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The map label for this gene is isdE

Identifier: 15926717

GI number: 15926717

Start: 1109815

End: 1110693

Strand: Direct

Name: isdE

Synonym: SA0980

Alternate gene names: 15926717

Gene position: 1109815-1110693 (Clockwise)

Preceding gene: 15926716

Following gene: 15926718

Centisome position: 39.43

GC content: 30.94

Gene sequence:

>879_bases
TTGAGAATCATAAAGTATTTAACCATTTTAGTGATAAGCGTCGTTATCTTAACCAGCTGTCAATCTTCCAGTTCTCAAGA
ATCAACTAAATCCGGCGAATTCAGAATCGTACCAACAACTGTTGCATTGACAATGACATTGGACAAATTGGATTTACCAA
TTGTCGGCAAACCCACGTCATATAAGACATTGCCTAATCGTTATAAAGATGTACCGGAAATTGGTCAACCAATGGAGCCG
AATGTTGAAGCTGTTAAAAAGTTAAAACCAACACATGTTTTGAGTGTGTCAACGATTAAAGATGAAATGCAACCATTTTA
CAAACAATTAAATATGAAAGGCTACTTTTATGATTTTGATAGTTTAAAAGGGATGCAAAAGTCGATTACACAATTAGGTG
ATCAATTTAATCGTAAAGCACAAGCAAAAGAATTAAATGACCATTTAAATTCTGTAAAGCAAAAAATTGAAAATAAAGCA
GCTAAACAAAAGAAACATCCCAAAGTATTAATATTAATGGGTGTACCGGGTAGCTATTTAGTAGCAACTGATAAATCATA
TATTGGTGATTTAGTTAAAATAGCAGGTGGAGAAAATGTTATTAAAGTGAAAGATCGTCAATATATTTCGTCTAATACTG
AAAATTTGTTGAATATCAATCCAGATATTATTTTACGATTACCACACGGAATGCCTGAAGAAGTTAAGAAAATGTTTCAA
AAAGAATTTAAACAAAATGATATTTGGAAACATTTTAAAGCTGTGAAAAATAATCATGTTTATGACTTAGAGGAAGTGCC
ATTCGGTATTACAGCAAATGTTGATGCTGATAAGGCAATGACTCAATTATATGATTTATTTTATAAGGATAAAAAATAG

Upstream 100 bases:

>100_bases
ATCATAAAAAGCAATATATGTTATTTGCAGCTGGCATTGTGTTAGCAACTATTTTACTTATTTCGGCACATTTATACAGC
AGAAAGAGAGGTAACCAAGT

Downstream 100 bases:

>100_bases
TGAGTTGATATGATGATAAAAAATAAAAAGAAACTACTATTTTTATGTTTGTTAGTCATTTTAATCGCAACTGCTTATAT
TTCGTTTGTAACCGGTACAA

Product: hypothetical protein

Products: NA

Alternate protein names: Iron-regulated surface determinant protein E; Staphylococcal iron-regulated protein F

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MRIIKYLTILVISVVILTSCQSSSSQESTKSGEFRIVPTTVALTMTLDKLDLPIVGKPTSYKTLPNRYKDVPEIGQPMEP
NVEAVKKLKPTHVLSVSTIKDEMQPFYKQLNMKGYFYDFDSLKGMQKSITQLGDQFNRKAQAKELNDHLNSVKQKIENKA
AKQKKHPKVLILMGVPGSYLVATDKSYIGDLVKIAGGENVIKVKDRQYISSNTENLLNINPDIILRLPHGMPEEVKKMFQ
KEFKQNDIWKHFKAVKNNHVYDLEEVPFGITANVDADKAMTQLYDLFYKDKK

Sequences:

>Translated_292_residues
MRIIKYLTILVISVVILTSCQSSSSQESTKSGEFRIVPTTVALTMTLDKLDLPIVGKPTSYKTLPNRYKDVPEIGQPMEP
NVEAVKKLKPTHVLSVSTIKDEMQPFYKQLNMKGYFYDFDSLKGMQKSITQLGDQFNRKAQAKELNDHLNSVKQKIENKA
AKQKKHPKVLILMGVPGSYLVATDKSYIGDLVKIAGGENVIKVKDRQYISSNTENLLNINPDIILRLPHGMPEEVKKMFQ
KEFKQNDIWKHFKAVKNNHVYDLEEVPFGITANVDADKAMTQLYDLFYKDKK
>Mature_292_residues
MRIIKYLTILVISVVILTSCQSSSSQESTKSGEFRIVPTTVALTMTLDKLDLPIVGKPTSYKTLPNRYKDVPEIGQPMEP
NVEAVKKLKPTHVLSVSTIKDEMQPFYKQLNMKGYFYDFDSLKGMQKSITQLGDQFNRKAQAKELNDHLNSVKQKIENKA
AKQKKHPKVLILMGVPGSYLVATDKSYIGDLVKIAGGENVIKVKDRQYISSNTENLLNINPDIILRLPHGMPEEVKKMFQ
KEFKQNDIWKHFKAVKNNHVYDLEEVPFGITANVDADKAMTQLYDLFYKDKK

Specific function: Involved in heme (porphyrin) scavenging. Binds Fe(2+) and Fe(3+) heme but the largest fraction is Fe(2+) heme. Functions as a high-affinity heme binding protein and probably has a role in relaying heme-iron from cell wall-anchored isd proteins receptors t

COG id: COG0614

COG function: function code P; ABC-type Fe3+-hydroxamate transport system, periplasmic component

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Fe/B12 periplasmic-binding domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISDE_STAA1 (A7X153)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001441714.1
- ProteinModelPortal:   A7X153
- SMR:   A7X153
- STRING:   A7X153
- EnsemblBacteria:   EBSTAT00000003398
- GeneID:   5560692
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1124
- eggNOG:   COG0614
- GeneTree:   EBGT00050000023814
- HOGENOM:   HBG306131
- OMA:   RYKGLPE
- ProtClustDB:   CLSK2297812
- BioCyc:   SAUR418127:SAHV_1124-MONOMER
- InterPro:   IPR019957
- InterPro:   IPR002491
- TIGRFAMs:   TIGR03659

Pfam domain/function: PF01497 Peripla_BP_2

EC number: NA

Molecular weight: Translated: 33271; Mature: 33271

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS50983 FE_B12_PBP; PS51257 PROKAR_LIPOPROTEIN; PS00013 PROKAR_LIPOPROTEIN

Important sites: BINDING 41-41 BINDING 42-42 BINDING 60-60 BINDING 61-61

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIIKYLTILVISVVILTSCQSSSSQESTKSGEFRIVPTTVALTMTLDKLDLPIVGKPTS
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEEEEEEHHCCCCCCCCCCC
YKTLPNRYKDVPEIGQPMEPNVEAVKKLKPTHVLSVSTIKDEMQPFYKQLNMKGYFYDFD
CCCCCHHHCCCHHHCCCCCCCHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCCEEEEHH
SLKGMQKSITQLGDQFNRKAQAKELNDHLNSVKQKIENKAAKQKKHPKVLILMGVPGSYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEE
VATDKSYIGDLVKIAGGENVIKVKDRQYISSNTENLLNINPDIILRLPHGMPEEVKKMFQ
EEECHHHHHHHHHHCCCCCEEEECCCHHHHCCCCCEEECCCCEEEECCCCCCHHHHHHHH
KEFKQNDIWKHFKAVKNNHVYDLEEVPFGITANVDADKAMTQLYDLFYKDKK
HHHHHHHHHHHHHHHHCCCCEEHHHCCCCEEECCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRIIKYLTILVISVVILTSCQSSSSQESTKSGEFRIVPTTVALTMTLDKLDLPIVGKPTS
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEEEEEEHHCCCCCCCCCCC
YKTLPNRYKDVPEIGQPMEPNVEAVKKLKPTHVLSVSTIKDEMQPFYKQLNMKGYFYDFD
CCCCCHHHCCCHHHCCCCCCCHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCCEEEEHH
SLKGMQKSITQLGDQFNRKAQAKELNDHLNSVKQKIENKAAKQKKHPKVLILMGVPGSYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEE
VATDKSYIGDLVKIAGGENVIKVKDRQYISSNTENLLNINPDIILRLPHGMPEEVKKMFQ
EEECHHHHHHHHHHCCCCCEEEECCCHHHHCCCCCEEECCCCEEEECCCCCCHHHHHHHH
KEFKQNDIWKHFKAVKNNHVYDLEEVPFGITANVDADKAMTQLYDLFYKDKK
HHHHHHHHHHHHHHHHCCCCEEHHHCCCCEEECCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA