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The map label for this gene is birA [H]

Identifier: 15927037

GI number: 15927037

Start: 1495745

End: 1496716

Strand: Reverse

Name: birA [H]

Synonym: SA1289

Alternate gene names: 15927037

Gene position: 1496716-1495745 (Counterclockwise)

Preceding gene: 15927038

Following gene: 15927036

Centisome position: 53.17

GC content: 30.45

Gene sequence:

>972_bases
ATGTCAAAATATAGTCAAGATGTACTTCAATTACTCTATAAAAATAAACCGAATTATATATCTGGACAAAGCATTGCGGA
ATCACTTAATATTTCACGCACTGCAGTAAAAAAGGTGATTGACCAATTAAAGTTAGAGGGATGTAAAATTGATTCAGTAA
ATCATAAAGGGCATTTATTACAACAACTCCCAGATATTTGGTATCAGGGTATAATAGACCAATATACAAAAAGTTCTGCT
TTGTTTGATTTTAGTGAAGTATACGATTCAATAGATTCTACACAACTTGCTGCGAAAAAGTCACTTGTTGGAAATCAATC
TTCATTTTTTATCTTGAGTGATGAACAAACGAAAGGTCGTGGGCGATTTAATAGACATTGGAGTTCTTCAAAAGGGCAAG
GACTTTGGATGTCTGTCGTGTTAAGACCTAACGTTGCATTCTCAATGATATCTAAATTTAATTTATTTATTGCATTAGGG
ATAAGAGATGCGATTCAACATTTTAGTCAAGATGAAGTCAAAGTGAAATGGCCGAATGATATATATATTGATAATGGTAA
AGTGTGTGGTTTCTTAACTGAAATGGTTGCTAATAATGATGGTATAGAAGCAATAATATGTGGTATAGGTATTAATTTGA
CGCAACAACTAGAAAACTTTGATGAAAGTATTAGACATAGAGCAACAAGTATACAATTACATGATAAAAATAAATTAGAT
AGATATCAATTTTTAGAGAGATTACTTCAAGAAATTGAAAAAAGATATAATCAATTTTTAACGTTACCTTTTTCTGAAAT
TCGTGAAGAATATATTGCAGCTTCTAATATTTGGAATAGAACGTTGCTATTTACAGAAAATGATAAACAGTTTAAAGGAC
AAGCAATTGATTTAGATTACGATGGCTATCTAATTGTTAGAGATGAAGCGGGTGAATCACACCGTTTAATTAGTGCAGAT
ATAGATTTTTAA

Upstream 100 bases:

>100_bases
GGTCCGTGGTTAAAAGATGTGCTAAGACAAATTGAGATAGCGATTGTAACAGGTAAAGTAAGCAACGAAGAAACTGAAAT
TTTGAAATGGGTGGATAATC

Downstream 100 bases:

>100_bases
CACTAAAGCAAGGAGAGATAGCTATGGGTATGGCAACCTATGCCGTTGTGGATTTGGAAACAACAGGCAACCAATTAGAT
TTTGACGATATCATTCAAAT

Product: hypothetical protein

Products: NA

Alternate protein names: Biotin operon repressor; Biotin--[acetyl-CoA-carboxylase] synthetase; Biotin--protein ligase [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MSKYSQDVLQLLYKNKPNYISGQSIAESLNISRTAVKKVIDQLKLEGCKIDSVNHKGHLLQQLPDIWYQGIIDQYTKSSA
LFDFSEVYDSIDSTQLAAKKSLVGNQSSFFILSDEQTKGRGRFNRHWSSSKGQGLWMSVVLRPNVAFSMISKFNLFIALG
IRDAIQHFSQDEVKVKWPNDIYIDNGKVCGFLTEMVANNDGIEAIICGIGINLTQQLENFDESIRHRATSIQLHDKNKLD
RYQFLERLLQEIEKRYNQFLTLPFSEIREEYIAASNIWNRTLLFTENDKQFKGQAIDLDYDGYLIVRDEAGESHRLISAD
IDF

Sequences:

>Translated_323_residues
MSKYSQDVLQLLYKNKPNYISGQSIAESLNISRTAVKKVIDQLKLEGCKIDSVNHKGHLLQQLPDIWYQGIIDQYTKSSA
LFDFSEVYDSIDSTQLAAKKSLVGNQSSFFILSDEQTKGRGRFNRHWSSSKGQGLWMSVVLRPNVAFSMISKFNLFIALG
IRDAIQHFSQDEVKVKWPNDIYIDNGKVCGFLTEMVANNDGIEAIICGIGINLTQQLENFDESIRHRATSIQLHDKNKLD
RYQFLERLLQEIEKRYNQFLTLPFSEIREEYIAASNIWNRTLLFTENDKQFKGQAIDLDYDGYLIVRDEAGESHRLISAD
IDF
>Mature_322_residues
SKYSQDVLQLLYKNKPNYISGQSIAESLNISRTAVKKVIDQLKLEGCKIDSVNHKGHLLQQLPDIWYQGIIDQYTKSSAL
FDFSEVYDSIDSTQLAAKKSLVGNQSSFFILSDEQTKGRGRFNRHWSSSKGQGLWMSVVLRPNVAFSMISKFNLFIALGI
RDAIQHFSQDEVKVKWPNDIYIDNGKVCGFLTEMVANNDGIEAIICGIGINLTQQLENFDESIRHRATSIQLHDKNKLDR
YQFLERLLQEIEKRYNQFLTLPFSEIREEYIAASNIWNRTLLFTENDKQFKGQAIDLDYDGYLIVRDEAGESHRLISADI
DF

Specific function: BirA acts both as a biotin-operon repressor and as the enzyme that synthesizes the corepressor, acetyl-CoA:carbon-dioxide ligase. This protein also activates biotin to form biotinyl-5'- adenylate and transfers the biotin moiety to biotin-accepting protein

COG id: COG0340

COG function: function code H; Biotin-(acetyl-CoA carboxylase) ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biotin--protein ligase family [H]

Homologues:

Organism=Escherichia coli, GI1790408, Length=291, Percent_Identity=25.085910652921, Blast_Score=95, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: =6.3.4.15 [H]

Molecular weight: Translated: 37142; Mature: 37011

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKYSQDVLQLLYKNKPNYISGQSIAESLNISRTAVKKVIDQLKLEGCKIDSVNHKGHLL
CCCHHHHHHHHHHCCCCCEECHHHHHHHHCCHHHHHHHHHHHHHHCCCEECCCCCCHHHH
QQLPDIWYQGIIDQYTKSSALFDFSEVYDSIDSTQLAAKKSLVGNQSSFFILSDEQTKGR
HHHHHHHHHHHHHHHHHHHHCEEHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCC
GRFNRHWSSSKGQGLWMSVVLRPNVAFSMISKFNLFIALGIRDAIQHFSQDEVKVKWPND
CCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHEEEEECHHHHHHHCCCCCEEEECCCE
IYIDNGKVCGFLTEMVANNDGIEAIICGIGINLTQQLENFDESIRHRATSIQLHDKNKLD
EEEECCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHEEEEECCCCCH
RYQFLERLLQEIEKRYNQFLTLPFSEIREEYIAASNIWNRTLLFTENDKQFKGQAIDLDY
HHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEECC
DGYLIVRDEAGESHRLISADIDF
CCEEEEECCCCCCCEEEEECCCC
>Mature Secondary Structure 
SKYSQDVLQLLYKNKPNYISGQSIAESLNISRTAVKKVIDQLKLEGCKIDSVNHKGHLL
CCHHHHHHHHHHCCCCCEECHHHHHHHHCCHHHHHHHHHHHHHHCCCEECCCCCCHHHH
QQLPDIWYQGIIDQYTKSSALFDFSEVYDSIDSTQLAAKKSLVGNQSSFFILSDEQTKGR
HHHHHHHHHHHHHHHHHHHHCEEHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCC
GRFNRHWSSSKGQGLWMSVVLRPNVAFSMISKFNLFIALGIRDAIQHFSQDEVKVKWPND
CCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHEEEEECHHHHHHHCCCCCEEEECCCE
IYIDNGKVCGFLTEMVANNDGIEAIICGIGINLTQQLENFDESIRHRATSIQLHDKNKLD
EEEECCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHEEEEECCCCCH
RYQFLERLLQEIEKRYNQFLTLPFSEIREEYIAASNIWNRTLLFTENDKQFKGQAIDLDY
HHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEECC
DGYLIVRDEAGESHRLISADIDF
CCEEEEECCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7730294 [H]