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The map label for this gene is parE

Identifier: 15926934

GI number: 15926934

Start: 1354328

End: 1356325

Strand: Direct

Name: parE

Synonym: SA1188

Alternate gene names: 15926934

Gene position: 1354328-1356325 (Clockwise)

Preceding gene: 15926931

Following gene: 15926935

Centisome position: 48.11

GC content: 35.04

Gene sequence:

>1998_bases
TTGGCAATGAATAAACAAAATAATTATTCAGATGATTCAATACAGGTTTTAGAGGGGTTAGAAGCAGTTCGTAAAAGACC
TGGTATGTATATTGGATCAACTGATAAACGGGGATTACATCATCTAGTATATGAAATTGTCGATAACTCCGTCGATGAAG
TATTGAATGGTTACGGTAACGAAATAGATGTAACAATTAATAAAGATGGTAGTATTTCTATAGAAGATAATGGACGTGGT
ATGCCAACAGGTATACATAAATCAGGTAAACCGACAGTCGAAGTTATCTTTACTGTTTTACATGCAGGAGGTAAATTTGG
ACAAGGCGGCTATAAAACTTCAGGTGGTCTTCACGGTGTTGGTGCTTCAGTTGTAAATGCATTGAGTGAATGGCTTGAAG
TTGAAATCCATCGAGATGGTAGTATATATCATCAAAGTTTTAAAAACGGTGGTTCGCCATCTTCTGGTTTAGTGAAAAAA
GGTAAAACTAAGAAAACAGGTACCAAAGTAACATTTAAACCTGATGACACAATTTTTAAAGCATCTACATCATTTAATTT
TGATGTTTTAAGCGAACGACTACAAGAGTCTGCGTTCTTATTGAAAAATTTAAAAATAACGCTTAATGATTTACGCAGTG
GTAAAGAGCGTCAAGAGCATTACCATTATGAAGAAGGAATCAAAGAGTTTGTTAGTTATGTCAATGAAGGAAAAGAAGTT
TTGCATGACGTGGCTACATTTTCAGGTGAAGCAAATGGTATAGAGGTAGACGTAGCTTTCCAATATAATGATCAATATTC
AGAAAGTATTTTAAGTTTTGTAAATAATGTACGTACTAAAGATGGTGGTACACATGAAGTTGGTTTTAAAACAGCAATGA
CACGTGTATTTAATGATTATGCACGTCGTATTAATGAACTTAAAACAAAAGATAAAAACTTAGATGGTAATGATATTCGT
GAAGGTTTAACAGCTGTTGTGTCTGTTCGTATTCCAGAAGAATTATTACAATTTGAAGGACAAACGAAATCTAAATTGGG
TACTTCTGAAGCTAGAAGTGCTGTTGATTCAGTTGTTGCAGACAAATTGCCATTCTATTTAGAAGAAAAAGGACAATTGT
CTAAATCACTTGTGAAAAAAGCGATTAAAGCACAACAAGCAAGGGAAGCTGCACGTAAAGCTCGTGAAGATGCTCGTTCA
GGTAAGAAAAACAAGCGTAAAGACACTTTGCTATCTGGTAAATTAACACCTGCACAAAGTAAAAACACTGAAAAAAATGA
ATTGTATTTAGTCGAAGGTGATTCTGCGGGAGGTTCAGCAAAACTTGGACGAGACCGCAAATTCCAAGCGATATTACCAT
TACGTGGTAAGGTAATTAATACAGAGAAAGCACGTCTAGAAGATATTTTTAAAAATGAAGAAATTAATACAATTATCCAC
ACAATCGGGGCAGGCGTTGGTACTGACTTTAAAATTGAAGATAGTAATTATAATCGTGTAATTATTATGACTGATGCTGA
TACTGATGGTGCGCATATTCAAGTGCTATTGTTAACATTCTTCTTCAAATATATGAAACCGCTTGTTCAAGCAGGTCGTG
TATTTATTGCTTTACCTCCACTTTATAAATTGGAAAAAGGTAAAGGCAAAACAAAGCGAGTTGAATACGCTTGGACAGAC
GAAGAGCTTAATAAATTGCAAAAAGAACTTGGTAAAGGCTTCACGTTACAACGTTACAAAGGTTTGGGTGAGATGAACCC
TGAACAATTATGGGAAACGACGATGAACCCAGAAACACGAACTTTAATTCGTGTACAAGTTGAAGATGAAGTGCGTTCAT
CTAAACGTGTAACAACATTAATGGGTGACAAAGTACAACCTAGACGTGAATGGATTGAAAAGCATGTTGAGTTTGGTATG
CAAGAGGACCAAAGTATTTTAGATAATTCTGAAGTACAAGTGCTTGAAAATGATCAATTTGATGAGGAGGAAATCTAG

Upstream 100 bases:

>100_bases
CTATGAAAGTTAATTGATACTTGCATTTTACGCTGATTTATATAAGAATAACTATTGTATAGTTTTAAAAACGAACGTAC
GTTTGCAGGAGGCGAAATCA

Downstream 100 bases:

>100_bases
TGAGTGAAATAATTCAAGATTTATCACTTGAAGATGTTTTAGGTGATCGCTTTGGAAGATATAGTAAATATATTATTCAA
GAGCGTGCATTGCCAGATGT

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 665; Mature: 664

Protein sequence:

>665_residues
MAMNKQNNYSDDSIQVLEGLEAVRKRPGMYIGSTDKRGLHHLVYEIVDNSVDEVLNGYGNEIDVTINKDGSISIEDNGRG
MPTGIHKSGKPTVEVIFTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLEVEIHRDGSIYHQSFKNGGSPSSGLVKK
GKTKKTGTKVTFKPDDTIFKASTSFNFDVLSERLQESAFLLKNLKITLNDLRSGKERQEHYHYEEGIKEFVSYVNEGKEV
LHDVATFSGEANGIEVDVAFQYNDQYSESILSFVNNVRTKDGGTHEVGFKTAMTRVFNDYARRINELKTKDKNLDGNDIR
EGLTAVVSVRIPEELLQFEGQTKSKLGTSEARSAVDSVVADKLPFYLEEKGQLSKSLVKKAIKAQQAREAARKAREDARS
GKKNKRKDTLLSGKLTPAQSKNTEKNELYLVEGDSAGGSAKLGRDRKFQAILPLRGKVINTEKARLEDIFKNEEINTIIH
TIGAGVGTDFKIEDSNYNRVIIMTDADTDGAHIQVLLLTFFFKYMKPLVQAGRVFIALPPLYKLEKGKGKTKRVEYAWTD
EELNKLQKELGKGFTLQRYKGLGEMNPEQLWETTMNPETRTLIRVQVEDEVRSSKRVTTLMGDKVQPRREWIEKHVEFGM
QEDQSILDNSEVQVLENDQFDEEEI

Sequences:

>Translated_665_residues
MAMNKQNNYSDDSIQVLEGLEAVRKRPGMYIGSTDKRGLHHLVYEIVDNSVDEVLNGYGNEIDVTINKDGSISIEDNGRG
MPTGIHKSGKPTVEVIFTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLEVEIHRDGSIYHQSFKNGGSPSSGLVKK
GKTKKTGTKVTFKPDDTIFKASTSFNFDVLSERLQESAFLLKNLKITLNDLRSGKERQEHYHYEEGIKEFVSYVNEGKEV
LHDVATFSGEANGIEVDVAFQYNDQYSESILSFVNNVRTKDGGTHEVGFKTAMTRVFNDYARRINELKTKDKNLDGNDIR
EGLTAVVSVRIPEELLQFEGQTKSKLGTSEARSAVDSVVADKLPFYLEEKGQLSKSLVKKAIKAQQAREAARKAREDARS
GKKNKRKDTLLSGKLTPAQSKNTEKNELYLVEGDSAGGSAKLGRDRKFQAILPLRGKVINTEKARLEDIFKNEEINTIIH
TIGAGVGTDFKIEDSNYNRVIIMTDADTDGAHIQVLLLTFFFKYMKPLVQAGRVFIALPPLYKLEKGKGKTKRVEYAWTD
EELNKLQKELGKGFTLQRYKGLGEMNPEQLWETTMNPETRTLIRVQVEDEVRSSKRVTTLMGDKVQPRREWIEKHVEFGM
QEDQSILDNSEVQVLENDQFDEEEI
>Mature_664_residues
AMNKQNNYSDDSIQVLEGLEAVRKRPGMYIGSTDKRGLHHLVYEIVDNSVDEVLNGYGNEIDVTINKDGSISIEDNGRGM
PTGIHKSGKPTVEVIFTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLEVEIHRDGSIYHQSFKNGGSPSSGLVKKG
KTKKTGTKVTFKPDDTIFKASTSFNFDVLSERLQESAFLLKNLKITLNDLRSGKERQEHYHYEEGIKEFVSYVNEGKEVL
HDVATFSGEANGIEVDVAFQYNDQYSESILSFVNNVRTKDGGTHEVGFKTAMTRVFNDYARRINELKTKDKNLDGNDIRE
GLTAVVSVRIPEELLQFEGQTKSKLGTSEARSAVDSVVADKLPFYLEEKGQLSKSLVKKAIKAQQAREAARKAREDARSG
KKNKRKDTLLSGKLTPAQSKNTEKNELYLVEGDSAGGSAKLGRDRKFQAILPLRGKVINTEKARLEDIFKNEEINTIIHT
IGAGVGTDFKIEDSNYNRVIIMTDADTDGAHIQVLLLTFFFKYMKPLVQAGRVFIALPPLYKLEKGKGKTKRVEYAWTDE
ELNKLQKELGKGFTLQRYKGLGEMNPEQLWETTMNPETRTLIRVQVEDEVRSSKRVTTLMGDKVQPRREWIEKHVEFGMQ
EDQSILDNSEVQVLENDQFDEEEI

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=613, Percent_Identity=25.6117455138662, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI19913408, Length=683, Percent_Identity=24.8901903367496, Blast_Score=112, Evalue=9e-25,
Organism=Escherichia coli, GI48994957, Length=565, Percent_Identity=49.9115044247788, Blast_Score=504, Evalue=1e-144,
Organism=Escherichia coli, GI1789408, Length=642, Percent_Identity=37.8504672897196, Blast_Score=405, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17535065, Length=673, Percent_Identity=26.1515601783061, Blast_Score=136, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI212645845, Length=545, Percent_Identity=26.605504587156, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI212645657, Length=207, Percent_Identity=28.5024154589372, Blast_Score=75, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=630, Percent_Identity=28.2539682539683, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17136538, Length=673, Percent_Identity=25.260029717682, Blast_Score=127, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005740 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 74540; Mature: 74409

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMNKQNNYSDDSIQVLEGLEAVRKRPGMYIGSTDKRGLHHLVYEIVDNSVDEVLNGYGN
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHCCHHHHHHCCCC
EIDVTINKDGSISIEDNGRGMPTGIHKSGKPTVEVIFTVLHAGGKFGQGGYKTSGGLHGV
EEEEEECCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCH
GASVVNALSEWLEVEIHRDGSIYHQSFKNGGSPSSGLVKKGKTKKTGTKVTFKPDDTIFK
HHHHHHHHHHHHEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEE
ASTSFNFDVLSERLQESAFLLKNLKITLNDLRSGKERQEHYHYEEGIKEFVSYVNEGKEV
ECCCCCHHHHHHHHHHHHHHHHHHHEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LHDVATFSGEANGIEVDVAFQYNDQYSESILSFVNNVRTKDGGTHEVGFKTAMTRVFNDY
HHHHHHHCCCCCCEEEEEEEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
ARRINELKTKDKNLDGNDIREGLTAVVSVRIPEELLQFEGQTKSKLGTSEARSAVDSVVA
HHHHHHHHHHCCCCCHHHHHHHHHHHEEEECCHHHHHCCCCCHHHCCHHHHHHHHHHHHH
DKLPFYLEEKGQLSKSLVKKAIKAQQAREAARKAREDARSGKKNKRKDTLLSGKLTPAQS
HHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCC
KNTEKNELYLVEGDSAGGSAKLGRDRKFQAILPLRGKVINTEKARLEDIFKNEEINTIIH
CCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCEEECCHHHHHHHHHCCCHHHHHHH
TIGAGVGTDFKIEDSNYNRVIIMTDADTDGAHIQVLLLTFFFKYMKPLVQAGRVFIALPP
HHCCCCCCCEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCC
LYKLEKGKGKTKRVEYAWTDEELNKLQKELGKGFTLQRYKGLGEMNPEQLWETTMNPETR
CHHHCCCCCCCEEEEEEECHHHHHHHHHHHCCCCEEHHHCCCCCCCHHHHHHHCCCCCCE
TLIRVQVEDEVRSSKRVTTLMGDKVQPRREWIEKHVEFGMQEDQSILDNSEVQVLENDQF
EEEEEEEHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHCCCCEEEEECCCC
DEEEI
CCCCC
>Mature Secondary Structure 
AMNKQNNYSDDSIQVLEGLEAVRKRPGMYIGSTDKRGLHHLVYEIVDNSVDEVLNGYGN
CCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHCCHHHHHHCCCC
EIDVTINKDGSISIEDNGRGMPTGIHKSGKPTVEVIFTVLHAGGKFGQGGYKTSGGLHGV
EEEEEECCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCH
GASVVNALSEWLEVEIHRDGSIYHQSFKNGGSPSSGLVKKGKTKKTGTKVTFKPDDTIFK
HHHHHHHHHHHHEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEE
ASTSFNFDVLSERLQESAFLLKNLKITLNDLRSGKERQEHYHYEEGIKEFVSYVNEGKEV
ECCCCCHHHHHHHHHHHHHHHHHHHEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LHDVATFSGEANGIEVDVAFQYNDQYSESILSFVNNVRTKDGGTHEVGFKTAMTRVFNDY
HHHHHHHCCCCCCEEEEEEEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
ARRINELKTKDKNLDGNDIREGLTAVVSVRIPEELLQFEGQTKSKLGTSEARSAVDSVVA
HHHHHHHHHHCCCCCHHHHHHHHHHHEEEECCHHHHHCCCCCHHHCCHHHHHHHHHHHHH
DKLPFYLEEKGQLSKSLVKKAIKAQQAREAARKAREDARSGKKNKRKDTLLSGKLTPAQS
HHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCC
KNTEKNELYLVEGDSAGGSAKLGRDRKFQAILPLRGKVINTEKARLEDIFKNEEINTIIH
CCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCEEECCHHHHHHHHHCCCHHHHHHH
TIGAGVGTDFKIEDSNYNRVIIMTDADTDGAHIQVLLLTFFFKYMKPLVQAGRVFIALPP
HHCCCCCCCEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCC
LYKLEKGKGKTKRVEYAWTDEELNKLQKELGKGFTLQRYKGLGEMNPEQLWETTMNPETR
CHHHCCCCCCCEEEEEEECHHHHHHHHHHHCCCCEEHHHCCCCCCCHHHHHHHCCCCCCE
TLIRVQVEDEVRSSKRVTTLMGDKVQPRREWIEKHVEFGMQEDQSILDNSEVQVLENDQF
EEEEEEEHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHCCCCEEEEECCCC
DEEEI
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA