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The map label for this gene is tdcB [H]

Identifier: 15927019

GI number: 15927019

Start: 1473100

End: 1474140

Strand: Reverse

Name: tdcB [H]

Synonym: SA1271

Alternate gene names: 15927019

Gene position: 1474140-1473100 (Counterclockwise)

Preceding gene: 15927020

Following gene: 15927018

Centisome position: 52.37

GC content: 35.06

Gene sequence:

>1041_bases
ATGACAACCAACACAGTTACATTACAAACAGCACATATTGTAAGTTTAGGAGATATCGAAGAAGCTAAAGCAAGCATTAA
ACCATTTATTCGTCGAACACCACTAATTAAATCTATGTATTTAAGTCAAAATATCACTAAAGGTAACGTATATTTAAAAC
TTGAAAATATGCAGTTTACAGGTTCATTTAAATTTAGAGGTGCTAGCAATAAAATTAATCATTTGTCAGATGAACAAAAA
GCTAAAGGTATTATTGGCGCATCAGCCGGAAATCATGCACAAGGTGTAGCTTTGACAGCAAAACTATTAGGTATTGATGC
AACGATTGTGATGCCAGAAACAGCACCAATTGCTAAACAGAATGCTACCAAAGGATATGGTGCAAAAGTCATTTTAAAAG
GTAAAAACTTTAATGAAACTAGACTTTATATGGAAGAATTAGCGAAAGAAAATGGTATGACAATTGTTCATCCATATGAT
GATAAGTTTGTCATGGCTGGTCAAGGAACAATAGGATTAGAAATTTTAGATGATATATGGAATGTTAATACGGTCATTGT
TCCAGTTGGTGGAGGTGGCCTAATTGCAGGTATTGCCACCGCTTTAAAATCATTCAACCCATCAATTCATATAATCGGCG
TTCAAGCTGAAAATGTGCATGGCATGGCAGAGTCATTCTATAAGAGAGCTTTAACTGAACATCGTGAAGATAGCACAATT
GCAGATGGTTGTGATGTAAAAGTACCAGGTGAAAAAACATACGAAGTAGTAAAACATTTAGTAGATGAATTTATTCTTGT
ATCAGAAGAGGAAATAGAACATGCAATGCAAGATTTAATGCAACGTGCCAAAATCATTACAGAAGGTGCAGGAGCTTTAC
CTACAGCAGCTATTTTAAGTGGGAAAATTGATAAAAAATGGCTAGAGGGTAAAAATGTCGTTGCATTAGTTTCAGGAGGA
AACGTTGACTTAACTAGAGTTTCTGGTGTCATTGAACATGGCTTAAATATCGCGGATACAAGTAAGGGTGTGGTAGGTTA
A

Upstream 100 bases:

>100_bases
GAATAGATAATAATTTAAATGAAATTGAGTGAAATGAATATTTTAAATATAGCATTATAGTTTGGACTAAAAATTTACAA
AACGGAAGGATGTAATTATT

Downstream 100 bases:

>100_bases
AACTTCCAATCTTAAAAATGAGGTGTAATTATGTCAAATGGTAAAGAATTACAAAAAAATATAGGTTTCTTCTCAGCGTT
TGCTATTGTTATGGGGACAG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MTTNTVTLQTAHIVSLGDIEEAKASIKPFIRRTPLIKSMYLSQNITKGNVYLKLENMQFTGSFKFRGASNKINHLSDEQK
AKGIIGASAGNHAQGVALTAKLLGIDATIVMPETAPIAKQNATKGYGAKVILKGKNFNETRLYMEELAKENGMTIVHPYD
DKFVMAGQGTIGLEILDDIWNVNTVIVPVGGGGLIAGIATALKSFNPSIHIIGVQAENVHGMAESFYKRALTEHREDSTI
ADGCDVKVPGEKTYEVVKHLVDEFILVSEEEIEHAMQDLMQRAKIITEGAGALPTAAILSGKIDKKWLEGKNVVALVSGG
NVDLTRVSGVIEHGLNIADTSKGVVG

Sequences:

>Translated_346_residues
MTTNTVTLQTAHIVSLGDIEEAKASIKPFIRRTPLIKSMYLSQNITKGNVYLKLENMQFTGSFKFRGASNKINHLSDEQK
AKGIIGASAGNHAQGVALTAKLLGIDATIVMPETAPIAKQNATKGYGAKVILKGKNFNETRLYMEELAKENGMTIVHPYD
DKFVMAGQGTIGLEILDDIWNVNTVIVPVGGGGLIAGIATALKSFNPSIHIIGVQAENVHGMAESFYKRALTEHREDSTI
ADGCDVKVPGEKTYEVVKHLVDEFILVSEEEIEHAMQDLMQRAKIITEGAGALPTAAILSGKIDKKWLEGKNVVALVSGG
NVDLTRVSGVIEHGLNIADTSKGVVG
>Mature_345_residues
TTNTVTLQTAHIVSLGDIEEAKASIKPFIRRTPLIKSMYLSQNITKGNVYLKLENMQFTGSFKFRGASNKINHLSDEQKA
KGIIGASAGNHAQGVALTAKLLGIDATIVMPETAPIAKQNATKGYGAKVILKGKNFNETRLYMEELAKENGMTIVHPYDD
KFVMAGQGTIGLEILDDIWNVNTVIVPVGGGGLIAGIATALKSFNPSIHIIGVQAENVHGMAESFYKRALTEHREDSTIA
DGCDVKVPGEKTYEVVKHLVDEFILVSEEEIEHAMQDLMQRAKIITEGAGALPTAAILSGKIDKKWLEGKNVVALVSGGN
VDLTRVSGVIEHGLNIADTSKGVVG

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=318, Percent_Identity=37.1069182389937, Blast_Score=204, Evalue=8e-53,
Organism=Homo sapiens, GI19923959, Length=310, Percent_Identity=29.0322580645161, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI33469958, Length=320, Percent_Identity=27.5, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1789505, Length=317, Percent_Identity=53.9432176656151, Blast_Score=308, Evalue=5e-85,
Organism=Escherichia coli, GI1790207, Length=298, Percent_Identity=38.255033557047, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71991565, Length=324, Percent_Identity=40.7407407407407, Blast_Score=214, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17537387, Length=327, Percent_Identity=39.1437308868502, Blast_Score=174, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17508781, Length=319, Percent_Identity=29.4670846394984, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6322631, Length=319, Percent_Identity=39.1849529780564, Blast_Score=213, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6320930, Length=325, Percent_Identity=38.7692307692308, Blast_Score=186, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6319788, Length=282, Percent_Identity=23.758865248227, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355833, Length=322, Percent_Identity=40.6832298136646, Blast_Score=177, Evalue=9e-45,
Organism=Drosophila melanogaster, GI24645328, Length=225, Percent_Identity=40.8888888888889, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 37147; Mature: 37016

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNTVTLQTAHIVSLGDIEEAKASIKPFIRRTPLIKSMYLSQNITKGNVYLKLENMQFT
CCCCEEEEEEEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEEECEEEE
GSFKFRGASNKINHLSDEQKAKGIIGASAGNHAQGVALTAKLLGIDATIVMPETAPIAKQ
EEEEECCCCCCCCCCCCHHHHCCEEECCCCCCCCCEEEEEEEECCCEEEEECCCCCCCCC
NATKGYGAKVILKGKNFNETRLYMEELAKENGMTIVHPYDDKFVMAGQGTIGLEILDDIW
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCHHHHHHHHC
NVNTVIVPVGGGGLIAGIATALKSFNPSIHIIGVQAENVHGMAESFYKRALTEHREDSTI
CCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCC
ADGCDVKVPGEKTYEVVKHLVDEFILVSEEEIEHAMQDLMQRAKIITEGAGALPTAAILS
CCCCCEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHC
GKIDKKWLEGKNVVALVSGGNVDLTRVSGVIEHGLNIADTSKGVVG
CCCCHHHHCCCCEEEEEECCCEEHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TTNTVTLQTAHIVSLGDIEEAKASIKPFIRRTPLIKSMYLSQNITKGNVYLKLENMQFT
CCCEEEEEEEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEEECEEEE
GSFKFRGASNKINHLSDEQKAKGIIGASAGNHAQGVALTAKLLGIDATIVMPETAPIAKQ
EEEEECCCCCCCCCCCCHHHHCCEEECCCCCCCCCEEEEEEEECCCEEEEECCCCCCCCC
NATKGYGAKVILKGKNFNETRLYMEELAKENGMTIVHPYDDKFVMAGQGTIGLEILDDIW
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCHHHHHHHHC
NVNTVIVPVGGGGLIAGIATALKSFNPSIHIIGVQAENVHGMAESFYKRALTEHREDSTI
CCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCC
ADGCDVKVPGEKTYEVVKHLVDEFILVSEEEIEHAMQDLMQRAKIITEGAGALPTAAILS
CCCCCEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHC
GKIDKKWLEGKNVVALVSGGNVDLTRVSGVIEHGLNIADTSKGVVG
CCCCHHHHCCCCEEEEEECCCEEHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA