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The map label for this gene is pyrE

Identifier: 15926788

GI number: 15926788

Start: 1187106

End: 1187717

Strand: Direct

Name: pyrE

Synonym: SA1048

Alternate gene names: 15926788

Gene position: 1187106-1187717 (Clockwise)

Preceding gene: 15926787

Following gene: 15926789

Centisome position: 42.17

GC content: 33.01

Gene sequence:

>612_bases
ATGGCTAAAGAAATTGCAAAATCATTATTAGATATTGAAGCTGTAACATTATCACCAAATGATTTATATACATGGAGTTC
AGGTATTAAATCACCGATTTACTGTGATAACCGTGTTACGTTAGGTTATCCTTTAGTTCGAGGCGCAATCCGCGATGGTT
TAATTAACTTAATTAAAGAACACTTTCCTGAAGTAGAAGTTATTTCTGGTACTGCAACAGCTGGTATTCCACATGCAGCT
TTTATTGCTGAAAAATTAAAATTACCAATGAATTATGTTCGTTCATCAAATAAGAGTCATGGTAAGCAAAATCAAATCGA
AGGTGCTAAAAGTGAAGGTAAAAAAGTAGTTGTGATAGAAGATTTAATTTCGACAGGGGGATCTTCAGTCACAGCAGTTG
AAGCCTTAAAACAAGCAGGTGCAGAAGTATTAGGTGTTGTAGCTATCTTTACTTACGGTTTGAAAAAAGCAGATGATACA
TTTAGCAATATTCAACTACCTTTTTACACTTTAAGTGATTACAATGAATTAATTGAAGTAGCTGAAAATGAAGGTAAAAT
TTCTAGTGAAGATATCCAAACATTAGTTGAATGGAGAGACAACTTAGCATAA

Upstream 100 bases:

>100_bases
GACAGCTTGGTTCGACGCATATTGTAGTCGGTAGACCGATTACACAAAGTGACAATCCAGTCGAAAGTTATCATAAAATT
AAAGAAAGTTGGTTAGTATA

Downstream 100 bases:

>100_bases
TATAGACACTAGAAGGAGGAATTCAACAAATGAATGACAAAACATCTAATGATTTATATGGGAAGATAAAACATTGTAAC
GAATTTATCAATCATTCAAA

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 203; Mature: 202

Protein sequence:

>203_residues
MAKEIAKSLLDIEAVTLSPNDLYTWSSGIKSPIYCDNRVTLGYPLVRGAIRDGLINLIKEHFPEVEVISGTATAGIPHAA
FIAEKLKLPMNYVRSSNKSHGKQNQIEGAKSEGKKVVVIEDLISTGGSSVTAVEALKQAGAEVLGVVAIFTYGLKKADDT
FSNIQLPFYTLSDYNELIEVAENEGKISSEDIQTLVEWRDNLA

Sequences:

>Translated_203_residues
MAKEIAKSLLDIEAVTLSPNDLYTWSSGIKSPIYCDNRVTLGYPLVRGAIRDGLINLIKEHFPEVEVISGTATAGIPHAA
FIAEKLKLPMNYVRSSNKSHGKQNQIEGAKSEGKKVVVIEDLISTGGSSVTAVEALKQAGAEVLGVVAIFTYGLKKADDT
FSNIQLPFYTLSDYNELIEVAENEGKISSEDIQTLVEWRDNLA
>Mature_202_residues
AKEIAKSLLDIEAVTLSPNDLYTWSSGIKSPIYCDNRVTLGYPLVRGAIRDGLINLIKEHFPEVEVISGTATAGIPHAAF
IAEKLKLPMNYVRSSNKSHGKQNQIEGAKSEGKKVVVIEDLISTGGSSVTAVEALKQAGAEVLGVVAIFTYGLKKADDTF
SNIQLPFYTLSDYNELIEVAENEGKISSEDIQTLVEWRDNLA

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=188, Percent_Identity=21.8085106382979, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 22057; Mature: 21926

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00626 RCC1_2 ; PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKEIAKSLLDIEAVTLSPNDLYTWSSGIKSPIYCDNRVTLGYPLVRGAIRDGLINLIKE
CHHHHHHHHHHHHEEEECCCCCEECCCCCCCCCEECCEEEECHHHHHHHHHHHHHHHHHH
HFPEVEVISGTATAGIPHAAFIAEKLKLPMNYVRSSNKSHGKQNQIEGAKSEGKKVVVIE
HCCCEEEECCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCCHHHCCCHHCCCCEEEEEH
DLISTGGSSVTAVEALKQAGAEVLGVVAIFTYGLKKADDTFSNIQLPFYTLSDYNELIEV
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCEEEEEEHHHHHHHHHH
AENEGKISSEDIQTLVEWRDNLA
HHCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKEIAKSLLDIEAVTLSPNDLYTWSSGIKSPIYCDNRVTLGYPLVRGAIRDGLINLIKE
HHHHHHHHHHHHEEEECCCCCEECCCCCCCCCEECCEEEECHHHHHHHHHHHHHHHHHH
HFPEVEVISGTATAGIPHAAFIAEKLKLPMNYVRSSNKSHGKQNQIEGAKSEGKKVVVIE
HCCCEEEECCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCCHHHCCCHHCCCCEEEEEH
DLISTGGSSVTAVEALKQAGAEVLGVVAIFTYGLKKADDTFSNIQLPFYTLSDYNELIEV
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCEEEEEEHHHHHHHHHH
AENEGKISSEDIQTLVEWRDNLA
HHCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA