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The map label for this gene is ctaB

Identifier: 15926701

GI number: 15926701

Start: 1096182

End: 1097096

Strand: Direct

Name: ctaB

Synonym: SA0965

Alternate gene names: 15926701

Gene position: 1096182-1097096 (Clockwise)

Preceding gene: 15926699

Following gene: 15926702

Centisome position: 38.94

GC content: 31.91

Gene sequence:

>915_bases
ATTATGAGCAAAGAGCATACTTTGTCACAAAATATTAGCAGAGTTAACTTCAAAGAATTGCAACAGATAATTAAAATGGG
ACTTGTTCAAGGTAACTTAATTCCGGCTTTTGCGGGCGCATGGCTAGCAGTTGTAATGACAAATCATTCCTTCTTATCAT
CAATACCTCAAATTTTATTAATGCTATTTGGATCTACTTTAATTATGGGTGGCGCATGTGCGTTAAATAATTATTACGAC
CAAGATATTGATCGTATTATGCCTAGTAAACAAAATAGACCAACTGTAAATAATAGAATTACAGATCAAAATTTATTACT
ATTAAGTTTTGGTATGATGTTAGTTGGAGAAATTTGTTTGTTTTTATTGAATATACCATCAGGCGTACTTGGTCTTATGG
GGATTGTAGGTTATGTGTCTTATTACTCAATATGGTCTAAAAGACATACAACATGGAACACAGTGATTGGGAGTTTTCCT
GGAGCAGTACCACCACTAATTGGATGGGTTGCAATTGAAGGACAAATTAGTTTAACAGCGATTGCGCTGTTTTTAGTTGT
ATTTTGTTGGCAACCAATTCATTTTTATGCCTTAGCTATTAAACGTAAAGATGAATATGCACTTGCAAATATTCCAATGT
TACCATCAGTTAAAGGCTTTAAACGTACACGTGTCAGTATGTTTATCTGGTTGATTATTTTATTGCCAGTACCTTTATTA
CTAATAAATTTAGGTGTCGTATTCGTAGTGTTAGCTACATTATTAAATTTAGGATGGATTGCATTAGGTTTAACAACATT
TAAGAAAAATTCAGATCAAACAAAATGGGCAACACAAATGTTTATATATTCACTAAATTATTTAGTGATCTTTTTCGTGT
TAGCTGTAATTGTTTCATTACTTACTTTGATCTAG

Upstream 100 bases:

>100_bases
TCTCTTGTCGTTAATTTGTCACATTTTAATTTTATTAAACCTAGTCTTTTTATGCAATCTAAGATATCATAATCTTATAT
GAACAAATTTAAGGAGGGGG

Downstream 100 bases:

>100_bases
ATTAATTAAGTTAGGATGAAAAATATGGGCGTTCCAATTTTACCAACGATTAGTACGACATGTATTGTCATTAGTGCAAT
TTTAATTGCCATTGGTTGGA

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MMSKEHTLSQNISRVNFKELQQIIKMGLVQGNLIPAFAGAWLAVVMTNHSFLSSIPQILLMLFGSTLIMGGACALNNYYD
QDIDRIMPSKQNRPTVNNRITDQNLLLLSFGMMLVGEICLFLLNIPSGVLGLMGIVGYVSYYSIWSKRHTTWNTVIGSFP
GAVPPLIGWVAIEGQISLTAIALFLVVFCWQPIHFYALAIKRKDEYALANIPMLPSVKGFKRTRVSMFIWLIILLPVPLL
LINLGVVFVVLATLLNLGWIALGLTTFKKNSDQTKWATQMFIYSLNYLVIFFVLAVIVSLLTLI

Sequences:

>Translated_304_residues
MMSKEHTLSQNISRVNFKELQQIIKMGLVQGNLIPAFAGAWLAVVMTNHSFLSSIPQILLMLFGSTLIMGGACALNNYYD
QDIDRIMPSKQNRPTVNNRITDQNLLLLSFGMMLVGEICLFLLNIPSGVLGLMGIVGYVSYYSIWSKRHTTWNTVIGSFP
GAVPPLIGWVAIEGQISLTAIALFLVVFCWQPIHFYALAIKRKDEYALANIPMLPSVKGFKRTRVSMFIWLIILLPVPLL
LINLGVVFVVLATLLNLGWIALGLTTFKKNSDQTKWATQMFIYSLNYLVIFFVLAVIVSLLTLI
>Mature_304_residues
MMSKEHTLSQNISRVNFKELQQIIKMGLVQGNLIPAFAGAWLAVVMTNHSFLSSIPQILLMLFGSTLIMGGACALNNYYD
QDIDRIMPSKQNRPTVNNRITDQNLLLLSFGMMLVGEICLFLLNIPSGVLGLMGIVGYVSYYSIWSKRHTTWNTVIGSFP
GAVPPLIGWVAIEGQISLTAIALFLVVFCWQPIHFYALAIKRKDEYALANIPMLPSVKGFKRTRVSMFIWLIILLPVPLL
LINLGVVFVVLATLLNLGWIALGLTTFKKNSDQTKWATQMFIYSLNYLVIFFVLAVIVSLLTLI

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=162, Percent_Identity=30.8641975308642, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1786631, Length=274, Percent_Identity=34.6715328467153, Blast_Score=147, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6325085, Length=188, Percent_Identity=28.7234042553192, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921064, Length=237, Percent_Identity=26.1603375527426, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 33990; Mature: 33990

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSKEHTLSQNISRVNFKELQQIIKMGLVQGNLIPAFAGAWLAVVMTNHSFLSSIPQILL
CCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHH
MLFGSTLIMGGACALNNYYDQDIDRIMPSKQNRPTVNNRITDQNLLLLSFGMMLVGEICL
HHHHHHHHHCCHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
FLLNIPSGVLGLMGIVGYVSYYSIWSKRHTTWNTVIGSFPGAVPPLIGWVAIEGQISLTA
HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHEECCCHHHHH
IALFLVVFCWQPIHFYALAIKRKDEYALANIPMLPSVKGFKRTRVSMFIWLIILLPVPLL
HHHHHHHHHHHHHHHHHHHHHCCCCHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LINLGVVFVVLATLLNLGWIALGLTTFKKNSDQTKWATQMFIYSLNYLVIFFVLAVIVSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTLI
HHHC
>Mature Secondary Structure
MMSKEHTLSQNISRVNFKELQQIIKMGLVQGNLIPAFAGAWLAVVMTNHSFLSSIPQILL
CCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHH
MLFGSTLIMGGACALNNYYDQDIDRIMPSKQNRPTVNNRITDQNLLLLSFGMMLVGEICL
HHHHHHHHHCCHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
FLLNIPSGVLGLMGIVGYVSYYSIWSKRHTTWNTVIGSFPGAVPPLIGWVAIEGQISLTA
HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHEECCCHHHHH
IALFLVVFCWQPIHFYALAIKRKDEYALANIPMLPSVKGFKRTRVSMFIWLIILLPVPLL
HHHHHHHHHHHHHHHHHHHHHCCCCHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LINLGVVFVVLATLLNLGWIALGLTTFKKNSDQTKWATQMFIYSLNYLVIFFVLAVIVSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTLI
HHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA