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The map label for this gene is uppS

Identifier: 15926843

GI number: 15926843

Start: 1248834

End: 1249604

Strand: Direct

Name: uppS

Synonym: SA1103

Alternate gene names: 15926843

Gene position: 1248834-1249604 (Clockwise)

Preceding gene: 15926842

Following gene: 15926844

Centisome position: 44.37

GC content: 29.96

Gene sequence:

>771_bases
ATGTTTAAAAAGCTAATAAATAAAAAGAACACTATAAATAATTATAATGAAGAATTAGACTCGTCTAATATACCTGAACA
TATCGCTATTATTATGGATGGTAATGGGCGATGGGCTAAGAAGCGAAAAATGCCTAGAATTAAAGGCCATTACGAAGGTA
TGCAAACAATAAAAAAAATTACTAGGATAGCTAGTGATATTGGTGTTAAGTACTTAACTTTATATGCCTTTTCCACTGAA
AATTGGTCAAGACCTGAAAGTGAAGTAAATTATATTATGAATTTGCCTGTCAATTTCTTAAAGACATTCTTACCGGAACT
AATTGAAAAAAATGTCAAAGTTGAAACAATTGGATTTACTGATAAGTTGCCAAAATCAACGATAGAAGCAATTAATAATG
CTAAAGAAAAGACAGCTAATAATACCGGCTTAAAATTAATATTTGCAATTAATTATGGTGGCAGAGCAGAACTTGTTCAT
AGTATTAAAAATATGTTTGACGAGCTTCATCAACAAGGTTTAAATAGTGATATCATAGATGAAACATATATAAACAATCA
TTTAATGACAAAAGACTATCCTGATCCAGAGTTGTTAATTCGTACTTCAGGAGAACAAAGAATAAGTAATTTCTTGATTT
GGCAAGTTTCGTATAGTGAATTTATCTTTAATCAAAAATTATGGCCTGACTTTGACGAAGATGAATTAATTAAATGTATA
AAAATTTATCAGTCACGTCAAAGACGCTTTGGCGGATTGAGTGAGGAGTAG

Upstream 100 bases:

>100_bases
ATTTGCTTATTCAATGCATTAAATGAGTATGATAAAATGATAATGATTGTTTAGTAACTTATATTATATGACAGAGATGA
TCAGGCTCGGAGGAAAGACC

Downstream 100 bases:

>100_bases
TATAGTATGAAAGTTAGAACGCTGACAGCTATTATTGCCTTAATCGTATTCTTGCCTATCTTGTTAAAAGGCGGCCTTGT
GTTAATGATATTTGCTAATA

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MFKKLINKKNTINNYNEELDSSNIPEHIAIIMDGNGRWAKKRKMPRIKGHYEGMQTIKKITRIASDIGVKYLTLYAFSTE
NWSRPESEVNYIMNLPVNFLKTFLPELIEKNVKVETIGFTDKLPKSTIEAINNAKEKTANNTGLKLIFAINYGGRAELVH
SIKNMFDELHQQGLNSDIIDETYINNHLMTKDYPDPELLIRTSGEQRISNFLIWQVSYSEFIFNQKLWPDFDEDELIKCI
KIYQSRQRRFGGLSEE

Sequences:

>Translated_256_residues
MFKKLINKKNTINNYNEELDSSNIPEHIAIIMDGNGRWAKKRKMPRIKGHYEGMQTIKKITRIASDIGVKYLTLYAFSTE
NWSRPESEVNYIMNLPVNFLKTFLPELIEKNVKVETIGFTDKLPKSTIEAINNAKEKTANNTGLKLIFAINYGGRAELVH
SIKNMFDELHQQGLNSDIIDETYINNHLMTKDYPDPELLIRTSGEQRISNFLIWQVSYSEFIFNQKLWPDFDEDELIKCI
KIYQSRQRRFGGLSEE
>Mature_256_residues
MFKKLINKKNTINNYNEELDSSNIPEHIAIIMDGNGRWAKKRKMPRIKGHYEGMQTIKKITRIASDIGVKYLTLYAFSTE
NWSRPESEVNYIMNLPVNFLKTFLPELIEKNVKVETIGFTDKLPKSTIEAINNAKEKTANNTGLKLIFAINYGGRAELVH
SIKNMFDELHQQGLNSDIIDETYINNHLMTKDYPDPELLIRTSGEQRISNFLIWQVSYSEFIFNQKLWPDFDEDELIKCI
KIYQSRQRRFGGLSEE

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=34.8214285714286, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=34.8214285714286, Blast_Score=139, Evalue=2e-33,
Organism=Escherichia coli, GI1786371, Length=226, Percent_Identity=43.3628318584071, Blast_Score=208, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI71993029, Length=229, Percent_Identity=34.061135371179, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319474, Length=229, Percent_Identity=37.117903930131, Blast_Score=128, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=214, Percent_Identity=33.1775700934579, Blast_Score=114, Evalue=1e-26,
Organism=Drosophila melanogaster, GI18857969, Length=224, Percent_Identity=33.0357142857143, Blast_Score=134, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29863; Mature: 29863

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKLINKKNTINNYNEELDSSNIPEHIAIIMDGNGRWAKKRKMPRIKGHYEGMQTIKKI
CCHHHHCCCCCCCHHHHHCCCCCCCCEEEEEECCCCCCHHHHCCCCHHHHHHHHHHHHHH
TRIASDIGVKYLTLYAFSTENWSRPESEVNYIMNLPVNFLKTFLPELIEKNVKVETIGFT
HHHHHHHCCEEEEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCC
DKLPKSTIEAINNAKEKTANNTGLKLIFAINYGGRAELVHSIKNMFDELHQQGLNSDIID
CCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
ETYINNHLMTKDYPDPELLIRTSGEQRISNFLIWQVSYSEFIFNQKLWPDFDEDELIKCI
HHHHCCCCCCCCCCCCCEEEECCCHHHHHHEEEEEEEHHHHHHCCCCCCCCCHHHHHHHH
KIYQSRQRRFGGLSEE
HHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFKKLINKKNTINNYNEELDSSNIPEHIAIIMDGNGRWAKKRKMPRIKGHYEGMQTIKKI
CCHHHHCCCCCCCHHHHHCCCCCCCCEEEEEECCCCCCHHHHCCCCHHHHHHHHHHHHHH
TRIASDIGVKYLTLYAFSTENWSRPESEVNYIMNLPVNFLKTFLPELIEKNVKVETIGFT
HHHHHHHCCEEEEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCC
DKLPKSTIEAINNAKEKTANNTGLKLIFAINYGGRAELVHSIKNMFDELHQQGLNSDIID
CCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
ETYINNHLMTKDYPDPELLIRTSGEQRISNFLIWQVSYSEFIFNQKLWPDFDEDELIKCI
HHHHCCCCCCCCCCCCCEEEECCCHHHHHHEEEEEEEHHHHHHCCCCCCCCCHHHHHHHH
KIYQSRQRRFGGLSEE
HHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA