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The map label for this gene is zraS [C]

Identifier: 159896976

GI number: 159896976

Start: 520012

End: 522153

Strand: Direct

Name: zraS [C]

Synonym: Haur_0444

Alternate gene names: 159896976

Gene position: 520012-522153 (Clockwise)

Preceding gene: 159896975

Following gene: 159896977

Centisome position: 8.19

GC content: 43.84

Gene sequence:

>2142_bases
ATGAAGCGTTTTGCTTGGTTGCGGCGCAAAGAATTACGCCCATTAATCGCTTTATTGAGTGTGGCTTTAGTTTCGATTGC
CCTGTTGCAATGGAATTATTACCAAATGCGCTCGATGATTCAATCGCAAATCACGGCGTTTAATGGGATGACTCAAGCCC
GTTTGAATATGAAACGTGGCTATTTGATTGCTGAGCAGGTATTAAATGGCAACCAAACCCTGCTGCCCCAAGATGCAATT
GCCTATCTTGATCAGGCGATTTTGGCGGTTGATGATTGGCAGCAAGGTAAAAATCCCGTTGTAGTCTTTGATCAATTGTT
GCCGCCAGATCCACCAACGCAGCAAGCGCTCACTGACTATCGCCAGCATTTGGTCAGCTTTCGAGCCTTATTATTGCAAC
ATCTCAATCGCCCACAAGAGCAAGCCCAAACCACGATTGATCGCCGAATTGCCTTCTCAGAGTTGGAATCTGAAGCTGAG
CAGTTGGAAAATCGTTTATACCTTGATTTGGAATTATCAATTAAACGGCAGGCCGAGCGCTATTCGTTGATGTTGGTTGG
CTGGCTGATTTTCTTGGTGATTATTGCGGGAGTTGTCTATCGTTTGTTGGGTTTGCAGCGCTTGGCGGTGGCTCAATTGG
CCGCCAGCGAAAAACAATTTCGAGCGCAATATCGTGGCATTCCAATTCCAACCTATACATGGCGTTGTATTGACGACGAT
TTTATTCTCGAAGGTTTTAACGATGCAGCGATGATTATTACCCAAGGAGCAATTACCAAATTTGTCAATCAATCAGCTAG
AATTGTCTATCGCAATGAGCCAGAGATTTTACACCATTTTGAGCGTTGTCAACGTGAAAAAATAACACTTCATCAAGAAA
TTCGCTATGAGTTTAAATTAATCAATCAAGTTAAAGATTTGTATGTGAGCTATGTGTTTATCGAACCAGATTTTATTATG
GTGCATACCGAAGATCGAACTGATCGCAATCAGTTGCAAATGCAATTAATTCGTGCCCAGAAAATGGAAAGTATTGGGCG
CTTGGCTGGTGGGGTAGCTCACGATTTCAATAATTTGTTAACTGCAATTAGCGGTTATACAACCTTGGCGATTGATAGTG
CTCAGCAAGGCTTTCCGGTGGTCGAAGAATTAACTGAAATTCAACATGCCACTGATCGAGCAGCAATGCTTACCAGTCAA
TTATTAACCTTTGCACGTAAGCAGCAAATCCAACCAAAAATTGTCAATATCAACGATTTAATTATGTCGATGGAGAAATT
GATTAGACGAGTTTTACCAGAATCAATTCAATGGCGAACTGTACTTAATGTTAATATTGATTTAGTTTTGGCTGATATCG
GCCAGATTGAGCAAGTATTATTGAATTTAGTAGTCAATGCGCGTGATGCTATGCCTCAGGGTGGAAATTTGCTGGTTGAA
ACAAATAATGTTGCAGTTGATGCAAATTATGCACGAACTCATATTGATGTACCAATTGGCAATTATGTTTTATTCGCGGT
GAGCGATACCGGCATCGGCATGACCCAAGAAGTCCAGAGTCGGGCATTTGAGCCATTTTTTACCACTAAAAGCGATCACG
AAGGTACTGGTTTGGGTTTAGCCACCTGTTATGGCATTATCAAGCAACATGGCGGCCATATTGGTTTGTATAGCGAAGTT
AATCATGGCACGACGATTAAAATTTATTTGCCACGTTCAGAGCAAGCTCAACTCGATGATGCTCCAAGCCTCATCCAAAA
CTTACCTCGTGGCACGGAAACGATTTTGGTGAGCGAGGATGAGCCGCAGGTACGGGCGGTTTTGGTGCGGATGCTCCAAG
GCTTGGGCTATAGCGTGCTCGAAGCACTGCATGGCTCCGAGGCCTTGGCCTTGCTCCAAGCCCAGGCGCTTGGCACAATT
CAGCTCTTAATTACTGATATGGTTATGCCACAAATGGGTGGTTTTGAGCTGAGCCAACGGGTTGCTGAGCTTGATCCTCA
GCTCAAAATTTTGTTTATTTCGGGCTACTCCGAGCATAGTTTGGCGCAACATCAGCAATTAGCCCAACAGCCTTTGTTGC
TGAGCAAGCCATTTTCACTGGCTACTTTGGCGCAAACAGTCCGCAAGGTGCTGGATGATTAG

Upstream 100 bases:

>100_bases
GTGACGAACATTATGGCTTAATTGCGCCGTTTGGGTTTTCGCGCGAGCAATTGCCCAATCGTTCAACCGCCAGTCTGCTC
CAAGGTTGTGAGAATGGCTC

Downstream 100 bases:

>100_bases
AGCGAATTAAGCCACAGATTGACACAGATGGTTAGGATTTGTTTTTGCATACTAACGATTCAATAGTTGTACCTACAAGC
GGTTTTGCCACGAATTGCAC

Product: integral membrane sensor hybrid histidine kinase

Products: NA

Alternate protein names: Blue-light-activated histidine kinase; Response regulator [H]

Number of amino acids: Translated: 713; Mature: 713

Protein sequence:

>713_residues
MKRFAWLRRKELRPLIALLSVALVSIALLQWNYYQMRSMIQSQITAFNGMTQARLNMKRGYLIAEQVLNGNQTLLPQDAI
AYLDQAILAVDDWQQGKNPVVVFDQLLPPDPPTQQALTDYRQHLVSFRALLLQHLNRPQEQAQTTIDRRIAFSELESEAE
QLENRLYLDLELSIKRQAERYSLMLVGWLIFLVIIAGVVYRLLGLQRLAVAQLAASEKQFRAQYRGIPIPTYTWRCIDDD
FILEGFNDAAMIITQGAITKFVNQSARIVYRNEPEILHHFERCQREKITLHQEIRYEFKLINQVKDLYVSYVFIEPDFIM
VHTEDRTDRNQLQMQLIRAQKMESIGRLAGGVAHDFNNLLTAISGYTTLAIDSAQQGFPVVEELTEIQHATDRAAMLTSQ
LLTFARKQQIQPKIVNINDLIMSMEKLIRRVLPESIQWRTVLNVNIDLVLADIGQIEQVLLNLVVNARDAMPQGGNLLVE
TNNVAVDANYARTHIDVPIGNYVLFAVSDTGIGMTQEVQSRAFEPFFTTKSDHEGTGLGLATCYGIIKQHGGHIGLYSEV
NHGTTIKIYLPRSEQAQLDDAPSLIQNLPRGTETILVSEDEPQVRAVLVRMLQGLGYSVLEALHGSEALALLQAQALGTI
QLLITDMVMPQMGGFELSQRVAELDPQLKILFISGYSEHSLAQHQQLAQQPLLLSKPFSLATLAQTVRKVLDD

Sequences:

>Translated_713_residues
MKRFAWLRRKELRPLIALLSVALVSIALLQWNYYQMRSMIQSQITAFNGMTQARLNMKRGYLIAEQVLNGNQTLLPQDAI
AYLDQAILAVDDWQQGKNPVVVFDQLLPPDPPTQQALTDYRQHLVSFRALLLQHLNRPQEQAQTTIDRRIAFSELESEAE
QLENRLYLDLELSIKRQAERYSLMLVGWLIFLVIIAGVVYRLLGLQRLAVAQLAASEKQFRAQYRGIPIPTYTWRCIDDD
FILEGFNDAAMIITQGAITKFVNQSARIVYRNEPEILHHFERCQREKITLHQEIRYEFKLINQVKDLYVSYVFIEPDFIM
VHTEDRTDRNQLQMQLIRAQKMESIGRLAGGVAHDFNNLLTAISGYTTLAIDSAQQGFPVVEELTEIQHATDRAAMLTSQ
LLTFARKQQIQPKIVNINDLIMSMEKLIRRVLPESIQWRTVLNVNIDLVLADIGQIEQVLLNLVVNARDAMPQGGNLLVE
TNNVAVDANYARTHIDVPIGNYVLFAVSDTGIGMTQEVQSRAFEPFFTTKSDHEGTGLGLATCYGIIKQHGGHIGLYSEV
NHGTTIKIYLPRSEQAQLDDAPSLIQNLPRGTETILVSEDEPQVRAVLVRMLQGLGYSVLEALHGSEALALLQAQALGTI
QLLITDMVMPQMGGFELSQRVAELDPQLKILFISGYSEHSLAQHQQLAQQPLLLSKPFSLATLAQTVRKVLDD
>Mature_713_residues
MKRFAWLRRKELRPLIALLSVALVSIALLQWNYYQMRSMIQSQITAFNGMTQARLNMKRGYLIAEQVLNGNQTLLPQDAI
AYLDQAILAVDDWQQGKNPVVVFDQLLPPDPPTQQALTDYRQHLVSFRALLLQHLNRPQEQAQTTIDRRIAFSELESEAE
QLENRLYLDLELSIKRQAERYSLMLVGWLIFLVIIAGVVYRLLGLQRLAVAQLAASEKQFRAQYRGIPIPTYTWRCIDDD
FILEGFNDAAMIITQGAITKFVNQSARIVYRNEPEILHHFERCQREKITLHQEIRYEFKLINQVKDLYVSYVFIEPDFIM
VHTEDRTDRNQLQMQLIRAQKMESIGRLAGGVAHDFNNLLTAISGYTTLAIDSAQQGFPVVEELTEIQHATDRAAMLTSQ
LLTFARKQQIQPKIVNINDLIMSMEKLIRRVLPESIQWRTVLNVNIDLVLADIGQIEQVLLNLVVNARDAMPQGGNLLVE
TNNVAVDANYARTHIDVPIGNYVLFAVSDTGIGMTQEVQSRAFEPFFTTKSDHEGTGLGLATCYGIIKQHGGHIGLYSEV
NHGTTIKIYLPRSEQAQLDDAPSLIQNLPRGTETILVSEDEPQVRAVLVRMLQGLGYSVLEALHGSEALALLQAQALGTI
QLLITDMVMPQMGGFELSQRVAELDPQLKILFISGYSEHSLAQHQQLAQQPLLLSKPFSLATLAQTVRKVLDD

Specific function: Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=245, Percent_Identity=31.4285714285714, Blast_Score=110, Evalue=4e-25,
Organism=Escherichia coli, GI1788549, Length=257, Percent_Identity=31.5175097276265, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1788713, Length=261, Percent_Identity=31.0344827586207, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI48994928, Length=274, Percent_Identity=27.7372262773723, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1790300, Length=252, Percent_Identity=29.3650793650794, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 80671; Mature: 80671

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRFAWLRRKELRPLIALLSVALVSIALLQWNYYQMRSMIQSQITAFNGMTQARLNMKRG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHCC
YLIAEQVLNGNQTLLPQDAIAYLDQAILAVDDWQQGKNPVVVFDQLLPPDPPTQQALTDY
HHHHHHHHCCCCCCCCHHHHHHHHHHHHEEHHHHCCCCCEEEECCCCCCCCCHHHHHHHH
RQHLVSFRALLLQHLNRPQEQAQTTIDRRIAFSELESEAEQLENRLYLDLELSIKRQAER
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEHHHHHHHH
YSLMLVGWLIFLVIIAGVVYRLLGLQRLAVAQLAASEKQFRAQYRGIPIPTYTWRCIDDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCH
FILEGFNDAAMIITQGAITKFVNQSARIVYRNEPEILHHFERCQREKITLHQEIRYEFKL
HHHCCCCCCEEEEEHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
INQVKDLYVSYVFIEPDFIMVHTEDRTDRNQLQMQLIRAQKMESIGRLAGGVAHDFNNLL
HHHHHHHHEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAISGYTTLAIDSAQQGFPVVEELTEIQHATDRAAMLTSQLLTFARKQQIQPKIVNINDL
HHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHH
IMSMEKLIRRVLPESIQWRTVLNVNIDLVLADIGQIEQVLLNLVVNARDAMPQGGNLLVE
HHHHHHHHHHHCCCCCCEEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
TNNVAVDANYARTHIDVPIGNYVLFAVSDTGIGMTQEVQSRAFEPFFTTKSDHEGTGLGL
ECCEEEECCCCEEEEECCCCCEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHH
ATCYGIIKQHGGHIGLYSEVNHGTTIKIYLPRSEQAQLDDAPSLIQNLPRGTETILVSED
HHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHCCCCCEEEEEECC
EPQVRAVLVRMLQGLGYSVLEALHGSEALALLQAQALGTIQLLITDMVMPQMGGFELSQR
CHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
VAELDPQLKILFISGYSEHSLAQHQQLAQQPLLLSKPFSLATLAQTVRKVLDD
HHHCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKRFAWLRRKELRPLIALLSVALVSIALLQWNYYQMRSMIQSQITAFNGMTQARLNMKRG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHCC
YLIAEQVLNGNQTLLPQDAIAYLDQAILAVDDWQQGKNPVVVFDQLLPPDPPTQQALTDY
HHHHHHHHCCCCCCCCHHHHHHHHHHHHEEHHHHCCCCCEEEECCCCCCCCCHHHHHHHH
RQHLVSFRALLLQHLNRPQEQAQTTIDRRIAFSELESEAEQLENRLYLDLELSIKRQAER
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEHHHHHHHH
YSLMLVGWLIFLVIIAGVVYRLLGLQRLAVAQLAASEKQFRAQYRGIPIPTYTWRCIDDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCH
FILEGFNDAAMIITQGAITKFVNQSARIVYRNEPEILHHFERCQREKITLHQEIRYEFKL
HHHCCCCCCEEEEEHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
INQVKDLYVSYVFIEPDFIMVHTEDRTDRNQLQMQLIRAQKMESIGRLAGGVAHDFNNLL
HHHHHHHHEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAISGYTTLAIDSAQQGFPVVEELTEIQHATDRAAMLTSQLLTFARKQQIQPKIVNINDL
HHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHH
IMSMEKLIRRVLPESIQWRTVLNVNIDLVLADIGQIEQVLLNLVVNARDAMPQGGNLLVE
HHHHHHHHHHHCCCCCCEEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
TNNVAVDANYARTHIDVPIGNYVLFAVSDTGIGMTQEVQSRAFEPFFTTKSDHEGTGLGL
ECCEEEECCCCEEEEECCCCCEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHH
ATCYGIIKQHGGHIGLYSEVNHGTTIKIYLPRSEQAQLDDAPSLIQNLPRGTETILVSED
HHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHCCCCCEEEEEECC
EPQVRAVLVRMLQGLGYSVLEALHGSEALALLQAQALGTIQLLITDMVMPQMGGFELSQR
CHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
VAELDPQLKILFISGYSEHSLAQHQQLAQQPLLLSKPFSLATLAQTVRKVLDD
HHHCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA