Click here to switch to the map view.

The map label for this gene is cvfA

Identifier: 15926869

GI number: 15926869

Start: 1281967

End: 1283526

Strand: Direct

Name: cvfA

Synonym: SA1129

Alternate gene names: 15926869

Gene position: 1281967-1283526 (Clockwise)

Preceding gene: 15926868

Following gene: 15926871

Centisome position: 45.54

GC content: 35.9

Gene sequence:

>1560_bases
GTGAATTTATTAAGCCTCCTACTCATTTTGCTGGGGATCATTCTAGGAGTTGTTGGAGGGTATGTTGTTGCCCGAAATTT
GTTGCTTCAAAAGCAATCACAAGCTAGACAAACTGCCGAAGATATTGTAAATCAAGCACATAAAGAAGCTGACAATATCA
AAAAAGAGAAATTACTTGAGGCAAAAGAAGAAAACCAAATCCTAAGAGAACAAACTGAAGCAGAACTACGAGAAAGACGT
AGCGAACTTCAAAGACAAGAAACCCGACTTCTTCAAAAAGAAGAAAACTTAGAGCGCAAATCTGATCTATTAGATAAAAA
AGATGAGATTTTAGAGCAAAAAGAATCAAAAATTGAAGAAAAACAACAACAAGTAGATGCAAAAGAGAGTAGTGTTCAAA
CGTTAATAATGAAGCATGAACAAGAATTAGAACGCATCTCCGGTCTCACTCAAGAAGAAGCTATTAATGAGCAACTTCAA
AGAGTAGAGGAAGAACTGTCACAAGATATTGCAGTACTTGTTAAAGAAAAAGAAAAAGAAGCTAAAGAAAAAGTTGATAA
AACAGCAAAAGAATTATTAGCTACAGCAGTACAAAGATTAGCAGCAGATCACACAAGTGAATCAACGGTATCAGTAGTTA
ACTTACCTAATGATGAGATGAAAGGTCGAATCATTGGACGAGAAGGACGAAACATCCGCACACTTGAAACTTTAACTGGC
ATTGATTTAATTATTGATGACACACCAGAAGCGGTTATATTATCTGGTTTTGATCCAATAAGAAGAGAAATTGCTAGAAC
AGCACTTGTTAACTTAGTATCTGATGGACGTATTCATCCAGGTAGAATTGAAGATATGGTCGAAAAAGCTAGAAAAGAAG
TAGACGATATTATTAGAGAAGCAGGTGAACAAGCTACATTTGAAGTGAACGCACATAATATGCATCCTGACTTAGTAAAA
ATTGTAGGGCGTTTAAACTATCGTACGAGTTACGGTCAAAATGTACTTAAACATTCAATTGAAGTTGCGCATCTTGCTAG
TATGTTAGCTGCTGAGCTAGGCGAAGATGAGACATTAGCGAAACGAGCTGGACTTTTACATGATGTTGGTAAAGCAATTG
ATCATGAAGTAGAAGGTAGTCATGTTGAAATCGGTGTAGAATTAGCGAAAAAATATGGTGAAAATGAAACAGTTATTAAT
GCAATCCATTCTCACCATGGTGATGTTGAACCTACATCTATTATATCTATCCTTGTTGCTGCTGCAGATGCATTGTCTGC
GGCTCGTCCAGGTGCAAGAAAAGAAACATTAGAGAATTATATTCGTCGATTAGAACGTTTAGAAACGTTATCAGAAAGTT
ATGATGGTGTAGAAAAAGCATTTGCGATTCAGGCAGGTAGAGAAATCCGAGTGATTGTATCTCCTGAAGAAATTGATGAT
TTAAAATCTTATCGATTGGCTAGAGATATTAAAAATCAGATTGAAGATGAATTACAATATCCTGGTCATATCAAGGTGAC
AGTTGTTCGAGAGACTAGAGCAGTAGAATATGCGAAATAA

Upstream 100 bases:

>100_bases
CCTATAAACCGTACAATTAATTTGTATGATTTATATATAATTTCATAAAGTCATATTGAATTTCATATAAAGAGCAAACC
CTAGAAAAGGAGGTGTTTGT

Downstream 100 bases:

>100_bases
TTTTTGTCTCCCTCACAAATTAGTGAGGGAGCTTTTTTAAGTTGTAGTCTCAATCTAATTAGACAGCACTTTATCGGTAA
TAACTATAGTAAACAGTGGT

Product: phosphodiesterase

Products: NA

Alternate protein names: Conserved virulence factor A

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MNLLSLLLILLGIILGVVGGYVVARNLLLQKQSQARQTAEDIVNQAHKEADNIKKEKLLEAKEENQILREQTEAELRERR
SELQRQETRLLQKEENLERKSDLLDKKDEILEQKESKIEEKQQQVDAKESSVQTLIMKHEQELERISGLTQEEAINEQLQ
RVEEELSQDIAVLVKEKEKEAKEKVDKTAKELLATAVQRLAADHTSESTVSVVNLPNDEMKGRIIGREGRNIRTLETLTG
IDLIIDDTPEAVILSGFDPIRREIARTALVNLVSDGRIHPGRIEDMVEKARKEVDDIIREAGEQATFEVNAHNMHPDLVK
IVGRLNYRTSYGQNVLKHSIEVAHLASMLAAELGEDETLAKRAGLLHDVGKAIDHEVEGSHVEIGVELAKKYGENETVIN
AIHSHHGDVEPTSIISILVAAADALSAARPGARKETLENYIRRLERLETLSESYDGVEKAFAIQAGREIRVIVSPEEIDD
LKSYRLARDIKNQIEDELQYPGHIKVTVVRETRAVEYAK

Sequences:

>Translated_519_residues
MNLLSLLLILLGIILGVVGGYVVARNLLLQKQSQARQTAEDIVNQAHKEADNIKKEKLLEAKEENQILREQTEAELRERR
SELQRQETRLLQKEENLERKSDLLDKKDEILEQKESKIEEKQQQVDAKESSVQTLIMKHEQELERISGLTQEEAINEQLQ
RVEEELSQDIAVLVKEKEKEAKEKVDKTAKELLATAVQRLAADHTSESTVSVVNLPNDEMKGRIIGREGRNIRTLETLTG
IDLIIDDTPEAVILSGFDPIRREIARTALVNLVSDGRIHPGRIEDMVEKARKEVDDIIREAGEQATFEVNAHNMHPDLVK
IVGRLNYRTSYGQNVLKHSIEVAHLASMLAAELGEDETLAKRAGLLHDVGKAIDHEVEGSHVEIGVELAKKYGENETVIN
AIHSHHGDVEPTSIISILVAAADALSAARPGARKETLENYIRRLERLETLSESYDGVEKAFAIQAGREIRVIVSPEEIDD
LKSYRLARDIKNQIEDELQYPGHIKVTVVRETRAVEYAK
>Mature_519_residues
MNLLSLLLILLGIILGVVGGYVVARNLLLQKQSQARQTAEDIVNQAHKEADNIKKEKLLEAKEENQILREQTEAELRERR
SELQRQETRLLQKEENLERKSDLLDKKDEILEQKESKIEEKQQQVDAKESSVQTLIMKHEQELERISGLTQEEAINEQLQ
RVEEELSQDIAVLVKEKEKEAKEKVDKTAKELLATAVQRLAADHTSESTVSVVNLPNDEMKGRIIGREGRNIRTLETLTG
IDLIIDDTPEAVILSGFDPIRREIARTALVNLVSDGRIHPGRIEDMVEKARKEVDDIIREAGEQATFEVNAHNMHPDLVK
IVGRLNYRTSYGQNVLKHSIEVAHLASMLAAELGEDETLAKRAGLLHDVGKAIDHEVEGSHVEIGVELAKKYGENETVIN
AIHSHHGDVEPTSIISILVAAADALSAARPGARKETLENYIRRLERLETLSESYDGVEKAFAIQAGREIRVIVSPEEIDD
LKSYRLARDIKNQIEDELQYPGHIKVTVVRETRAVEYAK

Specific function: Catalyzes the hydrolysis of both 2',3'-cyclic AMP and 2',3'-cyclic GMP into 3'-AMP and 3'-GMP, respectively, at the 3'- terminal of RNA. Activates sarZ and agr operon resulting in the expression of virulence genes such as hemolysin, DNase and protease

COG id: COG1418

COG function: function code R; Predicted HD superfamily hydrolase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CNPD_STAA1 (A7X1S5)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001441866.1
- ProteinModelPortal:   A7X1S5
- SMR:   A7X1S5
- STRING:   A7X1S5
- EnsemblBacteria:   EBSTAT00000004687
- GeneID:   5559637
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1276
- eggNOG:   COG1418
- GeneTree:   EBGT00050000024681
- HOGENOM:   HBG734610
- OMA:   HPGRIEE
- ProtClustDB:   PRK12704
- BioCyc:   SAUR418127:SAHV_1276-MONOMER
- GO:   GO:0009405
- HAMAP:   MF_00335
- InterPro:   IPR017705
- InterPro:   IPR022711
- InterPro:   IPR004087
- InterPro:   IPR004088
- InterPro:   IPR018111
- InterPro:   IPR003607
- InterPro:   IPR006675
- SMART:   SM00471
- SMART:   SM00322
- TIGRFAMs:   TIGR00277
- TIGRFAMs:   TIGR03319

Pfam domain/function: PF12072 DUF3552; PF00013 KH_1

EC number: =3.1.4.16

Molecular weight: Translated: 58513; Mature: 58513

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS50084 KH_TYPE_1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xc103380)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLSLLLILLGIILGVVGGYVVARNLLLQKQSQARQTAEDIVNQAHKEADNIKKEKLLE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKEENQILREQTEAELRERRSELQRQETRLLQKEENLERKSDLLDKKDEILEQKESKIEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
KQQQVDAKESSVQTLIMKHEQELERISGLTQEEAINEQLQRVEEELSQDIAVLVKEKEKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKEKVDKTAKELLATAVQRLAADHTSESTVSVVNLPNDEMKGRIIGREGRNIRTLETLTG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHCCCEECCCCCCCCHHHHHCC
IDLIIDDTPEAVILSGFDPIRREIARTALVNLVSDGRIHPGRIEDMVEKARKEVDDIIRE
CEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
AGEQATFEVNAHNMHPDLVKIVGRLNYRTSYGQNVLKHSIEVAHLASMLAAELGEDETLA
CCCCCEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
KRAGLLHDVGKAIDHEVEGSHVEIGVELAKKYGENETVINAIHSHHGDVEPTSIISILVA
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHH
AADALSAARPGARKETLENYIRRLERLETLSESYDGVEKAFAIQAGREIRVIVSPEEIDD
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHH
LKSYRLARDIKNQIEDELQYPGHIKVTVVRETRAVEYAK
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEECHHHHCCCH
>Mature Secondary Structure
MNLLSLLLILLGIILGVVGGYVVARNLLLQKQSQARQTAEDIVNQAHKEADNIKKEKLLE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKEENQILREQTEAELRERRSELQRQETRLLQKEENLERKSDLLDKKDEILEQKESKIEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
KQQQVDAKESSVQTLIMKHEQELERISGLTQEEAINEQLQRVEEELSQDIAVLVKEKEKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKEKVDKTAKELLATAVQRLAADHTSESTVSVVNLPNDEMKGRIIGREGRNIRTLETLTG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHCCCEECCCCCCCCHHHHHCC
IDLIIDDTPEAVILSGFDPIRREIARTALVNLVSDGRIHPGRIEDMVEKARKEVDDIIRE
CEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
AGEQATFEVNAHNMHPDLVKIVGRLNYRTSYGQNVLKHSIEVAHLASMLAAELGEDETLA
CCCCCEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
KRAGLLHDVGKAIDHEVEGSHVEIGVELAKKYGENETVINAIHSHHGDVEPTSIISILVA
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHH
AADALSAARPGARKETLENYIRRLERLETLSESYDGVEKAFAIQAGREIRVIVSPEEIDD
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHH
LKSYRLARDIKNQIEDELQYPGHIKVTVVRETRAVEYAK
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEECHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA