Click here to switch to the map view.

The map label for this gene is saeS

Identifier: 15926382

GI number: 15926382

Start: 755280

End: 756335

Strand: Reverse

Name: saeS

Synonym: SA0660

Alternate gene names: 15926382

Gene position: 756335-755280 (Counterclockwise)

Preceding gene: 15926383

Following gene: 15926371

Centisome position: 26.87

GC content: 30.49

Gene sequence:

>1056_bases
ATGGTGTTATCAATTAGAAGTCAAATCATTATTGGCGTCGTTTCGAGTATACTATTAACTTCAACTATTTTAGCAATTGC
ATATATTTTAATGTGGTTTAACGGCCATATGACACTAACTTTGACCTTAACGACAATAATTACAAGCTGTTTAACCTTAT
TAATATGTAGTATTTTTATTAATCCACTTATACAAAAAATTAAGCAGTTTAATATAAAAACTAAGCAATTTGCTAACGGA
AATTACGCAAGCAATGATAAAACGTTTAATTCACCAAAAGAAATTTATGAATTAAATCAATCTTTTAATAAAATGGCTTC
TGAAATTACGCAACAAATGAATCAAATTAAATCCGAACAACAAGAAAAAACAGAACTGATTCAAAACTTAGCCCATGATT
TAAAAACACCTTTAGCAAGCATTATTTCATATTCTGAAGGACTACGTGATGGTATAATCACAAAGGATCATGAGATTAAA
GAGTCATACGACATATTAATTAAACAAGCAAACAGATTATCAACATTATTTGATGATATGACTCATATTATCACTTTAAA
TACAGGTAAAACATATCCCCCAGAATTAATACAACTAGACCAATTACTTGTATCAATATTGCAACCATATGAGCAACGTA
TCAAACATGAAAACCGCACATTAGAAGTGAATTTCTGTAGCGAAATTGATGCATTTTATCAATATCGAACGCCACTTGAG
CGTATTTTAACAAACTTACTTGATAATGCGCTAAAATTTTCAAATGTTGGTAGTCGCATTGATATTAATATTAGTGAAAA
CAAAGATCAAGATACTATCGACATTGCTATTAGCGATGAAGGTATTGGCATTATACCAGAACTACAAGAACGTATATTCG
AACGTACATTCAGAGTAGAAAACTCTCGTAATACAAAAACGGGTGGTTCTGGATTAGGCTTATATATAGCTAATGAACTC
GCGCAACAAAATAACGCAAAAATCAGTGTAAGCAGTGATATAGATGTAGGAACTACGATGACTGTAACATTACACAAATT
AGACATTACGTCATAA

Upstream 100 bases:

>100_bases
ATATACACCGTATTAGAGAAAAATTAGAAAAAGAGAGCTTTACAACATATACCATCACAACTGTATGGGGATTAGGATAT
AAATTTGAAAGGAGCCGATA

Downstream 100 bases:

>100_bases
TCCGATTTATTTATAAAATAAAATGCAAAGACTAAAAAGAAGCTCCCATTAATGAGGGCTTCTTTTTTTGTTTATTTAGA
ATAAACTTTATGGGTATCCT

Product: histidine protein kinase

Products: NA

Alternate protein names: Sensor protein saeS; Staphylococcus exoprotein expression protein S [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MVLSIRSQIIIGVVSSILLTSTILAIAYILMWFNGHMTLTLTLTTIITSCLTLLICSIFINPLIQKIKQFNIKTKQFANG
NYASNDKTFNSPKEIYELNQSFNKMASEITQQMNQIKSEQQEKTELIQNLAHDLKTPLASIISYSEGLRDGIITKDHEIK
ESYDILIKQANRLSTLFDDMTHIITLNTGKTYPPELIQLDQLLVSILQPYEQRIKHENRTLEVNFCSEIDAFYQYRTPLE
RILTNLLDNALKFSNVGSRIDINISENKDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLYIANEL
AQQNNAKISVSSDIDVGTTMTVTLHKLDITS

Sequences:

>Translated_351_residues
MVLSIRSQIIIGVVSSILLTSTILAIAYILMWFNGHMTLTLTLTTIITSCLTLLICSIFINPLIQKIKQFNIKTKQFANG
NYASNDKTFNSPKEIYELNQSFNKMASEITQQMNQIKSEQQEKTELIQNLAHDLKTPLASIISYSEGLRDGIITKDHEIK
ESYDILIKQANRLSTLFDDMTHIITLNTGKTYPPELIQLDQLLVSILQPYEQRIKHENRTLEVNFCSEIDAFYQYRTPLE
RILTNLLDNALKFSNVGSRIDINISENKDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLYIANEL
AQQNNAKISVSSDIDVGTTMTVTLHKLDITS
>Mature_351_residues
MVLSIRSQIIIGVVSSILLTSTILAIAYILMWFNGHMTLTLTLTTIITSCLTLLICSIFINPLIQKIKQFNIKTKQFANG
NYASNDKTFNSPKEIYELNQSFNKMASEITQQMNQIKSEQQEKTELIQNLAHDLKTPLASIISYSEGLRDGIITKDHEIK
ESYDILIKQANRLSTLFDDMTHIITLNTGKTYPPELIQLDQLLVSILQPYEQRIKHENRTLEVNFCSEIDAFYQYRTPLE
RILTNLLDNALKFSNVGSRIDINISENKDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLYIANEL
AQQNNAKISVSSDIDVGTTMTVTLHKLDITS

Specific function: Member of the two-component regulatory system saeR/saeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a membrane- associated protein kinase that upon sensing the appropriate signal, aut

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=283, Percent_Identity=26.8551236749117, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790346, Length=270, Percent_Identity=27.037037037037, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786783, Length=325, Percent_Identity=23.3846153846154, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI48994928, Length=254, Percent_Identity=26.3779527559055, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787894, Length=273, Percent_Identity=26.3736263736264, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786600, Length=252, Percent_Identity=24.2063492063492, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1789149, Length=266, Percent_Identity=25.9398496240602, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788713, Length=228, Percent_Identity=23.6842105263158, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=269, Percent_Identity=25.6505576208178, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081816, Length=241, Percent_Identity=24.896265560166, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1787374, Length=260, Percent_Identity=25.7692307692308, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1789808, Length=256, Percent_Identity=23.4375, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI145693157, Length=259, Percent_Identity=26.2548262548263, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI87082128, Length=292, Percent_Identity=23.2876712328767, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1786912, Length=255, Percent_Identity=25.4901960784314, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 39714; Mature: 39714

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLSIRSQIIIGVVSSILLTSTILAIAYILMWFNGHMTLTLTLTTIITSCLTLLICSIFI
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHH
NPLIQKIKQFNIKTKQFANGNYASNDKTFNSPKEIYELNQSFNKMASEITQQMNQIKSEQ
HHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEKTELIQNLAHDLKTPLASIISYSEGLRDGIITKDHEIKESYDILIKQANRLSTLFDDM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
THIITLNTGKTYPPELIQLDQLLVSILQPYEQRIKHENRTLEVNFCSEIDAFYQYRTPLE
HHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCHHH
RILTNLLDNALKFSNVGSRIDINISENKDQDTIDIAISDEGIGIIPELQERIFERTFRVE
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCC
NSRNTKTGGSGLGLYIANELAQQNNAKISVSSDIDVGTTMTVTLHKLDITS
CCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEEEECCC
>Mature Secondary Structure
MVLSIRSQIIIGVVSSILLTSTILAIAYILMWFNGHMTLTLTLTTIITSCLTLLICSIFI
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHH
NPLIQKIKQFNIKTKQFANGNYASNDKTFNSPKEIYELNQSFNKMASEITQQMNQIKSEQ
HHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEKTELIQNLAHDLKTPLASIISYSEGLRDGIITKDHEIKESYDILIKQANRLSTLFDDM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
THIITLNTGKTYPPELIQLDQLLVSILQPYEQRIKHENRTLEVNFCSEIDAFYQYRTPLE
HHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCHHH
RILTNLLDNALKFSNVGSRIDINISENKDQDTIDIAISDEGIGIIPELQERIFERTFRVE
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCC
NSRNTKTGGSGLGLYIANELAQQNNAKISVSSDIDVGTTMTVTLHKLDITS
CCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA