLKLEAHAVAPLINRIVQTVQPLAWRQSRVEVLADCAAELDQALIDPQ
HHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
RFEQILRNLLHNALRYTPPGGLVVVQALNQANSIDIYVRDTGSGIDPTELSAIWQRFYRA
HHHHHHHHHHHHHHCCCCCCCEEHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHH
NNRANEQYQGAGLGLALVKELTESMAGSVAVESQLGVGTSFCICFPKA
CCCCCCHHCCCCHHHHHHHHHHHHHCCCEEEHHHCCCCCEEEEEECCC
>Mature Secondary Structure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CCCCCCHHCCCCHHHHHHHHHHHHHCCCEEEHHHCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]