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The map label for this gene is dhoM

Identifier: 15926909

GI number: 15926909

Start: 1325492

End: 1326772

Strand: Direct

Name: dhoM

Synonym: SA1164

Alternate gene names: 15926909

Gene position: 1325492-1326772 (Clockwise)

Preceding gene: 15926907

Following gene: 15926910

Centisome position: 47.09

GC content: 32.47

Gene sequence:

>1281_bases
ATGAAAAAATTAAATATAGCATTATTAGGATTAGGTACTGTCGGATCTGGTGTTGTTAAAATCATCGAAGAGAACCGACA
GCAAATTCAAGATACATTAAATAAAGATATTGTCATAAAGCATATTCTTGTTCGAGATAAATCTAAAAAGAGACCGCTAA
ATATTAGCCAATATCATTTAACTGAAGATGTTAATGAAATTTTAAATGATGATTCATTAGATATTATCGTTGAAGTCATG
GGAGGAATTGAACCAACTGTAGATTGGTTAAGAACAGCACTTAAAAATAAAAAACATGTTATTACCGCAAATAAAGATTT
ATTAGCAGTACATCTTAAACTTTTAGAAGATTTAGCAGAAGAAAATGGTGTAGCTTTAAAGTTTGAAGCGAGTGTAGCAG
GTGGTATTCCGATCGTAAATGCCATAAATAATGGTTTGAATGCGAATAATATTTCAAAATTTATGGGAATTTTAAATGGT
ACCTCTAATTTTATTTTATCTAAAATGACTAAAGAGCAAACGACATTTGAGGAAGCACTTGATGAAGCGAAAAGACTTGG
TTTTGCTGAAGCGGATCCAACTGATGATGTAGAAGGGGTAGATGCAGCGCGTAAAGTTGTCATTACATCATATTTATCAT
TTAACCAAGTCATTAAATTAAACGACGTTAAACGAAGAGGAATTAGTGGCGTAACTTTAACTGATATTAATGTAGCCGAT
CAACTGGGGTATAAAATTAAATTGATTGGTAAGGGAATATATGAAAATGGCAAAGTTAATGCATCGGTAGAACCAACGTT
AATTGATAAAAAGCATCAATTAGCAGCTGTAGAGGATGAATATAACGCGATTTATGTTATTGGTGATGCCGTTGGTGACA
CGATGTTTTATGGAAAAGGAGCAGGCAGTTTAGCAACAGGTAGTGCCGTTGTCAGTGATTTATTGAATGTAGCATTATTC
TTTGAATCAGATTTACACACATTGCCACCACATTTTGAATTAAAGACAGATAAAACAAGGGAAATGATGGATTCAGATGC
AGAAATTAATATTAAAGAAAAATCCAATTTCTTTGTAGTAGTGAATCATGTCAAAGGTTCAATTGAAAATTTTGAAAATG
AGTTAAAGGCAATATTACCATTTCACCGATCATTAAGAGTTGCAAATTACGATAATCAATCATATGCCGCTGTTATAGTT
GGATTGGAATCATCACCGGAAGAATTAATCACTAAGCATGGATACGAAGTTGACAAAGTATACCCAGTAGAAGGAGTTTA
A

Upstream 100 bases:

>100_bases
AACTTTACAAAAATAAAGAATAATTCTATACTATACTATCATCTAGTGTTTTTCAATAATACATTTGTTTTTCTCAAAAG
CACAAACGGAGGTACATAAA

Downstream 100 bases:

>100_bases
TTATAATGAGAAGATGGCAAGGATTAGTAGAAGAGTTTAAAGCACATTTACCAGTAAATGAAAATACACCAAAATTAACA
TTGAACGAGGGAAATACACC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MKKLNIALLGLGTVGSGVVKIIEENRQQIQDTLNKDIVIKHILVRDKSKKRPLNISQYHLTEDVNEILNDDSLDIIVEVM
GGIEPTVDWLRTALKNKKHVITANKDLLAVHLKLLEDLAEENGVALKFEASVAGGIPIVNAINNGLNANNISKFMGILNG
TSNFILSKMTKEQTTFEEALDEAKRLGFAEADPTDDVEGVDAARKVVITSYLSFNQVIKLNDVKRRGISGVTLTDINVAD
QLGYKIKLIGKGIYENGKVNASVEPTLIDKKHQLAAVEDEYNAIYVIGDAVGDTMFYGKGAGSLATGSAVVSDLLNVALF
FESDLHTLPPHFELKTDKTREMMDSDAEINIKEKSNFFVVVNHVKGSIENFENELKAILPFHRSLRVANYDNQSYAAVIV
GLESSPEELITKHGYEVDKVYPVEGV

Sequences:

>Translated_426_residues
MKKLNIALLGLGTVGSGVVKIIEENRQQIQDTLNKDIVIKHILVRDKSKKRPLNISQYHLTEDVNEILNDDSLDIIVEVM
GGIEPTVDWLRTALKNKKHVITANKDLLAVHLKLLEDLAEENGVALKFEASVAGGIPIVNAINNGLNANNISKFMGILNG
TSNFILSKMTKEQTTFEEALDEAKRLGFAEADPTDDVEGVDAARKVVITSYLSFNQVIKLNDVKRRGISGVTLTDINVAD
QLGYKIKLIGKGIYENGKVNASVEPTLIDKKHQLAAVEDEYNAIYVIGDAVGDTMFYGKGAGSLATGSAVVSDLLNVALF
FESDLHTLPPHFELKTDKTREMMDSDAEINIKEKSNFFVVVNHVKGSIENFENELKAILPFHRSLRVANYDNQSYAAVIV
GLESSPEELITKHGYEVDKVYPVEGV
>Mature_426_residues
MKKLNIALLGLGTVGSGVVKIIEENRQQIQDTLNKDIVIKHILVRDKSKKRPLNISQYHLTEDVNEILNDDSLDIIVEVM
GGIEPTVDWLRTALKNKKHVITANKDLLAVHLKLLEDLAEENGVALKFEASVAGGIPIVNAINNGLNANNISKFMGILNG
TSNFILSKMTKEQTTFEEALDEAKRLGFAEADPTDDVEGVDAARKVVITSYLSFNQVIKLNDVKRRGISGVTLTDINVAD
QLGYKIKLIGKGIYENGKVNASVEPTLIDKKHQLAAVEDEYNAIYVIGDAVGDTMFYGKGAGSLATGSAVVSDLLNVALF
FESDLHTLPPHFELKTDKTREMMDSDAEINIKEKSNFFVVVNHVKGSIENFENELKAILPFHRSLRVANYDNQSYAAVIV
GLESSPEELITKHGYEVDKVYPVEGV

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=170, Percent_Identity=30.5882352941176, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322599, Length=238, Percent_Identity=26.4705882352941, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46874; Mature: 46874

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLNIALLGLGTVGSGVVKIIEENRQQIQDTLNKDIVIKHILVRDKSKKRPLNISQYHL
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHEEHHHHHCCCCCCCCCCCHHHHH
TEDVNEILNDDSLDIIVEVMGGIEPTVDWLRTALKNKKHVITANKDLLAVHLKLLEDLAE
HHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHH
ENGVALKFEASVAGGIPIVNAINNGLNANNISKFMGILNGTSNFILSKMTKEQTTFEEAL
CCCEEEEEECCCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
DEAKRLGFAEADPTDDVEGVDAARKVVITSYLSFNQVIKLNDVKRRGISGVTLTDINVAD
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECHHHHCCCCCEEEEECCHHH
QLGYKIKLIGKGIYENGKVNASVEPTLIDKKHQLAAVEDEYNAIYVIGDAVGDTMFYGKG
HCCCEEEEEECCCCCCCEECCCCCCCEECCCHHEEEEECCCCEEEEEECCCCCCEEECCC
AGSLATGSAVVSDLLNVALFFESDLHTLPPHFELKTDKTREMMDSDAEINIKEKSNFFVV
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHCCCCEEEEEECCCEEEE
VNHVKGSIENFENELKAILPFHRSLRVANYDNQSYAAVIVGLESSPEELITKHGYEVDKV
EECCCCCHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEEECCCCHHHHHHHCCCCCCEE
YPVEGV
ECCCCC
>Mature Secondary Structure
MKKLNIALLGLGTVGSGVVKIIEENRQQIQDTLNKDIVIKHILVRDKSKKRPLNISQYHL
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHEEHHHHHCCCCCCCCCCCHHHHH
TEDVNEILNDDSLDIIVEVMGGIEPTVDWLRTALKNKKHVITANKDLLAVHLKLLEDLAE
HHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHH
ENGVALKFEASVAGGIPIVNAINNGLNANNISKFMGILNGTSNFILSKMTKEQTTFEEAL
CCCEEEEEECCCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
DEAKRLGFAEADPTDDVEGVDAARKVVITSYLSFNQVIKLNDVKRRGISGVTLTDINVAD
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECHHHHCCCCCEEEEECCHHH
QLGYKIKLIGKGIYENGKVNASVEPTLIDKKHQLAAVEDEYNAIYVIGDAVGDTMFYGKG
HCCCEEEEEECCCCCCCEECCCCCCCEECCCHHEEEEECCCCEEEEEECCCCCCEEECCC
AGSLATGSAVVSDLLNVALFFESDLHTLPPHFELKTDKTREMMDSDAEINIKEKSNFFVV
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHCCCCEEEEEECCCEEEE
VNHVKGSIENFENELKAILPFHRSLRVANYDNQSYAAVIVGLESSPEELITKHGYEVDKV
EECCCCCHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEEECCCCHHHHHHHCCCCCCEE
YPVEGV
ECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3139660; 9384377; 3098560 [H]