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The map label for this gene is fdh

Identifier: 15925881

GI number: 15925881

Start: 193987

End: 195111

Strand: Direct

Name: fdh

Synonym: SA0171

Alternate gene names: 15925881

Gene position: 193987-195111 (Clockwise)

Preceding gene: 15925880

Following gene: 15925882

Centisome position: 6.89

GC content: 34.84

Gene sequence:

>1125_bases
ATGTCAAACGGTGCCGTTTTTTTTGTCATATTTTTAAAACAAGCAACATGCAACACGTACTTTAAGGAAGTCAAAATTTA
TCATTTAGGAGAGATGGATATGAAAATCGTAGCATTATTTCCAGAAGCAGTAGAAGGTCAAGAAAATCAATTACTTAATA
CTAAAAAAGCAATAGGATTAAAAACATTTTTAGAGGAAAGAGGACATGAGTTCATTATATTAGCAGATAATGGTGAAGAC
TTAGATAAACATTTACCAGATATGGATGTGATTATTAGTGCGCCATTTTATCCTGCATATATGACTCGTGAACGTATTGA
AAAAGCACCGAACTTGAAATTAGCAATTACAGCAGGTGTAGGATCTGACCATGTAGATTTAGCGGCAGCAAGTGAACACA
ATATTGGTGTCGTTGAAGTTACAGGAAGTAATACAGTTAGTGTGGCAGAACATGCGGTTATGGATTTATTAATACTTCTT
AGAAACTATGAAGAAGGTCATCGTCAATCAGTAGAAGGTGAATGGAACTTGTCTCAAGTAGGTAATCATGCGCATGAATT
ACAACACAAAACAATTGGTATTTTTGGATTTGGTCGAATTGGACAACTTGTTGCTGAAAGATTAGCGCCATTTAATGTAA
CATTACAACACTATGATCCAATCAATCAACAAGACCATAAATTGTCTAAATTTGTAAGCTTTGATGAACTTGTTTCATCA
AGTGATGCGATTACAATTCATGCACCATTAACACCAGAAACTGATAACTTATTTGATAAAGATGTTTTAAGTCGTATGAA
AAAACACAGTTATTTAGTGAATACTGCACGTGGTAAAATTGTAAATCGCGATGCGTTAGTTGAAGCGTTAGCATCCGAGC
ATTTACAAGGATATGCTGGTGATGTTTGGTATCCACAACCTGCACCTGCTGATCATCCATGGAGAACAATGCCTAGAAAT
GCTATGACGGTTCACTATTCAGGTATGACTTTAGAAGCACAAAAACGCATTGAAGATGGAGTTAAAGATATTTTAGAGCG
TTTCTTCAATCATGAACCTTTCCAAGATAAAGATATTATTGTTGCAAGTGGTCGTATTGCTAGTAAAAGTTATACAGCTA
AATAG

Upstream 100 bases:

>100_bases
TTGTTTTCGATAAGTCAATAGAATAAGTGTTGCTGGTGTAAGGTACACGGTGCTGTTTGCTAACTTCGCTTTGAATTTAA
CAATAATTCAAGGGGGTGGT

Downstream 100 bases:

>100_bases
AATAAGGATGCTGGGCTAGCGATTAACGCTTTCAATTTTATATAAATGAATCATATAAGCACTACTGCTGTTGTAAAGAT
GGCAGTAGTTTTTTTATGAT

Product: formate dehydrogenase

Products: NA

Alternate protein names: NAD-dependent formate dehydrogenase; FDH [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MSNGAVFFVIFLKQATCNTYFKEVKIYHLGEMDMKIVALFPEAVEGQENQLLNTKKAIGLKTFLEERGHEFIILADNGED
LDKHLPDMDVIISAPFYPAYMTRERIEKAPNLKLAITAGVGSDHVDLAAASEHNIGVVEVTGSNTVSVAEHAVMDLLILL
RNYEEGHRQSVEGEWNLSQVGNHAHELQHKTIGIFGFGRIGQLVAERLAPFNVTLQHYDPINQQDHKLSKFVSFDELVSS
SDAITIHAPLTPETDNLFDKDVLSRMKKHSYLVNTARGKIVNRDALVEALASEHLQGYAGDVWYPQPAPADHPWRTMPRN
AMTVHYSGMTLEAQKRIEDGVKDILERFFNHEPFQDKDIIVASGRIASKSYTAK

Sequences:

>Translated_374_residues
MSNGAVFFVIFLKQATCNTYFKEVKIYHLGEMDMKIVALFPEAVEGQENQLLNTKKAIGLKTFLEERGHEFIILADNGED
LDKHLPDMDVIISAPFYPAYMTRERIEKAPNLKLAITAGVGSDHVDLAAASEHNIGVVEVTGSNTVSVAEHAVMDLLILL
RNYEEGHRQSVEGEWNLSQVGNHAHELQHKTIGIFGFGRIGQLVAERLAPFNVTLQHYDPINQQDHKLSKFVSFDELVSS
SDAITIHAPLTPETDNLFDKDVLSRMKKHSYLVNTARGKIVNRDALVEALASEHLQGYAGDVWYPQPAPADHPWRTMPRN
AMTVHYSGMTLEAQKRIEDGVKDILERFFNHEPFQDKDIIVASGRIASKSYTAK
>Mature_373_residues
SNGAVFFVIFLKQATCNTYFKEVKIYHLGEMDMKIVALFPEAVEGQENQLLNTKKAIGLKTFLEERGHEFIILADNGEDL
DKHLPDMDVIISAPFYPAYMTRERIEKAPNLKLAITAGVGSDHVDLAAASEHNIGVVEVTGSNTVSVAEHAVMDLLILLR
NYEEGHRQSVEGEWNLSQVGNHAHELQHKTIGIFGFGRIGQLVAERLAPFNVTLQHYDPINQQDHKLSKFVSFDELVSSS
DAITIHAPLTPETDNLFDKDVLSRMKKHSYLVNTARGKIVNRDALVEALASEHLQGYAGDVWYPQPAPADHPWRTMPRNA
MTVHYSGMTLEAQKRIEDGVKDILERFFNHEPFQDKDIIVASGRIASKSYTAK

Specific function: Serine biosynthesis; first step. [C]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=225, Percent_Identity=34.6666666666667, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI23308577, Length=262, Percent_Identity=32.4427480916031, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI145580578, Length=265, Percent_Identity=28.6792452830189, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI4557499, Length=265, Percent_Identity=28.6792452830189, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI4557497, Length=279, Percent_Identity=27.5985663082437, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI61743967, Length=279, Percent_Identity=27.5985663082437, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI145580575, Length=260, Percent_Identity=29.2307692307692, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1789279, Length=243, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87082289, Length=237, Percent_Identity=28.2700421940928, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1787645, Length=185, Percent_Identity=31.3513513513514, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788660, Length=262, Percent_Identity=27.0992366412214, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87081824, Length=229, Percent_Identity=29.2576419213974, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=287, Percent_Identity=31.7073170731707, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI25147481, Length=218, Percent_Identity=28.8990825688073, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324964, Length=358, Percent_Identity=44.1340782122905, Blast_Score=303, Evalue=3e-83,
Organism=Saccharomyces cerevisiae, GI6324980, Length=214, Percent_Identity=41.588785046729, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6324979, Length=128, Percent_Identity=50, Blast_Score=135, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6320925, Length=304, Percent_Identity=28.2894736842105, Blast_Score=116, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6322116, Length=263, Percent_Identity=28.8973384030418, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=228, Percent_Identity=28.0701754385965, Blast_Score=102, Evalue=9e-23,
Organism=Drosophila melanogaster, GI19921140, Length=245, Percent_Identity=30.6122448979592, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28574286, Length=223, Percent_Identity=33.1838565022422, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28571528, Length=234, Percent_Identity=31.1965811965812, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24585516, Length=278, Percent_Identity=28.0575539568345, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI45552429, Length=211, Percent_Identity=33.175355450237, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28574284, Length=211, Percent_Identity=33.175355450237, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24585514, Length=211, Percent_Identity=33.175355450237, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI28574282, Length=211, Percent_Identity=33.175355450237, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI45551003, Length=218, Percent_Identity=33.0275229357798, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24646446, Length=278, Percent_Identity=26.978417266187, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24646448, Length=278, Percent_Identity=26.978417266187, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24646452, Length=278, Percent_Identity=26.978417266187, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24646450, Length=278, Percent_Identity=26.978417266187, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI62472511, Length=278, Percent_Identity=26.978417266187, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 41932; Mature: 41801

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNGAVFFVIFLKQATCNTYFKEVKIYHLGEMDMKIVALFPEAVEGQENQLLNTKKAIGL
CCCCEEEEEEEEEHHHHHHHHHHEEEEEECCCCEEEEEECCHHHCCCCHHHHHHHHHHHH
KTFLEERGHEFIILADNGEDLDKHLPDMDVIISAPFYPAYMTRERIEKAPNLKLAITAGV
HHHHHHCCCEEEEEECCCCCHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEEECC
GSDHVDLAAASEHNIGVVEVTGSNTVSVAEHAVMDLLILLRNYEEGHRQSVEGEWNLSQV
CCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHH
GNHAHELQHKTIGIFGFGRIGQLVAERLAPFNVTLQHYDPINQQDHKLSKFVSFDELVSS
CCHHHHHHHCEEEEEECHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCC
SDAITIHAPLTPETDNLFDKDVLSRMKKHSYLVNTARGKIVNRDALVEALASEHLQGYAG
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHEEEECCCCCEECHHHHHHHHHHHHHCCCCC
DVWYPQPAPADHPWRTMPRNAMTVHYSGMTLEAQKRIEDGVKDILERFFNHEPFQDKDII
CCCCCCCCCCCCCCCCCCCCEEEEEECCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
VASGRIASKSYTAK
EECCCEECCCCCCC
>Mature Secondary Structure 
SNGAVFFVIFLKQATCNTYFKEVKIYHLGEMDMKIVALFPEAVEGQENQLLNTKKAIGL
CCCEEEEEEEEEHHHHHHHHHHEEEEEECCCCEEEEEECCHHHCCCCHHHHHHHHHHHH
KTFLEERGHEFIILADNGEDLDKHLPDMDVIISAPFYPAYMTRERIEKAPNLKLAITAGV
HHHHHHCCCEEEEEECCCCCHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEEECC
GSDHVDLAAASEHNIGVVEVTGSNTVSVAEHAVMDLLILLRNYEEGHRQSVEGEWNLSQV
CCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHH
GNHAHELQHKTIGIFGFGRIGQLVAERLAPFNVTLQHYDPINQQDHKLSKFVSFDELVSS
CCHHHHHHHCEEEEEECHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCC
SDAITIHAPLTPETDNLFDKDVLSRMKKHSYLVNTARGKIVNRDALVEALASEHLQGYAG
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHEEEECCCCCEECHHHHHHHHHHHHHCCCCC
DVWYPQPAPADHPWRTMPRNAMTVHYSGMTLEAQKRIEDGVKDILERFFNHEPFQDKDII
CCCCCCCCCCCCCCCCCCCCEEEEEECCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
VASGRIASKSYTAK
EECCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1954846; 2357236; 1597184; 8484798 [H]