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The map label for this gene is glyA

Identifier: 159897380

GI number: 159897380

Start: 960823

End: 962082

Strand: Reverse

Name: glyA

Synonym: Haur_0851

Alternate gene names: 159897380

Gene position: 962082-960823 (Counterclockwise)

Preceding gene: 159897381

Following gene: 159897379

Centisome position: 15.16

GC content: 53.49

Gene sequence:

>1260_bases
ATGTCGTTAATGGATGTATTGCGCCAACAAGATCCCGATTTGGCGCAAGCTATCGACTCTGAAGCTGAACGCCAACGCCA
TGGGATTGAGTTGATCGCCTCTGAAAACTATGTCAGCAGTGCTGTATTAGCTGCCCAAGGTTCGGTGTTGACCAATAAAT
ATGCTGAGGGTTATCCGCGCAAACGCTACTATGGCGGCTGCGAGTTTGTTGATGTCGCCGAAGATTTGGCGATCAAACGC
GCCAAGCAACTCTTTGGTGCTGAACATGTCAACGTGCAACCCCACTCGGGAGCGCAAGCCAATATGGCGGTGCAACTGGC
CACGCTTGAGCATGGCGATCGCGTCTTGGGCATGAGTTTGGCGCATGGCGGCCACTTAACCCATGGCCATCCACTCAACT
TCTCGGGCAAATCGTATGAGATCCACGGCTATGGCGTTGATCGCGAAACCGAACAGATCGATTATGAAGAAGTTGCCGAG
ATTGCCCACAAAACCCAGCCTAAGATGATTATCTGTGGAGCCAGTGCCTATCCTCGCAACATCAATTTCGATTTGCTGCG
CACGATCGCCGATAATGTTGGGGCGATTTTGATGGCCGATATTGCCCACATTGCAGGCCTTGTCGCCGCAGGTTTACACC
CATCGCCGATCGGCGTAGCTCAATATGTCACCACCACCACCCACAAAACCCTGCGCGGCCCGCGTGGCGGCATGATTATG
TGCAGTGCTGAGCATGGCAAAAATATCGATAAAACCGTATTTCCAGGCGTGCAAGGTGGGCCATTGATGCATGTAATCGC
GGCGAAGGCCGTGGCATTTGGCGAAGCCTTGCAACCCGAATATCGCGACTATATGCGACGGGTCGTCGAAAATGCCAAGG
TTTTGGCCGAAGCCTTGACCAACGAAGGCTTGCGAATCGTCAGCGGCGGCACCGATAATCACCTATTGCTGGTCGATTTG
ACTCCAGTGAATGCCACAGGCAAAGACGCAGAAAAAGCCCTTGACCACGCTGGTATCACCGTCAACAAAAACGCCATTCC
CTTCGATCCCAAGCCACCAATGACAGCCAGCGGCTTGCGCTTTGGTACGCCTGCTGCGACGACTCGCGGCTTTGGGCCAA
ACGAAATGCGCCAAATTGCGGTTTGGGTCGGCCAAATCGTGCGTGAATTGGGCAACAAGAGCCTGCAAGCCAAAATTGCT
GGCGAAGTTCGTGAATTGTGCGCGGCCTTCCCAGTACCAGGTCAACCAGAATACGTCTAA

Upstream 100 bases:

>100_bases
AGGCCCAAACCGTGTATCATAGGGAGCGGGTCAATTTCGCATCGTCGCACCACGCCCAACCGGCTGCAAGGATGTTTCCA
CGTAGACAAGGAGTGTACGC

Downstream 100 bases:

>100_bases
ATCAACCTACTTAACCAGCTTAGGCGAGGCAGTCGAACTACGACTGTCTCGCTTGGCGTTTGACAAGCGGCCATGGCTGC
GGTATCAATGAGATATATAA

Product: glycine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MSLMDVLRQQDPDLAQAIDSEAERQRHGIELIASENYVSSAVLAAQGSVLTNKYAEGYPRKRYYGGCEFVDVAEDLAIKR
AKQLFGAEHVNVQPHSGAQANMAVQLATLEHGDRVLGMSLAHGGHLTHGHPLNFSGKSYEIHGYGVDRETEQIDYEEVAE
IAHKTQPKMIICGASAYPRNINFDLLRTIADNVGAILMADIAHIAGLVAAGLHPSPIGVAQYVTTTTHKTLRGPRGGMIM
CSAEHGKNIDKTVFPGVQGGPLMHVIAAKAVAFGEALQPEYRDYMRRVVENAKVLAEALTNEGLRIVSGGTDNHLLLVDL
TPVNATGKDAEKALDHAGITVNKNAIPFDPKPPMTASGLRFGTPAATTRGFGPNEMRQIAVWVGQIVRELGNKSLQAKIA
GEVRELCAAFPVPGQPEYV

Sequences:

>Translated_419_residues
MSLMDVLRQQDPDLAQAIDSEAERQRHGIELIASENYVSSAVLAAQGSVLTNKYAEGYPRKRYYGGCEFVDVAEDLAIKR
AKQLFGAEHVNVQPHSGAQANMAVQLATLEHGDRVLGMSLAHGGHLTHGHPLNFSGKSYEIHGYGVDRETEQIDYEEVAE
IAHKTQPKMIICGASAYPRNINFDLLRTIADNVGAILMADIAHIAGLVAAGLHPSPIGVAQYVTTTTHKTLRGPRGGMIM
CSAEHGKNIDKTVFPGVQGGPLMHVIAAKAVAFGEALQPEYRDYMRRVVENAKVLAEALTNEGLRIVSGGTDNHLLLVDL
TPVNATGKDAEKALDHAGITVNKNAIPFDPKPPMTASGLRFGTPAATTRGFGPNEMRQIAVWVGQIVRELGNKSLQAKIA
GEVRELCAAFPVPGQPEYV
>Mature_418_residues
SLMDVLRQQDPDLAQAIDSEAERQRHGIELIASENYVSSAVLAAQGSVLTNKYAEGYPRKRYYGGCEFVDVAEDLAIKRA
KQLFGAEHVNVQPHSGAQANMAVQLATLEHGDRVLGMSLAHGGHLTHGHPLNFSGKSYEIHGYGVDRETEQIDYEEVAEI
AHKTQPKMIICGASAYPRNINFDLLRTIADNVGAILMADIAHIAGLVAAGLHPSPIGVAQYVTTTTHKTLRGPRGGMIMC
SAEHGKNIDKTVFPGVQGGPLMHVIAAKAVAFGEALQPEYRDYMRRVVENAKVLAEALTNEGLRIVSGGTDNHLLLVDLT
PVNATGKDAEKALDHAGITVNKNAIPFDPKPPMTASGLRFGTPAATTRGFGPNEMRQIAVWVGQIVRELGNKSLQAKIAG
EVRELCAAFPVPGQPEYV

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI261862352, Length=457, Percent_Identity=42.0131291028446, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI261862350, Length=457, Percent_Identity=42.0131291028446, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI261862348, Length=457, Percent_Identity=42.0131291028446, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI19923315, Length=457, Percent_Identity=42.0131291028446, Blast_Score=325, Evalue=6e-89,
Organism=Homo sapiens, GI22547186, Length=459, Percent_Identity=43.3551198257081, Blast_Score=317, Evalue=1e-86,
Organism=Homo sapiens, GI261862346, Length=453, Percent_Identity=41.5011037527594, Blast_Score=311, Evalue=9e-85,
Organism=Homo sapiens, GI22547189, Length=444, Percent_Identity=41.8918918918919, Blast_Score=290, Evalue=2e-78,
Organism=Escherichia coli, GI1788902, Length=405, Percent_Identity=56.5432098765432, Blast_Score=444, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI25144732, Length=461, Percent_Identity=40.5639913232104, Blast_Score=325, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI25144729, Length=461, Percent_Identity=40.5639913232104, Blast_Score=325, Evalue=4e-89,
Organism=Saccharomyces cerevisiae, GI6319739, Length=453, Percent_Identity=41.9426048565121, Blast_Score=343, Evalue=3e-95,
Organism=Saccharomyces cerevisiae, GI6323087, Length=405, Percent_Identity=42.4691358024691, Blast_Score=301, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24640005, Length=404, Percent_Identity=45.7920792079208, Blast_Score=344, Evalue=6e-95,
Organism=Drosophila melanogaster, GI221329721, Length=404, Percent_Identity=45.7920792079208, Blast_Score=344, Evalue=8e-95,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_HERA2 (A9AYB7)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001543627.1
- ProteinModelPortal:   A9AYB7
- SMR:   A9AYB7
- GeneID:   5732752
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_0851
- HOGENOM:   HBG301263
- OMA:   KTVFPGV
- BioCyc:   HAUR316274:HAUR_0851-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 45074; Mature: 44943

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLMDVLRQQDPDLAQAIDSEAERQRHGIELIASENYVSSAVLAAQGSVLTNKYAEGYPR
CCHHHHHHCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCHHHHHHHCCCCC
KRYYGGCEFVDVAEDLAIKRAKQLFGAEHVNVQPHSGAQANMAVQLATLEHGDRVLGMSL
CHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEEE
AHGGHLTHGHPLNFSGKSYEIHGYGVDRETEQIDYEEVAEIAHKTQPKMIICGASAYPRN
CCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHCCHHHHHHHHHCCCCCEEEEECCCCCCC
INFDLLRTIADNVGAILMADIAHIAGLVAAGLHPSPIGVAQYVTTTTHKTLRGPRGGMIM
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEE
CSAEHGKNIDKTVFPGVQGGPLMHVIAAKAVAFGEALQPEYRDYMRRVVENAKVLAEALT
EEHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
NEGLRIVSGGTDNHLLLVDLTPVNATGKDAEKALDHAGITVNKNAIPFDPKPPMTASGLR
CCCEEEEECCCCCEEEEEEEECCCCCCCHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCC
FGTPAATTRGFGPNEMRQIAVWVGQIVRELGNKSLQAKIAGEVRELCAAFPVPGQPEYV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SLMDVLRQQDPDLAQAIDSEAERQRHGIELIASENYVSSAVLAAQGSVLTNKYAEGYPR
CHHHHHHCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCHHHHHHHCCCCC
KRYYGGCEFVDVAEDLAIKRAKQLFGAEHVNVQPHSGAQANMAVQLATLEHGDRVLGMSL
CHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEEE
AHGGHLTHGHPLNFSGKSYEIHGYGVDRETEQIDYEEVAEIAHKTQPKMIICGASAYPRN
CCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHCCHHHHHHHHHCCCCCEEEEECCCCCCC
INFDLLRTIADNVGAILMADIAHIAGLVAAGLHPSPIGVAQYVTTTTHKTLRGPRGGMIM
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEE
CSAEHGKNIDKTVFPGVQGGPLMHVIAAKAVAFGEALQPEYRDYMRRVVENAKVLAEALT
EEHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
NEGLRIVSGGTDNHLLLVDLTPVNATGKDAEKALDHAGITVNKNAIPFDPKPPMTASGLR
CCCEEEEECCCCCEEEEEEEECCCCCCCHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCC
FGTPAATTRGFGPNEMRQIAVWVGQIVRELGNKSLQAKIAGEVRELCAAFPVPGQPEYV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA