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The map label for this gene is hslU

Identifier: 15926837

GI number: 15926837

Start: 1242651

End: 1244054

Strand: Direct

Name: hslU

Synonym: SA1097

Alternate gene names: 15926837

Gene position: 1242651-1244054 (Clockwise)

Preceding gene: 15926836

Following gene: 15926838

Centisome position: 44.15

GC content: 34.9

Gene sequence:

>1404_bases
ATGGATACAGCTGGAATAAGATTAACTCCAAAAGAAATCGTATCTAAATTAAATGAATATATCGTTGGACAAAATGATGC
TAAACGTAAAGTGGCAATTGCCCTACGTAATCGATACAGAAGAAGTTTATTAGATGAGGAATCAAAGCAAGAAATTTCAC
CTAAAAATATTTTGATGATTGGACCAACCGGCGTTGGTAAAACTGAAATTGCAAGAAGAATGGCCAAAGTTGTCGGCGCG
CCATTTATAAAAGTAGAAGCTACTAAATTTACTGAGCTAGGTTATGTAGGACGAGATGTTGAAAGTATGGTTAGAGATCT
TGTTGATGTTTCAGTAAGATTAGTCAAGGCGCAGAAAAAATCATTGGTACAAGATGAAGCAACAGCTAAGGCCAATGAAA
AACTTGTTAAGTTATTAGTTCCAAGTATGAAAAAGAAAGCGTCTCAAACGAATAATCCTTTAGAGTCACTTTTCGGAGGT
GCAATTCCAAATTTCGGACAAAATAACGAAGATGAAGAAGAACCACCTACTGAGGAAATTAAAACAAAACGTTCTGAAAT
TAAGAGACAGCTAGAAGAAGGCAAACTTGAAAAAGAAAAGGTAAGAATTAAAGTCGAACAAGATCCTGGTGCTTTAGGTA
TGCTAGGTACAAATCAAAATCAGCAAATGCAAGAGATGATGAATCAATTAATGCCTAAAAAGAAAGTTGAGCGAGAAGTT
GCTGTTGAGACGGCAAGGAAAATCTTAGCTGATAGTTATGCGGATGAACTAATTGATCAAGAAAGCGCTAACCAAGAAGC
GCTTGAATTAGCAGAACAAATGGGTATCATCTTTATAGATGAAATCGACAAAGTTGCGACGAATAATCATAATAGTGGTC
AAGATGTCTCAAGACAAGGTGTTCAAAGAGATATTTTACCTATACTTGAAGGTAGCGTTATTCAAACCAAATATGGTACT
GTGAATACTGAACATATGCTGTTTATAGGTGCTGGAGCTTTCCATGTATCTAAGCCGAGTGACTTGATACCAGAATTGCA
AGGTCGTTTTCCGATTAGAGTTGAACTTGATAGTTTATCGGTAGAAGATTTTGTAAGAATTTTGACAGAACCAAAATTGT
CATTAATTAAACAATATGAAGCATTGCTTCAAACAGAAGAAGTTACTGTAAACTTTACCGATGAAGCAATTACTCGCTTA
GCTGAGATTGCTTATCAAGTAAATCAAGATACAGACAACATTGGTGCACGTCGACTTCATACAATTTTAGAAAAGATGCT
AGAAGATTTATCATTCGAAGCACCAAGTATGCCGAATGCAGTTGTAGATATTACCCCACAATATGTTGATGATAAATTAA
AATCAATTTCAACAAATAAAGATTTAAGTGCATTTATTCTATAA

Upstream 100 bases:

>100_bases
TTACCAACGATAATATTGTTGTTGAAACACTATAATAATCAGAGCACGATAAATAATTACGACCAATTAATTTTAGTTAA
AAGACGGAGGAATGAAATTA

Downstream 100 bases:

>100_bases
AAATATACAAAAGGAGAAAAATTCATGAGCTTATTATCTAAAACGAGAGAGTTAAACACGTTACTTCAAAAACACAAAGG
TATTGCGGTTGATTTTAAAG

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MDTAGIRLTPKEIVSKLNEYIVGQNDAKRKVAIALRNRYRRSLLDEESKQEISPKNILMIGPTGVGKTEIARRMAKVVGA
PFIKVEATKFTELGYVGRDVESMVRDLVDVSVRLVKAQKKSLVQDEATAKANEKLVKLLVPSMKKKASQTNNPLESLFGG
AIPNFGQNNEDEEEPPTEEIKTKRSEIKRQLEEGKLEKEKVRIKVEQDPGALGMLGTNQNQQMQEMMNQLMPKKKVEREV
AVETARKILADSYADELIDQESANQEALELAEQMGIIFIDEIDKVATNNHNSGQDVSRQGVQRDILPILEGSVIQTKYGT
VNTEHMLFIGAGAFHVSKPSDLIPELQGRFPIRVELDSLSVEDFVRILTEPKLSLIKQYEALLQTEEVTVNFTDEAITRL
AEIAYQVNQDTDNIGARRLHTILEKMLEDLSFEAPSMPNAVVDITPQYVDDKLKSISTNKDLSAFIL

Sequences:

>Translated_467_residues
MDTAGIRLTPKEIVSKLNEYIVGQNDAKRKVAIALRNRYRRSLLDEESKQEISPKNILMIGPTGVGKTEIARRMAKVVGA
PFIKVEATKFTELGYVGRDVESMVRDLVDVSVRLVKAQKKSLVQDEATAKANEKLVKLLVPSMKKKASQTNNPLESLFGG
AIPNFGQNNEDEEEPPTEEIKTKRSEIKRQLEEGKLEKEKVRIKVEQDPGALGMLGTNQNQQMQEMMNQLMPKKKVEREV
AVETARKILADSYADELIDQESANQEALELAEQMGIIFIDEIDKVATNNHNSGQDVSRQGVQRDILPILEGSVIQTKYGT
VNTEHMLFIGAGAFHVSKPSDLIPELQGRFPIRVELDSLSVEDFVRILTEPKLSLIKQYEALLQTEEVTVNFTDEAITRL
AEIAYQVNQDTDNIGARRLHTILEKMLEDLSFEAPSMPNAVVDITPQYVDDKLKSISTNKDLSAFIL
>Mature_467_residues
MDTAGIRLTPKEIVSKLNEYIVGQNDAKRKVAIALRNRYRRSLLDEESKQEISPKNILMIGPTGVGKTEIARRMAKVVGA
PFIKVEATKFTELGYVGRDVESMVRDLVDVSVRLVKAQKKSLVQDEATAKANEKLVKLLVPSMKKKASQTNNPLESLFGG
AIPNFGQNNEDEEEPPTEEIKTKRSEIKRQLEEGKLEKEKVRIKVEQDPGALGMLGTNQNQQMQEMMNQLMPKKKVEREV
AVETARKILADSYADELIDQESANQEALELAEQMGIIFIDEIDKVATNNHNSGQDVSRQGVQRDILPILEGSVIQTKYGT
VNTEHMLFIGAGAFHVSKPSDLIPELQGRFPIRVELDSLSVEDFVRILTEPKLSLIKQYEALLQTEEVTVNFTDEAITRL
AEIAYQVNQDTDNIGARRLHTILEKMLEDLSFEAPSMPNAVVDITPQYVDDKLKSISTNKDLSAFIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily

Homologues:

Organism=Homo sapiens, GI7242140, Length=111, Percent_Identity=36.036036036036, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1790366, Length=464, Percent_Identity=46.7672413793103, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1786642, Length=219, Percent_Identity=33.3333333333333, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71988663, Length=258, Percent_Identity=27.906976744186, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319704, Length=169, Percent_Identity=28.9940828402367, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648291, Length=243, Percent_Identity=30.0411522633745, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24648289, Length=243, Percent_Identity=30.0411522633745, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HSLU_STAA1 (A7X1N1)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001441834.1
- ProteinModelPortal:   A7X1N1
- SMR:   A7X1N1
- STRING:   A7X1N1
- EnsemblBacteria:   EBSTAT00000003940
- GeneID:   5560054
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1244
- eggNOG:   COG1220
- GeneTree:   EBGT00050000023657
- HOGENOM:   HBG745965
- OMA:   EASKFTE
- ProtClustDB:   PRK05201
- BioCyc:   SAUR418127:SAHV_1244-MONOMER
- HAMAP:   MF_00249
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491
- PANTHER:   PTHR11262:SF3
- SMART:   SM00382
- TIGRFAMs:   TIGR00390

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small

EC number: NA

Molecular weight: Translated: 52330; Mature: 52330

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: BINDING 22-22 BINDING 280-280 BINDING 345-345 BINDING 417-417

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTAGIRLTPKEIVSKLNEYIVGQNDAKRKVAIALRNRYRRSLLDEESKQEISPKNILMI
CCCCCCEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCEEEE
GPTGVGKTEIARRMAKVVGAPFIKVEATKFTELGYVGRDVESMVRDLVDVSVRLVKAQKK
CCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
SLVQDEATAKANEKLVKLLVPSMKKKASQTNNPLESLFGGAIPNFGQNNEDEEEPPTEEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHH
KTKRSEIKRQLEEGKLEKEKVRIKVEQDPGALGMLGTNQNQQMQEMMNQLMPKKKVEREV
HHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEECCCCCCHHHHHHHHHHCCHHHHHHHH
AVETARKILADSYADELIDQESANQEALELAEQMGIIFIDEIDKVATNNHNSGQDVSRQG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEECHHHHHCCCCCCCCHHHHHH
VQRDILPILEGSVIQTKYGTVNTEHMLFIGAGAFHVSKPSDLIPELQGRFPIRVELDSLS
HHHHHHHHHCCCEEEEECCCCCCCEEEEEECCEEECCCCHHHHHHHCCCCCEEEEECCCC
VEDFVRILTEPKLSLIKQYEALLQTEEVTVNFTDEAITRLAEIAYQVNQDTDNIGARRLH
HHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHH
TILEKMLEDLSFEAPSMPNAVVDITPQYVDDKLKSISTNKDLSAFIL
HHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHCCCCCCCHHHCC
>Mature Secondary Structure
MDTAGIRLTPKEIVSKLNEYIVGQNDAKRKVAIALRNRYRRSLLDEESKQEISPKNILMI
CCCCCCEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCEEEE
GPTGVGKTEIARRMAKVVGAPFIKVEATKFTELGYVGRDVESMVRDLVDVSVRLVKAQKK
CCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
SLVQDEATAKANEKLVKLLVPSMKKKASQTNNPLESLFGGAIPNFGQNNEDEEEPPTEEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHH
KTKRSEIKRQLEEGKLEKEKVRIKVEQDPGALGMLGTNQNQQMQEMMNQLMPKKKVEREV
HHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEECCCCCCHHHHHHHHHHCCHHHHHHHH
AVETARKILADSYADELIDQESANQEALELAEQMGIIFIDEIDKVATNNHNSGQDVSRQG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEECHHHHHCCCCCCCCHHHHHH
VQRDILPILEGSVIQTKYGTVNTEHMLFIGAGAFHVSKPSDLIPELQGRFPIRVELDSLS
HHHHHHHHHCCCEEEEECCCCCCCEEEEEECCEEECCCCHHHHHHHCCCCCEEEEECCCC
VEDFVRILTEPKLSLIKQYEALLQTEEVTVNFTDEAITRLAEIAYQVNQDTDNIGARRLH
HHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHH
TILEKMLEDLSFEAPSMPNAVVDITPQYVDDKLKSISTNKDLSAFIL
HHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA