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The map label for this gene is mutL

Identifier: 15926879

GI number: 15926879

Start: 1293659

End: 1295668

Strand: Direct

Name: mutL

Synonym: SA1138

Alternate gene names: 15926879

Gene position: 1293659-1295668 (Clockwise)

Preceding gene: 15926878

Following gene: 15926880

Centisome position: 45.96

GC content: 31.24

Gene sequence:

>2010_bases
ATGGGGAAAATTAAAGAACTCCAAACCTCATTAGCAAATAAAATCGCAGCAGGTGAAGTAGTTGAAAGACCGAGTTCTGT
TGTGAAAGAACTGTTGGAAAATGCTATAGATGCAGGCGCTACAGAAATAAGCATTGAAGTAGAGGAATCTGGCGTCCAAT
CTATTCGCGTAGTCGATAATGGAAGCGGAATTGAAGCGGAAGACTTAGGATTAGTATTTCATAGACATGCGACTAGTAAA
TTAGATCAAGATGAAGATTTATTTCATATTAGGACATTAGGATTCCGTGGTGAAGCACTAGCCAGTATTTCATCAGTTGC
TAAAGTAACATTGAAGACTTGCACGGATAATGCTAATGGAAATGAAATATATGTAGAAAATGGTGAAATATTAAATCATA
AGCCTGCAAAAGCGAAAAAAGGAACAGATATACTTGTAGAATCATTATTTTATAATACACCAGCACGTTTAAAATATATT
AAAAGTTTATACACTGAACTAGGTAAAATAACAGATATTGTCAATAGAATGGCTATGAGCCATCCGGACATTCGAATAGC
ACTCATTTCAGATGGCAAAACAATGTTAAGTACAAATGGTTCAGGACGAACTAATGAAGTGATGGCAGAGATTTATGGGA
TGAAAGTTGCACGAGATTTAGTACATATATCTGGAGATACAAGTGATTATCACATTGAAGGTTTTGTTGCAAAGCCTGAA
CATTCTAGAAGTAATAAGCACTATATTTCTATTTTTATTAATGGACGATACATTAAAAACTTTATGCTAAATAAAGCGAT
TTTAGAAGGCTATCATACACTCTTAACAATAGGTAGGTTCCCGATTTGTTATATTAATATTGAAATGGATCCAATCTTAG
TAGACGTAAATGTTCATCCAACAAAACTAGAAGTGCGTTTATCAAAAGAAGAGCAACTATATCAATTGATAGTGAGCAAA
ATACAAGAAGCATTTAAAGACCGTATATTAATTCCTAAAAATAACTTGGATTATGTGCCAAAAAAAAATAAAGTATTATA
TTCATTCGAACAACAAAAAATCGAATTTGAACAAAGACAAAACACAGAGAATAACCAAGAGAAGACGTTTTCATCTGAAG
AAAGTAACAGTAAGTCATTTATGGCAGAAAATCAAAACGATGAGATAGTTATAAAAGAAGATTCATATAATCCATTCGTA
ACGAAAACATCTGAAAGTTTAATAACTGATGATGAATCTTCTGGTTATAATAATACACGTGAAAAAGATGAAGACTACTT
CAAAAAACAACAAGAAATTTTACAAGAAATGGATCAAACATTTGATTCAAATGAGGATGCATCTGTGCAAAATTATGAGA
ATAAAGCGTCTGATGATTATTATGATGTAAACGATATTAAAGGAACAAAAAGTAAAGACCCTAAACGAAGAATTCCATAT
ATGGAAATTGTTGGCCAAGTACATGGGACGTATATTATTGCTCAAAATGAATTTGGCATGTACATGATTGACCAGCATGC
AGCTCAAGAAAGAATAAAATATGAATATTTTCGAGATAAAATAGGTGAAGTTACCAATGAAGTACAAGATTTATTAATCC
CGTTAACATTTCATTTTTCAAAGGATGAACAATTAGTTATTGATCAATATAAAAATGAGCTTCAACAAGTAGGTATCATG
TTAGAACATTTTGGTGGTCATGATTATATTGTAAGTAGCTATCCAGTTTGGTTCCCTAAAGATGAAGTAGAAGAAATCAT
TAAAGATATGATTGAGCTAATTTTGGAAGAGAAAAAAGTAGATATTAAAAAATTACGTGAAGATGTAGCAATCATGATGT
CATGTAAAAAATCTATTAAAGCGAATCATTATTTACAAAAACATGAAATGTCTGATTTAATTGATCAATTAAGAGAAGCG
GAAGATCCATTTACATGTCCACATGGTCGTCCAATAATCATTAATTTTTCAAAATACGAATTAGAAAAATTATTTAAGCG
TGTGATGTAG

Upstream 100 bases:

>100_bases
ACTACAAATTAAAAATTTGAATTTATCTAATATGACACCAATTGAGGCATTGGTGAAGTTAAGTGAATTACAAAATCAAT
TAAAATAGAGGTGTTGCAAA

Downstream 100 bases:

>100_bases
AGAGGATGAATCAAGTGAATAACAACATATTGCCTGCTATAAGAAACATTAAAGATTTAGAGAAACTGATTAAAACAGAT
TATAAAATGTGTGTGCTTCT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 669; Mature: 668

Protein sequence:

>669_residues
MGKIKELQTSLANKIAAGEVVERPSSVVKELLENAIDAGATEISIEVEESGVQSIRVVDNGSGIEAEDLGLVFHRHATSK
LDQDEDLFHIRTLGFRGEALASISSVAKVTLKTCTDNANGNEIYVENGEILNHKPAKAKKGTDILVESLFYNTPARLKYI
KSLYTELGKITDIVNRMAMSHPDIRIALISDGKTMLSTNGSGRTNEVMAEIYGMKVARDLVHISGDTSDYHIEGFVAKPE
HSRSNKHYISIFINGRYIKNFMLNKAILEGYHTLLTIGRFPICYINIEMDPILVDVNVHPTKLEVRLSKEEQLYQLIVSK
IQEAFKDRILIPKNNLDYVPKKNKVLYSFEQQKIEFEQRQNTENNQEKTFSSEESNSKSFMAENQNDEIVIKEDSYNPFV
TKTSESLITDDESSGYNNTREKDEDYFKKQQEILQEMDQTFDSNEDASVQNYENKASDDYYDVNDIKGTKSKDPKRRIPY
MEIVGQVHGTYIIAQNEFGMYMIDQHAAQERIKYEYFRDKIGEVTNEVQDLLIPLTFHFSKDEQLVIDQYKNELQQVGIM
LEHFGGHDYIVSSYPVWFPKDEVEEIIKDMIELILEEKKVDIKKLREDVAIMMSCKKSIKANHYLQKHEMSDLIDQLREA
EDPFTCPHGRPIIINFSKYELEKLFKRVM

Sequences:

>Translated_669_residues
MGKIKELQTSLANKIAAGEVVERPSSVVKELLENAIDAGATEISIEVEESGVQSIRVVDNGSGIEAEDLGLVFHRHATSK
LDQDEDLFHIRTLGFRGEALASISSVAKVTLKTCTDNANGNEIYVENGEILNHKPAKAKKGTDILVESLFYNTPARLKYI
KSLYTELGKITDIVNRMAMSHPDIRIALISDGKTMLSTNGSGRTNEVMAEIYGMKVARDLVHISGDTSDYHIEGFVAKPE
HSRSNKHYISIFINGRYIKNFMLNKAILEGYHTLLTIGRFPICYINIEMDPILVDVNVHPTKLEVRLSKEEQLYQLIVSK
IQEAFKDRILIPKNNLDYVPKKNKVLYSFEQQKIEFEQRQNTENNQEKTFSSEESNSKSFMAENQNDEIVIKEDSYNPFV
TKTSESLITDDESSGYNNTREKDEDYFKKQQEILQEMDQTFDSNEDASVQNYENKASDDYYDVNDIKGTKSKDPKRRIPY
MEIVGQVHGTYIIAQNEFGMYMIDQHAAQERIKYEYFRDKIGEVTNEVQDLLIPLTFHFSKDEQLVIDQYKNELQQVGIM
LEHFGGHDYIVSSYPVWFPKDEVEEIIKDMIELILEEKKVDIKKLREDVAIMMSCKKSIKANHYLQKHEMSDLIDQLREA
EDPFTCPHGRPIIINFSKYELEKLFKRVM
>Mature_668_residues
GKIKELQTSLANKIAAGEVVERPSSVVKELLENAIDAGATEISIEVEESGVQSIRVVDNGSGIEAEDLGLVFHRHATSKL
DQDEDLFHIRTLGFRGEALASISSVAKVTLKTCTDNANGNEIYVENGEILNHKPAKAKKGTDILVESLFYNTPARLKYIK
SLYTELGKITDIVNRMAMSHPDIRIALISDGKTMLSTNGSGRTNEVMAEIYGMKVARDLVHISGDTSDYHIEGFVAKPEH
SRSNKHYISIFINGRYIKNFMLNKAILEGYHTLLTIGRFPICYINIEMDPILVDVNVHPTKLEVRLSKEEQLYQLIVSKI
QEAFKDRILIPKNNLDYVPKKNKVLYSFEQQKIEFEQRQNTENNQEKTFSSEESNSKSFMAENQNDEIVIKEDSYNPFVT
KTSESLITDDESSGYNNTREKDEDYFKKQQEILQEMDQTFDSNEDASVQNYENKASDDYYDVNDIKGTKSKDPKRRIPYM
EIVGQVHGTYIIAQNEFGMYMIDQHAAQERIKYEYFRDKIGEVTNEVQDLLIPLTFHFSKDEQLVIDQYKNELQQVGIML
EHFGGHDYIVSSYPVWFPKDEVEEIIKDMIELILEEKKVDIKKLREDVAIMMSCKKSIKANHYLQKHEMSDLIDQLREAE
DPFTCPHGRPIIINFSKYELEKLFKRVM

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=337, Percent_Identity=38.2789317507418, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI4505913, Length=350, Percent_Identity=29.7142857142857, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI310128478, Length=350, Percent_Identity=29.7142857142857, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI4505911, Length=325, Percent_Identity=29.5384615384615, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI189458898, Length=325, Percent_Identity=29.5384615384615, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI189458896, Length=318, Percent_Identity=29.874213836478, Blast_Score=134, Evalue=4e-31,
Organism=Homo sapiens, GI310128480, Length=299, Percent_Identity=28.0936454849498, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI263191589, Length=241, Percent_Identity=34.0248962655602, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI91992160, Length=271, Percent_Identity=28.4132841328413, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI91992162, Length=271, Percent_Identity=28.4132841328413, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI310128482, Length=245, Percent_Identity=24.4897959183673, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI310128484, Length=261, Percent_Identity=23.7547892720307, Blast_Score=70, Evalue=9e-12,
Organism=Escherichia coli, GI1790612, Length=597, Percent_Identity=29.1457286432161, Blast_Score=228, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI71991825, Length=319, Percent_Identity=36.3636363636364, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17562796, Length=359, Percent_Identity=30.9192200557103, Blast_Score=149, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6323819, Length=333, Percent_Identity=39.3393393393393, Blast_Score=212, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6324247, Length=368, Percent_Identity=27.445652173913, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6325093, Length=286, Percent_Identity=24.4755244755245, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323063, Length=362, Percent_Identity=26.7955801104972, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17136968, Length=335, Percent_Identity=35.2238805970149, Blast_Score=201, Evalue=2e-51,
Organism=Drosophila melanogaster, GI17136970, Length=358, Percent_Identity=28.7709497206704, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_STAA1 (A7X1T8)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001441876.1
- ProteinModelPortal:   A7X1T8
- SMR:   A7X1T8
- STRING:   A7X1T8
- EnsemblBacteria:   EBSTAT00000004530
- GeneID:   5559791
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1286
- eggNOG:   COG0323
- GeneTree:   EBGT00050000025719
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- ProtClustDB:   PRK00095
- BioCyc:   SAUR418127:SAHV_1286-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 76872; Mature: 76741

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKIKELQTSLANKIAAGEVVERPSSVVKELLENAIDAGATEISIEVEESGVQSIRVVDN
CCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEEC
GSGIEAEDLGLVFHRHATSKLDQDEDLFHIRTLGFRGEALASISSVAKVTLKTCTDNANG
CCCCCHHHHHHEEEHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCC
NEIYVENGEILNHKPAKAKKGTDILVESLFYNTPARLKYIKSLYTELGKITDIVNRMAMS
CEEEEECCCEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
HPDIRIALISDGKTMLSTNGSGRTNEVMAEIYGMKVARDLVHISGDTSDYHIEGFVAKPE
CCCEEEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEEECCC
HSRSNKHYISIFINGRYIKNFMLNKAILEGYHTLLTIGRFPICYINIEMDPILVDVNVHP
CCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECEEEEEEECCC
TKLEVRLSKEEQLYQLIVSKIQEAFKDRILIPKNNLDYVPKKNKVLYSFEQQKIEFEQRQ
CEEEEEECCHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCCCEEEEEHHHHHHHHHHC
NTENNQEKTFSSEESNSKSFMAENQNDEIVIKEDSYNPFVTKTSESLITDDESSGYNNTR
CCCCCHHHCCCCCCCCCCCEEECCCCCEEEEEECCCCCCEECCCCHHCCCCCCCCCCCCC
EKDEDYFKKQQEILQEMDQTFDSNEDASVQNYENKASDDYYDVNDIKGTKSKDPKRRIPY
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCH
MEIVGQVHGTYIIAQNEFGMYMIDQHAAQERIKYEYFRDKIGEVTNEVQDLLIPLTFHFS
HHHHHHHCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEC
KDEQLVIDQYKNELQQVGIMLEHFGGHDYIVSSYPVWFPKDEVEEIIKDMIELILEEKKV
CCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCC
DIKKLREDVAIMMSCKKSIKANHYLQKHEMSDLIDQLREAEDPFTCPHGRPIIINFSKYE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHH
LEKLFKRVM
HHHHHHHCC
>Mature Secondary Structure 
GKIKELQTSLANKIAAGEVVERPSSVVKELLENAIDAGATEISIEVEESGVQSIRVVDN
CCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEEC
GSGIEAEDLGLVFHRHATSKLDQDEDLFHIRTLGFRGEALASISSVAKVTLKTCTDNANG
CCCCCHHHHHHEEEHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCC
NEIYVENGEILNHKPAKAKKGTDILVESLFYNTPARLKYIKSLYTELGKITDIVNRMAMS
CEEEEECCCEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
HPDIRIALISDGKTMLSTNGSGRTNEVMAEIYGMKVARDLVHISGDTSDYHIEGFVAKPE
CCCEEEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEEECCC
HSRSNKHYISIFINGRYIKNFMLNKAILEGYHTLLTIGRFPICYINIEMDPILVDVNVHP
CCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECEEEEEEECCC
TKLEVRLSKEEQLYQLIVSKIQEAFKDRILIPKNNLDYVPKKNKVLYSFEQQKIEFEQRQ
CEEEEEECCHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCCCEEEEEHHHHHHHHHHC
NTENNQEKTFSSEESNSKSFMAENQNDEIVIKEDSYNPFVTKTSESLITDDESSGYNNTR
CCCCCHHHCCCCCCCCCCCEEECCCCCEEEEEECCCCCCEECCCCHHCCCCCCCCCCCCC
EKDEDYFKKQQEILQEMDQTFDSNEDASVQNYENKASDDYYDVNDIKGTKSKDPKRRIPY
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCH
MEIVGQVHGTYIIAQNEFGMYMIDQHAAQERIKYEYFRDKIGEVTNEVQDLLIPLTFHFS
HHHHHHHCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEC
KDEQLVIDQYKNELQQVGIMLEHFGGHDYIVSSYPVWFPKDEVEEIIKDMIELILEEKKV
CCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCC
DIKKLREDVAIMMSCKKSIKANHYLQKHEMSDLIDQLREAEDPFTCPHGRPIIINFSKYE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHH
LEKLFKRVM
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA