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The map label for this gene is cysK

Identifier: 15926190

GI number: 15926190

Start: 544265

End: 545197

Strand: Direct

Name: cysK

Synonym: SA0471

Alternate gene names: 15926190

Gene position: 544265-545197 (Clockwise)

Preceding gene: 15926189

Following gene: 15926191

Centisome position: 19.34

GC content: 38.05

Gene sequence:

>933_bases
ATGGCACAAAAACCAGTAGATAATATTACTCAAATTATTGGCGGTACACCGGTAGTCAAATTGAGAAATGTAGTAGATGA
CAATGCAGCAGATGTTTATGTAAAATTGGAATATCAAAATCCAGGTGGTTCTGTAAAGGATAGAATTGCTTTAGCAATGA
TTGAAAAAGCAGAGCGAGAAGGCAAAATTAAACCTGGCGACACAATTGTAGAACCAACAAGTGGTAATACAGGTATCGGT
TTAGCATTTGTATGTGCTGCTAAAGGATATAAAGCAGTATTTACTATGCCCGAAACAATGAGCCAAGAGCGTCGTAATTT
ATTAAAAGCATACGGTGCGGAATTAGTTTTAACGCCTGGATCAGAAGCGATGAAAGGTGCAATTAAAAAAGCTAAAGAAT
TAAAAGAAGAACATGGTTACTTCGAGCCACAACAATTTGAAAACCCTGCGAACCCTGAAGTTCATGAGTTAACTACAGGT
CCTGAGTTATTACAACAATTTGAAGGGAAAACTATCGATGCGTTCCTAGCTGGTGTTGGTACTGGTGGTACGTTATCTGG
TGTAGGTAAAGTTCTGAAAAAAGAATATCCTAACATCGAAATTGTTGCTATAGAGCCTGAGGCTTCTCCAGTATTGAGCG
GTGGTGAGCCAGGTCCACATAAATTACAAGGTTTAGGTGCTGGATTTATTCCAGGCACTTTGAATACAGAAATCTATGAC
AGTATTATTAAAGTAGGAAATGATACAGCGATGGAAATGTCTCGTCGAGTTGCTAAAGAGGAAGGTATTTTAGCAGGTAT
TTCATCAGGTGCTGCGATTTATGCTGCCATTCAAAAAGCAAAAGAATTAGGAAAAGGTAAAACAGTAGTAACAGTATTGC
CGAGTAATGGTGAACGCTACTTATCAACACCTTTATATTCATTCGATGACTAA

Upstream 100 bases:

>100_bases
TAGTGATTTTGTTTGCTTTCTAGAATTTATTTGATAAAATAATTCTATATCCGATAAATAAACTAAGATTTCAACAACTA
ACTAAAAAGGAGTGTTCTTA

Downstream 100 bases:

>100_bases
TTAATGTCATTTAAAAGAGTGAGTTATCTTTTTGAGATAACTTGCTCTTTTTTTCTACCATGTATAATTTTAAAAATATG
AGCGTTAAATTAAACATTTT

Product: hypothetical protein

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MAQKPVDNITQIIGGTPVVKLRNVVDDNAADVYVKLEYQNPGGSVKDRIALAMIEKAEREGKIKPGDTIVEPTSGNTGIG
LAFVCAAKGYKAVFTMPETMSQERRNLLKAYGAELVLTPGSEAMKGAIKKAKELKEEHGYFEPQQFENPANPEVHELTTG
PELLQQFEGKTIDAFLAGVGTGGTLSGVGKVLKKEYPNIEIVAIEPEASPVLSGGEPGPHKLQGLGAGFIPGTLNTEIYD
SIIKVGNDTAMEMSRRVAKEEGILAGISSGAAIYAAIQKAKELGKGKTVVTVLPSNGERYLSTPLYSFDD

Sequences:

>Translated_310_residues
MAQKPVDNITQIIGGTPVVKLRNVVDDNAADVYVKLEYQNPGGSVKDRIALAMIEKAEREGKIKPGDTIVEPTSGNTGIG
LAFVCAAKGYKAVFTMPETMSQERRNLLKAYGAELVLTPGSEAMKGAIKKAKELKEEHGYFEPQQFENPANPEVHELTTG
PELLQQFEGKTIDAFLAGVGTGGTLSGVGKVLKKEYPNIEIVAIEPEASPVLSGGEPGPHKLQGLGAGFIPGTLNTEIYD
SIIKVGNDTAMEMSRRVAKEEGILAGISSGAAIYAAIQKAKELGKGKTVVTVLPSNGERYLSTPLYSFDD
>Mature_309_residues
AQKPVDNITQIIGGTPVVKLRNVVDDNAADVYVKLEYQNPGGSVKDRIALAMIEKAEREGKIKPGDTIVEPTSGNTGIGL
AFVCAAKGYKAVFTMPETMSQERRNLLKAYGAELVLTPGSEAMKGAIKKAKELKEEHGYFEPQQFENPANPEVHELTTGP
ELLQQFEGKTIDAFLAGVGTGGTLSGVGKVLKKEYPNIEIVAIEPEASPVLSGGEPGPHKLQGLGAGFIPGTLNTEIYDS
IIKVGNDTAMEMSRRVAKEEGILAGISSGAAIYAAIQKAKELGKGKTVVTVLPSNGERYLSTPLYSFDD

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family

Homologues:

Organism=Homo sapiens, GI295821202, Length=313, Percent_Identity=38.9776357827476, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI295821200, Length=313, Percent_Identity=38.9776357827476, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI4557415, Length=313, Percent_Identity=38.9776357827476, Blast_Score=223, Evalue=2e-58,
Organism=Escherichia coli, GI1788754, Length=306, Percent_Identity=52.6143790849673, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI2367138, Length=301, Percent_Identity=40.8637873754153, Blast_Score=231, Evalue=6e-62,
Organism=Caenorhabditis elegans, GI115535073, Length=304, Percent_Identity=52.6315789473684, Blast_Score=288, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17535051, Length=301, Percent_Identity=49.5016611295681, Blast_Score=286, Evalue=9e-78,
Organism=Caenorhabditis elegans, GI17562970, Length=301, Percent_Identity=49.5016611295681, Blast_Score=278, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI32566674, Length=295, Percent_Identity=49.4915254237288, Blast_Score=271, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17561720, Length=298, Percent_Identity=46.9798657718121, Blast_Score=237, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI32566672, Length=217, Percent_Identity=48.8479262672811, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17534315, Length=313, Percent_Identity=39.6166134185303, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI25147552, Length=314, Percent_Identity=36.624203821656, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17561716, Length=119, Percent_Identity=44.5378151260504, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71996324, Length=313, Percent_Identity=27.1565495207668, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17539800, Length=336, Percent_Identity=25, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=314, Percent_Identity=37.8980891719745, Blast_Score=200, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6321449, Length=333, Percent_Identity=34.8348348348348, Blast_Score=152, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24643623, Length=311, Percent_Identity=39.871382636656, Blast_Score=215, Evalue=3e-56,
Organism=Drosophila melanogaster, GI20129101, Length=311, Percent_Identity=39.871382636656, Blast_Score=215, Evalue=3e-56,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): CYSK_STAAC (Q5HIG2)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_185445.1
- ProteinModelPortal:   Q5HIG2
- SMR:   Q5HIG2
- STRING:   Q5HIG2
- EnsemblBacteria:   EBSTAT00000010959
- GeneID:   3237125
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL0557
- TIGR:   SACOL0557
- eggNOG:   COG0031
- GeneTree:   EBGT00050000024422
- HOGENOM:   HBG748215
- OMA:   SAGANIH
- ProtClustDB:   CLSK884704
- BioCyc:   SAUR93062:SACOL0557-MONOMER
- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926
- TIGRFAMs:   TIGR01139
- TIGRFAMs:   TIGR01136

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =2.5.1.47

Molecular weight: Translated: 32976; Mature: 32845

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: BINDING 76-76 BINDING 268-268

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQKPVDNITQIIGGTPVVKLRNVVDDNAADVYVKLEYQNPGGSVKDRIALAMIEKAERE
CCCCCHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHC
GKIKPGDTIVEPTSGNTGIGLAFVCAAKGYKAVFTMPETMSQERRNLLKAYGAELVLTPG
CCCCCCCEEECCCCCCCCCHHHEEECCCCCEEEEECHHHHHHHHHHHHHHCCCEEEECCC
SEAMKGAIKKAKELKEEHGYFEPQQFENPANPEVHELTTGPELLQQFEGKTIDAFLAGVG
HHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHCCCCCHHHHHHHCCCEEEHHHHCCC
TGGTLSGVGKVLKKEYPNIEIVAIEPEASPVLSGGEPGPHKLQGLGAGFIPGTLNTEIYD
CCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHH
SIIKVGNDTAMEMSRRVAKEEGILAGISSGAAIYAAIQKAKELGKGKTVVTVLPSNGERY
HHHHCCCCHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEE
LSTPLYSFDD
ECCCCCCCCC
>Mature Secondary Structure 
AQKPVDNITQIIGGTPVVKLRNVVDDNAADVYVKLEYQNPGGSVKDRIALAMIEKAERE
CCCCHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHC
GKIKPGDTIVEPTSGNTGIGLAFVCAAKGYKAVFTMPETMSQERRNLLKAYGAELVLTPG
CCCCCCCEEECCCCCCCCCHHHEEECCCCCEEEEECHHHHHHHHHHHHHHCCCEEEECCC
SEAMKGAIKKAKELKEEHGYFEPQQFENPANPEVHELTTGPELLQQFEGKTIDAFLAGVG
HHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHCCCCCHHHHHHHCCCEEEHHHHCCC
TGGTLSGVGKVLKKEYPNIEIVAIEPEASPVLSGGEPGPHKLQGLGAGFIPGTLNTEIYD
CCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHH
SIIKVGNDTAMEMSRRVAKEEGILAGISSGAAIYAAIQKAKELGKGKTVVTVLPSNGERY
HHHHCCCCHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEE
LSTPLYSFDD
ECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA