Click here to switch to the map view.

The map label for this gene is hemE

Identifier: 15927408

GI number: 15927408

Start: 1886275

End: 1887312

Strand: Reverse

Name: hemE

Synonym: SA1652

Alternate gene names: 15927408

Gene position: 1887312-1886275 (Counterclockwise)

Preceding gene: 15927410

Following gene: 15927407

Centisome position: 67.05

GC content: 34.78

Gene sequence:

>1038_bases
ATGGTGCATAATAAAAACAATACAATTTTAAAAATGATCAAAGGTGAAGAAACATCACATACACCTGTTTGGTTTATGCG
ACAAGCTGGCCGTTCGCAACCAGAATATCGAAAATTGAAAGAAAAATATTCACTATTCGATATTACACATCAGCCGGAGT
TGTGCGCTTATGTAACACATTTACCAGTTGATAATTATCATACAGATGCAGCAATTTTATACAAAGATATTATGACACCA
TTAAAGCCAATTGGTGTCGATGTAGAAATTAAATCGGGTATTGGTCCAGTGATTCATAATCCTATCAAAACAATTCAAGA
TGTTGAGAAACTTTCTCAAATAGACCCCGAACGAGATGTACCATATGTATTAGATACAATTAAACTTTTAACAGAAGAAA
AGTTAAATGTGCCGCTAATAGGATTTACTGGGGCACCATTTACATTAGCGTCATATATGATTGAAGGCGGACCATCGAAA
AATTACAATTTTACAAAAGCGATGATGTATAGAGATGAAGCAACATGGTTTGCTTTAATGAATCATTTAGTTGATGTATC
TGTTAAATATGTAACAGCTCAAGTCGAAGCAGGTGCCGAATTGATTCAAATTTTCGATTCATGGGTAGGTGCATTAAATG
TCGAGGATTACAGACGTTACATTAAACCACATATGATTCGATTAATCAGTGAGGTTAAAGAAAAACATGATGTGCCGGTA
ATTTTATTCGGTGTAGGTGCCAGTCATTTAATCAATGAATGGAATGATTTACCGATTGATGTATTAGGCCTAGATTGGAG
AACGTCTATTAATCAGGCTCAACAATTAGGCGTTACTAAAACATTACAAGGGAATTTAGATCCATCAATTTTATTAGCAC
CATGGAATGTCATTGAAGAGAGATTGAAACCAATATTAGATCAAGGTATGGAGAACGGTAAACACATCTTTAATTTAGGA
CACGGTGTTTTCCCAGAAGTGCAACCAGAGACGTTACGTAAAGTAAGCGAATTCGTACACACATATACACAAAGATAA

Upstream 100 bases:

>100_bases
ATGATTAAATGTCAGTTTTATGACATTTATTTATTGAAAATACGAACGAATGAGCGATATGATAATATAGATAAGAATGA
TTTTAATTTAGGAGGCCTTT

Downstream 100 bases:

>100_bases
TCATAGTATTACATTGAAGCACATGAAAGATAATTCATTTAAAGGAAGGTATTATCAATGACTAAAAAAATGGGGTTATT
AGTTATGGCTTATGGCACAC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MVHNKNNTILKMIKGEETSHTPVWFMRQAGRSQPEYRKLKEKYSLFDITHQPELCAYVTHLPVDNYHTDAAILYKDIMTP
LKPIGVDVEIKSGIGPVIHNPIKTIQDVEKLSQIDPERDVPYVLDTIKLLTEEKLNVPLIGFTGAPFTLASYMIEGGPSK
NYNFTKAMMYRDEATWFALMNHLVDVSVKYVTAQVEAGAELIQIFDSWVGALNVEDYRRYIKPHMIRLISEVKEKHDVPV
ILFGVGASHLINEWNDLPIDVLGLDWRTSINQAQQLGVTKTLQGNLDPSILLAPWNVIEERLKPILDQGMENGKHIFNLG
HGVFPEVQPETLRKVSEFVHTYTQR

Sequences:

>Translated_345_residues
MVHNKNNTILKMIKGEETSHTPVWFMRQAGRSQPEYRKLKEKYSLFDITHQPELCAYVTHLPVDNYHTDAAILYKDIMTP
LKPIGVDVEIKSGIGPVIHNPIKTIQDVEKLSQIDPERDVPYVLDTIKLLTEEKLNVPLIGFTGAPFTLASYMIEGGPSK
NYNFTKAMMYRDEATWFALMNHLVDVSVKYVTAQVEAGAELIQIFDSWVGALNVEDYRRYIKPHMIRLISEVKEKHDVPV
ILFGVGASHLINEWNDLPIDVLGLDWRTSINQAQQLGVTKTLQGNLDPSILLAPWNVIEERLKPILDQGMENGKHIFNLG
HGVFPEVQPETLRKVSEFVHTYTQR
>Mature_345_residues
MVHNKNNTILKMIKGEETSHTPVWFMRQAGRSQPEYRKLKEKYSLFDITHQPELCAYVTHLPVDNYHTDAAILYKDIMTP
LKPIGVDVEIKSGIGPVIHNPIKTIQDVEKLSQIDPERDVPYVLDTIKLLTEEKLNVPLIGFTGAPFTLASYMIEGGPSK
NYNFTKAMMYRDEATWFALMNHLVDVSVKYVTAQVEAGAELIQIFDSWVGALNVEDYRRYIKPHMIRLISEVKEKHDVPV
ILFGVGASHLINEWNDLPIDVLGLDWRTSINQAQQLGVTKTLQGNLDPSILLAPWNVIEERLKPILDQGMENGKHIFNLG
HGVFPEVQPETLRKVSEFVHTYTQR

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=352, Percent_Identity=36.0795454545455, Blast_Score=219, Evalue=3e-57,
Organism=Escherichia coli, GI2367337, Length=351, Percent_Identity=38.1766381766382, Blast_Score=241, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6320252, Length=351, Percent_Identity=31.3390313390313, Blast_Score=193, Evalue=3e-50,
Organism=Drosophila melanogaster, GI221330099, Length=344, Percent_Identity=34.8837209302326, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI19921920, Length=344, Percent_Identity=34.8837209302326, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_STAA1 (A7X3T8)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001442409.1
- ProteinModelPortal:   A7X3T8
- SMR:   A7X3T8
- STRING:   A7X3T8
- EnsemblBacteria:   EBSTAT00000005049
- GeneID:   5559160
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1819
- eggNOG:   COG0407
- GeneTree:   EBGT00050000024385
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- BioCyc:   SAUR418127:SAHV_1819-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 39353; Mature: 39353

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 46-46 BINDING 76-76 BINDING 152-152 BINDING 207-207 BINDING 321-321

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVHNKNNTILKMIKGEETSHTPVWFMRQAGRSQPEYRKLKEKYSLFDITHQPELCAYVTH
CCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
LPVDNYHTDAAILYKDIMTPLKPIGVDVEIKSGIGPVIHNPIKTIQDVEKLSQIDPERDV
CCCCCCCCHHHHHHHHHHCCHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
PYVLDTIKLLTEEKLNVPLIGFTGAPFTLASYMIEGGPSKNYNFTKAMMYRDEATWFALM
CHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHH
NHLVDVSVKYVTAQVEAGAELIQIFDSWVGALNVEDYRRYIKPHMIRLISEVKEKHDVPV
HHHHHHHHHEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCE
ILFGVGASHLINEWNDLPIDVLGLDWRTSINQAQQLGVTKTLQGNLDPSILLAPWNVIEE
EEEECCHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCCHHHHCCCCCCCEEECCHHHHHH
RLKPILDQGMENGKHIFNLGHGVFPEVQPETLRKVSEFVHTYTQR
HHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVHNKNNTILKMIKGEETSHTPVWFMRQAGRSQPEYRKLKEKYSLFDITHQPELCAYVTH
CCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
LPVDNYHTDAAILYKDIMTPLKPIGVDVEIKSGIGPVIHNPIKTIQDVEKLSQIDPERDV
CCCCCCCCHHHHHHHHHHCCHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
PYVLDTIKLLTEEKLNVPLIGFTGAPFTLASYMIEGGPSKNYNFTKAMMYRDEATWFALM
CHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHH
NHLVDVSVKYVTAQVEAGAELIQIFDSWVGALNVEDYRRYIKPHMIRLISEVKEKHDVPV
HHHHHHHHHEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCE
ILFGVGASHLINEWNDLPIDVLGLDWRTSINQAQQLGVTKTLQGNLDPSILLAPWNVIEE
EEEECCHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCCHHHHCCCCCCCEEECCHHHHHH
RLKPILDQGMENGKHIFNLGHGVFPEVQPETLRKVSEFVHTYTQR
HHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA