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The map label for this gene is pyrC

Identifier: 15926784

GI number: 15926784

Start: 1180762

End: 1182036

Strand: Direct

Name: pyrC

Synonym: SA1044

Alternate gene names: 15926784

Gene position: 1180762-1182036 (Clockwise)

Preceding gene: 15926783

Following gene: 15926785

Centisome position: 41.95

GC content: 35.92

Gene sequence:

>1275_bases
ATGAAATTAATTAAAAACGGTAAAGTATTACAAAATGGAGAATTACAACAAGCAGATATTTTAATTGATGGTAAGGTAAT
TAAACAAATTGCACCTGCAATTGAACCAAGCAATGGTGTTGACATCATAGATGCGAAAGGTCACTTTGTGTCACCTGGAT
TTGTCGATGTTCATGTTCATTTACGTGAACCTGGTGGTGAATATAAAGAGACAATTGAAACTGGTACTAAAGCTGCTGCT
AGAGGCGGATTTACAACTGTATGTCCAATGCCTAACACAAGACCGGTACCAGATTCTGTAGAACATTTTGAAGCTTTACA
AAAATTAATCGATGACAATGCTCAAGTACGTGTATTACCTTATGCTTCAATTACAACACGTCAATTAGGTAAAGAATTGG
TTGATTTCCCAGCACTAGTAAAAGAAGGTGCCTTTGCGTTTACAGATGACGGTGTAGGAGTACAAACTGCAAGCATGATG
TATGAAGGCATGATTGAAGCTGCAAAAGTAAACAAAGCCATCGTAGCACACTGTGAAGATAATTCATTAATCTATGGTGG
TGCAATGCATGAAGGGAAACGCAGTAAAGAGTTAGGTATACCAGGTATTCCAAACATTTGTGAATCTGTTCAAATCGCAA
GAGATGTACTATTAGCTGAAGCAGCAGGTTGTCATTATCATGTATGTCATGTTTCTACTAAAGAAAGTGTTAGAGTCATT
CGTGACGCTAAACGCGCAGGCATTCATGTTACAGCTGAAGTTACACCACACCATTTATTGTTAACAGAAGATGATATTCC
TGGTAATAATGCCATTTATAAAATGAATCCACCATTGAGAAGTACTGAAGATAGAGAGGCTTTGTTAGAAGGGTTACTAG
ACGGTACAATTGACTGTATCGCAACAGACCATGCACCACATGCACGTGATGAAAAAGCACAACCAATGGAAAAAGCACCA
TTCGGAATTGTTGGTAGTGAAACAGCATTCCCATTATTATATACGCATTTTGTAAAAAATGGTGATTGGACATTACAACA
ATTAGTAGATTACTTAACAATTAAACCATGTGAGACATTTAATTTAGAATACGGCACATTAAAAGAAAATGGTTATGCAG
ATTTAACAATCATTGATTTAGATAGTGAACAAGAAATTAAAGGAGAAGATTTCTTATCAAAAGCAGATAATACACCATTT
ATCGGCTATAAAGTTTATGGAAATCCGATCTTAACAATGGTTGAAGGCGAAGTTAAATTTGAGGGGGATAAATAA

Upstream 100 bases:

>100_bases
AAGCTTCAAAATCAAGAATTTTTAAGCAAATGGAAAATGGCGTTTACTTAAGAATGGCAGTCATTGATGAATTATTAAAA
TAGGTAAGGGGACGAAAATG

Downstream 100 bases:

>100_bases
TATGCAAAGCAAACGTTATCTAGTGTTAGAAGACGGTTCTTTTTACGAAGGCTACCGTTTAGGATCTGATAACTTAACTG
TAGGAGAAATTGTATTTAAT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MKLIKNGKVLQNGELQQADILIDGKVIKQIAPAIEPSNGVDIIDAKGHFVSPGFVDVHVHLREPGGEYKETIETGTKAAA
RGGFTTVCPMPNTRPVPDSVEHFEALQKLIDDNAQVRVLPYASITTRQLGKELVDFPALVKEGAFAFTDDGVGVQTASMM
YEGMIEAAKVNKAIVAHCEDNSLIYGGAMHEGKRSKELGIPGIPNICESVQIARDVLLAEAAGCHYHVCHVSTKESVRVI
RDAKRAGIHVTAEVTPHHLLLTEDDIPGNNAIYKMNPPLRSTEDREALLEGLLDGTIDCIATDHAPHARDEKAQPMEKAP
FGIVGSETAFPLLYTHFVKNGDWTLQQLVDYLTIKPCETFNLEYGTLKENGYADLTIIDLDSEQEIKGEDFLSKADNTPF
IGYKVYGNPILTMVEGEVKFEGDK

Sequences:

>Translated_424_residues
MKLIKNGKVLQNGELQQADILIDGKVIKQIAPAIEPSNGVDIIDAKGHFVSPGFVDVHVHLREPGGEYKETIETGTKAAA
RGGFTTVCPMPNTRPVPDSVEHFEALQKLIDDNAQVRVLPYASITTRQLGKELVDFPALVKEGAFAFTDDGVGVQTASMM
YEGMIEAAKVNKAIVAHCEDNSLIYGGAMHEGKRSKELGIPGIPNICESVQIARDVLLAEAAGCHYHVCHVSTKESVRVI
RDAKRAGIHVTAEVTPHHLLLTEDDIPGNNAIYKMNPPLRSTEDREALLEGLLDGTIDCIATDHAPHARDEKAQPMEKAP
FGIVGSETAFPLLYTHFVKNGDWTLQQLVDYLTIKPCETFNLEYGTLKENGYADLTIIDLDSEQEIKGEDFLSKADNTPF
IGYKVYGNPILTMVEGEVKFEGDK
>Mature_424_residues
MKLIKNGKVLQNGELQQADILIDGKVIKQIAPAIEPSNGVDIIDAKGHFVSPGFVDVHVHLREPGGEYKETIETGTKAAA
RGGFTTVCPMPNTRPVPDSVEHFEALQKLIDDNAQVRVLPYASITTRQLGKELVDFPALVKEGAFAFTDDGVGVQTASMM
YEGMIEAAKVNKAIVAHCEDNSLIYGGAMHEGKRSKELGIPGIPNICESVQIARDVLLAEAAGCHYHVCHVSTKESVRVI
RDAKRAGIHVTAEVTPHHLLLTEDDIPGNNAIYKMNPPLRSTEDREALLEGLLDGTIDCIATDHAPHARDEKAQPMEKAP
FGIVGSETAFPLLYTHFVKNGDWTLQQLVDYLTIKPCETFNLEYGTLKENGYADLTIIDLDSEQEIKGEDFLSKADNTPF
IGYKVYGNPILTMVEGEVKFEGDK

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI18105007, Length=414, Percent_Identity=32.3671497584541, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4503375, Length=449, Percent_Identity=25.1670378619154, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI4503051, Length=445, Percent_Identity=24.4943820224719, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI62422571, Length=445, Percent_Identity=24.4943820224719, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI19923821, Length=448, Percent_Identity=25.4464285714286, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4503377, Length=445, Percent_Identity=24.7191011235955, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4503379, Length=443, Percent_Identity=23.4762979683973, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI190194363, Length=457, Percent_Identity=25.382932166302, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1786722, Length=433, Percent_Identity=29.3302540415704, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI87082175, Length=443, Percent_Identity=27.5395033860045, Blast_Score=132, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI193204318, Length=382, Percent_Identity=32.1989528795811, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17539558, Length=441, Percent_Identity=24.7165532879819, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71989490, Length=448, Percent_Identity=23.8839285714286, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI86575075, Length=442, Percent_Identity=23.3031674208145, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322218, Length=396, Percent_Identity=27.2727272727273, Blast_Score=117, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24642586, Length=372, Percent_Identity=34.6774193548387, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI17137462, Length=443, Percent_Identity=22.7990970654628, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI221377917, Length=457, Percent_Identity=22.5382932166302, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRC_STAAC (Q5HGN1)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_186076.1
- ProteinModelPortal:   Q5HGN1
- SMR:   Q5HGN1
- STRING:   Q5HGN1
- EnsemblBacteria:   EBSTAT00000010926
- GeneID:   3237656
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL1213
- TIGR:   SACOL1213
- eggNOG:   COG0044
- GeneTree:   EBGT00050000025365
- HOGENOM:   HBG724623
- OMA:   PRVAEES
- ProtClustDB:   PRK09357
- BioCyc:   SAUR93062:SACOL1213-MONOMER
- HAMAP:   MF_00220_B
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059
- TIGRFAMs:   TIGR00857

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.3

Molecular weight: Translated: 46372; Mature: 46372

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIKNGKVLQNGELQQADILIDGKVIKQIAPAIEPSNGVDIIDAKGHFVSPGFVDVHVH
CCCCCCCCEEECCCCCEEEEEECHHHHHHHHHCCCCCCCCEEEECCCCEECCCEEEEEEE
LREPGGEYKETIETGTKAAARGGFTTVCPMPNTRPVPDSVEHFEALQKLIDDNAQVRVLP
EECCCCHHHHHHHHCCHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEE
YASITTRQLGKELVDFPALVKEGAFAFTDDGVGVQTASMMYEGMIEAAKVNKAIVAHCED
CCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEECC
NSLIYGGAMHEGKRSKELGIPGIPNICESVQIARDVLLAEAAGCHYHVCHVSTKESVRVI
CCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHH
RDAKRAGIHVTAEVTPHHLLLTEDDIPGNNAIYKMNPPLRSTEDREALLEGLLDGTIDCI
HHHHHCCEEEEEEECCCEEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEE
ATDHAPHARDEKAQPMEKAPFGIVGSETAFPLLYTHFVKNGDWTLQQLVDYLTIKPCETF
EECCCCCCCCCCCCCHHHCCCCEECCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCC
NLEYGTLKENGYADLTIIDLDSEQEIKGEDFLSKADNTPFIGYKVYGNPILTMVEGEVKF
CCEECCCCCCCCEEEEEEECCCCCCCCCHHHHHHCCCCCEEEEEEECCEEEEEEECEEEE
EGDK
CCCC
>Mature Secondary Structure
MKLIKNGKVLQNGELQQADILIDGKVIKQIAPAIEPSNGVDIIDAKGHFVSPGFVDVHVH
CCCCCCCCEEECCCCCEEEEEECHHHHHHHHHCCCCCCCCEEEECCCCEECCCEEEEEEE
LREPGGEYKETIETGTKAAARGGFTTVCPMPNTRPVPDSVEHFEALQKLIDDNAQVRVLP
EECCCCHHHHHHHHCCHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEE
YASITTRQLGKELVDFPALVKEGAFAFTDDGVGVQTASMMYEGMIEAAKVNKAIVAHCED
CCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEECC
NSLIYGGAMHEGKRSKELGIPGIPNICESVQIARDVLLAEAAGCHYHVCHVSTKESVRVI
CCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHH
RDAKRAGIHVTAEVTPHHLLLTEDDIPGNNAIYKMNPPLRSTEDREALLEGLLDGTIDCI
HHHHHCCEEEEEEECCCEEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEE
ATDHAPHARDEKAQPMEKAPFGIVGSETAFPLLYTHFVKNGDWTLQQLVDYLTIKPCETF
EECCCCCCCCCCCCCHHHCCCCEECCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCC
NLEYGTLKENGYADLTIIDLDSEQEIKGEDFLSKADNTPFIGYKVYGNPILTMVEGEVKF
CCEECCCCCCCCEEEEEEECCCCCCCCCHHHHHHCCCCCEEEEEEECCEEEEEEECEEEE
EGDK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA