Definition Staphylococcus aureus subsp. aureus N315, complete genome.
Accession NC_002745
Length 2,814,816

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The map label for this gene is mnhA2

Identifier: 15926299

GI number: 15926299

Start: 669975

End: 672377

Strand: Direct

Name: mnhA2

Synonym: SA0578

Alternate gene names: 15926299

Gene position: 669975-672377 (Clockwise)

Preceding gene: 15926298

Following gene: 15926300

Centisome position: 23.8

GC content: 31.96

Gene sequence:

>2403_bases
ATGAGTTTGGTTTATTTATTAATTGCTATACTTGTGATTATGGCGATGATACTTCTAATGTCTAAACGTAGAGCATTGGC
TAAATATGCCGGGTACATAGCGTTGGTTGCACCTGTAATTTCATCTATCTATTTTTTGATTCAAATACCATCAGTAGCTA
AACTGCAATATCTTTCTACCTCTATTCCATGGATTAAGACATTAGATATTAATTTAGATTTACGTTTAGATGGTTTAAGT
TTAATGTTTTCTCTTATTATTTCACTTATTGGAATTGCAGTATTCTTCTATGCAACTCAATATTTATCCTCTCGAAAAGA
CAATTTACCAAGGTTTTATTTTTATTTAACGTTATTTATGTTCAGTATGATTGGTATTGTATTATCAGACAATACGATAT
TGATGTACATTTTTTGGGAATTAACGAGTGTATCATCATTTTTATTGATTTCATATTGGTATAACAATGGTGACAGTCAA
TTTGGTGCGATTCAATCATTTATGATTACAGTATTTGGTGGATTGGCGTTATTAGTTGGTTTTATTATGCTGTATATCAT
GACAGGAACGAATAATATCACTGACATATTAGGACAAGCAGATCATATTAAGAATCATGGATTGTTTATCCCTATGATTT
TTATGTTTTTATTAGGTGCATTTACAAAATCAGCACAATTTCCATTTCATATTTGGCTACCTAGAGCAATGGCTGCACCT
ACACCTGTAAGTGCTTATTTACATTCAGCCACGATGGTAAAAGCTGGTATCTTTTTATTACTTCGATTTACACCATTATT
AGGTCTTAGCAATATGTACATATATATCGTCACGTTTGTTGGTTTAATAACAATGTTATTTGGTTCAATCACAGCTTTAA
AACAATGGGATTTAAAAGGAATCCTAGCATATTCAACAATCAGTCAACTAGGAATGATTATGGCAATGGTCGGTATCGGT
GGTGGATATGCTCAACACCAACAAGACGCAATAGCATCTATTTATGTATTTGTATTATTTGGTGCGCTATTTCATCTAAT
GAATCATGCCATCTTTAAATGTGCGCTTTTCATGGGAGTAGGTATTTTAGATCATGAAGCAGGTTCAAGGGATATACGAA
TTTTAAGTGGAATGCGTCAACTATTTCCTAAAATGAATCTAGTCATGACGATAGCGGCTCTATCTATGGCTGGAGTACCA
TTTTTAAATGGATTTTTAAGTAAAGAAATGTTTTTAGATGCATTAACACAAACTGGACAATTATCCCAATTTAGTTTGAT
TTCAATGATAGCTATCGTGTTTGTTGGTGTTATTGCTAGTATTTTTACATTCACATATGCACTTTACATGGTTAAAGAAG
TATTTTGGACTAAATATGATTCTAAAGTGTTTACTAAAAAAAATATCCACGAACCATGGTTGTTTAGTTTACCCTCTCTT
ATATTAATGGTGCTAGTACCTGTAATCTTTTTTGTGCCAAATATATTTGGGAAGGGGATTATCGTTCCAGCATTAAGAGG
TGTATCAGGTGGTAATCATCAAATTGATCCATTGGCACCACATGTTTCGCAATGGCATGGATTTAACATACCGCTTCTTT
TAACCATCATCATTATTTTATTGGGTAGTGTACTAGCAATCAAAGTAGATTGGAAAAAAGTGTTCACAGGTAAAATTAGA
CAGATTTCAGTTTCAAAAGGGTATGAGATGGTATATCGACATTTTGAAAAGTTTGCTACGAAGCGATTTAAACGTGTTAT
GCAAGATCGTTTAAACCAATACATTATTATGACCTTAGGCATATTTATGATTATCATTGGATATGGTTATATTCGAATTG
GACTTCCTAAAGTACATCAGTTACATGTTTCTGAATTTGGGGCATTAGAAATTATATTAGCAATCGTAACTGTCACAATT
GGTATTTCTTTAATTTTTATACGTCAACGACTGACAATGGTCATTTTAAATGGAGTCATCGGATTTGTTGTGACCTTATT
CTTTATAGCAATGAAAGCCCCTGATTTAGCATTGACTCAGCTAGTAGTTGAAACAATAACGACGATACTATTTATTGTCA
GTTTTTCAAGATTACCAAACGTACCAAGATCTAACGCTAACAAAAAAAGAGAAATAATTAAAATTTCTGTATCACTCTTG
ATGGCACTTATTGTTGTATCATTAATTTTTATTACACAACAAACAGATGGTTTATCATCAATATCAGACTTTTATTTAAA
AGCTGACAAACTAACAGGTGGTAAAAATATTGTAAATGCGATACTTGGTGACTTTAGAGCATTAGATACATTATTTGAAG
GATTAGTGTTAATTATTACTGGGCTAGGTATTTACACATTATTAAATTATCAAGATCGGAGGGGACAAGATGAAAGAGAA
TGA

Upstream 100 bases:

>100_bases
TCAATCTGCTATTGAAACACTAAATTTTATCGGTTTAGAAAATGAGTGTGAACATAGTATTTATATTTCATTACAATTAT
AGAAACAAAGGAGGCTAATA

Downstream 100 bases:

>100_bases
TGTCGTGTTAAGAACGGTCACGAAACTTGTTGTATTTATTTTATTGACTTTCGGATTCTATGTCTTCTTCGCAGGTCATA
ATAATCCTGGTGGTGGCTTT

Product: putative monovalent cation/H+ antiporter subunit A

Products: NAD+; ubiquinol

Alternate protein names: Mrp complex subunit A2; Putative NADH-ubiquinone oxidoreductase subunit mnhA2

Number of amino acids: Translated: 800; Mature: 799

Protein sequence:

>800_residues
MSLVYLLIAILVIMAMILLMSKRRALAKYAGYIALVAPVISSIYFLIQIPSVAKLQYLSTSIPWIKTLDINLDLRLDGLS
LMFSLIISLIGIAVFFYATQYLSSRKDNLPRFYFYLTLFMFSMIGIVLSDNTILMYIFWELTSVSSFLLISYWYNNGDSQ
FGAIQSFMITVFGGLALLVGFIMLYIMTGTNNITDILGQADHIKNHGLFIPMIFMFLLGAFTKSAQFPFHIWLPRAMAAP
TPVSAYLHSATMVKAGIFLLLRFTPLLGLSNMYIYIVTFVGLITMLFGSITALKQWDLKGILAYSTISQLGMIMAMVGIG
GGYAQHQQDAIASIYVFVLFGALFHLMNHAIFKCALFMGVGILDHEAGSRDIRILSGMRQLFPKMNLVMTIAALSMAGVP
FLNGFLSKEMFLDALTQTGQLSQFSLISMIAIVFVGVIASIFTFTYALYMVKEVFWTKYDSKVFTKKNIHEPWLFSLPSL
ILMVLVPVIFFVPNIFGKGIIVPALRGVSGGNHQIDPLAPHVSQWHGFNIPLLLTIIIILLGSVLAIKVDWKKVFTGKIR
QISVSKGYEMVYRHFEKFATKRFKRVMQDRLNQYIIMTLGIFMIIIGYGYIRIGLPKVHQLHVSEFGALEIILAIVTVTI
GISLIFIRQRLTMVILNGVIGFVVTLFFIAMKAPDLALTQLVVETITTILFIVSFSRLPNVPRSNANKKREIIKISVSLL
MALIVVSLIFITQQTDGLSSISDFYLKADKLTGGKNIVNAILGDFRALDTLFEGLVLIITGLGIYTLLNYQDRRGQDERE

Sequences:

>Translated_800_residues
MSLVYLLIAILVIMAMILLMSKRRALAKYAGYIALVAPVISSIYFLIQIPSVAKLQYLSTSIPWIKTLDINLDLRLDGLS
LMFSLIISLIGIAVFFYATQYLSSRKDNLPRFYFYLTLFMFSMIGIVLSDNTILMYIFWELTSVSSFLLISYWYNNGDSQ
FGAIQSFMITVFGGLALLVGFIMLYIMTGTNNITDILGQADHIKNHGLFIPMIFMFLLGAFTKSAQFPFHIWLPRAMAAP
TPVSAYLHSATMVKAGIFLLLRFTPLLGLSNMYIYIVTFVGLITMLFGSITALKQWDLKGILAYSTISQLGMIMAMVGIG
GGYAQHQQDAIASIYVFVLFGALFHLMNHAIFKCALFMGVGILDHEAGSRDIRILSGMRQLFPKMNLVMTIAALSMAGVP
FLNGFLSKEMFLDALTQTGQLSQFSLISMIAIVFVGVIASIFTFTYALYMVKEVFWTKYDSKVFTKKNIHEPWLFSLPSL
ILMVLVPVIFFVPNIFGKGIIVPALRGVSGGNHQIDPLAPHVSQWHGFNIPLLLTIIIILLGSVLAIKVDWKKVFTGKIR
QISVSKGYEMVYRHFEKFATKRFKRVMQDRLNQYIIMTLGIFMIIIGYGYIRIGLPKVHQLHVSEFGALEIILAIVTVTI
GISLIFIRQRLTMVILNGVIGFVVTLFFIAMKAPDLALTQLVVETITTILFIVSFSRLPNVPRSNANKKREIIKISVSLL
MALIVVSLIFITQQTDGLSSISDFYLKADKLTGGKNIVNAILGDFRALDTLFEGLVLIITGLGIYTLLNYQDRRGQDERE
>Mature_799_residues
SLVYLLIAILVIMAMILLMSKRRALAKYAGYIALVAPVISSIYFLIQIPSVAKLQYLSTSIPWIKTLDINLDLRLDGLSL
MFSLIISLIGIAVFFYATQYLSSRKDNLPRFYFYLTLFMFSMIGIVLSDNTILMYIFWELTSVSSFLLISYWYNNGDSQF
GAIQSFMITVFGGLALLVGFIMLYIMTGTNNITDILGQADHIKNHGLFIPMIFMFLLGAFTKSAQFPFHIWLPRAMAAPT
PVSAYLHSATMVKAGIFLLLRFTPLLGLSNMYIYIVTFVGLITMLFGSITALKQWDLKGILAYSTISQLGMIMAMVGIGG
GYAQHQQDAIASIYVFVLFGALFHLMNHAIFKCALFMGVGILDHEAGSRDIRILSGMRQLFPKMNLVMTIAALSMAGVPF
LNGFLSKEMFLDALTQTGQLSQFSLISMIAIVFVGVIASIFTFTYALYMVKEVFWTKYDSKVFTKKNIHEPWLFSLPSLI
LMVLVPVIFFVPNIFGKGIIVPALRGVSGGNHQIDPLAPHVSQWHGFNIPLLLTIIIILLGSVLAIKVDWKKVFTGKIRQ
ISVSKGYEMVYRHFEKFATKRFKRVMQDRLNQYIIMTLGIFMIIIGYGYIRIGLPKVHQLHVSEFGALEIILAIVTVTIG
ISLIFIRQRLTMVILNGVIGFVVTLFFIAMKAPDLALTQLVVETITTILFIVSFSRLPNVPRSNANKKREIIKISVSLLM
ALIVVSLIFITQQTDGLSSISDFYLKADKLTGGKNIVNAILGDFRALDTLFEGLVLIITGLGIYTLLNYQDRRGQDERE

Specific function: Ndh-1 Shuttles Electrons From NADH, Via Fmn And Iron- Sulfur (Fe-S) Centers, To Quinones In The Respiratory Chain. The Immediate Electron Acceptor For The Enzyme In This Species Is Believed To Be Ubiquinone. Couples The Redox Reaction To Proton Translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family

Homologues:

Organism=Homo sapiens, GI251831117, Length=360, Percent_Identity=35.5555555555556, Blast_Score=189, Evalue=8e-48,
Organism=Homo sapiens, GI251831116, Length=294, Percent_Identity=25.5102040816327, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1788614, Length=454, Percent_Identity=31.9383259911894, Blast_Score=202, Evalue=8e-53,
Organism=Escherichia coli, GI1788829, Length=411, Percent_Identity=30.4136253041363, Blast_Score=166, Evalue=8e-42,
Organism=Escherichia coli, GI1788831, Length=376, Percent_Identity=30.0531914893617, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1788827, Length=345, Percent_Identity=30.1449275362319, Blast_Score=123, Evalue=5e-29,
Organism=Escherichia coli, GI1788613, Length=440, Percent_Identity=24.5454545454545, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI145693160, Length=352, Percent_Identity=26.4204545454545, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI2367154, Length=395, Percent_Identity=25.8227848101266, Blast_Score=84, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MNHA2_STAA1 (A7WZ76)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001441209.1
- STRING:   A7WZ76
- EnsemblBacteria:   EBSTAT00000004965
- GeneID:   5560820
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_0619
- eggNOG:   COG1009
- GeneTree:   EBGT00050000024644
- HOGENOM:   HBG672487
- OMA:   NTILMYV
- ProtClustDB:   PRK12646
- BioCyc:   SAUR418127:SAHV_0619-MONOMER
- InterPro:   IPR001750
- InterPro:   IPR001516

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N

EC number: 1.6.5.3

Molecular weight: Translated: 89611; Mature: 89480

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xc9c67e0)-; HASH(0xc630274)-; HASH(0xd154f94)-; HASH(0xd080294)-; HASH(0xc5b372c)-; HASH(0xd2fb8d4)-; HASH(0xc5a3e98)-; HASH(0xcf4ef88)-; HASH(0xd2fb700)-; HASH(0xcceb244)-; HASH(0xd290cf8)-; HASH(0xbdc7898)-; HASH(0xc362ab4)-; HASH(0xd33517c)-; HASH(0xc8be58c)-; HASH(0xd2f485c)-; HASH(0xd30f24c)-; HASH(0xd440934)-; HASH(0xd32d808)-; HASH(0xd316058)-;

Cys/Met content:

0.1 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVYLLIAILVIMAMILLMSKRRALAKYAGYIALVAPVISSIYFLIQIPSVAKLQYLST
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
SIPWIKTLDINLDLRLDGLSLMFSLIISLIGIAVFFYATQYLSSRKDNLPRFYFYLTLFM
CCCEEEEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
FSMIGIVLSDNTILMYIFWELTSVSSFLLISYWYNNGDSQFGAIQSFMITVFGGLALLVG
HHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
FIMLYIMTGTNNITDILGQADHIKNHGLFIPMIFMFLLGAFTKSAQFPFHIWLPRAMAAP
HHHHHHHCCCCHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHCCC
TPVSAYLHSATMVKAGIFLLLRFTPLLGLSNMYIYIVTFVGLITMLFGSITALKQWDLKG
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
ILAYSTISQLGMIMAMVGIGGGYAQHQQDAIASIYVFVLFGALFHLMNHAIFKCALFMGV
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GILDHEAGSRDIRILSGMRQLFPKMNLVMTIAALSMAGVPFLNGFLSKEMFLDALTQTGQ
CCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
LSQFSLISMIAIVFVGVIASIFTFTYALYMVKEVFWTKYDSKVFTKKNIHEPWLFSLPSL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHH
ILMVLVPVIFFVPNIFGKGIIVPALRGVSGGNHQIDPLAPHVSQWHGFNIPLLLTIIIIL
HHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHH
LGSVLAIKVDWKKVFTGKIRQISVSKGYEMVYRHFEKFATKRFKRVMQDRLNQYIIMTLG
HCCHHEEEEHHHHHHCCHHHEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFMIIIGYGYIRIGLPKVHQLHVSEFGALEIILAIVTVTIGISLIFIRQRLTMVILNGVI
HHHHHHHCCHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFVVTLFFIAMKAPDLALTQLVVETITTILFIVSFSRLPNVPRSNANKKREIIKISVSLL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
MALIVVSLIFITQQTDGLSSISDFYLKADKLTGGKNIVNAILGDFRALDTLFEGLVLIIT
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGIYTLLNYQDRRGQDERE
HHHHHHHHCCHHCCCCCCCH
>Mature Secondary Structure 
SLVYLLIAILVIMAMILLMSKRRALAKYAGYIALVAPVISSIYFLIQIPSVAKLQYLST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
SIPWIKTLDINLDLRLDGLSLMFSLIISLIGIAVFFYATQYLSSRKDNLPRFYFYLTLFM
CCCEEEEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
FSMIGIVLSDNTILMYIFWELTSVSSFLLISYWYNNGDSQFGAIQSFMITVFGGLALLVG
HHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
FIMLYIMTGTNNITDILGQADHIKNHGLFIPMIFMFLLGAFTKSAQFPFHIWLPRAMAAP
HHHHHHHCCCCHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHCCC
TPVSAYLHSATMVKAGIFLLLRFTPLLGLSNMYIYIVTFVGLITMLFGSITALKQWDLKG
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
ILAYSTISQLGMIMAMVGIGGGYAQHQQDAIASIYVFVLFGALFHLMNHAIFKCALFMGV
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GILDHEAGSRDIRILSGMRQLFPKMNLVMTIAALSMAGVPFLNGFLSKEMFLDALTQTGQ
CCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
LSQFSLISMIAIVFVGVIASIFTFTYALYMVKEVFWTKYDSKVFTKKNIHEPWLFSLPSL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHH
ILMVLVPVIFFVPNIFGKGIIVPALRGVSGGNHQIDPLAPHVSQWHGFNIPLLLTIIIIL
HHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHH
LGSVLAIKVDWKKVFTGKIRQISVSKGYEMVYRHFEKFATKRFKRVMQDRLNQYIIMTLG
HCCHHEEEEHHHHHHCCHHHEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFMIIIGYGYIRIGLPKVHQLHVSEFGALEIILAIVTVTIGISLIFIRQRLTMVILNGVI
HHHHHHHCCHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFVVTLFFIAMKAPDLALTQLVVETITTILFIVSFSRLPNVPRSNANKKREIIKISVSLL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
MALIVVSLIFITQQTDGLSSISDFYLKADKLTGGKNIVNAILGDFRALDTLFEGLVLIIT
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGIYTLLNYQDRRGQDERE
HHHHHHHHCCHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA