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The map label for this gene is accC [H]

Identifier: 159897278

GI number: 159897278

Start: 853715

End: 855082

Strand: Direct

Name: accC [H]

Synonym: Haur_0749

Alternate gene names: 159897278

Gene position: 853715-855082 (Clockwise)

Preceding gene: 159897277

Following gene: 159897279

Centisome position: 13.45

GC content: 52.34

Gene sequence:

>1368_bases
ATGTTACGCAAAATTTTAATTGCCAATCGTGGTGAAATTGCGGTGCGAATTATTCGTGCTTGCCACGAGCTAGGCATCAA
AGCAGTTGCCGCCTATTCCGAGGCCGATCGCGATTCGCTGGCGGTGCGTATGGCCGATGAGGCGATTTGTATTGGCCCGC
CACCACCTGCCAAATCCTATTTGAATGCGCCAGCCTTGATTAGCGCTGCGCTGATTAGCGATTGCGATGGGATTCACCCA
GGTTATGGCTTTTTGTCGGAAAACCCCTATTTTGCTGAAAGCTGCCGTGAGTGTGGTCTGACTTTTATTGGCCCTTCAGC
CGATTCGATTCAGCGCATGGGCGATAAAGCGCTGGCCAAGCAAGCCATGAAGTTGGCTGGCCTGCCGCTTGTGCCTGGCA
CCGAAAACCCCTTGACCAGCGTTGAAGAAGCTCAAAGCCTTGCTGATGGTATTGGCTACCCGGTTTTGCTCAAAGCTGTG
GCTGGCGGTGGCGGGCGGGGCATGCGCGTGGTCAATCAGCCTGATGAATTGGCCCGAGCTTTTAATACTGCCCGCGCTGA
GGCCGAAGCTGCCTTTGGCCGTGGCGATTTGTATATGGAAAAATACTTGCCAGTGGTGCGCCACGTTGAAATTCAGATTT
TGGCTGATCAACATGGCCATGCAATTCACCTTGGCGAGCGTGATTGCTCGTTGCAACGTCGCCACCAAAAAGTGGTGGAA
GAAGGCCCATCGCCTGCCTTGACCCCAGAATTACGCCAGAAAATGGGCGAAGCCGCCTTGCATGGCGTGCGCGAAATTGG
CTACTACAACGCTGGCACAATGGAATTTTTACTCGATCATCAGGGAAATTTCTATTTTATGGAAATGAACACCCGTTTGC
AGGTTGAGCACCCTGTGACTGAATGGCTGACCGGACTTGATCTGGTTAAGTGGCAAATTCGGATTGCTTCCGGCGAACGC
TTGACGCTCACTCAGGATGACATTAAAATACGCGGGCATGCGATTGAATGTCGGATTAATGCCGAAGATGCCGACCGTGA
TTTTATGCCTGCTGGCGGGACTGTCGATCTCTACTTGCCGCCAGGTGGCCCAGGGGTACGGGTCGATTCGCATCTTTATT
CAGGTTATCGCACTCCTACCAACTACGATTCGATGCTTGCCAAAGTGATCGTCTGGGGGGAAACGCGGCTTGAGGCAATT
GAACGTATGCGGCGAGCATTAAGCGAATGTGTGATCAATGGCATTACGACCACCTTGCCATTTCAACTGCGCATGATGAA
CGAGCCAGCTTTTGTGAGCGGCGATGTTGCAACGCACACCTTGGCTGATATTTTAAATCAACAGGCTGCCAAAGAAGCGA
CAGCGTAG

Upstream 100 bases:

>100_bases
CTACATCACTGGCCAAACCTTGGCAGTCGATGGCGGCATGACCATGTATTAGGCGGCAGCGTTGGAACGCTTGCTCGAAC
GCTTTAGCTGAGGAACCAAC

Downstream 100 bases:

>100_bases
GGCAGTCTTGGAGAAAACTGTGAATCAACCATTTGGAACTGTGACAATTGCCCCCGATGTGCTTTCAGCGATTGTCTCGC
TGACGGCGCAGGATGTTGCT

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MLRKILIANRGEIAVRIIRACHELGIKAVAAYSEADRDSLAVRMADEAICIGPPPPAKSYLNAPALISAALISDCDGIHP
GYGFLSENPYFAESCRECGLTFIGPSADSIQRMGDKALAKQAMKLAGLPLVPGTENPLTSVEEAQSLADGIGYPVLLKAV
AGGGGRGMRVVNQPDELARAFNTARAEAEAAFGRGDLYMEKYLPVVRHVEIQILADQHGHAIHLGERDCSLQRRHQKVVE
EGPSPALTPELRQKMGEAALHGVREIGYYNAGTMEFLLDHQGNFYFMEMNTRLQVEHPVTEWLTGLDLVKWQIRIASGER
LTLTQDDIKIRGHAIECRINAEDADRDFMPAGGTVDLYLPPGGPGVRVDSHLYSGYRTPTNYDSMLAKVIVWGETRLEAI
ERMRRALSECVINGITTTLPFQLRMMNEPAFVSGDVATHTLADILNQQAAKEATA

Sequences:

>Translated_455_residues
MLRKILIANRGEIAVRIIRACHELGIKAVAAYSEADRDSLAVRMADEAICIGPPPPAKSYLNAPALISAALISDCDGIHP
GYGFLSENPYFAESCRECGLTFIGPSADSIQRMGDKALAKQAMKLAGLPLVPGTENPLTSVEEAQSLADGIGYPVLLKAV
AGGGGRGMRVVNQPDELARAFNTARAEAEAAFGRGDLYMEKYLPVVRHVEIQILADQHGHAIHLGERDCSLQRRHQKVVE
EGPSPALTPELRQKMGEAALHGVREIGYYNAGTMEFLLDHQGNFYFMEMNTRLQVEHPVTEWLTGLDLVKWQIRIASGER
LTLTQDDIKIRGHAIECRINAEDADRDFMPAGGTVDLYLPPGGPGVRVDSHLYSGYRTPTNYDSMLAKVIVWGETRLEAI
ERMRRALSECVINGITTTLPFQLRMMNEPAFVSGDVATHTLADILNQQAAKEATA
>Mature_455_residues
MLRKILIANRGEIAVRIIRACHELGIKAVAAYSEADRDSLAVRMADEAICIGPPPPAKSYLNAPALISAALISDCDGIHP
GYGFLSENPYFAESCRECGLTFIGPSADSIQRMGDKALAKQAMKLAGLPLVPGTENPLTSVEEAQSLADGIGYPVLLKAV
AGGGGRGMRVVNQPDELARAFNTARAEAEAAFGRGDLYMEKYLPVVRHVEIQILADQHGHAIHLGERDCSLQRRHQKVVE
EGPSPALTPELRQKMGEAALHGVREIGYYNAGTMEFLLDHQGNFYFMEMNTRLQVEHPVTEWLTGLDLVKWQIRIASGER
LTLTQDDIKIRGHAIECRINAEDADRDFMPAGGTVDLYLPPGGPGVRVDSHLYSGYRTPTNYDSMLAKVIVWGETRLEAI
ERMRRALSECVINGITTTLPFQLRMMNEPAFVSGDVATHTLADILNQQAAKEATA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=459, Percent_Identity=46.4052287581699, Blast_Score=434, Evalue=1e-121,
Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=48.3069977426637, Blast_Score=404, Evalue=1e-113,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=48.3069977426637, Blast_Score=404, Evalue=1e-113,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=48.3069977426637, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI106049528, Length=445, Percent_Identity=45.3932584269663, Blast_Score=394, Evalue=1e-109,
Organism=Homo sapiens, GI106049295, Length=445, Percent_Identity=45.3932584269663, Blast_Score=394, Evalue=1e-109,
Organism=Homo sapiens, GI106049292, Length=445, Percent_Identity=45.3932584269663, Blast_Score=394, Evalue=1e-109,
Organism=Homo sapiens, GI38679971, Length=518, Percent_Identity=30.3088803088803, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI38679977, Length=518, Percent_Identity=30.3088803088803, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI38679967, Length=518, Percent_Identity=30.3088803088803, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI38679960, Length=518, Percent_Identity=30.3088803088803, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI38679974, Length=518, Percent_Identity=30.3088803088803, Blast_Score=235, Evalue=8e-62,
Organism=Homo sapiens, GI134142062, Length=520, Percent_Identity=29.2307692307692, Blast_Score=218, Evalue=7e-57,
Organism=Escherichia coli, GI1789654, Length=449, Percent_Identity=56.347438752784, Blast_Score=484, Evalue=1e-138,
Organism=Escherichia coli, GI1786216, Length=249, Percent_Identity=25.7028112449799, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71987519, Length=443, Percent_Identity=46.9525959367946, Blast_Score=419, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17562816, Length=445, Percent_Identity=46.5168539325843, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=43.5665914221219, Blast_Score=383, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI133931226, Length=468, Percent_Identity=31.1965811965812, Blast_Score=201, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI71997163, Length=504, Percent_Identity=25.7936507936508, Blast_Score=178, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI71997168, Length=504, Percent_Identity=25.7936507936508, Blast_Score=177, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=46.0850111856823, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=46.3087248322148, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6319685, Length=456, Percent_Identity=41.2280701754386, Blast_Score=351, Evalue=2e-97,
Organism=Saccharomyces cerevisiae, GI6324343, Length=526, Percent_Identity=30.4182509505703, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6323863, Length=471, Percent_Identity=28.8747346072187, Blast_Score=209, Evalue=8e-55,
Organism=Drosophila melanogaster, GI24651757, Length=439, Percent_Identity=45.7858769931663, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI281363050, Length=445, Percent_Identity=48.5393258426966, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652224, Length=445, Percent_Identity=48.5393258426966, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652222, Length=445, Percent_Identity=48.5393258426966, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652220, Length=445, Percent_Identity=48.5393258426966, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652218, Length=445, Percent_Identity=48.5393258426966, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652212, Length=445, Percent_Identity=48.5393258426966, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652210, Length=445, Percent_Identity=48.5393258426966, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652214, Length=445, Percent_Identity=48.5393258426966, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI19921944, Length=445, Percent_Identity=48.5393258426966, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652216, Length=445, Percent_Identity=48.5393258426966, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24651759, Length=401, Percent_Identity=45.1371571072319, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI161076409, Length=514, Percent_Identity=29.3774319066148, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI161076407, Length=514, Percent_Identity=29.3774319066148, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24586460, Length=514, Percent_Identity=29.3774319066148, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24586458, Length=514, Percent_Identity=29.3774319066148, Blast_Score=227, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49742; Mature: 49742

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRKILIANRGEIAVRIIRACHELGIKAVAAYSEADRDSLAVRMADEAICIGPPPPAKSY
CCCEEEEECCCHHHHHHHHHHHHCCHHHEEHHHHCCCCCEEEEEECCEEEECCCCCHHHH
LNAPALISAALISDCDGIHPGYGFLSENPYFAESCRECGLTFIGPSADSIQRMGDKALAK
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCHHHHHHHHHHHHHH
QAMKLAGLPLVPGTENPLTSVEEAQSLADGIGYPVLLKAVAGGGGRGMRVVNQPDELARA
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCEECCCHHHHHHH
FNTARAEAEAAFGRGDLYMEKYLPVVRHVEIQILADQHGHAIHLGERDCSLQRRHQKVVE
HHHHHHHHHHHCCCCCHHHHHHHHHHHEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
EGPSPALTPELRQKMGEAALHGVREIGYYNAGTMEFLLDHQGNFYFMEMNTRLQVEHPVT
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEECCEEEECCCHH
EWLTGLDLVKWQIRIASGERLTLTQDDIKIRGHAIECRINAEDADRDFMPAGGTVDLYLP
HHHHHCCEEEEEEEEECCCEEEEECCCEEEECEEEEEEECCCCCCCCCCCCCCEEEEEEC
PGGPGVRVDSHLYSGYRTPTNYDSMLAKVIVWGETRLEAIERMRRALSECVINGITTTLP
CCCCCCEECHHHHCCCCCCCCHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHCCCCCCC
FQLRMMNEPAFVSGDVATHTLADILNQQAAKEATA
EEEEEECCCCEEECCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLRKILIANRGEIAVRIIRACHELGIKAVAAYSEADRDSLAVRMADEAICIGPPPPAKSY
CCCEEEEECCCHHHHHHHHHHHHCCHHHEEHHHHCCCCCEEEEEECCEEEECCCCCHHHH
LNAPALISAALISDCDGIHPGYGFLSENPYFAESCRECGLTFIGPSADSIQRMGDKALAK
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCHHHHHHHHHHHHHH
QAMKLAGLPLVPGTENPLTSVEEAQSLADGIGYPVLLKAVAGGGGRGMRVVNQPDELARA
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCEECCCHHHHHHH
FNTARAEAEAAFGRGDLYMEKYLPVVRHVEIQILADQHGHAIHLGERDCSLQRRHQKVVE
HHHHHHHHHHHCCCCCHHHHHHHHHHHEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
EGPSPALTPELRQKMGEAALHGVREIGYYNAGTMEFLLDHQGNFYFMEMNTRLQVEHPVT
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEECCEEEECCCHH
EWLTGLDLVKWQIRIASGERLTLTQDDIKIRGHAIECRINAEDADRDFMPAGGTVDLYLP
HHHHHCCEEEEEEEEECCCEEEEECCCEEEECEEEEEEECCCCCCCCCCCCCCEEEEEEC
PGGPGVRVDSHLYSGYRTPTNYDSMLAKVIVWGETRLEAIERMRRALSECVINGITTTLP
CCCCCCEECHHHHCCCCCCCCHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHCCCCCCC
FQLRMMNEPAFVSGDVATHTLADILNQQAAKEATA
EEEEEECCCCEEECCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]