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The map label for this gene is tmk

Identifier: 15926159

GI number: 15926159

Start: 513540

End: 514157

Strand: Direct

Name: tmk

Synonym: SA0440

Alternate gene names: 15926159

Gene position: 513540-514157 (Clockwise)

Preceding gene: 15926158

Following gene: 15926160

Centisome position: 18.24

GC content: 33.01

Gene sequence:

>618_bases
ATGTCAGCTTTTATAACTTTTGAGGGCCCAGAAGGCTCTGGAAAAACAACTGTAATTAATGAAGTTTACCATAGATTAGT
AAAAGATTATGATGTCATTATGACTAGAGAACCAGGTGGTGTTCCTACTGGTGAAGAAATACGTAAAATTGTATTAGAAG
GCAATGATATGGACATTAGAACTGAAGCAATGTTATTTGCTGCATCTAGAAGAGAACATCTTGTATTAAAGGTCATACCA
GCTTTAAAAGAAGGTAAGGTTGTGTTGTGTGATCGCTATATCGATAGTTCATTAGCTTATCAAGGTTATGCTAGAGGGAT
TGGCGTTGAAGAAGTAAGAGCATTAAACGAATTTGCAATAAATGGATTATATCCAGACTTGACGATTTATTTAAATGTTA
GTGCTGAAGTAGGTCGCGAACGTATTATTAAAAATTCAAGAGATCAAAATAGATTAGATCAAGAAGATTTAAAGTTTCAC
GAAAAAGTAATTGAAGGTTACCAAGAAATCATTCATAATGAATCACAACGGTTCAAAAGCGTTAATGCAGATCAACCTCT
TGAAAATGTTGTTGAAGACACGTATCAAACTATCATCAAATATTTAGAAAAGATATGA

Upstream 100 bases:

>100_bases
ATAACTGAAAATATGATAGAATTGGTAAATGAATATCTGGAAACTGGAATGATAGTTGAAGGAATTAAAAATAATAAAAT
TTTAGTTGAGGATGAATAAA

Downstream 100 bases:

>100_bases
TATAATTGTTAGAAGAGGTGTTATAAAATGAAAATGATTATAGCGATCGTACAAGATCAAGATAGTCAGGAACTTGCAGA
TCAACTTGTTAAAAATAACT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 205; Mature: 204

Protein sequence:

>205_residues
MSAFITFEGPEGSGKTTVINEVYHRLVKDYDVIMTREPGGVPTGEEIRKIVLEGNDMDIRTEAMLFAASRREHLVLKVIP
ALKEGKVVLCDRYIDSSLAYQGYARGIGVEEVRALNEFAINGLYPDLTIYLNVSAEVGRERIIKNSRDQNRLDQEDLKFH
EKVIEGYQEIIHNESQRFKSVNADQPLENVVEDTYQTIIKYLEKI

Sequences:

>Translated_205_residues
MSAFITFEGPEGSGKTTVINEVYHRLVKDYDVIMTREPGGVPTGEEIRKIVLEGNDMDIRTEAMLFAASRREHLVLKVIP
ALKEGKVVLCDRYIDSSLAYQGYARGIGVEEVRALNEFAINGLYPDLTIYLNVSAEVGRERIIKNSRDQNRLDQEDLKFH
EKVIEGYQEIIHNESQRFKSVNADQPLENVVEDTYQTIIKYLEKI
>Mature_204_residues
SAFITFEGPEGSGKTTVINEVYHRLVKDYDVIMTREPGGVPTGEEIRKIVLEGNDMDIRTEAMLFAASRREHLVLKVIPA
LKEGKVVLCDRYIDSSLAYQGYARGIGVEEVRALNEFAINGLYPDLTIYLNVSAEVGRERIIKNSRDQNRLDQEDLKFHE
KVIEGYQEIIHNESQRFKSVNADQPLENVVEDTYQTIIKYLEKI

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=211, Percent_Identity=32.7014218009479, Blast_Score=108, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_STAA1 (A7WYM2)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001441069.1
- ProteinModelPortal:   A7WYM2
- SMR:   A7WYM2
- STRING:   A7WYM2
- EnsemblBacteria:   EBSTAT00000004560
- GeneID:   5559827
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_0479
- eggNOG:   COG0125
- GeneTree:   EBGT00050000024821
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   PRK00698
- BioCyc:   SAUR418127:SAHV_0479-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23425; Mature: 23294

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAFITFEGPEGSGKTTVINEVYHRLVKDYDVIMTREPGGVPTGEEIRKIVLEGNDMDIR
CCEEEEEECCCCCCCHHHHHHHHHHHHHCHHEEEEECCCCCCCHHHHHHHHHCCCCCCHH
TEAMLFAASRREHLVLKVIPALKEGKVVLCDRYIDSSLAYQGYARGIGVEEVRALNEFAI
HHHHHHHHCCCCCCCEEEECCCCCCCEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHH
NGLYPDLTIYLNVSAEVGRERIIKNSRDQNRLDQEDLKFHEKVIEGYQEIIHNESQRFKS
CCCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHC
VNADQPLENVVEDTYQTIIKYLEKI
CCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SAFITFEGPEGSGKTTVINEVYHRLVKDYDVIMTREPGGVPTGEEIRKIVLEGNDMDIR
CEEEEEECCCCCCCHHHHHHHHHHHHHCHHEEEEECCCCCCCHHHHHHHHHCCCCCCHH
TEAMLFAASRREHLVLKVIPALKEGKVVLCDRYIDSSLAYQGYARGIGVEEVRALNEFAI
HHHHHHHHCCCCCCCEEEECCCCCCCEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHH
NGLYPDLTIYLNVSAEVGRERIIKNSRDQNRLDQEDLKFHEKVIEGYQEIIHNESQRFKS
CCCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHC
VNADQPLENVVEDTYQTIIKYLEKI
CCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA