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The map label for this gene is pth

Identifier: 15926179

GI number: 15926179

Start: 530645

End: 531217

Strand: Direct

Name: pth

Synonym: SA0460

Alternate gene names: 15926179

Gene position: 530645-531217 (Clockwise)

Preceding gene: 15926178

Following gene: 15926180

Centisome position: 18.85

GC content: 32.81

Gene sequence:

>573_bases
ATGAAATGTATTGTAGGTCTAGGTAATATAGGTAAACGTTTTGAACTTACAAGACATAATATCGGCTTTGAAGTCGTTGA
TTATATTTTAGAGAAAAATAATTTTTCATTAGATAAACAAAAGTTTAAAGGTGCATATACAATTGAACGAATGAACGGAG
ATAAAGTGTTATTTATCGAACCAATGACAATGATGAATTTGTCAGGAGAAGCAGTTGCACCGATTATGGATTATTACAAT
GTTAATCCAGAAGATTTAATTGTCTTATATGATGATTTAGATTTAGAACAAGGACAAGTTCGCTTAAGACAAAAAGGAAG
TGCGGGCGGTCACAATGGTATGAAATCAATTATTAAAATGCTTGGTACAGACCAATTTAAACGTATTCGTATTGGTGTGG
GAAGACCAACGAATGGTATGACGGTACCTGATTATGTTTTACAACGCTTTTCAAATGATGAAATGGTAACGATGGAAAAA
GTTATCGAACACGCAGCACGCGCAATTGAAAAGTTTGTTGAAACATCACGATTTGACCATGTTATGAATGAATTTAATGG
TGAAGTGAAATAA

Upstream 100 bases:

>100_bases
CTTACTAAGCTAAAGAATAATGATAATTGATGGCAATGGCGGAAAATAGATGTTGTCATTATAATAATAAATGAAACAAT
TATGTTGGAGGTAAACACGC

Downstream 100 bases:

>100_bases
TGACAATATTGACAACGCTTATAAAAGAAGATAATCATTTTCAAGACCTTAATCAGGTATTTGGACAAGCAAACACACTA
GTAACTGGTCTTTCCCCGTC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIEPMTMMNLSGEAVAPIMDYYN
VNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKMLGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEK
VIEHAARAIEKFVETSRFDHVMNEFNGEVK

Sequences:

>Translated_190_residues
MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIEPMTMMNLSGEAVAPIMDYYN
VNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKMLGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEK
VIEHAARAIEKFVETSRFDHVMNEFNGEVK
>Mature_190_residues
MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIEPMTMMNLSGEAVAPIMDYYN
VNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKMLGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEK
VIEHAARAIEKFVETSRFDHVMNEFNGEVK

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=189, Percent_Identity=26.4550264550265, Blast_Score=88, Evalue=5e-18,
Organism=Escherichia coli, GI1787455, Length=174, Percent_Identity=37.9310344827586, Blast_Score=106, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6321983, Length=188, Percent_Identity=29.7872340425532, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_STAA1 (A7WYQ5)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001441089.1
- ProteinModelPortal:   A7WYQ5
- SMR:   A7WYQ5
- STRING:   A7WYQ5
- EnsemblBacteria:   EBSTAT00000003349
- GeneID:   5559965
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_0499
- eggNOG:   COG0193
- GeneTree:   EBGT00050000023899
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- ProtClustDB:   PRK05426
- BioCyc:   SAUR418127:SAHV_0499-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21703; Mature: 21703

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
6.3 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
6.3 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIE
CEEEEECCCCCCCEEEHHHCCCHHHHHHHHHCCCCCCCHHHCCCEEEEEEECCCEEEEEC
PMTMMNLSGEAVAPIMDYYNVNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKM
CHHHCCCCCCHHHHHHHHCCCCHHHEEEEEECCCCCCCHHHHHHCCCCCCCHHHHHHHHH
LGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEKVIEHAARAIEKFVETSRFDH
HCCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
VMNEFNGEVK
HHHHCCCCCC
>Mature Secondary Structure
MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIE
CEEEEECCCCCCCEEEHHHCCCHHHHHHHHHCCCCCCCHHHCCCEEEEEEECCCEEEEEC
PMTMMNLSGEAVAPIMDYYNVNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKM
CHHHCCCCCCHHHHHHHHCCCCHHHEEEEEECCCCCCCHHHHHHCCCCCCCHHHHHHHHH
LGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEKVIEHAARAIEKFVETSRFDH
HCCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
VMNEFNGEVK
HHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA